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GO-CAM-like Models Report — ZFIN

Model ID Title Date modified Contributors Pipeline result Result details Warnings 
5ee8120100001898
 Migrasome signaling involved in organ morphogenesis via cxcl12a, cxcr4b, tspan4a, tspan7 (D. rerio) 2026-07-14 Doug Howe, Sabrina Toro, Sridhar Ramachandran success
13 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: organelle localization [GO:0051640] (biological_process) —transports or maintains localization of→ migrasome [GO:0140494] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: determination of digestive tract left/right asymmetry [GO:0071907] (biological_process) —part of→ determination of left/right symmetry [GO:0007368] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: determination of liver left/right asymmetry [GO:0071910] (biological_process) —part of→ determination of left/right symmetry [GO:0007368] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: determination of intestine left/right asymmetry [GO:0071908] (biological_process) —part of→ determination of left/right symmetry [GO:0007368] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: determination of pancreatic left/right asymmetry [GO:0035469] (biological_process) —part of→ determination of left/right symmetry [GO:0007368] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: determination of heart left/right asymmetry [GO:0061371] (biological_process) —part of→ determination of left/right symmetry [GO:0007368] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: localization of cell [GO:0051674] (biological_process) —transports or maintains localization of→ forerunner cell group [ZFA:0000023] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of positive effect→ organelle assembly [GO:0070925] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: organelle localization [GO:0051640] (biological_process) —has target end location→ shield [ZFA:0000071] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: Kupffer's vesicle development [GO:0070121] (biological_process) —causally upstream of positive effect→ determination of left/right symmetry [GO:0007368] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within positive effect→ organelle assembly [GO:0070925] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: organelle assembly [GO:0070925] (biological_process) —RO:0002588→ migrasome [GO:0140494] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: organelle assembly [GO:0070925] (biological_process) —causally upstream of→ organelle localization [GO:0051640] (biological_process) 
5fb9cc0600000627
 Regulation of macrophage differntiation via irf2bp2b, cebpa, spi1b (D. rerio) 2026-07-14 Doug Howe, Sabrina Toro, Sridhar Ramachandran success 
5ae3b0f600000435
 Regulation of sprouting angiogenesis via dll4, egfl6, itgb1a (D. rerio) 2026-07-14 Doug Howe, Leyla Ruzicka, Sabrina Toro, Sridhar Ramachandran success
6 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: signaling receptor activity [GO:0038023] (molecular_function) —causally upstream of or within→ phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: ERK1 and ERK2 cascade [GO:0070371] (biological_process) —part of→ positive regulation of vascular endothelial cell proliferation [GO:1905564] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050] (biological_process) —occurs in→ tip cell [CL:0000423] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of vascular endothelial cell proliferation [GO:1905564] (biological_process) —part of→ positive regulation of sprouting angiogenesis [GO:1903672] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: signaling receptor activity [GO:0038023] (molecular_function) —causally upstream of or within→ ERK1 and ERK2 cascade [GO:0070371] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491] (biological_process) —part of→ positive regulation of vascular endothelial cell proliferation [GO:1905564] (biological_process) 
583f430000000041
 ZDB-PUB-160610-16 myb, cebp1 and neutrophil maturation 2026-07-14 David Hill, Doug Howe, Sabrina Toro success
1 warning
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: cell maturation [GO:0048469] (biological_process) —results in maturation of→ neutrophil [CL:0000775] (anatomical entity) 
5b91dbd100002145
 ZDB-PUB-170913-8 2026-07-14 Doug Howe, Leyla Ruzicka, Sabrina Toro filtered Model has at least one activity with no causal relations
2 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981] (molecular_function) —causally upstream of or within→ myoblast maturation [GO:0048628] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ myoblast maturation [GO:0048628] (biological_process) 
5b91dbd100000219
 ZDB-PUB-171204-8 2026-07-14 Doug Howe, Sabrina Toro, Sridhar Ramachandran filtered Model has at least one activity with no causal relations
14 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: cortical microtubule organization [GO:0043622] (biological_process) —occurs in→ yolk [ZFA:0000084] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of DNA-templated transcription [GO:0045892] (biological_process) —has input→ eomesa Drer [ZFIN:ZDB-GENE-001228-1] (information biomacromolecule)
  • SKIPPED_FACT: Subject 'negative regulation of DNA-templated transcription [GO:0045892] (biological_process)' has 'has input' relationship to 'eomesa Drer [ZFIN:ZDB-GENE-001228-1] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: sequence-specific DNA binding [GO:0043565] (molecular_function) —causally upstream of→ epiboly [GO:0090504] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: actin cytoskeleton organization [GO:0030036] (biological_process) —occurs in→ yolk syncytial layer [ZFA:0000088] (anatomical entity)
  • SKIPPED_FACT: Subject 'regulation of gene expression [GO:0010468] (biological_process)' has 'has input' relationship to 'mxtx2 Drer [ZFIN:ZDB-GENE-000710-6] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ epiboly [GO:0090504] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: cortical microtubule organization [GO:0043622] (biological_process) —part of→ epiboly [GO:0090504] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ negative regulation of DNA-templated transcription [GO:0045892] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ cortical microtubule organization [GO:0043622] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ actin cytoskeleton organization [GO:0030036] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ regulation of gene expression [GO:0010468] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of gene expression [GO:0010468] (biological_process) —has input→ mxtx2 Drer [ZFIN:ZDB-GENE-000710-6] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: actin cytoskeleton organization [GO:0030036] (biological_process) —part of→ epiboly [GO:0090504] (biological_process) 
5b91dbd100001365
 ZDB-PUB-171226-1 2026-07-14 Doug Howe, Sabrina Toro success
5 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —has input→ dusp4 Drer [ZFIN:ZDB-GENE-040426-709] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: nodal signaling pathway [GO:0038092] (biological_process) —causally upstream of→ RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: nodal signaling pathway [GO:0038092] (biological_process) —causally upstream of→ DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228] (molecular_function)
  • SKIPPED_FACT: Subject 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' has 'has input' relationship to 'dusp4 Drer [ZFIN:ZDB-GENE-040426-709] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: 'MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'negative regulation of endodermal cell differentiation [GO:1903225] (biological_process)' 
5f46c3b700003107
 ZDB-PUB-190922-3 2026-07-14 Doug Howe, Sabrina Toro filtered Model has at least one activity with no causal relations
3 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of retrograde axon cargo transport [GO:2001017] (biological_process) —occurs in→ secondary motor neuron [ZFA:0009247] (anatomical entity)
  • SKIPPED_FACT: 'dynein complex binding [GO:0070840] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of retrograde axon cargo transport [GO:2001017] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: motor neuron axon guidance [GO:0008045] (biological_process) —occurs in→ secondary motor neuron [ZFA:0009247] (anatomical entity) 
5e72450500003881
 ZDB-PUB-191218-5 trpm2 2026-07-14 Ceri Van Slyke, Doug Howe, Sabrina Toro filtered Model has at least one activity with no causal relations 
5b91dbd100000281
 ZDB-PUB-171025-5 2026-05-06 Doug Howe, Sabrina Toro filtered Model has at least one activity with no causal relations
2 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ axonogenesis [GO:0007409] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: axonogenesis [GO:0007409] (biological_process) —occurs in→ motor neuron [ZFA:0009052] (anatomical entity) 
5f46c3b700001855
 microridges elongationin epidermis 2026-04-28 Doug Howe, Sabrina Toro filtered Model has at least one activity with no causal relations
10 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: plasma membrane bounded cell projection assembly [GO:0120031] (biological_process) —occurs in→ actin-based cell projection [GO:0098858] (anatomical entity)
  • SKIPPED_FACT: Subject 'apical protein localization [GO:0045176] (biological_process)' has 'has input' relationship to 'llgl2 Drer [ZFIN:ZDB-GENE-030131-9877] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'apical protein localization [GO:0045176] (biological_process)' has 'has input' relationship to 'llgl1 Drer [ZFIN:ZDB-GENE-060825-69] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of positive effect→ plasma membrane bounded cell projection assembly [GO:0120031] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: apical protein localization [GO:0045176] (biological_process) —has input→ llgl1 Drer [ZFIN:ZDB-GENE-060825-69] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: apical protein localization [GO:0045176] (biological_process) —causally upstream of positive effect→ molecular_function [GO:0003674] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: apical protein localization [GO:0045176] (biological_process) —has input→ llgl2 Drer [ZFIN:ZDB-GENE-030131-9877] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within positive effect→ plasma membrane bounded cell projection assembly [GO:0120031] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of negative effect→ apical protein localization [GO:0045176] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: actin-based cell projection [GO:0098858] (anatomical entity) —part of→ peridermal cell [ZFA:0009041] (anatomical entity) 
60418ffa00001930
 ZDB-PUB-191206-9 enabled by glis3 Drer 2026-04-28 Doug Howe, Sabrina Toro success 
56170d5200000012
 kctd10 in heart development PMID:24430697 2026-04-16 Doug Howe, Paul Thomas success
1 warning
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-binding transcription factor activity [GO:0003700] (molecular_function) —causally upstream of→ atrioventricular canal development [GO:0036302] (biological_process) 
5ee8120100002841
 Inflammatory signaling involved in regulation of hematopoietic stem cell differentiation via notch1a, tnfa, tnfrsf1b, jag1a (D.rerio) 2026-03-12 Sabrina Toro, Sridhar Ramachandran success
4 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: Notch signaling pathway [GO:0007219] (biological_process) —occurs in→ hematopoietic stem cell [ZFA:0009014] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: signaling receptor activity [GO:0038023] (molecular_function) —causally upstream of or within positive effect→ regulation of non-canonical NF-kappaB signal transduction [GO:1901222] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of non-canonical NF-kappaB signal transduction [GO:1901222] (biological_process) —occurs in→ hematopoietic stem cell [ZFA:0009014] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of non-canonical NF-kappaB signal transduction [GO:1901222] (biological_process) —part of→ hematopoietic stem cell differentiation [GO:0060218] (biological_process) 
60418ffa00001019
 NLRP3 inflammasome in pyroptosis via nlrp3, caspa, caspb etc. (D. rerio) 2026-01-20 Doug Howe, Sabrina Toro, Sridhar Ramachandran filtered Model has at least one activity with no causal relations
6 warnings
  • SKIPPED_FACT: Subject 'positive regulation of protein processing [GO:0010954] (biological_process)' has 'has input' relationship to 'il1b Drer [ZFIN:ZDB-GENE-040702-2] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of protein processing [GO:0010954] (biological_process) —has input→ il1b Drer [ZFIN:ZDB-GENE-040702-2] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of programmed cell death [GO:0043067] (biological_process) —positively regulates→ pyroptotic inflammatory response [GO:0070269] (biological_process)
  • SKIPPED_FACT: Subject 'positive regulation of protein processing [GO:0010954] (biological_process)' has 'has input' relationship to 'il1b Drer [ZFIN:ZDB-GENE-040702-2] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within positive effect→ pyroptotic inflammatory response [GO:0070269] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: pycard Drer [ZFIN:ZDB-GENE-000511-2] (information biomacromolecule) —part of→ NLRP3 inflammasome complex [GO:0072559] (cellular_component) 
5a5fc23a00000137
 ZDB-PUB-170709-3 clocka in mesoderm development and primitive hematopoiesis 2025-10-24 Kimberly Van Auken, Leyla Ruzicka, Sabrina Toro success
7 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —has input→ gomodel:5a5fc23a00000137/5b91dbd100001405
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: nodal signaling pathway [GO:0038092] (biological_process) —causally upstream of positive effect→ mesoderm development [GO:0007498] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —causally upstream of positive effect→ molecular_function [GO:0003674] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: mesoderm development [GO:0007498] (biological_process) —causally upstream of positive effect→ primitive hemopoiesis [GO:0060215] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981] (molecular_function) —has input→ gomodel:5a5fc23a00000137/5b91dbd100001405
  • MISSING_TERM: While processing 'DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981] (molecular_function)' has input 'gomodel:5a5fc23a00000137/5b91dbd100001405', the object could not be mapped to a term; skipping this fact.
  • MISSING_TERM: While processing 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' has input 'gomodel:5a5fc23a00000137/5b91dbd100001405', the object could not be mapped to a term; skipping this fact. 
5e72450500001740
 ZDB-PUB-190423-3 2025-09-25 Sabrina Toro success
7 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of positive effect→ hematopoietic stem cell differentiation [GO:0060218] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: endothelial cell-matrix adhesion [GO:0090673] (biological_process) —occurs in→ somite [ZFA:0000155] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: Notch signaling pathway [GO:0007219] (biological_process) —occurs in→ posterior lateral plate mesoderm [ZFA:0005042] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: Notch signaling pathway [GO:0007219] (biological_process) —part of→ hematopoietic stem cell differentiation [GO:0060218] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: cell adhesion mediated by integrin [GO:0033627] (biological_process) —occurs in→ posterior lateral plate mesoderm [ZFA:0005042] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: cell adhesion mediated by integrin [GO:0033627] (biological_process) —causally upstream of positive effect→ Notch signaling pathway [GO:0007219] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hematopoietic stem cell differentiation [GO:0060218] (biological_process) —occurs in→ ventral wall of dorsal aorta [ZFA:0005028] (anatomical entity) 
5b318d0900000550
 ZDB-PUB-170412-6 2025-02-18 Doug Howe, Sabrina Toro success
1 warning
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of positive effect→ digestive tract development [GO:0048565] (biological_process) 
5b91dbd100001104
 ZDB-PUB-171213-5 2024-10-10 Sabrina Toro success
4 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of positive effect→ obsolete positive regulation of cysteine-type endopeptidase activity [GO:2001056] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of negative effect→ obsolete positive regulation of cysteine-type endopeptidase activity [GO:2001056] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: cell maturation [GO:0048469] (biological_process) —results in maturation of→ T cell [ZFA:0009046] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: obsolete positive regulation of cysteine-type endopeptidase activity [GO:2001056] (biological_process) —causally upstream of negative effect→ cell maturation [GO:0048469] (biological_process) 
59dc728000000555
 Wnt-FGF-Notch signaling inregulation of HSC specification via dlc, dld, fgfr4, wnt16 (D. rerio) 2024-04-24 Leyla Ruzicka, Sabrina Toro, Sridhar Ramachandran success
4 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: Notch signaling pathway [GO:0007219] (biological_process) —causally upstream of positive effect→ hematopoietic progenitor cell differentiation [GO:0002244] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: Notch signaling pathway [GO:0007219] (biological_process) —occurs in→ somite [UBERON:0002329] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hematopoietic progenitor cell differentiation [GO:0002244] (biological_process) —occurs in→ posterior lateral mesoderm [ZFA:0005040] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: fibroblast growth factor receptor signaling pathway [GO:0008543] (biological_process) —occurs in→ somite [UBERON:0002329] (anatomical entity) 
5ce58dde00000937
 Granulocyte differentiation via cebpa, rnf4 (D. rerio) 2024-04-23 Sabrina Toro, Sridhar Ramachandran success
4 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of gene expression [GO:0010629] (biological_process) —has input→ cebpa Drer [ZFIN:ZDB-GENE-020111-2] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ granulocyte differentiation [GO:0030851] (biological_process)
  • SKIPPED_FACT: Subject 'negative regulation of gene expression [GO:0010629] (biological_process)' has 'has input' relationship to 'cebpa Drer [ZFIN:ZDB-GENE-020111-2] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: SUMO-ubiquitin ligase activity [GO:0140082] (molecular_function) —causally upstream of positive effect→ granulocyte differentiation [GO:0030851] (biological_process) 
5b91dbd100000676
 regulation of transcription of gja1b enabled by smc3 Dre 2023-08-30 Doug Howe, Sabrina Toro success
3 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of transcription by RNA polymerase II [GO:0006357] (biological_process) —has input→ gja1b Drer [ZFIN:ZDB-GENE-991105-4] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ fin regeneration [GO:0031101] (biological_process)
  • SKIPPED_FACT: Subject 'regulation of transcription by RNA polymerase II [GO:0006357] (biological_process)' has 'has input' relationship to 'gja1b Drer [ZFIN:ZDB-GENE-991105-4] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association 
5b318d0900000386
 ZDB-PUB-170531-9 2023-08-01 Sabrina Toro, Sridhar Ramachandran filtered Model has at least one activity with no causal relations
8 warnings
  • SKIPPED_FACT: Subject 'regulation of gene expression [GO:0010468] (biological_process)' has 'has input' relationship to 'nod2 Drer [ZFIN:ZDB-GENE-061108-4] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of positive effect→ regulation of canonical NF-kappaB signal transduction [GO:0043122] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of gene expression [GO:0010468] (biological_process) —has input→ rigi Drer [ZFIN:ZDB-GENE-090821-7] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of positive effect→ type II interferon-mediated signaling pathway [GO:0060333] (biological_process)
  • SKIPPED_FACT: Subject 'regulation of gene expression [GO:0010468] (biological_process)' has 'has input' relationship to 'rigi Drer [ZFIN:ZDB-GENE-090821-7] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of gene expression [GO:0010468] (biological_process) —has input→ nod2 Drer [ZFIN:ZDB-GENE-061108-4] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of positive effect→ regulation of gene expression [GO:0010468] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ regulation of gene expression [GO:0010468] (biological_process) 
5b528b1100001803
 ZDB-PUB-170910-4 2023-07-20 Leyla Ruzicka, Sabrina Toro success
5 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: transforming growth factor beta receptor signaling pathway [GO:0007179] (biological_process) —part of→ mesodermal cell fate specification [GO:0007501] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981] (molecular_function) —causally upstream of or within positive effect→ transforming growth factor beta receptor signaling pathway [GO:0007179] (biological_process)
  • SKIPPED_FACT: 'DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'transforming growth factor beta receptor signaling pathway [GO:0007179] (biological_process)'
  • SKIPPED_FACT: 'DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'transforming growth factor beta receptor signaling pathway [GO:0007179] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: transforming growth factor beta receptor signaling pathway [GO:0007179] (biological_process) —part of→ endodermal cell fate specification [GO:0001714] (biological_process) 
63894f2500001000
 Regulation of blood vessel remodeling enabled by klf6a and tagln2 Drer 2023-06-22 David Fashena success
7 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ endothelial cell migration [GO:0043542] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: endothelial cell migration [GO:0043542] (biological_process) —part of→ blood vessel remodeling [GO:0001974] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ actin cytoskeleton organization [GO:0030036] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: actin cytoskeleton organization [GO:0030036] (biological_process) —occurs in→ caudal vein plexus [UBERON:2001286] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: endothelial cell migration [GO:0043542] (biological_process) —occurs in→ caudal vein plexus [UBERON:2001286] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: actin cytoskeleton organization [GO:0030036] (biological_process) —part of→ blood vessel remodeling [GO:0001974] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: blood vessel remodeling [GO:0001974] (biological_process) —occurs in→ caudal vein plexus [UBERON:2001286] (anatomical entity) 
6482692800000462
 hematopoietic stem cell specification enabled by jag2b Drer 2023-06-13 David Fashena filtered Model has at least one activity with no causal relations
5 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hematopoietic stem cell differentiation [GO:0060218] (biological_process) —occurs in→ ventral wall of dorsal aorta [ZFA:0005028] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: Notch signaling pathway [GO:0007219] (biological_process) —occurs in→ somite [ZFA:0000155] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ hematopoietic stem cell differentiation [GO:0060218] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: Notch signaling pathway [GO:0007219] (biological_process) —causally upstream of or within→ molecular_function [GO:0003674] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ Notch signaling pathway [GO:0007219] (biological_process) 
5ae3b0f600001579
 ZDB-PUB-070601-1 2023-06-13 Leyla Ruzicka, Sabrina Toro success 
5df932e000002650
 Regulation of BMP signaling via mgaa, zmynd11 (D. rerio) 2023-06-09 Sabrina Toro, Sridhar Ramachandran success
2 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: SMAD protein signal transduction [GO:0060395] (biological_process) —part of→ BMP signaling pathway [GO:0030509] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within positive effect→ SMAD protein signal transduction [GO:0060395] (biological_process) 
5fb9cc0600000156
 circadian rhythm and hematopoiesis via ezh2, per1b, cry1a etc. (D. rerio) 2023-03-16 Sabrina Toro, Sridhar Ramachandran success
6 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —has input→ ezh2 Drer [ZFIN:ZDB-GENE-041111-259] (information biomacromolecule)
  • SKIPPED_FACT: Subject 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' has 'has input' relationship to 'ezh2 Drer [ZFIN:ZDB-GENE-041111-259] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: 'DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)'
  • SKIPPED_FACT: 'DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'circadian regulation of gene expression [GO:0032922] (biological_process)'
  • SKIPPED_FACT: Subject 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' has 'has input' relationship to 'ezh2 Drer [ZFIN:ZDB-GENE-041111-259] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ circadian rhythm [GO:0007623] (biological_process) 
5966411600000170
 Intestinal smooth muscle cell differentiation via foxo1a, mir145, tgfr1b, ltbp3, zeb1a (D. rerio) 2023-03-16 Sabrina Toro, Sridhar Ramachandran success
18 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: smooth muscle [ZFA:0005274] (anatomical entity) —part of→ intestine [ZFA:0001338] (anatomical entity)
  • SKIPPED_FACT: Subject 'miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process)' has 'has input' relationship to 'zeb1a Drer [ZFIN:ZDB-GENE-070912-124] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of→ cell maturation [GO:0048469] (biological_process)
  • SKIPPED_FACT: Subject 'miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process)' has 'has input' relationship to 'tgfbr1b Drer [ZFIN:ZDB-GENE-091027-1] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: tissue migration [GO:0090130] (biological_process) —part of→ smooth muscle tissue development [GO:0048745] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: smooth muscle tissue development [GO:0048745] (biological_process) —results in development of→ smooth muscle [ZFA:0005274] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ smooth muscle cell differentiation [GO:0051145] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: smooth muscle cell differentiation [GO:0051145] (biological_process) —part of→ smooth muscle tissue development [GO:0048745] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ tissue migration [GO:0090130] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: tissue migration [GO:0090130] (biological_process) —occurs in→ lateral plate mesoderm [ZFA:0000121] (anatomical entity)
  • SKIPPED_FACT: Subject 'miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process)' has 'has input' relationship to 'foxo1a Drer [ZFIN:ZDB-GENE-061013-59] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process) —has input→ foxo1a Drer [ZFIN:ZDB-GENE-061013-59] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process) —has input→ tgfbr1b Drer [ZFIN:ZDB-GENE-091027-1] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process) —has input→ zeb1a Drer [ZFIN:ZDB-GENE-070912-124] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: cell maturation [GO:0048469] (biological_process) —causally upstream of→ gastro-intestinal system smooth muscle contraction [GO:0014831] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: smooth muscle cell proliferation [GO:0048659] (biological_process) —part of→ smooth muscle tissue development [GO:0048745] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ smooth muscle cell proliferation [GO:0048659] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: cell maturation [GO:0048469] (biological_process) —results in maturation of→ smooth muscle [ZFA:0005274] (anatomical entity) 
5df932e000000330
 Protease activity in epithelial morphogenesis via f2rl1.2, spint1a, st14a (D. rerio) 2023-03-16 Sabrina Toro, Sridhar Ramachandran success
10 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ morphogenesis of an epithelium [GO:0002009] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: cell population proliferation [GO:0008283] (biological_process) —occurs in→ epidermal superficial stratum [ZFA:0001179] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: protein processing [GO:0016485] (biological_process) —has input→ f2rl1.2 Drer [ZFIN:ZDB-GENE-070615-24] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: cell population proliferation [GO:0008283] (biological_process) —occurs in→ epidermal basal stratum [ZFA:0001180] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of negative effect→ cell population proliferation [GO:0008283] (biological_process)
  • SKIPPED_FACT: Subject 'protein processing [GO:0016485] (biological_process)' has 'has input' relationship to 'f2rl1.2 Drer [ZFIN:ZDB-GENE-070615-24] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within negative effect→ cell population proliferation [GO:0008283] (biological_process)
  • SKIPPED_FACT: Subject 'protein processing [GO:0016485] (biological_process)' has 'has input' relationship to 'f2rl1.2 Drer [ZFIN:ZDB-GENE-070615-24] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: morphogenesis of an epithelium [GO:0002009] (biological_process) —occurs in→ epidermal superficial stratum [ZFA:0001179] (anatomical entity)
  • SKIPPED_FACT: Subject 'protein processing [GO:0016485] (biological_process)' has 'has input' relationship to 'f2rl1.2 Drer [ZFIN:ZDB-GENE-070615-24] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association 
5b528b1100000965
 ZDB-PUB-151231-7 2023-03-16 Sabrina Toro filtered Model has at least one activity with no causal relations
16 warnings
  • SKIPPED_FACT: Subject 'negative regulation of transcription by RNA polymerase II [GO:0000122] (biological_process)' has 'has input' relationship to 'dtx1 Drer [ZFIN:ZDB-GENE-130503-1] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ glial cell differentiation [GO:0010001] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of transcription by RNA polymerase II [GO:0006357] (biological_process) —has input→ her8a Drer [ZFIN:ZDB-GENE-030131-2376] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of negative effect→ Notch signaling pathway [GO:0007219] (biological_process)
  • SKIPPED_FACT: Subject 'regulation of transcription by RNA polymerase II [GO:0006357] (biological_process)' has 'has input' relationship to 'her2 Drer [ZFIN:ZDB-GENE-980526-274] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'negative regulation of transcription by RNA polymerase II [GO:0000122] (biological_process)' has 'has input' relationship to 'dtx1 Drer [ZFIN:ZDB-GENE-130503-1] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'regulation of transcription by RNA polymerase II [GO:0006357] (biological_process)' has 'has input' relationship to 'her8a Drer [ZFIN:ZDB-GENE-030131-2376] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of transcription by RNA polymerase II [GO:0000122] (biological_process) —has input→ dtx1 Drer [ZFIN:ZDB-GENE-130503-1] (information biomacromolecule)
  • SKIPPED_FACT: Subject 'regulation of transcription by RNA polymerase II [GO:0006357] (biological_process)' has 'has input' relationship to 'her8a Drer [ZFIN:ZDB-GENE-030131-2376] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'negative regulation of transcription by RNA polymerase II [GO:0000122] (biological_process)' has 'has input' relationship to 'dtx1 Drer [ZFIN:ZDB-GENE-130503-1] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'negative regulation of transcription by RNA polymerase II [GO:0000122] (biological_process)' has 'has input' relationship to 'dtx1 Drer [ZFIN:ZDB-GENE-130503-1] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of transcription by RNA polymerase II [GO:0006357] (biological_process) —causally upstream of→ DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of transcription by RNA polymerase II [GO:0006357] (biological_process) —has input→ her2 Drer [ZFIN:ZDB-GENE-980526-274] (information biomacromolecule)
  • SKIPPED_FACT: Subject 'regulation of transcription by RNA polymerase II [GO:0006357] (biological_process)' has 'has input' relationship to 'her2 Drer [ZFIN:ZDB-GENE-980526-274] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ neuron differentiation [GO:0030182] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: Notch signaling pathway [GO:0007219] (biological_process) —causally upstream of or within→ regulation of transcription by RNA polymerase II [GO:0006357] (biological_process) 
5ae3b0f600001361
 ZDB-PUB-160310-11 heart contraction 2023-03-16 Sabrina Toro filtered Model has at least one activity with no causal relations
4 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ regulation of protein localization [GO:0032880] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: focal adhesion [GO:0005925] (anatomical entity) —part of→ cardiac muscle cell [CL:0000746] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of protein localization [GO:0032880] (biological_process) —transports or maintains localization of→ vcla Drer [ZFIN:ZDB-GENE-050506-61] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of protein localization [GO:0032880] (biological_process) —has target end location→ focal adhesion [GO:0005925] (anatomical entity) 
5b91dbd100000738
 ZDB-PUB-170214-237 2023-03-16 Sabrina Toro success
10 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ hemopoiesis [GO:0030097] (biological_process)
  • SKIPPED_FACT: Subject 'miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process)' has 'has input' relationship to 'tp53 Drer [ZFIN:ZDB-GENE-990415-270] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hematopoietic stem cell proliferation [GO:0071425] (biological_process) —part of→ hemopoiesis [GO:0030097] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: apoptotic process [GO:0006915] (biological_process) —part of→ hemopoiesis [GO:0030097] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process) —has input→ tp53 Drer [ZFIN:ZDB-GENE-990415-270] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process) —has input→ irf7 Drer [ZFIN:ZDB-GENE-040426-1518] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of transcription by RNA polymerase II [GO:0006357] (biological_process) —causally upstream of→ apoptotic process [GO:0006915] (biological_process)
  • SKIPPED_FACT: Subject 'miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process)' has 'has input' relationship to 'tp53 Drer [ZFIN:ZDB-GENE-990415-270] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process)' has 'has input' relationship to 'irf7 Drer [ZFIN:ZDB-GENE-040426-1518] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of transcription by RNA polymerase II [GO:0006357] (biological_process) —causally upstream of→ hematopoietic stem cell proliferation [GO:0071425] (biological_process) 
5b91dbd100000000
 ZDB-PUB-170505-9 2023-03-16 Sabrina Toro success
4 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: protein deubiquitination [GO:0016579] (biological_process) —has input→ smad4a Drer [ZFIN:ZDB-GENE-990603-8] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ protein deubiquitination [GO:0016579] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ convergent extension [GO:0060026] (biological_process)
  • SKIPPED_FACT: Subject 'protein deubiquitination [GO:0016579] (biological_process)' has 'has input' relationship to 'smad4a Drer [ZFIN:ZDB-GENE-990603-8] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association 
5df932e000000112
 ZDB-PUB-170624-8 tgfb1 regulation of hematopoietic stem cells 2023-03-16 Sabrina Toro filtered Model has at least one activity with no causal relations
7 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within positive effect→ JNK cascade [GO:0007254] (biological_process)
  • SKIPPED_FACT: Subject 'regulation of transcription by RNA polymerase II [GO:0006357] (biological_process)' has 'has input' relationship to 'g6pc3 Drer [ZFIN:ZDB-GENE-061215-19] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: JNK cascade [GO:0007254] (biological_process) —causally upstream of positive effect→ DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ hematopoietic progenitor cell differentiation [GO:0002244] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: JNK cascade [GO:0007254] (biological_process) —occurs in→ endothelial cell [ZFA:0009065] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of transcription by RNA polymerase II [GO:0006357] (biological_process) —occurs in→ endothelial cell [ZFA:0009065] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of transcription by RNA polymerase II [GO:0006357] (biological_process) —has input→ g6pc3 Drer [ZFIN:ZDB-GENE-061215-19] (information biomacromolecule) 
5b318d0900001027
 ZDB-PUB-170806-6 2023-03-16 Sabrina Toro success
2 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: nodal signaling pathway [GO:0038092] (biological_process) —part of→ mesendoderm development [GO:0048382] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981] (molecular_function) —causally upstream of positive effect→ nodal signaling pathway [GO:0038092] (biological_process) 
5b528b1100002293
 ZDB-PUB-171204-53 2023-03-16 Sabrina Toro success
5 warnings
  • SKIPPED_FACT: Subject 'regulation of mRNA cis splicing, via spliceosome [GO:1905744] (biological_process)' has 'has input' relationship to 'smad2 Drer [ZFIN:ZDB-GENE-990603-7] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'regulation of mRNA cis splicing, via spliceosome [GO:1905744] (biological_process)' has 'has input' relationship to 'smad2 Drer [ZFIN:ZDB-GENE-990603-7] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ convergent extension involved in axis elongation [GO:0060028] (biological_process)
  • SKIPPED_FACT: Subject 'regulation of mRNA cis splicing, via spliceosome [GO:1905744] (biological_process)' has 'has input' relationship to 'smad2 Drer [ZFIN:ZDB-GENE-990603-7] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of mRNA cis splicing, via spliceosome [GO:1905744] (biological_process) —has input→ smad2 Drer [ZFIN:ZDB-GENE-990603-7] (information biomacromolecule) 
5b91dbd100001682
 ZDB-PUB-180223-12 2023-03-16 Sabrina Toro success
12 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: ubiquitin protein ligase activity [GO:0061630] (molecular_function) —causally upstream of or within→ non-canonical NF-kappaB signal transduction [GO:0038061] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ non-canonical NF-kappaB signal transduction [GO:0038061] (biological_process)
  • SKIPPED_FACT: Subject 'miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process)' has 'has input' relationship to 'tab1 Drer [ZFIN:ZDB-GENE-060628-1] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process) —has input→ cul1a Drer [ZFIN:ZDB-GENE-030131-2603] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process) —has input→ cul1b Drer [ZFIN:ZDB-GENE-040426-2887] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process) —has input→ traf6 Drer [ZFIN:ZDB-GENE-030131-5735] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process) —has input→ tab1 Drer [ZFIN:ZDB-GENE-060628-1] (information biomacromolecule)
  • SKIPPED_FACT: Subject 'miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process)' has 'has input' relationship to 'cul1b Drer [ZFIN:ZDB-GENE-040426-2887] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process)' has 'has input' relationship to 'cul1a Drer [ZFIN:ZDB-GENE-030131-2603] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: non-canonical NF-kappaB signal transduction [GO:0038061] (biological_process) —part of→ neutrophil chemotaxis [GO:0030593] (biological_process)
  • SKIPPED_FACT: Subject 'miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process)' has 'has input' relationship to 'traf6 Drer [ZFIN:ZDB-GENE-030131-5735] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: non-canonical NF-kappaB signal transduction [GO:0038061] (biological_process) —occurs in→ epidermal basal stratum [ZFA:0001180] (anatomical entity) 
5df932e000000699
 ZDB-PUB-180622-31 s1pr1 and cardiovascular development 2023-03-16 Sabrina Toro filtered Model has at least one activity with no causal relations
3 warnings
  • SKIPPED_FACT: Subject 'miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process)' has 'has input' relationship to 's1pr1 Drer [ZFIN:ZDB-GENE-001228-2] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ heart development [GO:0007507] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process) —has input→ s1pr1 Drer [ZFIN:ZDB-GENE-001228-2] (information biomacromolecule) 
5ee8120100002053
 ZDB-PUB-181228-6 2023-03-16 Sabrina Toro success
3 warnings
  • SKIPPED_FACT: Subject 'regulation of transcription by RNA polymerase II [GO:0006357] (biological_process)' has 'has input' relationship to 'cyp19a1a Drer [ZFIN:ZDB-GENE-990415-43] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of positive effect→ ovarian follicle development [GO:0001541] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of transcription by RNA polymerase II [GO:0006357] (biological_process) —has input→ cyp19a1a Drer [ZFIN:ZDB-GENE-990415-43] (information biomacromolecule) 
5f46c3b700004346
 ZDB-PUB-190516-21 hdac1 in Secondary heart field development 2023-03-16 Sabrina Toro success
4 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: transcription corepressor activity [GO:0003714] (molecular_function) —causally upstream of or within positive effect→ secondary heart field specification [GO:0003139] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of transcription by RNA polymerase II [GO:0000122] (biological_process) —has input→ ripply3 Drer [ZFIN:ZDB-GENE-060113-3] (information biomacromolecule)
  • SKIPPED_FACT: Subject 'negative regulation of transcription by RNA polymerase II [GO:0000122] (biological_process)' has 'has input' relationship to 'ripply3 Drer [ZFIN:ZDB-GENE-060113-3] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: transcription corepressor activity [GO:0003714] (molecular_function) —causally upstream of or within negative effect→ secondary heart field specification [GO:0003139] (biological_process) 
5f46c3b700002935
 ZDB-PUB-190904-2 2023-03-16 Sabrina Toro success
3 warnings
  • SKIPPED_FACT: Subject 'miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process)' has 'has input' relationship to 'nfatc1 Drer [ZFIN:ZDB-GENE-060503-677] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within negative effect→ lymphangiogenesis [GO:0001946] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process) —has input→ nfatc1 Drer [ZFIN:ZDB-GENE-060503-677] (information biomacromolecule) 
5f46c3b700002667
 ZDB-PUB-191212-11 eye, sox2, rbm24a 2023-03-16 David Fashena success 
60418ffa00002431
 ZDB-PUB-200301-3 enabled by caspb Drer 2023-03-16 Sabrina Toro success
4 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aspartic-type peptidase activity [GO:0070001] (molecular_function) —causally upstream of or within positive effect→ pyroptotic inflammatory response [GO:0070269] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: pyroptotic inflammatory response [GO:0070269] (biological_process) —occurs in→ renal tubule [ZFA:0001287] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within positive effect→ pyroptotic inflammatory response [GO:0070269] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: pyroptotic inflammatory response [GO:0070269] (biological_process) —part of→ response to bacterium [GO:0009617] (biological_process) 
5e72450500000000
 ZDB-PUB-190219-8 sas10 and mpp10 2022-04-14 Sabrina Toro filtered Model has at least one activity with no causal relations
10 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ digestive system development [GO:0055123] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: protein binding [GO:0005515] (molecular_function) —causally upstream of or within positive effect→ protein-containing complex localization [GO:0031503] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: Mpp10 complex [GO:0034457] (cellular_component) —has part→ mphosph10 Drer [ZFIN:ZDB-GENE-030131-2146] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: protein-containing complex localization [GO:0031503] (biological_process) —has target end location→ nucleolus [GO:0005730] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within positive effect→ digestive system development [GO:0055123] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: Mpp10 complex [GO:0034457] (cellular_component) —has part→ imp4 Drer [ZFIN:ZDB-GENE-040718-474] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: protein-containing complex localization [GO:0031503] (biological_process) —has input→ Mpp10 complex [GO:0034457] (cellular_component)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: Mpp10 complex [GO:0034457] (cellular_component) —has part→ imp3 Drer [ZFIN:ZDB-GENE-040426-1062] (information biomacromolecule)
  • SKIPPED_FACT: Subject 'protein-containing complex localization [GO:0031503] (biological_process)' has 'has input' relationship to 'Mpp10 complex [GO:0034457] (cellular_component)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'protein-containing complex localization [GO:0031503] (biological_process)' has 'has input' relationship to 'Mpp10 complex [GO:0034457] (cellular_component)', but that subject is not the molecular function of an activity unit; skipping molecular association 
5d29221b00002847
 Pronephric distal tubule development via emx1, mecom, tbx2b (D. rerio) 2021-08-24 Sabrina Toro, Sridhar Ramachandran filtered Model has at least one activity with no causal relations
2 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ pronephric distal tubule development [GO:0035777] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: pronephric distal tubule development [GO:0035777] (biological_process) —results in development of→ pronephric distal late tubule [ZFA:0001624] (anatomical entity) 
5f46c3b700000011
 ret signaling regulating axon outgrowth via ret, mapk8ip3, myo10l1 (D. rerio) 2021-08-24 Sabrina Toro, Sridhar Ramachandran success
5 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: axon extension [GO:0048675] (biological_process) —occurs in→ posterior lateral line ganglion [ZFA:0001314] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ axon extension [GO:0048675] (biological_process)
  • SKIPPED_FACT: Subject 'retrograde axonal protein transport [GO:0099642] (biological_process)' has 'has input' relationship to 'ret Drer [ZFIN:ZDB-GENE-980526-307] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: cargo adaptor activity [GO:0140312] (molecular_function) —causally upstream of or within→ retrograde axonal protein transport [GO:0099642] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: retrograde axonal protein transport [GO:0099642] (biological_process) —has input→ ret Drer [ZFIN:ZDB-GENE-980526-307] (information biomacromolecule) 
6086f4f200000000
 ZDB-PUB-200307-2 bach2a regulates angiogenesis, lymphangiogenesis via vegfc 2021-04-26 David Fashena success
4 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: angiogenesis [GO:0001525] (biological_process) —occurs in→ primordial hindbrain channel [ZFA:0001052] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —regulates→ lymphangiogenesis [GO:0001946] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: lymphangiogenesis [GO:0001946] (biological_process) —occurs in→ thoracic duct [ZFA:0005110] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —regulates→ angiogenesis [GO:0001525] (biological_process) 
5ee8120100001366
 ZDB-PUB-180829-2 2021-04-15 Sabrina Toro success
4 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical inflammasome complex [GO:0061702] (cellular_component) —has part→ caspb Drer [ZFIN:ZDB-GENE-020812-1] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical inflammasome complex [GO:0061702] (cellular_component) —has part→ nlrp1 Drer [ZFIN:ZDB-GENE-120709-59] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical inflammasome complex [GO:0061702] (cellular_component) —has part→ caspa Drer [ZFIN:ZDB-GENE-000616-3] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical inflammasome complex [GO:0061702] (cellular_component) —has part→ pycard Drer [ZFIN:ZDB-GENE-000511-2] (information biomacromolecule) 
5df932e000002440
 enabled by gata5 Drer 2021-01-26 Sabrina Toro filtered Model has at least one activity with no causal relations
15 warnings
  • SKIPPED_FACT: Subject 'miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process)' has 'has input' relationship to 'foxj1b Drer [ZFIN:ZDB-GENE-041212-76] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ mir210 Drer [ZFIN:ZDB-MIRNAG-041228-8] (information biomacromolecule)
  • SKIPPED_FACT: Subject 'miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process)' has 'has input' relationship to 'slc3a2a Drer [ZFIN:ZDB-GENE-000831-3] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process)' has 'has input' relationship to 'foxj1b Drer [ZFIN:ZDB-GENE-041212-76] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process)' has 'has input' relationship to 'slc3a2a Drer [ZFIN:ZDB-GENE-000831-3] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of negative effect→ myeloid dendritic cell differentiation [GO:0043011] (biological_process)
  • SKIPPED_FACT: Subject 'miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process)' has 'has input' relationship to 'slc3a2a Drer [ZFIN:ZDB-GENE-000831-3] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process) —has input→ foxj1b Drer [ZFIN:ZDB-GENE-041212-76] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of negative effect→ gene expression [GO:0010467] (biological_process)
  • SKIPPED_FACT: Subject 'miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process)' has 'has input' relationship to 'foxj1b Drer [ZFIN:ZDB-GENE-041212-76] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process) —has input→ slc3a2a Drer [ZFIN:ZDB-GENE-000831-3] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of→ miRNA-mediated post-transcriptional gene silencing [GO:0035195] (biological_process)
  • SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'mir210 Drer [ZFIN:ZDB-MIRNAG-041228-8] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'mir210 Drer [ZFIN:ZDB-MIRNAG-041228-8] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association 
5f46c3b700000759
 ZDB-PUB-190811-5 neural tube development 2021-01-26 Sabrina Toro success
6 warnings
  • SKIPPED_FACT: Subject 'membrane protein intracellular domain proteolysis [GO:0031293] (biological_process)' has 'has input' relationship to 'neo1a Drer [ZFIN:ZDB-GENE-021031-1] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ cell morphogenesis [GO:0000902] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of positive effect→ membrane protein intracellular domain proteolysis [GO:0031293] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: membrane protein intracellular domain proteolysis [GO:0031293] (biological_process) —has input→ neo1a Drer [ZFIN:ZDB-GENE-021031-1] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: cell morphogenesis [GO:0000902] (biological_process) —part of→ neural rod formation [GO:0014023] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: cell morphogenesis [GO:0000902] (biological_process) —results in morphogenesis of→ neuroepithelial cell [ZFA:0009306] (anatomical entity) 
5d29221b00001177
 ZDB-PUB-170407-2 - zbtb11 and neutrophil development 2021-01-15 Sabrina Toro success
4 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of gene expression [GO:0010628] (biological_process) —has input→ zbtb11 Drer [ZFIN:ZDB-GENE-030131-5055] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ positive regulation of gene expression [GO:0010628] (biological_process)
  • SKIPPED_FACT: Subject 'positive regulation of gene expression [GO:0010628] (biological_process)' has 'has input' relationship to 'zbtb11 Drer [ZFIN:ZDB-GENE-030131-5055] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ neutrophil differentiation [GO:0030223] (biological_process) 
5ae3b0f600001522
 ZDB-PUB-161204-10 2020-12-21 Sabrina Toro success
2 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: protein kinase activity [GO:0004672] (molecular_function) —causally upstream of positive effect→ canonical Wnt signaling pathway [GO:0060070] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical Wnt signaling pathway [GO:0060070] (biological_process) —part of→ dorsal/ventral axis specification [GO:0009950] (biological_process) 
5fce9b7300000451
 ZDB-PUB-190622-4 Left-right patterning 2020-12-15 Sabrina Toro filtered Model has at least one activity with no causal relations
8 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: apelin receptor activity [GO:0060182] (molecular_function) —causally upstream of or within positive effect→ determination of liver left/right asymmetry [GO:0071910] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: receptor ligand activity [GO:0048018] (molecular_function) —causally upstream of or within positive effect→ determination of liver left/right asymmetry [GO:0071910] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within positive effect→ Kupffer's vesicle development [GO:0070121] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: Kupffer's vesicle development [GO:0070121] (biological_process) —causally upstream of→ determination of left/right symmetry [GO:0007368] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: apelin receptor binding [GO:0031704] (molecular_function) —causally upstream of positive effect→ Kupffer's vesicle development [GO:0070121] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: apelin receptor activity [GO:0060182] (molecular_function) —causally upstream of or within positive effect→ determination of heart left/right asymmetry [GO:0061371] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: apelin receptor activity [GO:0060182] (molecular_function) —causally upstream of positive effect→ Kupffer's vesicle development [GO:0070121] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: receptor ligand activity [GO:0048018] (molecular_function) —causally upstream of or within positive effect→ determination of heart left/right asymmetry [GO:0061371] (biological_process) 
5df932e000000567
 ZDB-PUB-180814-17 insulin receptors and glucose homeostasis 2020-11-19 Sabrina Toro filtered Model has at least one activity with no causal relations
3 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within positive effect→ glycolytic process [GO:0006096] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within positive effect→ gluconeogenesis [GO:0006094] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within negative effect→ gluconeogenesis [GO:0006094] (biological_process) 
5e72450500000869
 ZDB-PUB-180722-24 2020-03-31 Sabrina Toro filtered Model has at least one activity with no causal relations
1 warning
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within positive effect→ neural crest cell migration [GO:0001755] (biological_process) 
5d29221b00002807
 ZDB-PUB-170805-4 lmo2 and sphk1 in endothelial cell migration 2019-09-25 Sabrina Toro success
2 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: blood vessel endothelial cell migration [GO:0043534] (biological_process) —occurs in→ intersegmental vessel [ZFA:0001285] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ blood vessel endothelial cell migration [GO:0043534] (biological_process) 
5d29221b00001945
 ZDB-PUB-181127-81 ppargc1a in nephron segmentation 2019-09-05 Sabrina Toro success
2 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ proximal straight tubule development [GO:0072020] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ late distal convoluted tubule development [GO:0072068] (biological_process) 
5d29221b00001607
 ZDB-PUB-181118-19 left-right asymmetry 2019-09-03 Sabrina Toro success
1 warning
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ establishment of left/right asymmetry [GO:0061966] (biological_process) 
5c4605cc00004193
 ZDB-PUB-180805-1 2019-07-09 Sabrina Toro success
1 warning
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: cysteine-type endopeptidase activity [GO:0004197] (molecular_function) —causally upstream of or within→ pyroptotic inflammatory response [GO:0070269] (biological_process)
Release date
2026-08-28
Pipeline name
pipeline-from-goa
Pipeline branch
main
Generated on
2026-08-29T14:10:14+00:00
gocam-py version
0.12.0.post65.dev0+8382d25a