636d9ce800001276
|
TRIM7 activation by E2s (Human) |
2026-08-26 |
Patrick Masson, Sylvain Poux |
success |
|
|
682fbcd000004233
|
PS/PI4P exchange via OSBP5/8 regulates cholesterol transport via GRAMD1B (Human) |
2026-08-25 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
684b6c8100001669
|
Canonical Glycolysis (Human) |
2026-08-21 |
Lucille Pourcel, Sylvain Poux |
success |
|
|
67086be200000529
|
GPR87 role as a LPA receptor (Human) |
2026-08-21 |
Patrick Masson, Sylvain Poux |
success |
|
|
62b4ffe300004953
|
Arginine ADP-riboxanation of CASP3 by by C.violaceum CopC that blocks CASP3 activity, subsequent apoptosis and pyroptosis (Human)
|
2026-08-20 |
Sylvain Poux |
success |
|
|
62b4ffe300004857
|
Arginine ADP-riboxanation of CASP7 by by C.violaceum CopC blocks CASP7 activity and apoptosis (Human) |
2026-08-20 |
Sylvain Poux |
success |
|
|
6a0784b700000502
|
cGMP recovery by CGAP2 and RetGC2 through negative feedback loop in rods_Visual perception (Human) |
2026-08-20 |
Lucille Pourcel |
success |
|
|
68b0f0d000005840
|
PC transfer by STARD7 mitochondrial intermembrane space (Human) |
2026-08-20 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
6a18a9ba00001648
|
Role of SLC24A1 (NCKX1) in rod phototransduction, photoresponse recovery step (Human) |
2026-08-20 |
Livia Famiglietti |
filtered |
Model has at least one activity with no causal relations |
|
6a0784b700000336
|
cGMP recovery by CGAP1 and RetGC1 through negative feedback loop in cones_Visual perception (Human) |
2026-08-19 |
Lucille Pourcel |
success |
|
|
6a0784b700005841
|
cGMP recovery by CGAP3 and RetGC1 through negative feedback loop in cones_Visual perception (Human) |
2026-08-19 |
Lucille Pourcel |
success |
|
|
6a2b236300001621
|
Deactivation of photoactivated rhodopsin (RHO) by rhodopsin kinase GRK1 and S-arrestin (SAG) in rod photoreceptors (Human) |
2026-08-18 |
Livia Famiglietti, Lucille Pourcel |
success |
|
|
6a18a9ba00000549
|
GNAT1 (transducin) recovery mediated by the RGS9-1-Gbeta5L-RGS9BP complex_Visual perception (Human) |
2026-08-18 |
Lucille Pourcel |
success |
|
|
6a2b236300000742
|
GNAT2 (transducin) recovery mediated by the RGS9-1-Gbeta5L-RGS9BP complex_Visual perception (Human) |
2026-08-18 |
Lucille Pourcel |
success |
|
|
68fac5ed00000330
|
Phosphatidylinositol and phosphatidylcholine transfer enabled by PITPNB (Human) |
2026-08-18 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
680ad14200004675
|
Phosphatidylinositol and phosphatidic acid transport by PITPNC1 (response to PLD) (Human) |
2026-08-13 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
6197061700002544
|
Activation of NOD1 signaling pathway by AKT1-ZDHHC5 axis (Human) |
2026-08-12 |
Patrick Masson, Sylvain Poux |
success |
|
|
682fbcd000003781
|
OSBPL1A sensor for cholesterol transport between late endosome/lysosome and ER (Human) |
2026-08-12 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
6a2b236300000598
|
IRGM promotes autophagy-dependent degradation of RIGI (Human) |
2026-08-11 |
Sylvain Poux |
success |
|
|
671ae02600003194
|
Negative regulation of cytokine production involved in inflammatory response via calcium influx by CHRNA7 homopentameric and PKC signaling in macrophages (Human). |
2026-08-11 |
Cristina Casals |
success |
|
|
671ae02600003150
|
Negative regulation of cytokine production involved in inflammatory response via calcium influx by CHRNA7 homopentameric nAchR and PKC signaling in macrophages (Mouse). |
2026-08-11 |
Cristina Casals |
success |
|
|
66b5638000002450
|
GRIM1 GPCR signaling in Purkinje cells (Human). |
2026-08-10 |
Cristina Casals |
success |
|
|
62f58d8800001738
|
Gut Microbiota tryptophan metabolism: Regulation of intestinal transit by 5-hydroxy-L-tryptophan(Human-E.coli) |
2026-08-10 |
Cristina Casals, Kimberly Van Auken |
success |
|
|
68b0f0d000009094
|
Cholesterol transport regulated by NPC1, NPC2 and GRAMD1B. (Human) |
2026-08-07 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
6a4c244800008725
|
Negative regulation of canonical NF-kB via IKIP (Human) |
2026-08-04 |
Lionel Breuza |
success |
|
|
6197061700001485
|
Silencing of fetal hemoglobin by ZNF410 (Human) |
2026-08-03 |
Sylvain Poux |
success |
|
|
657ba49f00001182
|
astrocytic Best1-mediated glutamate on
postsynaptic NMDARs upon PAR-1 activation (Human) |
2026-07-28 |
Guilaine Argoud-Puy |
success |
|
|
67c10cc400002057
|
WalKR operon & spdC/lyrA in biofilm formation (S. aureus) |
2026-07-24 |
Paul Denny |
success |
|
|
6a4c244800006629
|
vancomycin resistance enabled by proteins encoded in vanA gene cluster (E. faecium) |
2026-07-23 |
Paul Denny |
success |
|
|
682fbcd000006470
|
regulation of phosphorelay signal transduction enabled by SafA (Ecoli) |
2026-07-21 |
Paul Denny |
success |
|
|
680ad14200002460
|
Xenobiotic detoxification enabled by efflux pump complex mexAB-OprM (P. aeruginosa PA01) |
2026-07-21 |
Paul Denny |
success |
|
|
685de18700004975
|
Xenobiotic detoxification enabled by EmrAB-TolC complex (E.coli) |
2026-07-20 |
Paul Denny |
success |
|
3 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: TolC Ecol [EcoCyc:EG11009-MONOMER] (information biomacromolecule) —located in→ outer membrane [GO:0019867] (anatomical entity)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: EmrB Ecol [EcoCyc:EMRB-MONOMER] (information biomacromolecule) —located in→ plasma membrane [GO:0005886] (anatomical entity)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: EmrA Ecol [EcoCyc:EG11354-MONOMER] (information biomacromolecule) —located in→ periplasmic side of plasma membrane [GO:0098567] (anatomical entity)
|
69729a3800001593
|
SL degradation: GalCer degradation enabled by GALC and Saposin-A (Human) |
2026-07-17 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
6870555700000320
|
Xenobiotic detoxification enabled by efflux complex AcrABZ-TolC (E.coli) |
2026-07-17 |
Paul Denny |
success |
|
|
6918f23700000035
|
Dim light signaling mediated by RHO photoreceptor via G-alpha-t (transducin)_Visual perception (Human) |
2026-07-16 |
Lucille Pourcel |
success |
|
|
68b0f0d000008690
|
Endolysosomal degradation SL: GM2A stimulates breakdown of GM2 by HEXA (Human) |
2026-07-16 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
689e7a5d00005750
|
SL biosynthesis: Glycolipid transport by PLEKHA8 RHEA:77263 (Human) |
2026-07-16 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
69d8496c00002973
|
SL degradation: SM2 catabolism enabled by HEXA (S isoform) and ARSA. (Human) |
2026-07-16 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
682fbcd000003765
|
Regulation of focal adhesion assembly: OSBPL3 transports PI4P and PC between PM and ER (Human) |
2026-07-15 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
6870555700000795
|
antibiotic resistance enabled by ampR (PSEAE) |
2026-07-14 |
Paul Denny |
success |
|
|
6870555700002007
|
Ara4N-lipid-A biosynthetic pathway (ECOLI) |
2026-07-14 |
Paul Denny |
success |
|
1 warning
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: carbohydrate derivative transmembrane transporter activity [GO:1901505] (molecular_function) —causally upstream of positive effect→ transmembrane transporter activity [GO:0022857] (molecular_function)
|
6870555700001503
|
Ara4N-lipid-A biosynthetic pathway (SALTY) |
2026-07-14 |
Paul Denny |
success |
|
|
6870555700000275
|
involved in biofilm formation CpxA-CpxR-CpxP (ECOLI) |
2026-07-14 |
Paul Denny |
success |
|
|
68d5ebd600001111
|
KISS1/KISS1R signaling pathway induces membrane depolarization in GnRH neurons and stimulate GnRH release (Human) |
2026-07-14 |
Livia Famiglietti |
success |
|
|
6882d2b800000609
|
lipid IV(A) biosynthesis pathway (Ecol) |
2026-07-14 |
Paul Denny |
success |
|
|
6870555700001284
|
phosphorelay signal transduction system basS / basR (SALTY) |
2026-07-14 |
Paul Denny |
success |
|
|
69729a3800006987
|
putrescine polyamine catabolism enabled by AcrR (E. coli) |
2026-07-14 |
Paul Denny |
success |
|
|
6870555700001135
|
ramR-ramA transcriptional regulation of acrAB-tolC efflux pump (SALTY) |
2026-07-14 |
Paul Denny |
success |
|
|
68fac5ed00003196
|
Regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process. (Human) |
2026-07-14 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
6a2b236300001809
|
Aldosterone biosynthetic pathway from cholesterol in the zona fasciculata of the adrenal cortex (Human). |
2026-07-07 |
Patrick Masson |
success |
|
|
6a4c244800000182
|
Regulation of microtubule polymerization or depolymerization by Cdkl5. (Human) |
2026-07-07 |
Cristina Casals |
success |
|
|
6a4c244800000137
|
Regulation of microtubule polymerization or depolymerization by Cdkl5. (Mouse) |
2026-07-07 |
Cristina Casals |
success |
|
|
6a4c244800000036
|
Positive regulation of excitatory synapse assembly by Cdkl5. (Human) |
2026-07-06 |
Cristina Casals |
success |
|
|
6a4c244800000008
|
Positive regulation of excitatory synapse assembly by Cdkl5. (Mouse) |
2026-07-06 |
Cristina Casals |
success |
|
|
6a46ef0600000018
|
PDE6D-mediated ciliary targeting transport of RPGR_Visual perception (Human) |
2026-07-03 |
Lucille Pourcel |
success |
|
|
6a46ef0600000065
|
PDE6D-mediated cone OS transport of GRK1_Visual perception (Human) |
2026-07-03 |
Lucille Pourcel |
success |
|
|
6a2b236300003566
|
PDE6D-mediated cone OS transport of PDE6C subunit_Visual perception (Human) |
2026-07-03 |
Lucille Pourcel |
success |
|
|
6a46ef0600000159
|
PDE6D-mediated cone OS transport of RAB28_Visual perception (Human) |
2026-07-03 |
Lucille Pourcel |
success |
|
|
69b3372b00003343
|
FSH delivery to granulosa cells promotes follicle development (Human) |
2026-06-30 |
Patrick Masson |
success |
|
|
69169b7400000023
|
SLC25A45 mediates mitochondrial uptake of methylated lysine for carnitine biosynthesis (Human). |
2026-06-30 |
Sylvain Poux |
success |
|
|
680ad14200004624
|
C14-ceramide transport activity of CERT1 (Human) |
2026-06-29 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
680ad14200004532
|
C16-ceramide transport activity of CERT1 (Human) |
2026-06-29 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
68b0f0d000008519
|
C16-Ceramide-1-P transport enabled by CPTP (CERT1 transports Cer for C1P synthesis) (Human) |
2026-06-29 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
680ad14200004594
|
C18-ceramide transport activity of CERT1 (Human) |
2026-06-29 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
680ad14200003909
|
C20-ceramide transport activity of CERT1 (Human) |
2026-06-29 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
68fac5ed00003700
|
Green light signaling mediated by OPN1MW3 photoreceptor via G-alpha-t (transducin)_Visual perception (Human) |
2026-06-29 |
Lucille Pourcel |
success |
|
|
6a18a9ba00001280
|
Insulin synthesis and delivery to skeletal muscle promotes glucose uptake (Human) |
2026-06-29 |
Patrick Masson |
success |
|
|
68b0f0d000008149
|
Lipid sensor activity enabled by GLTP (Human) |
2026-06-29 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
6870555700000578
|
PS/PtdIns4P exchange by OSBPL9/OSBPL10 in ER-TGN membrane contact site (Human) |
2026-06-29 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
680ad14200005355
|
PS/PtdIns4P exchange by OSBPL9/OSBPL11 in the ER-trans Gogi membrane contact site (Human) |
2026-06-29 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
696022cd00002259
|
Endolysosomal degradation of galactocerebroside sulfate by arylsulfatase A (Human) |
2026-06-25 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
69729a3800002480
|
Endolysosomal degradation of SM enabled by SMPD1 Hsap |
2026-06-25 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
69ea894900001736
|
PTH synthesis and continuous delivery to osteoblasts promotes bone resorption (Human) |
2026-06-23 |
Patrick Masson |
success |
|
|
69ea894900003047
|
PTH synthesis and delivery to proximal tubule inhibits renal phosphate ion absorption (Human) |
2026-06-23 |
Patrick Masson |
success |
|
|
6a2b236300001490
|
Deactivation of photoactivated M opsin (OPN1MW) by opsin kinase GRK7 and C-arrestin (ARR3) in cone photoreceptors (Human) |
2026-06-19 |
Livia Famiglietti |
success |
|
|
6a2b236300001298
|
Deactivation of photoactivated M opsin (OPN1MW) by rhodopsin kinase GRK1 and C-arrestin (ARR3) in cone photoreceptors (Human) |
2026-06-19 |
Livia Famiglietti |
success |
|
|
6a2b236300001426
|
Deactivation of photoactivated M opsin (OPN1MW2) by opsin kinase GRK7 and C-arrestin (ARR3) in cone photoreceptors (Human) |
2026-06-19 |
Livia Famiglietti |
success |
|
|
6a2b236300001213
|
Deactivation of photoactivated M opsin (OPN1MW2) by rhodopsin kinase GRK1 and C-arrestin (ARR3) in cone photoreceptors (Human) |
2026-06-19 |
Livia Famiglietti |
success |
|
|
6a2b236300001362
|
Deactivation of photoactivated M opsin (OPN1MW3) by opsin kinase GRK7 and C-arrestin (ARR3) in cone photoreceptors (Human) |
2026-06-19 |
Livia Famiglietti |
success |
|
|
6a2b236300001117
|
Deactivation of photoactivated M opsin (OPN1MW3) by rhodopsin kinase GRK1 and C-arrestin (ARR3) in cone photoreceptors (Human) |
2026-06-19 |
Livia Famiglietti |
success |
|
|
6a2b236300001559
|
Deactivation of photoactivated S opsin (OPN1SW) by opsin kinase GRK7 and C-arrestin (ARR3) in cone photoreceptors (Human) |
2026-06-19 |
Livia Famiglietti |
success |
|
|
67c10cc400005671
|
The classical complement pathway (Human). |
2026-06-19 |
Sylvain Poux |
success |
|
|
67e5e74400000919
|
The lectin complement pathway following activation by FCN1 lectin (Human). |
2026-06-19 |
Sylvain Poux |
success |
|
|
67e5e74400001094
|
The lectin complement pathway following activation by FCN2 lectin (Human). |
2026-06-19 |
Sylvain Poux |
success |
|
|
67e5e74400000671
|
The lectin complement pathway following activation by MBL2 lectin (Human). |
2026-06-19 |
Sylvain Poux |
success |
|
|
646ff70100004144
|
Major histocompatibility complex class I (MHC I) peptide loading (Human) |
2026-06-18 |
Lionel Breuza, Pascale Gaudet |
success |
|
|
67e5e74400001614
|
The alternative complement pathway (Human). |
2026-06-18 |
Sylvain Poux |
success |
|
|
67e5e74400001888
|
The GZMK complement pathway (Human). |
2026-06-18 |
Sylvain Poux |
success |
|
|
67e5e74400001269
|
The lectin complement pathway following activation by FCN3 lectin (Human). |
2026-06-18 |
Sylvain Poux |
success |
|
|
66f5faaa00000026
|
AARS2 mediates lactylation and inactivation of CGAS (Human) |
2026-06-17 |
Sylvain Poux |
success |
|
|
69d8496c00000972
|
Activation of cGAS-STING signaling following ISGylation of CGAS and STING1 by HERC5 (Human). |
2026-06-17 |
Sylvain Poux |
success |
|
|
69d8496c00003439
|
Activation of cGAS-STING signaling following STING1 ubiquitination by MUL1 (Human) |
2026-06-17 |
Sylvain Poux |
success |
|
|
69d8496c00004416
|
Activation of cGAS-STING signaling following STING1 ubiquitination by TRIM10 (Human) |
2026-06-17 |
Sylvain Poux |
success |
|
|
69d8496c00001257
|
Activation of cGAS-STING signaling following STING1 ubiquitination by TRIM69 (Human) |
2026-06-17 |
Sylvain Poux |
success |
|
|
64c3044100002205
|
Activation of cGAS-STING signaling following ubiquitination of CGAS by RNF185 (Human) |
2026-06-17 |
Sylvain Poux |
success |
|
|
69d8496c00002117
|
ARFGAP2 promotes STING1 proton channel activity in the trans-Golgi (Human). |
2026-06-17 |
Sylvain Poux |
success |
|
|
64c3044100001129
|
cGAS-STING signaling in the cytosol (Human) |
2026-06-17 |
Sylvain Poux |
success |
|
|
64c3044100000910
|
cGAS-STING signaling in the nucleus (Human) |
2026-06-17 |
Sylvain Poux |
success |
|
|
69ea894900004256
|
CNG channel transport by ankyrin-G/ANK3_Visual perception (Human) |
2026-06-17 |
Lucille Pourcel |
success |
|
|
69d8496c00000667
|
Inhibition of cGAS-STING signaling following CGAS methylation by PRMT5 (Human) |
2026-06-17 |
Sylvain Poux |
success |
|
|
69d8496c00001117
|
Inhibition of cGAS-STING signaling following DeISGylation of CGAS by USP18 (Human). |
2026-06-17 |
Sylvain Poux |
success |
|
|
69d8496c00001193
|
Inhibition of cGAS-STING signaling following DeISGylation of STING1 by SARS-CoV-2 viral protein NSP3 (Human). |
2026-06-17 |
Sylvain Poux |
success |
|
|
613aae0000000061
|
Inhibition of cGAS-STING signaling following dephosphorylation of CGAS by PPP6C (Human) |
2026-06-17 |
Sylvain Poux |
success |
|
|
64d5781900000281
|
Inhibition of cGAS-STING signaling following phosphorylation of CGAS by AKT1 (Human) |
2026-06-17 |
Sylvain Poux |
success |
|
|
64c3044100001787
|
Inhibition of cGAS-STING signaling in the nucleus by BANF1 (Human) |
2026-06-17 |
Sylvain Poux |
success |
|
|
63c0ac2b00000792
|
IRGM promotes autophagy-dependent degradation of CGAS (Human) |
2026-06-17 |
Sylvain Poux |
success |
|
|
69d8496c00000739
|
MYO1F promotes CGAS localization to the plasma membrane (Human) |
2026-06-17 |
Sylvain Poux |
success |
|
|
69d8496c00003045
|
Phosphorylation of STING1 by EGFR promotes cGAS-STING signaling, while inhibiting STING1 ability to promotes autophagy (Human) |
2026-06-17 |
Sylvain Poux |
success |
|
|
627d95ee00000718
|
Regulation of CGAS activity by PARP1 (Human) |
2026-06-17 |
Sylvain Poux |
success |
|
|
627d95ee00000757
|
Regulation of CGAS activity by ZDHHC18 (Human) |
2026-06-17 |
Sylvain Poux |
success |
|
|
6a18a9ba00002973
|
Role of SLC24A2 (NCKX2) in cone phototransduction, photoresponse recovery step (Human) |
2026-06-17 |
Livia Famiglietti |
filtered |
Model has at least one activity with no causal relations |
|
6a18a9ba00003203
|
SPTBN4-mediated intercalated disc targeting of CAMK2D and ANK3 involved in regulation of membrane depolarization of SCN5A during cardiac muscle cell action potential |
2026-06-17 |
Guilaine Argoud-Puy |
success |
|
|
65288b2200000194
|
STING1 acts as a proton channel and promotes autophagosome assembly (Human) |
2026-06-17 |
Sylvain Poux |
success |
|
|
69d8496c00002424
|
STING1 proton channel activity inhibits the non-canonical mTORC1 signaling leading to TFEB and TFE3 activation (Human) |
2026-06-17 |
Sylvain Poux |
success |
|
|
65288b2200000643
|
STING1 trafficking from the endoplasmic reticulum to the ERGIC following phosphorylation by MAP3K7/TAK1, interaction with STEEP1 and association with SEC24C component of COPII vesicles (Human). |
2026-06-17 |
Sylvain Poux |
success |
|
|
66187e4700000906
|
The ECS(SPSB3) complex mediates ubiquitination and degradation of CGAS in the nucleus during mitotic interphase (Human). |
2026-06-17 |
Sylvain Poux |
success |
|
|
66187e4700002670
|
EBV entry into host cell via BLLF1-CR2 interaction (Human-Epstein-Barr virus) |
2026-06-11 |
Patrick Masson |
success |
|
|
689e7a5d00004202
|
FBXO44-mediated degradation of BRCA1 via CUL1/SKP1 complex (Human) |
2026-06-11 |
Patrick Masson |
success |
|
|
62e3212700001602
|
FMDV-3A inhibition of host IRF3 via DDX56 (Human-Aphthovirus) |
2026-06-11 |
Patrick Masson |
success |
|
|
66187e4700002881
|
IFNA1-CR2 role in B-cell ISGs induction (Human) |
2026-06-11 |
Patrick Masson |
success |
|
|
62f58d8800003277
|
Import of ATM into peroxisomes y in response to reactive oxygen species via the PEX5-dependent import pathway, leading to PEX5 ubiquitination and pexophagy (Human) |
2026-06-11 |
Sylvain Poux |
success |
|
|
6690711d00001844
|
Nuclear import of AARS1 (Human). |
2026-06-11 |
Sylvain Poux |
success |
|
|
65bc474400000788
|
Nuclear import of KAT8 (Human). |
2026-06-11 |
Sylvain Poux |
success |
|
|
62f58d8800002367
|
Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (S.cerevisiae) |
2026-06-11 |
Sylvain Poux |
success |
|
|
62f58d8800003536
|
Protein import into peroxisomes of PTS2-containing proteins by the PEX7 receptor and isoform PEX5L of PEX5 (Human) |
2026-06-11 |
Sylvain Poux |
success |
|
|
62f58d8800002485
|
Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (Human) |
2026-06-11 |
Sylvain Poux |
success |
|
|
663d668500000296
|
Regulation of TNF-alpha-mediated signaling pathway by TMC8 (Human) |
2026-06-11 |
Lucille Pourcel, Sylvain Poux |
success |
|
2 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: signaling adaptor activity [GO:0035591] (molecular_function) —directly positively regulates→ signaling adaptor activity [GO:0035591] (molecular_function)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: signaling adaptor activity [GO:0035591] (molecular_function) —directly positively regulates→ IkappaB kinase activity [GO:0008384] (molecular_function)
|
63c0ac2b00000506
|
Degradation of NMNAT2 via the PAM (SKP1-FBXO45-MYCBP2) E3 ligase complex (Human) |
2026-06-09 |
Patrick Masson |
success |
|
2 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: protein ubiquitination [GO:0016567] (biological_process) —has input→ MYCBP2 Hsap [UniProtKB:O75592] (information biomacromolecule)
-
SKIPPED_FACT: Subject 'protein ubiquitination [GO:0016567] (biological_process)' has 'has input' relationship to 'MYCBP2 Hsap [UniProtKB:O75592] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
|
67c10cc400004380
|
CASR-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by extracellular calcium (Human). |
2026-06-05 |
Sylvain Poux |
success |
|
|
69ea894900000726
|
FBXO39-mediated degradation of KDM5A via CUL1 (Human) |
2026-06-05 |
Patrick Masson |
success |
|
|
69ea894900002023
|
PTH synthesis and delivery to renal distal tubule promotes calcium reabsorption (Human) |
2026-06-05 |
Patrick Masson |
success |
|
|
6a0784b700000143
|
Role of TRIP12 in ubiquitination and degradation of NFE2L2/NRF2 by KEAP1 for stress response silencing (Human). |
2026-06-05 |
Patrick Masson |
success |
|
|
65a1f4f800000999
|
Coating step in COPII-mediated ER to Golgi transport - SAR1A (Human) |
2026-05-28 |
Lionel Breuza |
success |
|
|
65a1f4f800004312
|
Coating step in COPII-mediated ER to Golgi transport - SAR1B (Human) |
2026-05-28 |
Lionel Breuza |
success |
|
|
65a1f4f800002943
|
Lipoprotein cargo loading in COPII-mediated ER to Golgi transport (Human) |
2026-05-28 |
Lionel Breuza |
success |
|
|
69ea894900003713
|
Blue light signaling mediated by OPN1SW photoreceptor via G-alpha-t (transducin)_Visual perception (Human) |
2026-05-21 |
Lucille Pourcel |
success |
|
|
69ea894900003563
|
Green light signaling mediated by OPN1MW photoreceptor via G-alpha-t (transducin)_Visual perception (Human) |
2026-05-21 |
Lucille Pourcel |
success |
|
|
69ea894900003638
|
Green light signaling mediated by OPN1MW2 photoreceptor via G-alpha-t (transducin)_Visual perception (Human) |
2026-05-21 |
Lucille Pourcel |
success |
|
|
68fac5ed00002108
|
Light signaling mediated by OPN4 receptor via G-alpha-q/11 (phospholipase c-activating, IP3, DAG) (Human). |
2026-05-21 |
Lucille Pourcel |
success |
|
|
68fac5ed00003872
|
Red light signaling mediated by OPN1LW photoreceptor via G-alpha-t (transducin)_Visual perception (Human) |
2026-05-21 |
Lucille Pourcel |
success |
|
|
69ea894900004104
|
Regulation of synaptic transmission by IQSEC2 in a GEF activity-independent manner (Hsap) |
2026-05-12 |
Livia Famiglietti |
success |
|
|
69ea894900004171
|
IQSEC2 GEF activity is regulated by Ca(2+) and calmodulin (Hsap) |
2026-05-12 |
Livia Famiglietti |
success |
|
|
68b0f0d000005568
|
De novo sphingomyelin synthesis (Human) CerS4 |
2026-05-11 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
62b4ffe300006212
|
Activation of GSDMA following cleavage by S.pyogenes speB, leading to pyroptosis (Human) |
2026-05-05 |
Sylvain Poux |
success |
|
|
62f58d8800007064
|
Activation of GSDME--mediated pyroptosis by NLRP1 in absence of GSDMD (Human) |
2026-05-05 |
Sylvain Poux |
success |
|
|
62b4ffe300006086
|
Activation of IL1B following cleavage by S.pyogenes speB, leading to inflammatory response (Human) |
2026-05-05 |
Sylvain Poux |
success |
|
|
639bc18f00000693
|
Activation of the CARD8 inflammasome by HIV-1 protease, leading to pyroptosis (Human) |
2026-05-05 |
Sylvain Poux |
success |
|
|
62e3212700001956
|
Activation of the NLRP1 inflammasome by isoform ZAKalpha of MAP3K20 in response to UV-B irradiation and ribotoxic stress (Human) |
2026-05-05 |
Sylvain Poux |
success |
|
|
61b2b68300000000
|
Activation of the NLRP6 inflammasome in response to lipoteichoic acid (Human) |
2026-05-05 |
Sylvain Poux |
success |
|
|
662af8fa00002657
|
Activation of the non-canonical inflammasome mediated by CASP4 upon lipopolysaccharide-binding can lead to blood-brain barrier breakdown (Human) |
2026-05-05 |
Sylvain Poux |
success |
|
|
62b4ffe300002385
|
Arginine ADP-riboxanation of CASP4 by S.flexneri OspC3 that blocks CASP4 activity and pyroptosis (Human) |
2026-05-05 |
Sylvain Poux |
success |
|
|
62b4ffe300000010
|
CASP7 activates SMPD1 to repair Gasdermin pores in intestinal epithelial cells (Human) |
2026-05-05 |
Sylvain Poux |
success |
|
|
62f58d8800006929
|
Cleavage of NLRP1cand GSDMD by SARS-CoV-2 protease Nsp5, leading to inhibition of GSDMD-mediated pyroptosis and concomitant initiation of GSDME-mediated pyroptosis in lung epithelial cells (Human and SARS-CoV-2) |
2026-05-05 |
Sylvain Poux |
success |
|
|
61e0e55600001659
|
Granzyme-mediated (GZMB) activation of pyroptosis (GSDME) (Human) |
2026-05-05 |
Sylvain Poux |
success |
|
|
662af8fa00002099
|
GSDMD palmitoylation by ZDHHC5 and ZDHHC9 promotes pyroptosis (Human). |
2026-05-05 |
Sylvain Poux |
success |
|
|
62f58d8800000011
|
Inactivation of GSDMD by Protease 3C from Human enterovirus 71 (EV71) (Human) |
2026-05-05 |
Sylvain Poux |
success |
|
|
635b1e3e00002003
|
Inhibition of GSDMD-mediated pyroptosis by M.tuberculosis PtpB phosphatase that alters membrane phospholipid composition (Human and M.tuberculosis) |
2026-05-05 |
Sylvain Poux |
success |
|
|
61e0e55600001295
|
NLRP1 inflammasome leading to pyroptosis (Human) |
2026-05-05 |
Sylvain Poux |
success |
|
|
662af8fa00002457
|
O-GlcNAcylation of GSDMD by OGT inhibits the non-canonical inflammasome assembly (Human) |
2026-05-05 |
Sylvain Poux |
success |
|
|
663d668500001246
|
Pyroptotic cell death mediated by GSDMD and NINJ1 (Human). |
2026-05-05 |
Sylvain Poux |
success |
|
|
69ea894900001492
|
Regulation of removal of superoxide radicals by ATOX1 through regulation of SOD3 activity. (Human) |
2026-05-05 |
Cristina Casals |
success |
|
|
6205c24300000050
|
SIRT6 inactivation by lncPRESS1 RNA (Human) |
2026-05-05 |
Pascale Gaudet, Sylvain Poux |
success |
|
|
69ea894900001449
|
SOD3 uptake and release from vesicles modulate macrophage inlfammatory response. (Human) |
2026-05-05 |
Cristina Casals |
success |
|
|
63c0ac2b00000008
|
The AIM2 inflammasome (Human) |
2026-05-05 |
Sylvain Poux |
success |
|
|
635b1e3e00001811
|
The NLRP3 inflammasome (Human) |
2026-05-05 |
Sylvain Poux |
success |
|
|
63a86a8600001653
|
The non-canonical inflammasome mediated by CASP4 upon lipopolysaccharide-binding (Human) |
2026-05-05 |
Sylvain Poux |
success |
|
|
69ea894900000181
|
PARP1 stabilizes AFF1 involved in transcriptional restart after DNA damage (Human) |
2026-05-01 |
Livia Famiglietti |
success |
|
|
6205c24300000330
|
Microtubule polyglutamylation regulation (Human) |
2026-04-30 |
Cristina Casals |
success |
|
|
6348a65d00001191
|
Nociceptor-derived Reg3g prevents endotoxic death by targeting kynurenine pathway in microglia. (Mouse) |
2026-04-30 |
Cristina Casals |
success |
|
|
66a3e0bb00000156
|
Positive regulation of cholesterol biosynthesis by PAQR3 by anchoring SREBF1-SCAP complex to the Golgi. (Human) |
2026-04-30 |
Cristina Casals |
success |
|
|
66a3e0bb00000443
|
Positive regulation of cholesterol biosynthesis by PAQR3 by anchoring SREBF2-SCAP complex to the Golgi. (Human) |
2026-04-30 |
Cristina Casals |
success |
|
|
665912ed00002885
|
PTGER1, prostaglandin E2 receptor. (Human) |
2026-04-30 |
Cristina Casals |
success |
|
|
680ad14200005137
|
YTHDC1 promotes BAT development by stabilizing PPARG (Human) |
2026-04-30 |
Nadine Gruaz |
success |
|
|
69ea894900001010
|
OR1A1-mediated olfactory signaling via G-alpha-olf ("olfactory", activating adenylate cyclase) following activation by 3- methyl-2,4-nonanedione(Human). |
2026-04-29 |
Sylvain Poux |
success |
|
|
69ea894900000425
|
OR51E2-mediated olfactory signaling via G-alpha-olf ("olfactory", activating adenylate cyclase) following activation by propionate (Human). |
2026-04-29 |
Sylvain Poux |
success |
|
|
6690711d00000142
|
OR5AN1-mediated olfactory signaling via G-alpha-olf ("olfactory", activating adenylate cyclase) following activation by muscone (Human). |
2026-04-29 |
Sylvain Poux |
success |
|
|
69ea894900000521
|
OR5V1-mediated olfactory signaling via G-alpha-olf ("olfactory", activating adenylate cyclase) following activation by methyl (9R,10E,12E)-9-methoxyoctadeca-10,12-dienoate (Human). |
2026-04-29 |
Sylvain Poux |
success |
|
|
69d8496c00005445
|
OR6A2-mediated olfactory signaling via G-alpha-olf ("olfactory", activating adenylate cyclase) following activation by octanal (Human). |
2026-04-29 |
Sylvain Poux |
success |
|
|
69ea894900000468
|
Activation of OXGR1 by 2-oxoglutarate promotes vascular smooth muscle cell contraction via G-alpha-q (phospholipase c-activating, IP3, DAG) signaling (Human). |
2026-04-28 |
Sylvain Poux |
success |
|
|
69d8496c00002213
|
ARFGAP2 has GTPase activating activity for ARF1 during COPI vesicle formation (Human). |
2026-04-28 |
Sylvain Poux |
success |
|
|
69ea894900000564
|
In liver, 12(S)-HEPE activates OR5V1-mediated signaling via G-alpha-s ("stimulatory", activating adenylate cyclase) and regulating glucose homeostasis (Human). |
2026-04-28 |
Sylvain Poux |
success |
|
|
69d8496c00005490
|
In macrophages, octanal activates OR6A2-mediated signaling via G-alpha-s ("stimulatory", activating adenylate cyclase), promoting NLRP3 inflammasome assembly (Human). |
2026-04-28 |
Sylvain Poux |
success |
|
|
6413ac9800000256
|
MYD88-dependent TLR4 signaling pathway leading to autophagy activation (Human) |
2026-04-28 |
Lucille Pourcel, Patrick Masson |
success |
|
|
6882d2b800001018
|
ASGR1-mediated recycling of N-acetylgalactosamine-units (Human) |
2026-04-27 |
Patrick Masson |
success |
|
|
65a1f4f800003542
|
Cell contact inhibition by Hippo signaling (Human). |
2026-04-27 |
Cristina Casals |
success |
|
|
69d8496c00003152
|
FBXO42-mediated degradation of p53 via CUL1/RBX1 (Human) |
2026-04-27 |
Patrick Masson |
success |
|
|
69ea894900000668
|
FBXO42-mediated degradation of PPP2C via CUL1 (Human) |
2026-04-27 |
Patrick Masson |
success |
|
|
69d8496c00003234
|
FBXO42-mediated degradation of PPP4C via CUL1 (Human) |
2026-04-27 |
Patrick Masson |
success |
|
|
66e382fb00001606
|
Hepcidin induction by BMP6 signaling (Human) |
2026-04-27 |
Patrick Masson |
success |
|
|
62900b6400000265
|
IL13-mediated signaling pathway (Human) |
2026-04-27 |
Patrick Masson |
success |
|
|
62900b6400000999
|
IL19-mediated signaling pathway |
2026-04-27 |
Patrick Masson |
success |
|
|
6246724f00001114
|
IL8-mediated signaling pathway (Human) |
2026-04-27 |
Patrick Masson |
success |
|
|
5f46c3b700001031
|
MYD88-dependent TLR4 signaling pathway leading to NF-kappa-B activation (Human) |
2026-04-27 |
Cristina Casals, Kimberly Van Auken, Pascale Gaudet, Patrick Masson |
success |
|
|
62900b6400002448
|
NSP14 inhibition of SIRT1-NRF2 axis (Human-SARS-COV-2) |
2026-04-27 |
Patrick Masson |
success |
|
|
5e72450500004019
|
SARS-COV2/HOST
|
2026-04-27 |
Patrick Masson |
success |
|
|
69d8496c00000831
|
STING1 is activated by c-di-GMP, a second messenger produced by bacteria, activating the antibacterial innate immune response (Human) |
2026-04-27 |
Sylvain Poux |
success |
|
|
6690711d00000055
|
TAAR5-mediated olfactory signaling via G-alpha-olf ("olfactory", activating adenylate cyclase) following activation by trimethylamine (Human). |
2026-04-27 |
Sylvain Poux |
success |
|
|
6690711d00000012
|
TAAR6-mediated olfactory signaling via G-alpha-olf ("olfactory", activating adenylate cyclase) following activation by beta-phenylethylamine (Human). |
2026-04-27 |
Sylvain Poux |
success |
|
|
6690711d00000101
|
TAAR9-mediated olfactory signaling via G-alpha-olf ("olfactory", activating adenylate cyclase) following activation by beta-phenylethylamine (Human). |
2026-04-27 |
Sylvain Poux |
success |
|
|
689e7a5d00000098
|
Alpha-dystroglycan is a receptor for agrin required for upregulation of SOX9, a transcription factor involved in chondrocyte differentiation (Human) |
2026-04-23 |
Livia Famiglietti |
success |
|
|
67b1629100002092
|
Cardiolipin metabolic process (GO:0032048) (Human) |
2026-04-23 |
Antonia Lock |
success |
|
|
67c10cc400001765
|
GPR65-mediated signaling via G-alpha-s ("stimulatory", activating adenylate cyclase) following activation by protons (Human). |
2026-04-23 |
Sylvain Poux |
success |
|
|
69d8496c00003493
|
HIV-2 virus Vpx protein inhibits STING1 ability to activate NF-kappa-B signaling (HIV-2 and Human). |
2026-04-23 |
Sylvain Poux |
success |
|
|
69d8496c00001461
|
IKBKE/IKKepsilon promote NF-kappa-B signaling by mediating phosphorylation of different proteins of NF-kappa-B signaling , such as RELA, CYLD and NFKBIA (Human). |
2026-04-23 |
Sylvain Poux |
success |
|
|
69d8496c00001701
|
Influenza virus M protein inhibits STING1 ability to activate NF-kappa-B signaling (Influenza virus and Human). |
2026-04-23 |
Sylvain Poux |
success |
|
|
68d5ebd600001504
|
KISS1/KISS1R signaling pathway is involved in the negative regulation of bone resorption by osteoclasts (Human) |
2026-04-23 |
Livia Famiglietti |
success |
|
|
689e7a5d00004412
|
Lactate regulates dendritic cell function trhough ROS production inhibition by COXFA4L2. (Human) |
2026-04-23 |
Cristina Casals |
success |
|
|
6870555700001180
|
Laminin-1 binding to alpha-dystroglycan increases agrin-induced acetylcholine receptor aggregation (Human) |
2026-04-23 |
Livia Famiglietti |
success |
|
|
69d8496c00004472
|
PELI2 mediates ubiquitination of TBK1, inhibiting cGAS-STING signaling while promoting STING1 ability to activate NF-kappa-B signaling (Human). |
2026-04-23 |
Sylvain Poux |
success |
|
|
62f58d8800005094
|
Regulation of oolemmal binding multimeric complex formation (Mouse) |
2026-04-23 |
Cristina Casals |
success |
|
|
69d8496c00001576
|
STING1 promotes NF-kappa-B signaling in response to virus infection (Human). |
2026-04-23 |
Sylvain Poux |
success |
|
|
66b5638000002817
|
Trans-synaptic comples NRXN3B-CBLN2-GRID1 regulates AMPAR signaling. (Mouse) |
2026-04-23 |
Cristina Casals |
success |
|
|
66b5638000002719
|
trans-synaptic complex NRXN1B-CBLN2-GRID1 regulates NMDAR signaling. (Human) |
2026-04-23 |
Cristina Casals |
success |
|
|
66b5638000002885
|
Trans-synaptic complex NRXN1B-CBLN2-GRID1 regulates NMDAR signaling. (Mouse) |
2026-04-23 |
Cristina Casals |
success |
|
|
66b5638000002847
|
Trans-synaptic complex NRXN3B-CBLN2-GRID1 regulates AMPAR signaling. (Human) |
2026-04-23 |
Cristina Casals |
success |
|
|
6606056e00001551
|
TREM2 activated by LDL. (Human) |
2026-04-23 |
Cristina Casals |
success |
|
|
6606056e00001598
|
TREM2 activated by VLDL. (Human) |
2026-04-23 |
Cristina Casals |
success |
|
|
63c0ac2b00001143
|
IRGM promotes autophagy-dependent degradation of RIPosomes (NOD1, NOD2 and RIPK2) (Human) |
2026-04-22 |
Sylvain Poux |
success |
|
|
641ce4dc00000214
|
NOD1 signaling in response to gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) leading to NF-kappa-B and MAP kinase activation (Human) |
2026-04-22 |
Sylvain Poux |
success |
|
|
641ce4dc00000430
|
NOD2 localization to the plasma membrane following palmitoylation by ZDHHC5 (Human) |
2026-04-22 |
Sylvain Poux |
success |
|
|
641ce4dc00000050
|
NOD2 signaling in response to muramyl dipeptide (MDP) leading to NF-kappa-B and MAPK kinase activation (Human) |
2026-04-22 |
Sylvain Poux |
success |
|
|
6205c24300000880
|
Regulation of cholesterol biosynthesis by SREBP (SREBF1 and SREBF2) and retention by the SREBP-SCAP complex (Human) |
2026-04-22 |
Sylvain Poux |
success |
|
|
627d95ee00002067
|
Regulation of PARP2 activity by PARP1 and recruitment of APLF to DNA damage sites (Human) |
2026-04-22 |
Sylvain Poux |
success |
|
|
6246724f00000331
|
Regulation of the NOD2 signaling pathway via RIPK2 ubiquitination by ZNRF4 (Human) |
2026-04-22 |
Sylvain Poux |
success |
|
|
627d95ee00000775
|
ADP-ribosylation of histones by PARP1 leading to recruitment of CHD1L (Human) |
2026-04-21 |
Sylvain Poux |
success |
|
|
627d95ee00001139
|
Extraction of PARP1 trapped to chromatin by VCP/p97 following sumoylation by PIAS4 and ubiquitination by RNF4 (Human) |
2026-04-21 |
Sylvain Poux |
success |
|
|
689e7a5d00003524
|
HCRTR1 binds the neuropeptide orexin-B to regulate food behavior. (Human) |
2026-04-21 |
Nadine Gruaz, Sylvain Poux |
success |
|
|
63c0ac2b00000738
|
Negative regulation of the NLRP3 inflammasome by IRGM (Human) |
2026-04-21 |
Sylvain Poux |
success |
|
|
63c0ac2b00001252
|
Palmitoylation of NLRP3 by ZDHHC12, leading to NLRP3 degradation by the chaperone-mediated autophagy process (Human) |
2026-04-21 |
Sylvain Poux |
success |
|
|
6882d2b800003436
|
Regulation of the tRNA-splicing ligase (Human) |
2026-04-21 |
Lionel Breuza |
success |
|
|
63d320cd00001688
|
Response to ribosome stalling by GCN1, RNF14 and RNF25, leading to ubiquitination and degradation of EEF1A1 (Human) |
2026-04-21 |
Sylvain Poux |
success |
|
|
63a86a8600001720
|
The non-canonical inflammasome mediated by Casp11 upon lipopolysaccharide-binding (Mouse) |
2026-04-21 |
Sylvain Poux |
success |
|
|
61f34dd300001044
|
Yeast ergosterol |
2026-04-21 |
Kimberly Van Auken, Marc Feuermann, Sylvain Poux |
success |
|
|
6246724f00001921
|
ZDHHC20-ZDHHC9 Palmitoyltransferase activity of Sars-Cov-2 S protein (Human-Sars-Cov-2) |
2026-04-21 |
Cristina Casals |
success |
|
|
62900b6400001749
|
ZDHHC7 Hsap regulates SCRIB in polarized cell differentiation (Human) |
2026-04-21 |
Lionel Breuza |
success |
|
|
6482692800001029
|
Activation of the canonical mTORC1 signaling by GATOR2, which inactivates GATOR1 in response to abundant amino acids (Human) |
2026-04-20 |
Sylvain Poux |
success |
|
|
685de18700003890
|
CTLA4 inhibits T-cell activation by acting as a decoy receptor for CD80 (Human). |
2026-04-20 |
Sylvain Poux |
success |
|
|
685de18700004045
|
CTLA4 inhibits T-cell activation by acting as a decoy receptor for CD86 (Human). |
2026-04-20 |
Sylvain Poux |
success |
|
|
64d5781900000615
|
Activation of canonical mTORC1 following glycosylation of RPTOR by OGT in response to glucose sufficiency (Human) |
2026-04-20 |
Sylvain Poux |
success |
|
|
685de18700004471
|
Activation of PDCD1/PD-1 by CD274 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). |
2026-04-20 |
Sylvain Poux |
success |
|
|
685de18700004682
|
Activation of PDCD1/PD-1 by PDCD1LG2 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). |
2026-04-20 |
Sylvain Poux |
success |
|
|
6482692800000701
|
Activation of the canonical mTORC1 signaling by BMT2/SAMTOR in response to S-adenosyl-L-methionine influx (Human) |
2026-04-20 |
Sylvain Poux |
success |
|
|
6482692800002004
|
Activation of the mTORC1 signaling by CASTOR1 in response to abundant arginine (Human)
|
2026-04-20 |
Sylvain Poux |
success |
|
1 warning
-
INDIVIDUAL_HAS_MULTIPLE_TYPES: Individual has multiple types; using the first type for translation
|
6482692800002068
|
Activation of the mTORC1 signaling by SESN2 in response to abundant leucine (Human). |
2026-04-20 |
Sylvain Poux |
success |
|
|
662af8fa00002572
|
Activation of the non-canonical inflammasome mediated by Casp11 upon lipopolysaccharide-binding can lead to blood-brain barrier breakdown (Mouse) |
2026-04-20 |
Sylvain Poux |
success |
|
|
613aae0000000040
|
cGAS-Sting pathway (Drosophila) |
2026-04-20 |
Sylvain Poux |
success |
|
|
65f3ae5c00002132
|
Control of GABAAR clustering to GABAergic synapses by Gephyrin (Human) |
2026-04-20 |
Lucille Pourcel, Sylvain Poux |
success |
|
|
6348a65d00000661
|
Cytotoxic T cell pyroptosis mediated by GSDMB isoform 1 in response to infection by Gram-negative bacteria and its inhibition by S.flexneri IpaH7.8 (Human and S.flexneri) |
2026-04-20 |
Sylvain Poux |
success |
|
|
641ce4dc00001047
|
Generation of NFKB1 p50 subunit of NF-kappa-B via limited processing by the KPC1 complex (RNF123), leading to NF-kappa-B inhibitor (Human) |
2026-04-20 |
Sylvain Poux |
success |
|
|
6348a65d00000594
|
Granzyme-mediated (GZMA) activation of pyroptosis (GSDMB isoform 4) (Human) |
2026-04-20 |
Sylvain Poux |
success |
|
|
662af8fa00002225
|
Gsdmd palmitoylation by Zdhhc5 and Zdhhc9 promotes pyroptosis (Mouse) |
2026-04-20 |
Sylvain Poux |
success |
|
|
6482692800001514
|
Inactivation of the canonical mTORC1 signaling via phosphorylation of WDR24 by AMPK in response to glucose starvation (Human) |
2026-04-20 |
Sylvain Poux |
success |
|
1 warning
-
SKIPPED_FACT: 'protein K6-linked ubiquitination [GO:0085020] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'positive regulation of TORC1 signaling [GO:1904263] (biological_process)'
|
64b9cb1500000603
|
Inhibition of proton channel activity of TMEM175 by LAMP1 and LAMP2 (Human) |
2026-04-20 |
Sylvain Poux |
success |
|
|
685de18700005545
|
Inhibition of T cell receptor signaling by LAG3 following binding to FGL1 and ubiquitination by CBL (Human). |
2026-04-20 |
Sylvain Poux |
success |
|
|
685de18700005690
|
Inhibition of T cell receptor signaling by LAG3 following binding to FGL1 and ubiquitination by CBLB (Human). |
2026-04-20 |
Sylvain Poux |
success |
|
|
685de18700005171
|
Inhibition of T cell receptor signaling by LAG3 following binding to MHC class II and ubiquitination by CBL (Human). |
2026-04-20 |
Sylvain Poux |
success |
|
|
685de18700005414
|
Inhibition of T cell receptor signaling by LAG3 following binding to MHC class II and ubiquitination by CBLB (Human). |
2026-04-20 |
Sylvain Poux |
success |
|
|
648d0dc100001272
|
Inhibition of the non-canonical mTORC1 signaling following phosphorylation of FNIP1 by AMPK in response to mitochondrial stress (Human). |
2026-04-20 |
Sylvain Poux |
success |
|
|
617b481400000559
|
KAT5 regulation of lipid droplet disassembly (Human) |
2026-04-20 |
Sylvain Poux |
success |
|
|
617b481400000720
|
KAT5 regulation of myoblast differentiation (Human) |
2026-04-20 |
Sylvain Poux |
success |
|
|
613aae0000000813
|
Liver apoptosis regulation by CASP6 (Human) |
2026-04-20 |
Sylvain Poux |
success |
|
|
63c0ac2b00000641
|
Lysosome biogenesis by TFEB and regulation of nuclear translocation via dephosphorylation by PPP3CB and regulation by IRGM (Human) |
2026-04-20 |
Sylvain Poux |
success |
|
|
66a3e0bb00002706
|
MYH9 is the receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B (Human). |
2026-04-20 |
Sylvain Poux |
success |
|
|
646ff70100002557
|
Negative regulation of autophagy via phosphorylation of ULK1 by canonical mTORC1 signaling (Human) |
2026-04-20 |
Sylvain Poux |
success |
|
|
6482692800002614
|
Non-canonical mTORC1 signaling leading to TFEB and TFE3 phosphorylation and inactivation (Human) |
2026-04-20 |
Sylvain Poux |
success |
|
|
645d887900000967
|
O-mannosylation of MET and MST1R/RON by TMEM260 is required for their maturation (Human). |
2026-04-20 |
Sylvain Poux |
success |
|
|
6205c24300000366
|
Phosphorylation of NELFE by CDK9 and regulation of chromatin-binding by SIRT6 (Human) |
2026-04-20 |
Sylvain Poux |
success |
|
|
61f34dd300000863
|
PKM2 acetylation by EP300 and deacetylation by SIRT6 leading to conversion into a protein kinase (Human) |
2026-04-20 |
Sylvain Poux |
success |
|
|
622aace900000480
|
Protein demyristoylase activity of SIRT6 that regulate protein localization of TNF (Human) |
2026-04-20 |
Sylvain Poux |
success |
|
|
623d156d00000918
|
Protein depalmitoyltransferase activity of SIRT6 that regulate protein localization of RRAS2 (Human) |
2026-04-20 |
Sylvain Poux |
success |
|
|
61f34dd300000981
|
Regulation of gluconeogenesis by SIRT6, FOXO1 and KAT2A/GCN5 (Human) |
2026-04-20 |
Sylvain Poux |
success |
|
|
6205c24300000421
|
Regulation of Nelfe binding to chromatin by Sirt6 (Mouse) |
2026-04-20 |
Sylvain Poux |
success |
|
|
6482692800000198
|
Regulation of the canonical mTORC1 signaling via ubiquitination and deubiquitination of RHEB by RNF152 and USP4, respectively (Human) |
2026-04-20 |
Sylvain Poux |
success |
|
|
685de18700003315
|
Stimulation ot T cell receptor signaling by CD28 following binding to CD80 (Human). |
2026-04-20 |
Sylvain Poux |
success |
|
|
685de18700003492
|
Stimulation ot T cell receptor signaling by CD28 following binding to CD86 (Human). |
2026-04-20 |
Sylvain Poux |
success |
|
|
685de18700002961
|
T cell receptor signaling (Human). |
2026-04-20 |
Sylvain Poux |
success |
|
|
6482692800000498
|
Activation of the canonical mTORC1 signaling by GPR155/LYCHOS in response to cholesterol influx (Human) |
2026-04-19 |
Sylvain Poux |
success |
|
|
65692e7e00000243
|
Activation of the canonical mTORC1 signaling by PRMT1 in response to S-adenosyl-L-methionine influx (Human) |
2026-04-19 |
Guilaine Argoud-Puy, Sylvain Poux |
success |
|
|
646ff70100004025
|
Activation of the canonical mTORC1 signaling via non-catalytic deubiquitination of RPTOR by OTUB1 (Human) |
2026-04-19 |
Sylvain Poux |
success |
|
|
646ff70100001561
|
Activation of the mTORC1 signaling by ubiquitination and degradation of GATOR1 subunit DEPDC5 by KLHL22 (Human) |
2026-04-19 |
Sylvain Poux |
success |
|
|
646ff70100000391
|
Canonical mTORC1 signaling (Human) |
2026-04-19 |
Sylvain Poux |
success |
|
|
653b0ce600000673
|
G2/M transition of the cell cycle via phosphorylation of LMNA by CDK1 (Human). |
2026-04-19 |
Sylvain Poux |
success |
|
|
63a86a8600001780
|
GBP2 and GBP5 inhibit FURIN-mediated cleavage of HIV-1 envelope protein, inhibiting viral infectivity (Human) |
2026-04-19 |
Sylvain Poux |
success |
|
|
64c3044100001348
|
Inhibition of cGAS-STING signaling by AURKB (Human) |
2026-04-19 |
Sylvain Poux |
success |
|
|
646ff70100001312
|
Inhibition of the canonical mTORC1 signaling by the GATOR1 complex (Human) |
2026-04-19 |
Sylvain Poux |
success |
|
|
646ff70100001877
|
Inhibition of the canonical mTORC1 signaling via ubiquitination and degradation of LAMTOR1 by UBE3A (Human) |
2026-04-19 |
Sylvain Poux |
success |
|
|
617b481400000460
|
KAT5 involvement in DNA repair via homologous recombination (Human) |
2026-04-19 |
Pascale Gaudet, Sylvain Poux |
success |
|
|
617b481400000521
|
KAT5 involvement in nucleotide excision repair (Human) |
2026-04-19 |
Sylvain Poux |
success |
|
|
646ff70100000838
|
N-terminal myristoylation and palmitoylation of LAMTOR1 mediates its recruitment to lysosome membranes (Human) |
2026-04-19 |
Sylvain Poux |
success |
|
|
653b0ce600000623
|
Negative regulation of the G2/M transition of the cell cycle via inhibition of CDK1 (Human). |
2026-04-19 |
Sylvain Poux |
success |
|
|
682fbcd000002172
|
PRDM16 and MECOM catalyze histone H3 H3K9me monomethylation in the cytoplasm, before histone H3 import in the nucleus, incorporation into nucleosome and trimethylation by SUV39H1 (Human). |
2026-04-19 |
Sylvain Poux |
success |
|
|
698e557b00000391
|
PSENEN binds metformin in response to calorie restriction and inhibits the V-ATPase complex, inhibiting mTORC1 signaling (Human). |
2026-04-19 |
Sylvain Poux |
success |
|
|
60ff660000000635
|
Regulation of autophagosome assembly by ubiquitination of PIK3C3/VPS34 (Human) |
2026-04-19 |
Sylvain Poux |
success |
|
|
6246724f00000369
|
Regulation of the mTORC1 signaling via ubiquitination and degradation of CASTOR1 by RNF167 (Human)
|
2026-04-19 |
Sylvain Poux |
success |
|
1 warning
-
INDIVIDUAL_HAS_MULTIPLE_TYPES: Individual has multiple types; using the first type for translation
|
6246724f00000283
|
Regulation of the mTORC1 signaling via ubiquitination and deubiquitnation of SESN2 by RNF167 and STAMBPL1 (Human) |
2026-04-19 |
Sylvain Poux |
success |
|
|
698e557b00000129
|
The V-ATPase complex promotes the guanyl-nucleotide exchange factor activity of the Ragulator complex during mTORC1 signaling (Human). |
2026-04-19 |
Sylvain Poux |
success |
|
|
646ff70100000611
|
Ubiquitination of RagA/RRAGA by RNF152 inhibits the mTORC1 signaling (Human) |
2026-04-19 |
Sylvain Poux |
success |
|
|
65f3ae5c00001357
|
Ufmylation of TP53/p53 counteracts ubiquitination and degradation of TP53/p53 by MDM2 (Human). |
2026-04-19 |
Sylvain Poux |
success |
|
|
641ce4dc00000914
|
Activation of Nf-kappa-B via ubiquitination and degradation of the NF-kappa-B inhibitor (Human) |
2026-04-17 |
Sylvain Poux |
success |
|
|
646ff70100003125
|
Inhibition of the canonical mTORC1 signaling by NLK in response to osmotic stress (Human) |
2026-04-17 |
Sylvain Poux |
success |
|
|
63a86a8600001865
|
Irgb10/Gm12250 mediates disruption of the pathogen membrane, liberating ligands that are detected by inflammasomes (Mouse) |
2026-04-17 |
David Hill, Sylvain Poux |
success |
|
|
69c59f8a00002811
|
KRT14 positive regulation of Hippo signaling via YAP1_ON state_Human |
2026-04-17 |
Lucille Pourcel |
success |
|
|
69c59f8a00001359
|
KRT15 negative regulation of Hippo signaling via YAP1_OFF state_Human |
2026-04-17 |
Lucille Pourcel |
success |
|
|
69d8496c00002245
|
Regulation of HSPA9/mt-Hsp70 by GRPEL2_mitochondrial protein import (Human) |
2026-04-17 |
Lucille Pourcel |
success |
|
|
61bcf0b700000560
|
tRNA methylation by METTL6 and regulation by SARS1-binding (Human) |
2026-04-17 |
Sharan Prakash, Sylvain Poux |
success |
|
|
62900b6400001385
|
Lysosome biogenesis by TFEB and regulation of cytoplasmic retention via phosphorylation by MTOR or alkylation (Human) |
2026-04-16 |
Pascale Gaudet, Sylvain Poux |
success |
|
4 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of protein localization to nucleus [GO:1900181] (biological_process) —has input→ TFEB Hsap [UniProtKB:P19484] (information biomacromolecule)
-
SKIPPED_FACT: Subject 'negative regulation of protein localization to nucleus [GO:1900181] (biological_process)' has 'has input' relationship to 'TFEB Hsap [UniProtKB:P19484] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
-
SKIPPED_FACT: Subject 'negative regulation of protein localization to nucleus [GO:1900181] (biological_process)' has 'has input' relationship to 'TFEB Hsap [UniProtKB:P19484] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
-
SKIPPED_FACT: Subject 'negative regulation of protein localization to nucleus [GO:1900181] (biological_process)' has 'has input' relationship to 'TFEB Hsap [UniProtKB:P19484] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
|
69c59f8a00001474
|
DRD2 forms a heteromer with GHSR in spinal cord neurons, promoting G-alpha-q/11 (phospholipase c-activating, IP3, DAG)-mediated signaling (Human). |
2026-04-13 |
Sylvain Poux |
success |
|
|
69b3372b00003969
|
Activation of ALK by ALKAL2 cytokine (Human) |
2026-04-13 |
Sylvain Poux |
success |
|
|
69a0c46f00002483
|
BRCA2 promotes formation of RAD51 nucleoprotein filaments during homologous recombination-mediated repair of DSBs (Human). |
2026-04-13 |
Sylvain Poux |
success |
|
|
69a0c46f00002570
|
Deubiquitination of RAD51 by UCHL3 promotes association between BRA2 and RAD51 and formation of nucleoprotein filaments during homologous recombination-mediated repair of DSBs (Human). |
2026-04-13 |
Sylvain Poux |
success |
|
|
69c59f8a00000117
|
Dopamine biosynthesis (Human). |
2026-04-13 |
Sylvain Poux |
success |
|
|
69c59f8a00000139
|
DRD1 forms a heteromer with GHSR in hippocampal neurons, promoting G-alpha-q/11 (phospholipase c-activating, IP3, DAG)-mediated signaling (Human). |
2026-04-13 |
Sylvain Poux |
success |
|
|
69c59f8a00000043
|
DRD1-mediated signaling via G-alpha-s ("stimulatory", activating adenylate cyclase) following activation by dopamine (Human). |
2026-04-13 |
Sylvain Poux |
success |
|
|
69c59f8a00001439
|
DRD2-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by dopamine (Human). |
2026-04-13 |
Sylvain Poux |
success |
|
|
69c59f8a00002981
|
DRD3-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by dopamine (Human). |
2026-04-13 |
Sylvain Poux |
success |
|
|
69c59f8a00003141
|
DRD4-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by adrenaline (Human). |
2026-04-13 |
Sylvain Poux |
success |
|
|
69c59f8a00003111
|
DRD4-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by dopamine (Human). |
2026-04-13 |
Sylvain Poux |
success |
|
|
69c59f8a00003173
|
DRD4-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by noradrenaline (Human). |
2026-04-13 |
Sylvain Poux |
success |
|
|
69c59f8a00003487
|
DRD5-mediated signaling via G-alpha-s ("stimulatory", activating adenylate cyclase) following activation by dopamine (Human). |
2026-04-13 |
Sylvain Poux |
success |
|
|
69a0c46f00002608
|
FIRRM and FIGNL1 inhibit formation of RAD51 nucleoprotein filaments during homologous recombination-mediated repair of DSBs (Human). |
2026-04-13 |
Sylvain Poux |
success |
|
|
69a0c46f00002668
|
Formation of double-strand breaks (DSB) to initiate meiotic recombination (Human). |
2026-04-13 |
Sylvain Poux |
success |
|
|
69c59f8a00001396
|
In the central nervous system, DRD2 signaling is mainly mediated via G-alpha-o (inhibitory), inhibiting adenylate cyclase (Human). |
2026-04-13 |
Sylvain Poux |
success |
|
|
69b3372b00001414
|
Intestinal absorption of citrate by the luminal and basolateral citrate transporters SLC13A2 and SLC35G1, respectively (Human). |
2026-04-13 |
Sylvain Poux |
success |
|
|
69c59f8a00000079
|
Negative regulation of DRD1-mediated signaling following phosphorylation by PKC (Human). |
2026-04-13 |
Sylvain Poux |
success |
|
|
69c59f8a00001524
|
Palmitoylation of dopamine receptor DRD2 by ZDHHC3, ZDHHC4 or ZDHHC8 promotes DRD2 localization to the plasma membrane (Human). |
2026-04-13 |
Sylvain Poux |
success |
|
|
62b4ffe300000906
|
Poxvirus-OPG065 inhibition of ISG15 conjugation (Human-Poxvirus) |
2026-04-13 |
Kimberly Van Auken, Patrick Masson, Sylvain Poux |
success |
|
|
69b3372b00001929
|
SLC6A6 mediates taurine import in cell and mitochondrion (Human). |
2026-04-13 |
Sylvain Poux |
success |
|
|
67369e7600001710
|
Heme B biosynthetic process, including ammonium detoxification by GLUL (Human). |
2026-04-07 |
Sylvain Poux |
success |
|
|
693b3c0900002518
|
Signaling by MCH mediated by MCHR1 receptor via G-alpha-q/11 (phospholipase c-activating, IP3, DAG)-Feeding (Human). |
2026-04-07 |
Lucille Pourcel |
success |
|
|
69b3372b00002031
|
Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase (Human) |
2026-04-02 |
Patrick Masson |
success |
|
2 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] (biological_process) —has input→ DEPDC5 Hsap [UniProtKB:O75140] (information biomacromolecule)
-
SKIPPED_FACT: Subject 'proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] (biological_process)' has 'has input' relationship to 'DEPDC5 Hsap [UniProtKB:O75140] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
|
69b3372b00001963
|
MDM2-UBE4B cooperation to ubiquitinate P53 (Human) |
2026-04-02 |
Patrick Masson |
success |
|
|
69c59f8a00000997
|
L-lyxonate catabolism (P. aeruginosa) |
2026-03-31 |
Antonia Lock |
success |
|
|
69b3372b00003740
|
C1QTNF5 antagonizes ADIPOR1 activity in retinal pigment epithelium and is involved in the regulation of lipid metabolism (Human) |
2026-03-30 |
Livia Famiglietti |
success |
|
|
61e0e55600002253
|
Activation of LTK by ALKAL1 and ALKAL2 cytokines (Human) |
2026-03-26 |
Sylvain Poux |
success |
|
|
69b3372b00001100
|
CLEC12a is an inhibitory receptor for uric acid crystals (Human) |
2026-03-19 |
Patrick Masson |
success |
|
|
69b3372b00001688
|
Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation (Human) |
2026-03-19 |
Lionel Breuza, Patrick Masson |
success |
|
|
69b3372b00001462
|
Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB (Human) |
2026-03-19 |
Patrick Masson |
success |
|
|
62b4ffe300003747
|
Response to IFN-beta, leading to JAK-STAT activation (Human) |
2026-03-12 |
Patrick Masson, Sylvain Poux |
success |
|
|
682fbcd000002323
|
CCL17-CCR4 mediated recruitment of ARRB2 in T-cell chemotaxis (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
685de18700005909
|
GPR171 a receptor for Big LEN, a neuropeptide regulating feeding behavior. (Human) |
2026-03-12 |
Nadine Gruaz |
success |
|
|
6870555700002216
|
HCRTR1 binds the neuropeptide orexin-A to regulate food behavior. (Human) |
2026-03-12 |
Nadine Gruaz |
success |
|
|
69729a3800003304
|
Processing, maturation and transport of vasopressin (AVP) hormone (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
6606056e00000859
|
TREM2 activated by APOE. (Human) |
2026-03-12 |
Cristina Casals |
success |
|
|
68b0f0d000006001
|
Activation of GPR12 by sphingosine-1-phosphate (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
65d7e4ac00001732
|
Activation of GPR75 by CCL5 in neurons (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
65bc474400001544
|
Activation of the GDF15-GFRAL aversive signaling pathway in response to stress (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
696022cd00001370
|
Activation of the smoothened signaling pathway by DHH, which relieves SMO inhibition by PTCH1 (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
696022cd00001246
|
Activation of the smoothened signaling pathway by IHH, which relieves SMO inhibition by PTCH1 (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
696022cd00000812
|
Activation of the smoothened signaling pathway by SHH, which relieves SMO inhibition by PTCH1 (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
696022cd00001416
|
Activation of the smoothened signaling pathway by SHH, which relieves SMO inhibition by PTCH2 (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
67b1629100002705
|
Activin A signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
663d668500002824
|
Activin E signaling pathway leading to inhibition of adipose tissue development (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
68b0f0d000002755
|
ADORA3-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by adenosine (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
68b0f0d000002796
|
ADORA3-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by N(6)-methyladenosine (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
67c10cc400005105
|
Adropin-GPR19 axis regulating energy homeostasis (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
67c10cc400005742
|
AMH-AMHR2 signaling leading to anti-mullerian signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
6690711d00002607
|
ANG tRNA ribonuclease activity inhibits translation in response to stress (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
665912ed00003542
|
Angiopoietin-1-Thrombomodulin pair inhibiting Protein C activation (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
665912ed00003594
|
Angiopoietin-2-Thrombomodulin pair inhibiting Protein C activation (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
67c10cc400009138
|
ANTXR1/PLAU interaction leading to activation of the EGF signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
6606056e00001371
|
APP clearance through CLU:TREM2 interaction. (Human) |
2026-03-12 |
Cristina Casals |
success |
|
|
67e5e74400004286
|
AVPR2 -mediated signaling G-alpha-s ("stimulatory", activating adenylate cyclase) following activation by vasopressin (AVP) (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
663d668500002770
|
Bacterial flagellin recognition by TLR5 (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
684b6c8100004302
|
Bacterial queuine and queuosine salvage for tRNA modification (Human) |
2026-03-12 |
Lionel Breuza |
success |
|
|
66b5638000000321
|
BCAM-LAMA5 pair role in cell adhesion (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
65692e7e00002024
|
BLVRB negatively regulates insulin signaling by mediating S-nitrosylation of INSR and IRS1 (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
645d887900001795
|
BMP2 signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
66e382fb00001097
|
BMP3 signaling leading to bone formation inhibition (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
66e382fb00001148
|
BMP3b/GDF10 signaling leading to bone formation inhibition (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
66e382fb00001232
|
BMP4 signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
66e382fb00001388
|
BMP5 role in dendritic growth via SMAD1 (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
645d887900000999
|
BMP7 signaling leading to osteoblast differentiation (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
66e382fb00002105
|
BMP8A role in spermatogenesis via SMAD1, SMAD5 and SMAD9 (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
66e382fb00002243
|
BMP8B role in adipocyte differentiation inhibition (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
600ced8500002343
|
BMP9 signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
6246724f00000632
|
Bradykinin degradation by ACE and bradykin-binding to its receptor (Human) |
2026-03-12 |
Sylvain Poux |
success |
|
|
67f85f2b00004288
|
C3AR1-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by anaphylatoxin C3a (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
67f85f2b00004380
|
C5AR1-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by anaphylatoxin C5a (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
62900b6400002267
|
Casp7 activates Smpd1 to repair Gasdermin pores in intestinal epithelial cells (Mouse) |
2026-03-12 |
Sylvain Poux |
success |
|
|
62b4ffe300000081
|
CASP7 activates SMPD1 to repair perforin pores in hepatocytes (Human) |
2026-03-12 |
Sylvain Poux |
success |
|
|
62900b6400002353
|
Casp7 activates Smpd1 to repair perforin pores in hepatocytes (Mouse) |
2026-03-12 |
Sylvain Poux |
success |
|
|
67c10cc400004342
|
CASR-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by extracellular calcium (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
67c10cc400004457
|
CASR-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) promotes assembly of the NLRP3 inflammasome (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
680ad14200006125
|
CCL1-CCR8 axis (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
680ad14200007665
|
CCL11-CCR3 axis involved in cell chemotaxis (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
67e5e74400001887
|
CCL15-CCR1 association leading to inflammatory response (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
67e5e74400002539
|
CCL2-CCR2 signaling via GNAI1 (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
67e5e74400002640
|
CCL2-CCR3 signaling via GNAI1 (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
682fbcd000002354
|
CCL22-CCR4 mediated recruitment of ARRB2 in T-cell chemotaxis (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
680ad14200007765
|
CCL24-CCR3 axis involved in cell chemotaxis (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
680ad14200007827
|
CCL26-CCR3 axis involved in cell chemotaxis (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
67e5e74400002668
|
CCL5-CCR1 axis promotes neuroinflammation via ERK1/ERK2 (Human) |
2026-03-12 |
Patrick Masson |
success |
|
1 warning
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: obsolete cytoplasmic sequestering of NF-kappaB [GO:0007253] (biological_process) —part of→ toll-like receptor 4 signaling pathway [GO:0034142] (biological_process)
|
67e5e74400002819
|
CCL7-CRR1 signaling leading to canonical NF-kappa activation in macrophages (Human). |
2026-03-12 |
Patrick Masson |
success |
|
|
66187e4700002637
|
CD21/FCRL5 receptor role in B-cell activation (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
69729a3800001528
|
CD36 transport to the plasma membrane for muscle regeneration (Human) |
2026-03-12 |
Lionel Breuza |
success |
|
|
663d668500001599
|
CD40-CD40L distal activation of TRAF6 (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
663d668500001704
|
CD40-CD40L proximal activation of TRAF2 and TRAF5 (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
6606056e00000234
|
CD69-OxydizedLDL pair leading to PD-1 expression in T-cells (Human) |
2026-03-12 |
Patrick Masson |
success |
|
2 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidised LDL [CHEBI:60151] (information biomacromolecule) —directly positively regulates→ transmembrane signaling receptor activity [GO:0004888] (molecular_function)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidised LDL [CHEBI:60151] (information biomacromolecule) —located in→ extracellular region [GO:0005576] (anatomical entity)
|
6606056e00002011
|
CD72 and BCR co-stimulation by sn/RNP self antigen (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
666b894f00000196
|
CD93/Multimerin-2/β1 integrin complex function in angiogenesis (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
657ba49f00001888
|
CDK1-mediated deubiquitination of CCNB1 by USP22 leading to G2/M progression (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
68fac5ed00000440
|
Ceruloplasmin (CP) is an inhibitor of
myeloperoxidase (MPO) (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
665912ed00000552
|
Cholesterol synthesis regulation by Cholesin and GPR146 |
2026-03-12 |
Cristina Casals |
success |
|
|
68fac5ed00002909
|
CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR (human) |
2026-03-12 |
Guilaine Argoud-Puy |
success |
|
|
68fac5ed00000166
|
CNTF signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) |
2026-03-12 |
Guilaine Argoud-Puy |
success |
|
|
68d5ebd600003246
|
CNTF signaling pathway involving soluble CNTFR and the IL6ST-LIFR complex (human) |
2026-03-12 |
Guilaine Argoud-Puy |
success |
|
|
645d887900000439
|
Contracted-muscle secreted FN1 activates liver autophagy via hepatic Itga5:Itgb1 integrin receptor signaling. (Mouse) |
2026-03-12 |
Cristina Casals |
success |
|
|
69729a3800006465
|
CRHBP inhibits corticotropin-releasing hormone activity (CRH) (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
68d5ebd600002260
|
CRLF-CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) |
2026-03-12 |
Guilaine Argoud-Puy |
success |
|
|
68d5ebd600002406
|
CRLF-CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR complex via PTPN11 (human) |
2026-03-12 |
Guilaine Argoud-Puy |
success |
|
|
69729a3800000296
|
CTF1 signaling pathway involving IL6ST-LIFR receptor complex (human) |
2026-03-12 |
Guilaine Argoud-Puy |
success |
|
|
68fac5ed00003102
|
CXCL17 activation of MAS receptor leading to chemotaxis (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
68fac5ed00003166
|
CXCL17 activation of MRGPRX1receptor leading to chemotaxis (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
68fac5ed00003136
|
CXCL17 activation of MRGPRX2 receptor leading to chemotaxis (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
67e5e74400004191
|
CXCR4-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by CXCL12/SDF-1 (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
67f85f2b00004426
|
Desensitization of C5AR1-mediated signaling following phosphorylation by GRK2 or GRK3 (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
5fce9b7300000030
|
Diacyl lipopeptide and bacteriocin activation of TLR6_TLR2 receptor (Human)
|
2026-03-12 |
Patrick Masson |
success |
|
2 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355] (cellular_component) —has part→ TLR6 Hsap [UniProtKB:Q9Y2C9] (information biomacromolecule)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355] (cellular_component) —has part→ TLR2 Hsap [UniProtKB:O60603] (information biomacromolecule)
|
67c10cc400009089
|
EGF signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
69a0c46f00001110
|
FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
663d668500001551
|
FASL-FAS interaction leading to apoptosis (human) |
2026-03-12 |
Patrick Masson |
success |
|
|
66187e4700002129
|
Feedback regulation of erythropoietin-mediated signaling via ubiquitination and degradation of EPOR by the ECS(SOCS2) complex (Human). |
2026-03-12 |
Suzi Aleksander, Sylvain Poux |
success |
|
|
66187e4700001644
|
Feedback regulation of growth hormone receptor signaling pathway via ubiquitination and degradation of GHR by the ECS(SOCS2) complex (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
66187e4700001156
|
Ferroportin/Hephaestin/Transferrin complex in iron absorption (Human) |
2026-03-12 |
Lionel Breuza |
success |
|
|
63894f2500000740
|
FIP200 ubiquitination by TRIM21 leading to autophagy inhibition (Human) |
2026-03-12 |
Kimberly Van Auken, Patrick Masson |
success |
|
|
663d668500001188
|
FLVCR2 mediates choline uptake at the blood-brain-barrier (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
68b0f0d000000625
|
Galectin-9-CD44 pair leading to NK cell activation (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
68d5ebd600001044
|
Gastrin-CCKBR pair leading to GNAI1 activation (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
68d5ebd600001015
|
Gastrin-CCKBR pair leading to GNAQ activation (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
68d5ebd600000330
|
GCGR-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by glucagon (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
68d5ebd600000298
|
GCGR-mediated signaling via G-alpha-s ("stimulatory", activating adenylate cyclase) following activation by glucagon (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
671ae02600000676
|
GDF8 role in trophoblast invasion (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
68d5ebd600002088
|
GDPD2 regulates different cannabinoid receptors (Human) |
2026-03-12 |
Lionel Breuza |
filtered |
Model has at least one activity with no causal relations |
|
693b3c0900002985
|
GDPD5 regulates amyloid-beta processing (Human) |
2026-03-12 |
Lionel Breuza |
success |
|
|
67f85f2b00000823
|
Ghrelin-GHSR pair leading to G-alphaQ activation (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
675b862c00000861
|
GluR2/GluR3 receptor signaling upon glutamate binding (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
67369e7600002455
|
GluR2/GluR4 receptor signaling upon glutamate binding (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
665912ed00001822
|
GPCR NPFFR1 activation by neuropeptide NPFF. (Human) |
2026-03-12 |
Cristina Casals |
success |
|
|
665912ed00001850
|
GPCR NPFFR1 activation by neuropeptides RFRP-1 and RFRP-3. (Human) |
2026-03-12 |
Cristina Casals |
success |
|
|
665912ed00001925
|
GPCR NPFFR2 activation by neuropeptide NPFF. (Human) |
2026-03-12 |
Cristina Casals |
success |
|
|
67c10cc400005003
|
GPR15/GPR15LG signaling via G-alpha-i (inhibiting adenylate cyclase (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
65288b2200000062
|
GPR174 signaling pathway (Human) |
2026-03-12 |
Patrick Masson, Sylvain Poux |
success |
|
|
680ad14200002702
|
GPR25 G protein-coupled receptor signaling following activation by CXCL17 (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
68b0f0d000006060
|
GPR3 activation by sphingosine-1-phosphate (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
68b0f0d000006296
|
GPR6 activation by sphingosine-1-phosphate (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
6348a65d00000809
|
Gut Microbiota lactate metabolism: Improvement of glucose tolerance by induction of REG3A. (Human-Lactobacillus) |
2026-03-12 |
Cristina Casals |
success |
|
|
6348a65d00000394
|
Gut Microbiota lactate metabolism: Improvement of glucose tolerance by induction of REG3G. (Mouse-Lactobacillus) |
2026-03-12 |
Cristina Casals, David Hill, Suzi Aleksander |
success |
|
|
62e3212700001653
|
Gut microbiota Quorum-Sensing CSF: Regulation of intestinal homeostasis via SLC22A5/OCTN2 (Human-Bacillus subtilis) |
2026-03-12 |
Cristina Casals |
success |
|
3 warnings
-
SKIPPED_FACT: 'extracellular region [GO:0005576] (anatomical entity)' already has 'part of' relationship; ignoring 'part of' relationship to 'Bacillus subtilis [NCBITaxon:1423] (anatomical entity)'
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: gomodel:62e3212700001653/62e3212700001677 —part of→ intestinal epithelial structure maintenance [GO:0060729] (biological_process)
-
MISSING_TERM: While processing 'protein folding chaperone [GO:0044183] (molecular_function)' part of 'gomodel:62e3212700001653/62e3212700001677', the object could not be mapped to a term; skipping this fact.
|
66e382fb00001786
|
Hepcidin induction by BMP2/BMP6 complex signaling (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
632cf60a00000169
|
HHV1-ICP0 modulation of interferon production via MORC3 degradation (Human-Herpesvirus) |
2026-03-12 |
Patrick Masson |
success |
|
2 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of transcription by RNA polymerase II [GO:0000122] (biological_process) —has input→ IFNB1 Hsap [UniProtKB:P01574] (information biomacromolecule)
-
SKIPPED_FACT: Subject 'negative regulation of transcription by RNA polymerase II [GO:0000122] (biological_process)' has 'has input' relationship to 'IFNB1 Hsap [UniProtKB:P01574] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
|
667dfe8d00000454
|
Histamine/Histamine H1 ligand/receptor (Human) |
2026-03-12 |
Lionel Breuza |
success |
|
|
684b6c8100002679
|
Histamine/HRH2 ligand/receptor (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
684b6c8100003249
|
Histamine/HRH3 ligand/receptor (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
684b6c8100003287
|
Histamine/HRH4 ligand/receptor (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
67f85f2b00000459
|
HLA-C triggers CD160-mediated NK-cell cytotoxicity (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
666b894f00000332
|
HSPA8-IGSF8 pair involved in dendritic cell migration (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
66a3e0bb00001036
|
IGF1-mediated signaling via IGF1R receptor (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
66a3e0bb00001076
|
IGF2-mediated signaling via IGF1R receptor (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
666b894f00000284
|
IGFBP7-CD93 pair role in angiogenesis (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
626b20c100000681
|
IL10-mediated signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
626b20c100001212
|
IL11-mediated signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
2 warnings
-
SKIPPED_FACT: Subject 'cell differentiation [GO:0030154] (biological_process)' has 'has input' relationship to 'myeloid suppressor cell [CL:0000889] (anatomical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: cell differentiation [GO:0030154] (biological_process) —has input→ myeloid suppressor cell [CL:0000889] (anatomical entity)
|
627d95ee00000024
|
IL12-mediated signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
66b5638000002701
|
IL13RA2-mediated alternative IL13 pathway leading to TGFB1 production (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
627d95ee00000472
|
IL15 signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
627d95ee00001405
|
Il17A mediated signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
6205c24300001663
|
IL2 signaling pathway (Human) |
2026-03-12 |
Pascale Gaudet, Patrick Masson |
success |
|
|
61f34dd300000787
|
IL23 signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
623d156d00000340
|
IL3-mediated signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
696022cd00002619
|
IL31 signaling pathway involving IL31RA-OSMR (human) |
2026-03-12 |
Guilaine Argoud-Puy |
success |
|
|
646ff70100005137
|
IL33-signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
623d156d00000290
|
IL4-mediated signaling pathway (human) |
2026-03-12 |
Patrick Masson |
success |
|
|
623d156d00000673
|
IL5-mediated signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
5 warnings
-
SKIPPED_FACT: 'protein tyrosine kinase activity [GO:0004713] (molecular_function)' already has 'occurs in' relationship; ignoring 'occurs in' relationship to 'eosinophil [CL:0000771] (anatomical entity)'
-
SKIPPED_FACT: 'protein tyrosine kinase activity [GO:0004713] (molecular_function)' already has 'occurs in' relationship; ignoring 'occurs in' relationship to 'cytoplasmic side of plasma membrane [GO:0009898] (anatomical entity)'
-
SKIPPED_FACT: 'coreceptor activity [GO:0015026] (molecular_function)' already has 'occurs in' relationship; ignoring 'occurs in' relationship to 'eosinophil [CL:0000771] (anatomical entity)'
-
SKIPPED_FACT: 'interleukin-5 receptor activity [GO:0004914] (molecular_function)' already has 'occurs in' relationship; ignoring 'occurs in' relationship to 'plasma membrane [GO:0005886] (anatomical entity)'
-
SKIPPED_FACT: 'DNA-binding transcription factor activity [GO:0003700] (molecular_function)' already has 'occurs in' relationship; ignoring 'occurs in' relationship to 'nucleus [GO:0005634] (anatomical entity)'
|
5f46c3b700002685
|
IL6:sIL6R Trans-signaling pathway (Human) |
2026-03-12 |
Cristina Casals, Patrick Masson |
success |
|
|
65d7e4ac00001856
|
IL7 signaling role in iNKT cells homeostasis (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
6246724f00000675
|
IL7-mediated signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
626b20c100000025
|
IL9-mediated signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
678073a900001673
|
Inhibin A-mediated suppression of activin A signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
6606056e00000363
|
Inhibition by CD69 of S1PR1-mediated T-cell migration (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
65692e7e00001542
|
Inhibition of IL17 signaling by USP25 via TRAF6 (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
66187e4700002704
|
Inhibition of reelin signaling via ubiquitination and degradation of DAB1 by the ECS(SOCS7) complex in the cortical plate of the developing cerebral cortex (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
65c57c3400000000
|
Inhibition of the GDF15-GFRAL aversive signaling pathway following cleavage of GFRAL by MMP14 (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
69729a3800004953
|
Inhibition of the oxytocin receptor (OXTR) by progesterone (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
64d5781900002033
|
Insulin-mediated activation of the ARF6-RAC1 axis in neurite outgrowth (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
69729a3800005900
|
KCTD10-mediated degradation of SLC7A11 leading to regulation of ferroptosis (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
653b0ce600001285
|
KSHV-ORF37 inhibition of host inflammasome activation via AIM2 (Human-HHV8) |
2026-03-12 |
Patrick Masson |
success |
|
2 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: double-stranded DNA [CHEBI:4705] (information biomacromolecule) —directly positively regulates→ double-stranded DNA binding [GO:0003690] (molecular_function)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: double-stranded DNA [CHEBI:4705] (information biomacromolecule) —located in→ cytoplasm [GO:0005737] (anatomical entity)
|
685de18700006762
|
Lactate inhibits lipolysis through activation of G-protein coupled receptor HCAR1 (Human) |
2026-03-12 |
Nadine Gruaz |
success |
|
|
67b1629100002554
|
LGI1-ADAM22 pair functions in synaptic transmission (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
6918f23700003265
|
LIF signaling pathway involving IL6ST-LIFR (human) |
2026-03-12 |
Guilaine Argoud-Puy |
success |
|
|
6870555700000106
|
Macrophage foam formation upon APO28-APOBR interaction (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
6882d2b800000297
|
Mast cell degranulation via MRGPRX2-mediated signaling via G-alpha-i (inhibitory) inhibiting adenylate cyclase) following activation by substance P (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
6882d2b800000251
|
Mast cell degranulation via MRGPRX2-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by substance P (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
684b6c8100002544
|
MRGPRE-mediated signaling via G-alpha-s ("stimulatory", activating adenylate cyclase) and arrestin (ARRB1) following activation by L-tryptophocholate (Trp-CA), an amino-acid-conjugated bile acid produced by the microbiome (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
66e382fb00000490
|
NEDD4L regulates ENaC (Human) |
2026-03-12 |
Lionel Breuza |
success |
|
|
6348a65d00001727
|
Negative regulation of inflammatory response to wounding by REG3A. (Human) |
2026-03-12 |
Cristina Casals |
success |
|
|
63e5937500000487
|
Negative regulation of inflammatory response to wounding by Reg3g. (Mouse) |
2026-03-12 |
Cristina Casals |
success |
|
|
6870555700002860
|
Negative regulation of MC1R receptor activity by Agouti_Melanogenesis (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
6870555700002917
|
Negative regulation of MC1R receptor activity by OPN3 via G-alpha-i (inhibitory)_Melanogenesis (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
6870555700002703
|
Negative regulation of MC1R receptor signaling by MGRN1_Melanogenesis (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
68b0f0d000003050
|
Negative regulation of MC3R receptor by AgoutiRP_Feeding bevaviour (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
689e7a5d00004884
|
Negative regulation of MC4R receptor activity by AgoutiRP_ Food intake (Human) |
2026-03-12 |
Lucille Pourcel, Sylvain Poux |
success |
|
|
689e7a5d00005052
|
Negative regulation of MC4R receptor activity by OPN3 via G-alpha-i (inhibitory)_Food intake (Human) |
2026-03-12 |
Lucille Pourcel, Sylvain Poux |
success |
|
|
689e7a5d00004928
|
Negative regulation of MC4R receptor signaling by MGRN1_Food intake (Human) |
2026-03-12 |
Lucille Pourcel, Sylvain Poux |
success |
|
|
662af8fa00000863
|
Negative regulation of PIEZO2 channel activity by TMC7 (Human)
|
2026-03-12 |
Lucille Pourcel |
success |
|
|
65692e7e00001241
|
Negative regulation of the Rab11-Rab8-Rabin8 cascade-mediated preciliary trafficking by WDR44 (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
1 warning
-
SKIPPED_FACT: 'Golgi to plasma membrane protein transport [GO:0043001] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'protein localization to cilium [GO:0061512] (biological_process)'
|
68b0f0d000009814
|
Neurokinin A (substance K) binding to its receptor (TACR2/NK2R) triggers adenylate cyclase-activating G protein-coupled receptor signaling pathway (Human) |
2026-03-12 |
Livia Famiglietti |
success |
|
|
68b0f0d000009768
|
Neurokinin A (substance K) binding to its receptor (TACR2/NK2R) triggers phospholipase C-activating G protein-coupled receptor signaling pathway (Human) |
2026-03-12 |
Livia Famiglietti |
success |
|
|
68d5ebd600000043
|
Neuromedin K (Neurokinin B/NKB) binding to its receptor (TACR3/NK3R) triggers adenylate cyclase-activating G protein-coupled receptor signaling pathway (Human) |
2026-03-12 |
Livia Famiglietti |
success |
|
|
68d5ebd600000736
|
Neuromedin K (Neurokinin B/NKB) binding to its receptor (TACR3/NK3R) triggers phospholipase C-activating G protein-coupled receptor signaling pathway (Human) |
2026-03-12 |
Livia Famiglietti |
success |
|
|
68d5ebd600002219
|
Neuropeptide S (NPS) and NPSR1 signaling via GNAQ/phospholipase C (Human) |
2026-03-12 |
Livia Famiglietti |
success |
|
|
68fac5ed00000260
|
Neuropeptide Y (NPY) and Neuropeptide Y receptor type 1 (NPY1R) are involved in regulation of eating behavior (Human) |
2026-03-12 |
Livia Famiglietti |
success |
|
|
68d5ebd600003621
|
Neuropeptide Y (NPY) and Neuropeptide Y receptor type 2 (NPY2R) (Human) |
2026-03-12 |
Livia Famiglietti |
success |
|
|
68d5ebd600000274
|
Neuroprotection involving MT-RNR2 binding to
a receptor complex containing IL27RA, CNTFR and IL6ST (human) |
2026-03-12 |
Guilaine Argoud-Puy |
success |
|
|
665912ed00002823
|
NK T cell inhibition by LGALS3:NCR3 interaction. (Human) |
2026-03-12 |
Cristina Casals |
success |
|
|
67369e7600000015
|
NK-cell activation by HLA-E via KLRD1-KLRC2 receptor complex (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
69729a3800004445
|
NMUR1-mediated signaling via G-alpha-11 (phospholipase c-activating, IP3) following NMU-25 binding (Human). |
2026-03-12 |
Guilaine Argoud-Puy |
success |
|
|
69729a3800004117
|
NMUR1-mediated signaling via G-alpha-i (inhibiting adenylate cyclase) following NMU-25 (Human) inflammatory response (Human) |
2026-03-12 |
Guilaine Argoud-Puy |
success |
|
|
69729a3800004605
|
NMUR1-mediated signaling via G-alpha-q (phospholipase c-activating, IP3) following NMU-25 binding (Human). |
2026-03-12 |
Guilaine Argoud-Puy |
success |
|
|
69729a3800004523
|
NMUR2-mediated signaling via G-alpha-11 (phospholipase c-activating, IP3) following NMU-25 binding (Human). |
2026-03-12 |
Guilaine Argoud-Puy |
success |
|
|
69729a3800004304
|
NMUR2-mediated signaling via G-alpha-i (inhibiting adenylate cyclase) following NMU-25 (Human) |
2026-03-12 |
Guilaine Argoud-Puy |
success |
|
|
69729a3800004564
|
NMUR2-mediated signaling via G-alpha-q (phospholipase c-activating, IP3) following NMU-25 binding (Human). |
2026-03-12 |
Guilaine Argoud-Puy |
success |
|
|
67c10cc400005877
|
NPPA activation of NPR1 receptor regulating vascular permeability (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
67c10cc400007645
|
NPPB activation of NPR1 receptor regulating vascular permeability (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
67c10cc400007733
|
NPPC activation of NPR2 receptor regulating bone growth (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
696022cd00002138
|
OSM signaling pathway involving IL6ST-LIFR receptor complex (human) |
2026-03-12 |
Guilaine Argoud-Puy |
success |
|
|
696022cd00002481
|
OSM signaling pathway involving IL6ST-OSMR receptor complex (human) |
2026-03-12 |
Guilaine Argoud-Puy |
success |
|
|
65d7e4ac00001084
|
oxLDL-CD36 interaction leading to TLR4 signaling and subsequent sterile inflammation in macrophages (Human) |
2026-03-12 |
Patrick Masson |
success |
|
3 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: plasma membrane [GO:0005886] (anatomical entity) —part of→ macrophage [CL:0000235] (anatomical entity)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidised LDL [CHEBI:60151] (information biomacromolecule) —located in→ extracellular region [GO:0005576] (anatomical entity)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidised LDL [CHEBI:60151] (information biomacromolecule) —directly positively regulates→ oxidised low-density lipoprotein particle receptor activity [GO:0150025] (molecular_function)
|
69729a3800005034
|
OXTR phosphorylation by PRKD1 promotes G-alpha-q (phospholipase c-activating, IP3, DAG) signaling (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
69729a3800006530
|
Oxytocin (OXT) binding to its receptor OXTR indirectly inhibits corticotropin release (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
69729a3800005136
|
Oxytocin (OXT) binding to its receptor OXTR regulates social behavior via G-alpha-o (inhibitory), inhibiting adenylate cyclase (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
69729a3800005091
|
Oxytocin (OXT) binding to its receptor OXTR regulates social behavior via G-alpha-q (phospholipase c-activating, IP3, DAG) signaling (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
68fac5ed00000296
|
Peptide YY (PYY) and Neuropeptide Y receptor type 2 (NPY2R) are involved in downregulation of appetite (Human) |
2026-03-12 |
Livia Famiglietti |
success |
|
|
684b6c8100001012
|
Perception of itch via MRGPRX1-mediated signaling via G-alpha-i (inhibitory) inhibiting adenylate cyclase) following activation by BAM8-22 peptide from PENK (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
684b6c8100001054
|
Perception of itch via MRGPRX1-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by BAM8-22 peptide from PENK (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
666b894f00000010
|
PF4-Thrombomodulin pair activating Protein C activation (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
663d668500000606
|
Phosphatidylcholine biosynthetic pathway (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
663d668500000695
|
Phosphatidylethanolamine biosynthetic pathway (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
68fac5ed00001527
|
Plasminogen/plasmin function in extracellular matrix disassembly (Human) |
2026-03-12 |
Lionel Breuza |
success |
|
|
68d5ebd600003314
|
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction by SLC9D1. (Human) |
2026-03-12 |
Cristina Casals |
success |
|
|
62b4ffe300000241
|
Poxvirus-CRMB inhibition of TNF signaling pathway (Human-Poxvirus) |
2026-03-12 |
Patrick Masson |
success |
|
|
62b4ffe300005096
|
Poxvirus-OPG022 inhibition of host IL18 signaling pathway (Human-Poxvirus) |
2026-03-12 |
Patrick Masson |
success |
|
|
62b4ffe300000717
|
Poxvirus-OPG025 inhibition of antiviral IFITs (Human-Poxvirus) |
2026-03-12 |
Patrick Masson |
success |
|
|
62b4ffe300003382
|
Poxvirus-OPG038 inhibition of host CD80/CD86 (Human-Poxvirus) |
2026-03-12 |
Patrick Masson |
success |
|
|
62b4ffe300002753
|
Poxvirus-OPG106 inhibition of interferon-gamma signaling (Human-Poxvirus) |
2026-03-12 |
Patrick Masson |
success |
|
|
62b4ffe300005014
|
Poxvirus-OPG176 inhibition of hostTLR4 signaling (Human-Poxvirus) |
2026-03-12 |
Patrick Masson |
success |
|
|
62b4ffe300004362
|
Poxvirus-OPG193 interferon gamma decoy receptor (Human-Poxvirus) |
2026-03-12 |
Patrick Masson |
success |
|
|
62b4ffe300002814
|
Poxvirus-OPG204 inhibition of type I interferon signaling (Human-Poxvirus) |
2026-03-12 |
Patrick Masson |
success |
|
|
69729a3800006347
|
Processing, maturation and transport of corticotropin-releasing hormone (CRH) hormone (Human) |
2026-03-12 |
Sylvain Poux |
success |
|
|
69729a3800003258
|
Processing, maturation and transport of oxytocin (OXT) hormone (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
696022cd00000016
|
Protein maturation of SHH by autocleavage, autocholesterylation and palmitoylation by HHAT (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
67c10cc400004508
|
PTH1R-mediated signaling via G-alpha-s ("stimulatory", activating adenylate cyclase) following activation by parathyroid hormone (PTH) (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
67c10cc400004549
|
PTH1R-mediated signaling via G-alpha-s ("stimulatory", activating adenylate cyclase) following activation by Parathyroid hormone-related protein (PTHLH) (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
67e5e74400004179
|
R-carvone-OR4C12 receptor pair (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
6348a65d00000486
|
Regulation by IL17 and REG3A of keratinocyte differentiation after skin injury (Human) |
2026-03-12 |
Cristina Casals |
success |
|
|
6348a65d00000452
|
Regulation by IL17 and REG3A of keratinocyte proliferation after skin injury (Human) |
2026-03-12 |
Cristina Casals |
success |
|
|
6348a65d00000519
|
Regulation by IL17 and Reg3g of keratinocyte differentiation after skin injury (Mouse) |
2026-03-12 |
Cristina Casals |
success |
|
|
6348a65d00000552
|
Regulation by IL17 and Reg3g of keratinocyte proliferation after skin injury (Mouse) |
2026-03-12 |
Cristina Casals |
success |
|
|
6348a65d00000848
|
Regulation by IL22 and REG3A of allergic airway inflammation. (Human) |
2026-03-12 |
Cristina Casals |
success |
|
|
6348a65d00000724
|
Regulation by IL22 and Reg3g of allergic airway inflammation. (Mouse) |
2026-03-12 |
Cristina Casals, David Hill |
success |
|
|
67086be200002801
|
Regulation of P4HB/PDI enzyme by Galectin/LGALS9 (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
67369e7600005223
|
Regulation of appetite by (CHRNA3)3:(CHRNB4)2 nAChR activated by nicotine in POMC neurons. (Human) |
2026-03-12 |
Cristina Casals |
success |
|
|
654d809000002825
|
Regulation of endosomal membrane tethering to cleavage furrow during cytokinesis by the FIP3-Rab11 complex (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
2 warnings
-
SKIPPED_FACT: Subject 'protein localization to cleavage furrow [GO:1905345] (biological_process)' has 'has primary input' relationship to 'ARF6 Hsap [UniProtKB:P62330] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: protein localization to cleavage furrow [GO:1905345] (biological_process) —has primary input→ ARF6 Hsap [UniProtKB:P62330] (information biomacromolecule)
|
62e3212700001890
|
Regulation of energy homeostasis by OTUD3 (Human) |
2026-03-12 |
Cristina Casals |
success |
|
|
67369e7600000521
|
Regulation of HAVCR2/TIM-3 receptor by ZDHHC9-mediated palmitoylation (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
653b0ce600000016
|
Regulation of T-helper 17 cell lineage commitment by acetylation and deacetylation of STAT3 (Human) |
2026-03-12 |
Sylvain Poux |
success |
|
|
693b3c0900005257
|
Regulation of the TLR signaling by SMAD6-SMURF1 (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
6246724f00000549
|
Renin-angiotensin pathway (Human) |
2026-03-12 |
Sylvain Poux |
success |
|
|
67369e7600004124
|
Resolvin D2/GPR18-mediated activation of phagocytosis (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
65039e8700000921
|
RNF170-mediated ubiquitination of TLR3 leading to TLR3 degradation (Human) |
2026-03-12 |
Patrick Masson |
success |
|
2 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: double-stranded RNA [CHEBI:67208] (information biomacromolecule) —directly positively regulates→ pattern recognition receptor activity [GO:0038187] (molecular_function)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: double-stranded RNA [CHEBI:67208] (information biomacromolecule) —located in→ extracellular region [GO:0005576] (anatomical entity)
|
6690711d00002652
|
RNH1 inhibits the tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
667dfe8d00000848
|
Role of IGFBP2/PTPRB in osteoblast differentitiation (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
67c10cc400007867
|
Role of NPR3 as receptor for OSTN (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
666b894f00002484
|
ROR1 activation by IGFB5 leading to cell proliferation (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
682fbcd000006862
|
S1P-S1PR4 pair activation leading to regulatory T-cell differentiation (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
65692e7e00001413
|
Scn7a activates Atp1a1 (Mouse) |
2026-03-12 |
Lionel Breuza |
success |
|
|
68d5ebd600002652
|
sCNTFR-CLCF1 signaling pathway involving IL6ST-LIFR complex (human) |
2026-03-12 |
Guilaine Argoud-Puy |
success |
|
|
696022cd00000908
|
SCUBE2, CDON, BOC and GAS1 promote SHH transport to PTCH1 receptor (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
66187e4700002599
|
SECTM1-CD7 interaction leading to cytokine production upon T-cell activation (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
6870555700002144
|
Signaling by ACTH mediated by MC1R receptor via G-alpha-s (activatory)_Melanogenesis (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
68b0f0d000002640
|
Signaling by ACTH mediated by MC2R receptor via G-alpha-s (activatory)_Glucocorticoid biosynthesis (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
68b0f0d000002686
|
Signaling by ACTH mediated by MC3R receptor via G-alpha-s (activatory)_Feeding bevaviour (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
689e7a5d00004366
|
Signaling by ACTH mediated by MC4R receptor via G-alpha-s (activatory)_Food intake (Human) |
2026-03-12 |
Lucille Pourcel, Sylvain Poux |
success |
|
|
68b0f0d000003135
|
Signaling by ACTH mediated by MC5R receptor via G-alpha-s (activatory)_Exocrine gland function (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
66a3e0bb00001159
|
Signaling by Adrenomedullin mediated by ADM ligand activating CALCRL-RAMP2 receptor complex (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
1 warning
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: adrenomedullin receptor signaling pathway [GO:1990410] (biological_process) —transports or maintains localization of→ CALCRL Hsap [UniProtKB:Q16602] (information biomacromolecule)
|
66a3e0bb00001555
|
Signaling by Adrenomedullin mediated by ADM ligand activating CALCRL-RAMP3 receptor complex (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
1 warning
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: adrenomedullin receptor signaling pathway [GO:1990410] (biological_process) —transports or maintains localization of→ CALCRL Hsap [UniProtKB:Q16602] (information biomacromolecule)
|
66a3e0bb00001633
|
Signaling by Adrenomedullin mediated by ADM2 ligand activating CALCRL-RAMP3 receptor complex (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
1 warning
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: adrenomedullin receptor signaling pathway [GO:1990410] (biological_process) —transports or maintains localization of→ CALCRL Hsap [UniProtKB:Q16602] (information biomacromolecule)
|
6870555700003497
|
Signaling by alpha-MSH mediated by MC1R receptor via G-alpha-s (activatory)_Melanogenesis (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
68b0f0d000002848
|
Signaling by alpha-MSH mediated by MC3R receptor via G-alpha-s (activatory)_Feeding bevaviour (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
689e7a5d00004460
|
Signaling by alpha-MSH mediated by MC4R receptor via G-alpha-s (activatory)_Food intake (Human) |
2026-03-12 |
Lucille Pourcel, Sylvain Poux |
success |
|
|
68b0f0d000003260
|
Signaling by alpha-MSH mediated by MC5R receptor via ERK1/2_Immunosuppression (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
68b0f0d000003216
|
Signaling by alpha-MSH mediated by MC5R receptor via G-alpha-s (activatory)_Exocrine gland function (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
66b5638000001825
|
Signaling by Amylin mediated by IAPP ligand activating CALCR receptor (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
66a3e0bb00001796
|
Signaling by Amylin mediated by IAPP ligand activating CALCR-RAMP1 (AMYR1) receptor complex (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
1 warning
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: amylin receptor 1 signaling pathway [GO:0150059] (biological_process) —transports or maintains localization of→ CALCRL Hsap [UniProtKB:Q16602] (information biomacromolecule)
|
66a3e0bb00001882
|
Signaling by Amylin mediated by IAPP ligand activating CALCR-RAMP2 (AMYR2) receptor complex (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
1 warning
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: amylin receptor 2 signaling pathway [GO:0150060] (biological_process) —transports or maintains localization of→ CALCRL Hsap [UniProtKB:Q16602] (information biomacromolecule)
|
66a3e0bb00001935
|
Signaling by Amylin mediated by IAPP ligand activating CALCR-RAMP3 (AMYR3) receptor complex (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
1 warning
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: amylin receptor 3 signaling pathway [GO:0150061] (biological_process) —transports or maintains localization of→ CALCRL Hsap [UniProtKB:Q16602] (information biomacromolecule)
|
671ae02600002587
|
Signaling by APELA mediated by APLNR receptor (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
671ae02600002051
|
Signaling by Apelin/APLN mediated by APLNR receptor (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
6870555700002749
|
Signaling by beta-MSH mediated by MC1R receptor via G-alpha-s (activatory)_Melanogenesis (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
68b0f0d000002890
|
Signaling by beta-MSH mediated by MC3R receptor via G-alpha-s (activatory)_Feeding bevaviour (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
689e7a5d00004800
|
Signaling by beta-MSH mediated by MC4R receptor via G-alpha-s (activatory)_Food intake (Human) |
2026-03-12 |
Lucille Pourcel, Sylvain Poux |
success |
|
|
68b0f0d000003320
|
Signaling by beta-MSH mediated by MC5R receptor via G-alpha-s (activatory)_Exocrine gland function (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
66b5638000001772
|
Signaling by Calcitonin mediated by CALCA/CT ligand activating CALCR receptor (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
66b5638000001665
|
Signaling by Calcitonin mediated by CALCA/CT ligand activating CALCR-RAMP2 (AMYR2) receptor complex (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
1 warning
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: amylin receptor 2 signaling pathway [GO:0150060] (biological_process) —transports or maintains localization of→ CALCRL Hsap [UniProtKB:Q16602] (information biomacromolecule)
|
66c7d41500000163
|
Signaling by Calcitonin/CGRP mediated by CALCA/CGRP1 ligand activating CALCR-RAMP1 (AMYR1) receptor complex (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
1 warning
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: amylin receptor 1 signaling pathway [GO:0150059] (biological_process) —transports or maintains localization of→ CALCRL Hsap [UniProtKB:Q16602] (information biomacromolecule)
|
66a3e0bb00001687
|
Signaling by Calcitonin/CGRP mediated by CALCA/CGRP1 ligand activating CALCRL-RAMP1 receptor complex (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
1 warning
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: calcitonin gene-related peptide receptor signaling pathway [GO:1990408] (biological_process) —transports or maintains localization of→ CALCRL Hsap [UniProtKB:Q16602] (information biomacromolecule)
|
66a3e0bb00001742
|
Signaling by Calcitonin/CGRP mediated by CALCB/CGRP2 ligand activating CALCRL-RAMP1 receptor complex (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
1 warning
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: calcitonin gene-related peptide receptor signaling pathway [GO:1990408] (biological_process) —transports or maintains localization of→ CALCRL Hsap [UniProtKB:Q16602] (information biomacromolecule)
|
67086be200002905
|
Signaling by Galectin/LGALS9 mediated by HAVCR2/TIM-3 receptor (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
6870555700002816
|
Signaling by gamma-MSH mediated by MC1R receptor via G-alpha-s (activatory)_Melanogenesis (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
68b0f0d000002932
|
Signaling by gamma-MSH mediated by MC3R receptor via G-alpha-s (activatory)_Feeding bevaviour (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
68b0f0d000003364
|
Signaling by gamma-MSH mediated by MC5R receptor via G-alpha-s (activatory)_Exocrine gland function (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
693b3c0900002472
|
Signaling by MCH mediated by MCHR1 receptor via G-alpha-i (inhibiting adenylate cyclase)_Feeding (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
693b3c0900002636
|
Signaling by MCH mediated by MCHR2 receptor via G-alpha-q/11 (phospholipase c-activating, IP3, DAG)(Human). |
2026-03-12 |
Lucille Pourcel |
success |
|
|
66e382fb00000583
|
Signaling by PACAP/ADCYAP1 mediated by PAC1R/ADCYAP1R1 receptor (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
1 warning
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: neuropeptide hormone activity [GO:0005184] (molecular_function) —has part→ pituitary adenylate cyclase activating polypeptide activity [GO:0016521] (molecular_function)
|
66e382fb00000408
|
Signaling by PACAP/ADCYAP1 mediated by VIPR1 receptor (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
2 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: neuropeptide hormone activity [GO:0005184] (molecular_function) —has part→ pituitary adenylate cyclase activating polypeptide activity [GO:0016521] (molecular_function)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: neuropeptide hormone activity [GO:0005184] (molecular_function) —has part→ type 1 vasoactive intestinal polypeptide receptor binding [GO:0031891] (molecular_function)
|
66e382fb00000449
|
Signaling by PACAP/ADCYAP1 mediated by VIPR2 receptor (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
2 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: neuropeptide hormone activity [GO:0005184] (molecular_function) —has part→ pituitary adenylate cyclase activating polypeptide activity [GO:0016521] (molecular_function)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: neuropeptide hormone activity [GO:0005184] (molecular_function) —has part→ type 2 vasoactive intestinal polypeptide receptor binding [GO:0031892] (molecular_function)
|
66e382fb00002293
|
Signaling by Secretin/SCT mediated by SCTR receptor (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
|
66e382fb00000178
|
Signaling by Vasoactive Intestinal Peptide/VIP mediated by VIPR1 receptor (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
1 warning
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: neuropeptide hormone activity [GO:0005184] (molecular_function) —has part→ type 1 vasoactive intestinal polypeptide receptor binding [GO:0031891] (molecular_function)
|
66e382fb00000254
|
Signaling by Vasoactive Intestinal Peptide/VIP mediated by VIPR2 receptor (Human) |
2026-03-12 |
Lucille Pourcel |
success |
|
1 warning
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: neuropeptide hormone activity [GO:0005184] (molecular_function) —has part→ type 2 vasoactive intestinal polypeptide receptor binding [GO:0031892] (molecular_function)
|
646ff70100002308
|
SMAD6 arginine methylation inhibits SMAD1 signaling (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
5fadbcf000002129
|
Sphingomyelin phosphodiesterase activity involved in viral entry (Human-Sars-Cov-2) |
2026-03-12 |
Cristina Casals |
success |
|
4 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: symbiont entry into host cell [GO:0046718] (biological_process) —occurs in→ host cell plasma membrane [GO:0020002] (anatomical entity)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: symbiont entry into host cell [GO:0046718] (biological_process) —has input→ Severe acute respiratory syndrome coronavirus 2 [NCBITaxon:2697049] (anatomical entity)
-
SKIPPED_FACT: Subject 'symbiont entry into host cell [GO:0046718] (biological_process)' has 'has input' relationship to 'Severe acute respiratory syndrome coronavirus 2 [NCBITaxon:2697049] (anatomical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: sphingomyelin phosphodiesterase activity [GO:0004767] (molecular_function) —positively regulates→ symbiont entry into host cell [GO:0046718] (biological_process)
|
5fce9b7300001590
|
SPModule-PGLYRP1/HSP701A |
2026-03-12 |
Patrick Masson |
success |
|
|
5fce9b7300001616
|
SPModule-PGRP1-S100A4 |
2026-03-12 |
Patrick Masson |
success |
|
|
5fce9b7300002336
|
SPModule-TREM1-DAP12 |
2026-03-12 |
Patrick Masson |
success |
|
|
68fac5ed00001259
|
Staphylococcus aureus protein EaG is an inhibitor of neutrophil serine proteases ELANE and CTSG (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
68b0f0d000009694
|
Substance P binding to NK1 receptor triggers adenylate cyclase-activating G protein-coupled receptor signaling pathway (Human) |
2026-03-12 |
Livia Famiglietti |
success |
|
|
689e7a5d00003704
|
Substance P binding to NK1 receptor triggers phospholipase C-activating G protein-coupled receptor signaling (Human) |
2026-03-12 |
Livia Famiglietti |
success |
|
|
6494e2e900002525
|
SUCNR1 in adipocytes controls energy homeostasis by modulating circadian clock and LEP expression. (Human) |
2026-03-12 |
Cristina Casals |
success |
|
|
648d0dc100000022
|
SUCNR1 in adipocytes controls energy homeostasis by modulating circadian clock and LEP expression. (Mouse) |
2026-03-12 |
Cristina Casals, Guilaine Argoud-Puy |
success |
|
|
5fadbcf000001962
|
T-helper 17 cell lineage commitment by IL6 cluster (Human) |
2026-03-12 |
Cristina Casals |
success |
|
|
63f809ec00001734
|
TGF-beta-mediated inhibition of TAF7 via TRIM26 |
2026-03-12 |
Patrick Masson |
success |
|
|
663d668500003144
|
TGFB1-mediated signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
663d668500003182
|
TGFB2-mediated signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
663d668500003232
|
TGFB3-mediated signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
613aae0000000338
|
TGM2 dopaminyltransferase activity towards Histone H3 (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
65c57c3400001909
|
The ARTN-GFRA3 signaling pathway (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
66187e4700002082
|
The erythropoietin-mediated signaling pathway (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
65c57c3400001994
|
The GDNF-GFRA1 signaling pathway (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
66187e4700001597
|
The growth hormone receptor signaling pathway (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
65c57c3400001964
|
The NRTN-GFRA2 signaling pathway (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
65c57c3400002024
|
The PSPN-GFRA4 signaling pathway (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
66187e4700002778
|
The reelin signaling pathway (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
666b894f00000232
|
Thrombin-Thrombomodulin pair activating Protein C activation (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
66a3e0bb00002890
|
Thrombopoeitin-mediated signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
662af8fa00002877
|
TRAIL/TRAILR1 interaction leading to apoptosis |
2026-03-12 |
Patrick Masson |
success |
|
|
663d668500001492
|
TRAIL/TRAILR2 interaction leading to apoptosis |
2026-03-12 |
Patrick Masson |
success |
|
|
6606056e00001462
|
TREM2 activated by APOA1. (Human) |
2026-03-12 |
Cristina Casals |
success |
|
|
6606056e00001507
|
TREM2 activated by APOA2. (Human) |
2026-03-12 |
Cristina Casals |
success |
|
|
6606056e00001418
|
TREM2 activated by APOB. (Human) |
2026-03-12 |
Cristina Casals |
success |
|
|
5fce9b7300002436
|
TREM2 activated by APP |
2026-03-12 |
Cristina Casals, Patrick Masson |
success |
|
|
5fb9cc0600000727
|
Triacyl lipopetide activation of TLR1-TLR2 complex (Human) |
2026-03-12 |
Patrick Masson |
success |
|
3 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: Toll-like receptor 1-Toll-like receptor 2 protein complex [GO:0035354] (cellular_component) —has part→ TLR2 Hsap [UniProtKB:O60603] (information biomacromolecule)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular carrier activity [GO:0140104] (molecular_function) —positively regulates→ Toll-like receptor 1-Toll-like receptor 2 protein complex [GO:0035354] (cellular_component)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: Toll-like receptor 1-Toll-like receptor 2 protein complex [GO:0035354] (cellular_component) —has part→ TLR1 Hsap [UniProtKB:Q15399] (information biomacromolecule)
|
685de18700003677
|
TSHR-mediated signaling via G-alpha-s ("stimulatory", activating adenylate cyclase) following activation by TSH (Human). |
2026-03-12 |
Patrick Masson |
success |
|
|
6246724f00000763
|
TSLP-mediated signaling pathway (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
6438950a00000766
|
Ubiquitination of WNK4 in the distal nephron by KLHL3 and its regulation by phosphorylation and dephosphorylation (Human) |
2026-03-12 |
Sylvain Poux |
success |
|
|
685de18700001720
|
Urotensin‐II/US2R leading to ERK1/ERK2 signaling (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
6348a65d00002236
|
USP44-mediated deubiquitination of CDC20 controlling anaphase initiation (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
6348a65d00002174
|
USP44-mediated FOXP3 deubiquitination leading to regulatory T-cell differentiation (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
67b1629100001426
|
USP5 deubiquitnation of YTHDF1 after activation by insulin-MTOR axis (Human) |
2026-03-12 |
Patrick Masson |
success |
|
|
69729a3800006407
|
Whole body adaptation to stress following activation of CRHR1 by CRH, leading to signaling via G-alpha-s ("stimulatory", activating adenylate cyclase) (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
69729a3800006846
|
Whole body adaptation to stress following activation of CRHR1 by UCN, leading to signaling via G-alpha-s ("stimulatory", activating adenylate cyclase) (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
69729a3800006791
|
Whole body adaptation to stress following activation of CRHR2 by CRH, leading to signaling via G-alpha-s ("stimulatory", activating adenylate cyclase) (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
69729a3800006901
|
Whole body adaptation to stress following activation of CRHR2 by UCN, leading to signaling via G-alpha-s ("stimulatory", activating adenylate cyclase) (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
69729a3800007354
|
Whole body adaptation to stress following activation of CRHR2 by UCN2, leading to signaling via G-alpha-s ("stimulatory", activating adenylate cyclase) (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
69729a3800007299
|
Whole body adaptation to stress following activation of CRHR2 by UCN3, leading to signaling via G-alpha-s ("stimulatory", activating adenylate cyclase) (Human). |
2026-03-12 |
Sylvain Poux |
success |
|
|
67f85f2b00001619
|
CD180-CD19 activation of B-cells by LPS (Human) |
2026-03-05 |
Patrick Masson |
success |
|
|
68b0f0d000003584
|
CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1 (Human). |
2026-03-05 |
Sylvain Poux |
success |
|
|
62f58d8800002115
|
Gut Microbiota tryptophan metabolism: Regulation of colon transit by tryptamine (Human-Clostridium sporogenes) |
2026-03-05 |
Cristina Casals |
success |
|
|
68b0f0d000001211
|
De novo sphingomyelin biosynthesis (CerS1) |
2026-03-04 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
68b0f0d000004290
|
De novo sphingomyelin synthesis (Human) CerS5 |
2026-03-04 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
6205c24300000814
|
PCK1 phosphoenolpyruvate carboxykinase and protein kinase activites and their regulation by acetylation (EP300), deacetylation (SIRT1) and phosphorylation (AKT1) (Human) |
2026-03-04 |
Sylvain Poux |
success |
|
|
69729a3800008725
|
SLC45A1 mediates hexose efflux from lysosomes and is required for V-ATPase activity (Human). |
2026-02-27 |
Sylvain Poux |
success |
|
|
654d809000002780
|
Early endosome to recycling endosome transport by the FIP3-Rab11 complex (Human) |
2026-02-26 |
Lucille Pourcel, Patrick Masson |
success |
|
|
6086f4f200000298
|
SARS-CoV-2/autophagy |
2026-02-26 |
Patrick Masson |
success |
|
7 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: HOPS complex [GO:0030897] (cellular_component) —has part→ VPS41 Hsap [UniProtKB:P49754] (information biomacromolecule)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: HOPS complex [GO:0030897] (cellular_component) —has part→ VPS11 Hsap [UniProtKB:Q9H270] (information biomacromolecule)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: HOPS complex [GO:0030897] (cellular_component) —has part→ VPS33A Hsap [UniProtKB:Q96AX1] (information biomacromolecule)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: HOPS complex [GO:0030897] (cellular_component) —has part→ VPS16 Hsap [UniProtKB:Q9H269] (information biomacromolecule)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: HOPS complex [GO:0030897] (cellular_component) —has part→ VPS39 Hsap [UniProtKB:Q96JC1] (information biomacromolecule)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: HOPS complex [GO:0030897] (cellular_component) —has part→ VPS18 Hsap [UniProtKB:Q9P253] (information biomacromolecule)
-
SKIPPED_FACT: 'molecular adaptor activity [GO:0060090] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'HOPS complex [GO:0030897] (cellular_component)'
|
5e72450500004237
|
SARS-COV2/cycle from polyprotein processing to viral genome replication (SRAS-COV-2) |
2026-02-26 |
Kimberly Van Auken, Patrick Masson |
success |
|
2 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: viral RNA genome replication [GO:0039694] (biological_process) —occurs in→ double membrane vesicle viral factory [GO:0039718] (anatomical entity)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: double membrane vesicle viral factory assembly [GO:0140526] (biological_process) —part of→ lipid binding [GO:0008289] (molecular_function)
|
5ee8120100000524
|
SP_N4BP3on MAVS |
2026-02-26 |
Patrick Masson |
success |
|
|
61e0e55600000338
|
SP_RNF186onEPHRINs |
2026-02-26 |
Patrick Masson |
success |
|
|
69729a3800004162
|
Vesicle fusion in cytotoxic T cell degranulation (Human) |
2026-02-24 |
Lionel Breuza |
success |
|
|
66187e4700002956
|
CD21-CD23 ligand receptor pair modulates IgE production (Human) |
2026-02-19 |
Patrick Masson |
success |
|
|
62f58d8800002151
|
Gut Microbiota tryptophan metabolism: Regulation of colon transit by tryptamine (Human-Ruminococcus gnavus) |
2026-02-19 |
Cristina Casals |
success |
|
|
698e557b00001137
|
Inhibition of mTORC1 signaling by the AXIN1-STK11 axis in response to glucose starvation (Human). |
2026-02-17 |
Sylvain Poux |
success |
|
|
6446bfcb00001774
|
Autophagosome assembly (Human) |
2026-02-15 |
Lucille Pourcel, Marc Feuermann, Suzi Aleksander, Sylvain Poux |
success |
|
|
62d0afa500001250
|
Regulation of lysosomal lumen pH by protein influx (V-ATPase) and proton efflux (TMEM175 and SLC7A11) (Human) |
2026-02-12 |
Sylvain Poux |
success |
|
|
62b4ffe300004209
|
Terrequinone A biosynthesis (Emericella nidulans) |
2026-02-12 |
Marc Feuermann |
success |
|
|
66b5638000002630
|
GRIM1 activates GRID1 via GNAQ in dopamine neurons (Human). |
2026-02-09 |
Cristina Casals |
success |
|
|
66b5638000002273
|
GRIM1 activates GRID2 via GNAQ in Purkinje cells (Human). |
2026-02-09 |
Cristina Casals |
success |
|
|
67f85f2b00003584
|
CHRM2-mediated signaling via G-alpha-o (inhibitory), inhibiting adenylate cyclase following activation by acetylcholine (Human). |
2026-02-03 |
Sylvain Poux |
success |
|
|
69729a3800003224
|
Biosynthesis of 4-Vinylanisole, the aggregation pheromone in locusts, and activation of its pheromone receptor (Locusta migratoria). |
2026-02-02 |
Sylvain Poux |
success |
|
|
696022cd00000056
|
HSD11B2 and CYP27A1 generate oxysterols that activate SMO (Human). |
2026-02-02 |
Sylvain Poux |
success |
|
|
696022cd00000124
|
SMO is translocated in primary cilium via a beta-arrestin and KIF3A-dependent mechanism (Human). |
2026-02-02 |
Sylvain Poux |
success |
|
|
696022cd00001645
|
Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by STK36 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). |
2026-02-02 |
Sylvain Poux |
success |
|
|
696022cd00001523
|
Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by ULK3 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). |
2026-02-02 |
Sylvain Poux |
success |
|
|
696022cd00001146
|
SMURF1 acts as a positive regulator of smoothened signaling by ubiquitinating PTCH1, leading to its degradation (Human). |
2026-02-02 |
Sylvain Poux |
success |
|
|
696022cd00001204
|
SMURF2 acts as a positive regulator of smoothened signaling by ubiquitinating PTCH1, leading to its degradation (Human). |
2026-02-02 |
Sylvain Poux |
success |
|
|
69729a3800003422
|
CUL3/KLHL6/RBX1 complex ubiquitinates RC3H2 leading to its proteasomal degradation (Human) |
2026-01-29 |
Patrick Masson |
success |
|
|
68b0f0d000006733
|
CUL3/LZTR1/RBX1 complex ubiquitinates HRAS leading to its proteasomal degradation (Human) |
2026-01-29 |
Patrick Masson |
success |
|
|
696022cd00003836
|
Regulation of NOTCH1 by the Cyclin C-CDK19 pair (Human) |
2026-01-29 |
Patrick Masson |
success |
|
|
696022cd00003889
|
TRIM36-mediated inhibition of the GPX4-NRF2 axis (Human) |
2026-01-29 |
Patrick Masson |
success |
|
|
6197061700002397
|
Fatty acid transport by CD36 via LYN-mediated endocytosis (Human) |
2026-01-27 |
Lucille Pourcel, Patrick Masson |
success |
|
|
69729a3800000481
|
MAST3 kinase regulates ARPP19 phosphatase activity and is down-regulated by PKA |
2026-01-27 |
Livia Famiglietti |
success |
|
|
696022cd00000603
|
Regulation of the TCA cycle by SIRT3 (Human) |
2026-01-26 |
Patrick Masson |
success |
|
|
64d5781900002076
|
Role of ARF6 in CD36 localization to the plasma membrane (Human) |
2026-01-26 |
Patrick Masson |
success |
|
|
60ff660000000007
|
IL4I1 inhibition of T cell mediated immune response to tumor cell (Human) |
2026-01-22 |
Sylvain Poux |
success |
|
2 warnings
-
SKIPPED_FACT: 'nuclear receptor activity [GO:0004879] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of transcription by RNA polymerase II [GO:0006357] (biological_process)'
-
SKIPPED_FACT: 'L-amino-acid oxidase activity [GO:0001716] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'negative regulation of T cell mediated immune response to tumor cell [GO:0002841] (biological_process)'
|
696022cd00000535
|
MIMS1 involved in mitochondrial
inner membrane fusion in BAT through modulation of YME1L1 metalloendopeptidase activity. (Human) |
2026-01-22 |
Cristina Casals |
success |
|
|
696022cd00000497
|
MIMS1 involved in mitochondrial inner membrane fusion in BAT through modulation of YME1L1 metalloendopeptidase activity. (Mouse) |
2026-01-22 |
Cristina Casals |
success |
|
|
696022cd00000700
|
Regulation of Heme biosynthesis by MIMS2. (Human) |
2026-01-22 |
Cristina Casals |
success |
|
|
696022cd00000662
|
Regulation of Heme biosynthesis by MIMS2. (Mouse) |
2026-01-22 |
Cristina Casals |
success |
|
|
696022cd00003683
|
ZNFX1 inhibits NLRP3 inflammasome. (Human) |
2026-01-22 |
Cristina Casals |
success |
|
|
684b6c8100001511
|
Glucose-6-phosphate isomerase, anomerase and epimerase activites of GPI (Human) |
2026-01-15 |
Lucille Pourcel |
success |
|
|
680ad14200006724
|
Signaling by noradrenaline mediated by ADRB3 receptor via G-alpha-s (activatory)_Lipolysis & thermogenesis (Human) |
2026-01-15 |
Lucille Pourcel |
success |
|
|
693b3c0900000434
|
GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI1 transcription factor (Human). |
2026-01-13 |
Sylvain Poux |
success |
|
|
693b3c0900000331
|
GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI2 transcription factor (Human). |
2026-01-13 |
Sylvain Poux |
success |
|
|
693b3c0900000157
|
GPR161 acts as a negative regulator of smoothened pathway by promoting protein processing of GLI3 into transcription repressor GLI3R (Human). |
2026-01-13 |
Sylvain Poux |
success |
|
|
693b3c0900001575
|
Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by DYRK2 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). |
2026-01-13 |
Sylvain Poux |
success |
|
|
693b3c0900001501
|
Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI3 transcription activator activity via phosphorylation of GLI3 by DYRK2 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). |
2026-01-13 |
Sylvain Poux |
success |
|
|
693b3c0900001389
|
Smoothened (SMO) activation by cholesterol triggers a signaling that promotes GLI1 transcription activator activity and inhibits the smoothened signaling inhibitor GPR161 (Human). |
2026-01-13 |
Sylvain Poux |
success |
|
|
693b3c0900001715
|
Modulation of TRIM32 activity by Seneca virus Protease 3C (Human-Seneca virus) |
2026-01-12 |
Patrick Masson |
success |
|
|
693b3c0900005183
|
SMAD6-SMURF1-mediated degradation of RUNX2 leading to inhibition of osteoblast differentiation (Human) |
2026-01-12 |
Patrick Masson |
success |
|
|
693b3c0900005133
|
SMAD6-SMURF1-mediated degradation of TBX6 (Human) |
2026-01-12 |
Patrick Masson |
success |
|
|
693b3c0900000008
|
TRIM25 inhibition of SQSTM1 (Human). |
2026-01-12 |
Patrick Masson |
success |
|
|
65f3ae5c00000585
|
Ufmylation of CYB5R3 promotes reticulophagy and CYB5R3 degradation (Human). |
2026-01-08 |
Sylvain Poux |
success |
|
|
693b3c0900000716
|
GPR161 is exported from primary cilium in response to smoothened signaling via a beta-arrestin, BBSome and IFT-B complex-dependent mechanism (Human). |
2026-01-06 |
Sylvain Poux |
success |
|
|
693b3c0900001641
|
SETD7 acts as a positive regulator of smoothened signaling by mediating methylation of GLI3 transcription activator, promoting its activity (Human). |
2026-01-06 |
Sylvain Poux |
success |
|
|
68fac5ed00001906
|
Formation of H3K14ub by rbx1 component of the CLRC complex promotes formation of H3K9me3 by clr4 (S.pombe). |
2025-12-24 |
Sylvain Poux |
success |
|
|
68fac5ed00000028
|
Formation of neutrophil extracellular traps (NETs) by PADI4 and MPO via dissociation of chromatin and microbicidal activity of NETs by ELANE and MPO (Human). |
2025-12-24 |
Sylvain Poux |
success |
|
|
68fac5ed00001851
|
G2E3 promotes heterochromatin formation by catalyzing ubiquitination of histone H3, leading to recruitment of SUV39H1 and/SUV39H2 (Human). |
2025-12-24 |
Sylvain Poux |
success |
|
|
6918f23700000529
|
GPR45 acts as a regulator of food intake in the paraventricular nucleus of the hypothalamus by mediating transport of GNAS/G(s) into primary cilia (Human) |
2025-12-24 |
Sylvain Poux |
success |
|
|
68fac5ed00002309
|
LRRC58 is a negative regulator of taurine biosynthesis by mediating by mediating ubiquitination and degradation of CDO1 (Human). |
2025-12-24 |
Sylvain Poux |
success |
|
|
68fac5ed00001192
|
Staphylococcus aureus SPIN is an inhibitor of myeloperoxidase (MPO) (Human). |
2025-12-24 |
Sylvain Poux |
success |
|
|
693b3c0900000051
|
TULP3 and IFT-A complex mediate transport of GPR161 to primary cilium (Human). |
2025-12-24 |
Sylvain Poux |
success |
|
|
6918f23700000069
|
Ubiquitination and degradation of RHOA by a CUL3-RING complex containing KCDT13 (Human) |
2025-12-24 |
Sylvain Poux |
success |
|
|
6918f23700000167
|
Ubiquitination and degradation of RHOA by a CUL3-RING complex containing TNFAIP1 (Human) |
2025-12-24 |
Sylvain Poux |
success |
|
|
68fac5ed00003409
|
XKR4 promotes phosphatidylserine exposure on apoptotic cell surface following activation by a cleavage product of XRCC4 and CASP3 (Human). |
2025-12-24 |
Sylvain Poux |
success |
|
|
68fac5ed00003572
|
XKR8 promotes phosphatidylserine exposure on apoptotic cell surface following activation by CASP3 (Human). |
2025-12-24 |
Sylvain Poux |
success |
|
|
68fac5ed00003609
|
XKR8 promotes synapse pruning by mediating phosphatidylserine exposure following activation by CASP3 (Human). |
2025-12-24 |
Sylvain Poux |
success |
|
|
68fac5ed00003307
|
XKR9 promotes phosphatidylserine exposure on apoptotic cell surface following activation by CASP3 (Human). |
2025-12-24 |
Sylvain Poux |
success |
|
|
69169b7400000113
|
ZNF800 acts as a master repressor of enteroendocrine differentiation (Human). |
2025-12-24 |
Sylvain Poux |
success |
|
|
680ad14200002493
|
Signaling by noradrenaline mediated by ADRA2C receptor via G-alpha-o (inhibitory) (Human) |
2025-12-18 |
Lucille Pourcel, Sylvain Poux |
success |
|
|
67b1629100001304
|
ADGRG3-mediated signaling via G-alpha-o (inhibitory), inhibiting adenylate cyclase following activation by cortisol (Human). |
2025-12-18 |
Sylvain Poux |
success |
|
|
645d887900000245
|
Glycine-binding to metabotropic glycine receptor GPR158 leads to inhibition of the GTPase activator activity of RGS7 (Human). |
2025-12-18 |
Sylvain Poux |
success |
|
|
666b894f00000989
|
HTR1B-mediated serotonin signaling via G-alpha-o (inhibitory), inhibiting adenylate cyclase) (Human). |
2025-12-18 |
Sylvain Poux |
success |
|
|
645d887900000271
|
In absence of glycine, the metabotropic glycine receptor GPR158 activates the GTPase activator activity of RGS7 (Human). |
2025-12-18 |
Sylvain Poux |
success |
|
|
68fac5ed00002250
|
Phosphatidylinositol and phosphatidic acid transport by PITPNM1 in ER-PM MCS (response to PLC) (Human) |
2025-12-18 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
67f85f2b00003986
|
RAB26 Golgi-to-cell membrane transport of ADRA2B (Human) |
2025-12-18 |
Lucille Pourcel, Sylvain Poux |
success |
|
|
67f85f2b00003167
|
RAB43 ER-Golgi anterograde transport of ADRA2B (Human) |
2025-12-18 |
Lucille Pourcel, Sylvain Poux |
success |
|
|
680ad14200003112
|
Signaling by adrenaline mediated by ADRA2A receptor via G-alpha-o (inhibitory) (Human) |
2025-12-18 |
Lucille Pourcel, Sylvain Poux |
success |
|
|
680ad14200003143
|
Signaling by adrenaline mediated by ADRA2B receptor via G-alpha-o (inhibitory) (Human) |
2025-12-18 |
Lucille Pourcel, Sylvain Poux |
success |
|
|
680ad14200003082
|
Signaling by adrenaline mediated by ADRA2C receptor via G-alpha-o (inhibitory) (Human) |
2025-12-18 |
Lucille Pourcel, Sylvain Poux |
success |
|
|
67f85f2b00004554
|
Signaling by noradrenaline mediated by ADRA2A receptor via G-alpha-o (inhibitory) (Human) |
2025-12-18 |
Lucille Pourcel, Sylvain Poux |
success |
|
|
67f85f2b00003942
|
Signaling by noradrenaline mediated by ADRA2B receptor via G-alpha-o (inhibitory) (Human) |
2025-12-18 |
Lucille Pourcel, Sylvain Poux |
success |
|
|
667dfe8d00000011
|
CD48-CD244 ligand receptor binding in NK cell activation (Human) |
2025-12-17 |
Guilaine Argoud-Puy, Kimberly Van Auken |
success |
|
|
67b1629100002643
|
ADGRG1-mediated signaling via G-alpha-13activating RhoA following activation by 17alpha-hydroxypregnenolone (Human). |
2025-12-15 |
Sylvain Poux |
success |
|
|
671ae02600003459
|
P2RY8-mediated signaling via G-alpha-13activating RhoA following activation by S-geranylgeranyl-glutathione (Human). |
2025-12-15 |
Sylvain Poux |
success |
|
|
62b4ffe300005140
|
Poxvirus-OPG188 inhibition of host cGAS-STING pathway (Human-Poxvirus) |
2025-12-15 |
Patrick Masson |
success |
|
|
6918f23700000328
|
TLR9 signaling pathway leading to IRF5 activation (Human) |
2025-12-15 |
Patrick Masson |
success |
|
|
6918f23700004278
|
Activation of TLR7 by PLD3 (Human) |
2025-12-10 |
Lionel Breuza |
success |
|
|
6918f23700004582
|
Activation of TLR7 by PLD4 (Human) |
2025-12-10 |
Lionel Breuza |
success |
|
|
626b20c100000443
|
Regulation of gluconeogenesis by TOX4 (Mouse) |
2025-12-08 |
Cristina Casals, David Hill, Suzi Aleksander |
success |
|
|
636d9ce800001222
|
DCAF12 controls MOV10 during spermatogeneis. (Human) |
2025-12-04 |
Cristina Casals |
success |
|
2 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627] (biological_process) —has input→ MOV10 Hsap [UniProtKB:Q9HCE1] (information biomacromolecule)
-
SKIPPED_FACT: Subject 'ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627] (biological_process)' has 'has input' relationship to 'MOV10 Hsap [UniProtKB:Q9HCE1] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
|
68b0f0d000006388
|
ADCY7 activates the NLRP3 inflammasome downstream of TLR9 by catalyzing synthesis of cyclic di-AMP (c-di-AMP) (Human) |
2025-12-03 |
Sylvain Poux |
success |
|
|
636d9ce800001192
|
DCAF12 controls MOV10 during T cell activation. (Human) |
2025-12-03 |
Cristina Casals |
success |
|
|
62f58d8800006248
|
Gut Microbiota bile acid metabolism: Inhibition of Th17 differentiation by 3-oxoLCA and isoLCA. (Human-R.gnavus/E.lenta) |
2025-12-03 |
Cristina Casals |
success |
|
|
689e7a5d00000225
|
Neuron cell-leukocyte adhesion mediated by ICAM5 receptor ligand and integrin ITGAL:ITGB2 complex receptor (HUMAN) |
2025-12-03 |
Guilaine Argoud-Puy |
success |
|
|
67f85f2b00000861
|
RAB5A regulation of Rabaptin-5/RABEP1-mediated endocytic trafficking (Human) |
2025-12-03 |
Lucille Pourcel, Sylvain Poux |
success |
|
|
62f58d8800002207
|
Gut Microbiota tryptophan metabolism: Regulation of mucus release by tryptamine through GPCR HTR4. (Human-Bacteroides thetaiotaomicron) |
2025-12-02 |
Cristina Casals |
success |
|
|
62900b6400001630
|
PTEN in excitatory hippocampal synapse long-term depression (Human) |
2025-12-02 |
Cristina Casals |
success |
|
|
65c57c3400000173
|
The MSL complex, composed of MSL1, MSL2, MSL3 and KAT8, mediates acetylation of histone H4 at Lys-16 (H4K16ac) (Human). |
2025-12-02 |
Sylvain Poux |
success |
|
|
5f46c3b700002320
|
Recombinant bridges in male meiosis (Mouse) |
2025-12-01 |
Cristina Casals, David Hill, Patrick Masson |
filtered |
Model has at least one activity with no causal relations |
8 warnings
-
SKIPPED_FACT: 'DNA strand exchange activity [GO:0000150] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'reciprocal meiotic recombination [GO:0007131] (biological_process)'
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: protein localization to site of double-strand break [GO:1990166] (biological_process) —causally upstream of positive effect→ DNA strand exchange activity [GO:0000150] (molecular_function)
-
SKIPPED_FACT: 'DNA strand exchange activity [GO:0000150] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'double-strand break repair involved in meiotic recombination [GO:1990918] (biological_process)'
-
SKIPPED_FACT: 'DNA strand exchange activity [GO:0000150] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'double-strand break repair via homologous recombination [GO:0000724] (biological_process)'
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: double-strand break repair involved in meiotic recombination [GO:1990918] (biological_process) —occurs in→ testis [UBERON:0000473] (anatomical entity)
-
SKIPPED_FACT: 'DNA strand exchange activity [GO:0000150] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'double-strand break repair via homologous recombination [GO:0000724] (biological_process)'
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: reciprocal meiotic recombination [GO:0007131] (biological_process) —occurs in→ testis [UBERON:0000473] (anatomical entity)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: double-strand break repair via homologous recombination [GO:0000724] (biological_process) —occurs in→ testis [UBERON:0000473] (anatomical entity)
|
6918f23700001532
|
TLR9 activation by EGFR and SYK (Human) |
2025-11-27 |
Patrick Masson |
success |
|
|
68d5ebd600001161
|
GDPD2 in regulation of cell-matrix adhesion via uPAR (Human) |
2025-11-26 |
Lionel Breuza |
success |
|
|
68fac5ed00004201
|
GSGMD activation by TRAF1/TRAF2 ubiquitin complex (Human) |
2025-11-18 |
Patrick Masson |
success |
|
|
6606056e00002524
|
HIV-1 Vif protein hijacks a cullin-5-RING E3 ubiquitin-protein ligase to mediate ubiquitination and degradation of APOBEC3G (Human). |
2025-11-13 |
Sylvain Poux |
success |
|
|
63f809ec00000027
|
Trans-negative regulation of Sars-CoV-2 viral entry into host cell by LRRC15. (Human-Sars-CoV-2) |
2025-11-13 |
Cristina Casals |
success |
|
|
68b0f0d000000536
|
HHV1-ICP0 ubiquitinates MORC2, leading to its degradation by the proteasome (Human). |
2025-11-11 |
Sylvain Poux |
success |
|
|
68fac5ed00003259
|
Role of TRIM28 palmitoylation in DNA damage response (Human) |
2025-11-11 |
Patrick Masson |
success |
|
|
68d5ebd600003613
|
SELP/SELPLG pair leading to leukocyte rolling (Human) |
2025-11-11 |
Patrick Masson |
success |
|
|
68b0f0d000000047
|
The HUSH complex mediates silencing of transposable elements (Human). |
2025-11-11 |
Sylvain Poux |
success |
|
|
68b0f0d000000123
|
The HUSH2 complex mediates epigenetic repression of interferon-stimulated genes. (Human). |
2025-11-11 |
Sylvain Poux |
success |
|
|
68fac5ed00003348
|
TRIM28 negative regulation of of NF-kappa-B signaling via TRAF6 SUMOylation (Human) |
2025-11-11 |
Patrick Masson |
success |
|
|
68fac5ed00002608
|
Phosphatidylinositol intermembrane transport enabled by PITPNA (Human) |
2025-11-05 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
63c0ac2b00001566
|
DCAF13 regulates chromatin reprogramming in the zygote through SUV39H1 and SUV39H2 degradation. (Human) |
2025-10-30 |
Cristina Casals |
success |
|
|
68fac5ed00001966
|
Light signaling mediated by OPN4 photoreceptor via G-alpha-i (inhibitory) (Human) |
2025-10-30 |
Lucille Pourcel |
success |
|
|
68fac5ed00002046
|
Light signaling mediated by OPN4 receptor via G-alpha-s (activatory) (Human) |
2025-10-30 |
Lucille Pourcel |
success |
|
|
68fac5ed00000572
|
De novo sphingomyelin synthesis via CERS5. (Human) |
2025-10-28 |
Cristina Casals |
success |
|
|
68b0f0d000008614
|
EPHA5 and EFNA5 in glucose stimulated insulin secretion (Human) |
2025-10-28 |
Lionel Breuza |
success |
|
|
68d5ebd600002746
|
GPR142 mediates tryptophan-stimulated insulin release and glucose homeostasis regulation. |
2025-10-23 |
Nadine Gruaz |
success |
|
|
68d5ebd600003015
|
Blue light signaling mediated by OPN3 photoreceptor via G-alpha-i (inhibitory)_Keratinocyte differenciation (Human) |
2025-10-23 |
Lucille Pourcel |
success |
|
|
68b0f0d000002100
|
RAB27A degradation in a FBXO28-dependent manner (Human) |
2025-10-23 |
Patrick Masson |
success |
|
|
68d5ebd600003358
|
UVA signaling mediated by OPN5 photoreceptor via G-alpha-i (inhibitory)_Circadian clock entrainment (Human) |
2025-10-23 |
Lucille Pourcel |
success |
|
|
68d5ebd600002906
|
UVA signaling mediated by OPN3 photoreceptor via G-alpha-i (inhibitory)_Melanin cap formation (Human) |
2025-10-22 |
Lucille Pourcel |
success |
|
|
68d5ebd600001954
|
PDK1 and MTOR-mediated activation of AKT1 (Human) |
2025-10-21 |
Patrick Masson |
success |
|
|
6606056e00000903
|
Activation of the integrated stress response via activation of EIF2AK1/HRI by DELE1 in response to mitochondrial stress (Human) |
2025-10-03 |
Kimberly Van Auken, Pascale Gaudet, Sylvain Poux |
success |
|
|
6796b94c00004884
|
Mo-molybdopterin cofactor biosynthetic process (Dmel) |
2025-10-02 |
Antonia Lock, Helen Attrill, Rossana Zaru |
success |
|
|
68b0f0d000008577
|
EPHA5 activation by EFNA5 in axon fasciculation (Human) |
2025-09-30 |
Lionel Breuza |
success |
|
|
68b0f0d000000731
|
Ephrin-A5/EPHA2 functions in lens fiber cell morphogenesis (Human) |
2025-09-30 |
Lionel Breuza |
success |
|
|
68b0f0d000008340
|
Nuclear 'de novo' pyrimidine nucleobase biosynthetic process involving SHMT1, TYMS and DHFR (human) |
2025-09-25 |
Guilaine Argoud-Puy |
success |
|
|
68b0f0d000005302
|
Activation of the kinase activity of EIF2AK4/GCN2 in response to ribosome stalling leads to monoubiquitination of RPS2/us5 and RPS3/us3, followed by activation of RIOK3 and degradation of the 40S ribosome (Human) |
2025-09-17 |
Sylvain Poux |
success |
|
|
68b0f0d000004152
|
CDK11 regulates a RNA polymerase II pause-checkpoint upstream of CDK9 (Human) |
2025-09-17 |
Sylvain Poux |
success |
|
|
68b0f0d000007160
|
Detoxification of itaconate in macrophages (Human). |
2025-09-17 |
Sylvain Poux |
success |
|
|
68b0f0d000007269
|
Detoxification of malyl-CoA by CLYBL (Human). |
2025-09-17 |
Sylvain Poux |
success |
|
|
68b0f0d000003631
|
Detoxification of N(6)-methyladenosine by ADK and MAPDA/ADAL (Human). |
2025-09-17 |
Sylvain Poux |
success |
|
|
68b0f0d000007115
|
Malyl-CoA and Itaconyl-CoA inhibit the methylmalonyl-CoA mutase activity of MMUT (Human) |
2025-09-17 |
Sylvain Poux |
success |
|
|
68b0f0d000003705
|
N(6)-methyl-AMP is an inhibitor of AMP-activated protein kinase (Human). |
2025-09-17 |
Sylvain Poux |
success |
|
|
689e7a5d00004722
|
TGDS promotes the completion of UXS1 catalytic cycle when NAD(+) levels are low (Human). |
2025-09-17 |
Sylvain Poux |
success |
|
|
689e7a5d00000052
|
ZNF652 and CBFA2T3 repress expression of TCF12 (Human). |
2025-09-17 |
Sylvain Poux |
success |
|
|
62f58d8800004747
|
ZDHHC2 in regulation of long-term synaptic potentiation via AKAP5 (Human) |
2025-09-16 |
Lionel Breuza |
success |
|
|
67369e7600002132
|
IRGQ promotes degradation of misfolded MHC class I proteins b promoting their degradation by autophagy (Human). |
2025-09-15 |
Sylvain Poux |
success |
|
|
61bcf0b700000524
|
tRNA methylation by METTL8 and regulation by tRNA dimethylallyltransferase activity of TRIT1 (Human) |
2025-09-15 |
Sylvain Poux |
success |
|
|
6494e2e900001921
|
Activation of the integrated stress response via activation of EIF2AK1/HRI by DELE1 in response to iron deficiency (Human) |
2025-09-12 |
Sylvain Poux |
success |
|
|
66b5638000000624
|
Activation of the integrated stress response via activation of EIF2AK3/PERK in response to unfolded protein response (Human). |
2025-09-12 |
Sylvain Poux |
success |
|
|
66b5638000001589
|
Activation of the integrated stress response via activation of EIF2AK3/PERK in response to unfolded protein response promotes expression of COX7A2L/SCAF1, increasing formation of respiratory chain supercomplexes (Human). |
2025-09-12 |
Sylvain Poux |
success |
|
|
63d320cd00001779
|
Activation of the kinase activity of EIF2AK4/GCN2 by GCN1 in response to ribosome collisions (Human) |
2025-09-12 |
Sylvain Poux |
success |
|
|
62f58d8800000037
|
Activation of the kinase activity of EIF2AK4/GCN2 by isoform ZAKalpha of MAP3K20 in response to ribosome collisions (Human) |
2025-09-12 |
Sylvain Poux |
success |
|
|
66b5638000001719
|
AKT1 inhibits EIF2AK3/PERK (Human). |
2025-09-12 |
Sylvain Poux |
success |
|
|
66b5638000001329
|
ATAD3A inhibits the PERK-mediated unfolded protein response in mitochondria by inhibiting EIF2AK3/PERK (Human). |
2025-09-12 |
Sylvain Poux |
success |
|
|
6494e2e900001856
|
Inhibition of the HRI-mediated signaling by the SIFI complex via ubiquitination of DELE1 and EIF2AK1 by UBR4 and KCMF1 (Human). |
2025-09-12 |
Sylvain Poux |
success |
|
|
66b5638000000739
|
Inhibition of the PERK-mediated unfolded protein response by HSPA5/BiP in absence of stress (Human). |
2025-09-12 |
Sylvain Poux |
success |
|
|
61e0e55600000407
|
SP_GADD34- PPP1CA |
2025-09-10 |
Patrick Masson, Sylvain Poux |
success |
|
1 warning
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: double-stranded RNA [CHEBI:67208] (information biomacromolecule) —directly positively regulates→ protein serine/threonine kinase activity [GO:0004674] (molecular_function)
|
627d95ee00001242
|
Regulation of transcription elongation by the P-TEFb complex, NELFE and PARP1 (Human) |
2025-09-09 |
Sylvain Poux |
success |
|
|
67b1629100004023
|
The INTAC complex mediates RNA polymerase II transcription initiation surveillance by catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A and degrading the exiting nascent RNA transcript (Human). |
2025-09-04 |
Sylvain Poux |
success |
|
|
685de18700004252
|
CERS2 galactosylceramide synthesis (Human) |
2025-09-03 |
Cristina Casals, Vitalina Kharchenko |
success |
|
|
65d7e4ac00002121
|
Apoptosis-induced by calcium import into mitochondria at ER-mitochondria contact sites mediated by the ITPR1:HSPA9:VDAC1 complex (Human) |
2025-09-02 |
Guilaine Argoud-Puy |
success |
|
|
654d809000001587
|
Atg7-mediated autophagosome assembly via ATM-CHK2-TRIM32 axis (Human) |
2025-09-02 |
Guilaine Argoud-Puy |
success |
|
|
68b0f0d000001117
|
CD31-CD38 activation of T cells (Human) |
2025-09-02 |
Patrick Masson |
success |
|
|
66b5638000000353
|
FXR1 forms mRNP networks that act as signaling scaffold for actomyosin remodeling (Human) |
2025-09-02 |
Cristina Casals |
success |
|
|
65a1f4f800003760
|
Hippo signaling positive regulation by TAZ cytoplasmic retention (Human). |
2025-09-02 |
Cristina Casals |
success |
|
|
685de18700005103
|
Leukocyte cell-cell adhesion mediated by ICAM3 receptor ligand and integrin ITGAD:ITGB2 complex receptor (HUMAN) |
2025-09-02 |
Guilaine Argoud-Puy |
success |
|
|
68b0f0d000000486
|
Negative regulation of BCR signaling by CD72-CD5 interaction (Human) |
2025-09-02 |
Patrick Masson |
success |
|
|
65bc474400000955
|
Negative regulation of Hippo signaling by STRIPAK complex via STRN4:MAP4K4(Human). |
2025-09-02 |
Cristina Casals |
success |
|
|
689e7a5d00004061
|
Regulation of Respiratory chain complex I by COXFA4L2 upon hypoxia. (Human) |
2025-09-02 |
Cristina Casals |
success |
|
|
689e7a5d00003515
|
Ephrin-A1/EPHA2 negative regulation of cell adhesion mediated by integrin (Human) |
2025-09-01 |
Lionel Breuza |
success |
|
|
66f5faaa00001170
|
RVFV NSs-FBXO3 E3 ligase mediates TFIIH complex degradation. (Human) |
2025-08-29 |
Cristina Casals |
success |
|
|
613aae0000001005
|
Activation of RECQL5 by CDK1 leading to mitotic DNA replication activation (Human) |
2025-08-28 |
Patrick Masson |
success |
|
|
65c57c3400001053
|
CLSTN3beta promotes adipocyte multilocularity to facilitate lipid utilization by inhibiting CIDEC activity (Human). |
2025-08-28 |
Sylvain Poux |
success |
|
|
6348a65d00002885
|
Positive regulation of cold-induced thermogenesis by OVOL2 in brown adipose tissue. (Human) |
2025-08-28 |
Cristina Casals |
success |
|
|
617b481400003575
|
Role of RNF169 in double-strand break repair upon DYRK1A activation (Human) |
2025-08-28 |
Patrick Masson |
success |
|
|
6197061700000027
|
SIK2 activates VCP leading to ERAD pathway activation (Human) |
2025-08-28 |
Patrick Masson |
success |
|
|
657ba49f00001143
|
tRNA queuosine promotes further glycosylation by GTDC1 and B3GNTL1, and methylation by TRDMT1 (Human). |
2025-08-28 |
Sylvain Poux |
success |
|
|
689e7a5d00005183
|
Positive regulation of KCNJ13 channel by OPN3 via G-alpha-i (inhibitory)_Membrane potential (Human) |
2025-08-26 |
Lucille Pourcel |
success |
|
|
685de18700005910
|
Dendritic cell migration mediated by ICAM2 receptor ligand and CD209 signaling receptor |
2025-08-25 |
Guilaine Argoud-Puy |
success |
|
|
689e7a5d00000050
|
EPHA3 activation by EFNA1 in EMT (Human) |
2025-08-25 |
Lionel Breuza |
success |
|
|
6882d2b800004512
|
EPHA3 activation by EFNA5 in cell adhesion (Human) |
2025-08-25 |
Lionel Breuza |
success |
|
|
6882d2b800004114
|
Ephrin-B2/EphA4-mediated activation of endothelial cells (Human) |
2025-08-25 |
Lionel Breuza |
success |
|
|
6870555700000202
|
Erythrocyte cell-platelet cell adhesion mediated by ICAM4 receptor ligand and integrin ITGA2B:ITGB3 complex receptor (HUMAN) |
2025-08-25 |
Guilaine Argoud-Puy |
success |
|
|
685de18700007362
|
Erythrocyte phagocytosis mediated by ICAM4 receptor ligand and integrin ITGAX:ITGB2 complex receptor (HUMAN) |
2025-08-25 |
Guilaine Argoud-Puy |
success |
|
|
689e7a5d00003489
|
FBXO44-mediated degradation of RGS2 via CUL4B/DDB1 complex (Human) |
2025-08-25 |
Patrick Masson |
success |
|
|
689e7a5d00004320
|
Lactate regulates dendritic cell function trhough ROS production inhibition by COXFA4L2. (Mouse) |
2025-08-25 |
Cristina Casals |
success |
|
|
685de18700006487
|
Leukocyte adhesion to vascular endothelial cell mediated by ICAM1 receptor ligand and integrin ITGAM:ITGB2 complex receptor (HUMAN) |
2025-08-25 |
Guilaine Argoud-Puy |
success |
|
|
6796b94c00002996
|
Leukocyte cell-cell adhesion mediated by ICAM1 receptor ligand and integrin ITGAL:ITGB2 complex receptor (HUMAN) |
2025-08-25 |
Guilaine Argoud-Puy |
success |
|
|
685de18700003080
|
Leukocyte cell-cell adhesion mediated by ICAM2 receptor ligand and integrin ITGAL:ITGB2 complex receptor (HUMAN) |
2025-08-25 |
Guilaine Argoud-Puy |
success |
|
|
685de18700005035
|
Leukocyte cell-cell adhesion mediated by ICAM3 receptor ligand and integrin ITGAL:ITGB2 complex receptor (HUMAN) |
2025-08-25 |
Guilaine Argoud-Puy |
success |
|
|
685de18700005170
|
Leukocyte cell-dendritic cell adhesion mediated by ICAM3 receptor ligand and CD209 signaling receptor |
2025-08-25 |
Guilaine Argoud-Puy |
success |
|
|
622aace900000522
|
ADP-ribosyltransferase activity of SIRT6 and ADP-ribosylation of PARP1 during DNA repair (Human) |
2025-08-22 |
Sylvain Poux |
success |
|
|
653b0ce600000800
|
LMNA (Lamin-A/C) maturation (Human). |
2025-08-22 |
Sylvain Poux |
success |
|
|
6494e2e900001469
|
Mpeg1/perforin-2 forms a pore for to deliver antigens for cross-presentation (Mouse) |
2025-08-22 |
Sylvain Poux |
success |
|
|
645d887900000758
|
Osteocalcin (BGLAP) hormone produced by osteoblasts binds GPR158 receptor and regulates brain development (Human). |
2025-08-22 |
Sylvain Poux |
success |
|
|
62b4ffe300000240
|
Perforin maturation leading to granzyme-mediated programmed cell death signaling pathway (Mouse) |
2025-08-22 |
David Hill, Sylvain Poux |
success |
|
|
6438950a00000624
|
Activation of the WNK1-SPAK/OSR1 kinase cascade in response to hyperosmotic stress, leading to promote ion influx and prevent ion efflux (Human) |
2025-08-21 |
Sylvain Poux |
success |
|
|
62b4ffe300004892
|
Arginine ADP-riboxanation of CASP8 by by C.violaceum CopC blocks CASP8 activity and extrinsic apoptosis (Human) |
2025-08-21 |
Sylvain Poux |
success |
|
|
62b4ffe300005060
|
Arginine ADP-riboxanation of CASP9 by by C.violaceum CopC that blocks CASP9 activity and intrinsic apoptosis (Human)
|
2025-08-21 |
Sylvain Poux |
success |
|
|
682fbcd000004638
|
BCAT2 provides acetyl-CoA upstream of EP300, leading to acetylation and inhibition of PRDM16 (Human). |
2025-08-21 |
Sylvain Poux |
success |
|
|
680ad14200007322
|
BRD9 regulates RAD51 and RAD54L in double-strand break repair via homologous recombination (Human) |
2025-08-21 |
Lionel Breuza |
success |
|
|
684b6c8100000067
|
CRL2(APPBP2) complex inhibits beige fat cell differentiation by mediating ubiquitination of PRDM16, leading to its degradation by the proteasome (Human). |
2025-08-21 |
Sylvain Poux |
success |
|
|
65c57c3400000687
|
Dolichol-linked oligosaccharides biosynthetic pathway (Human) |
2025-08-21 |
Lionel Breuza |
success |
|
|
63894f2500001378
|
FMR1 and CAPRIN1 undergo liquid-liquid phase separation following phosphorylation, leading to formation of non-membrane-bounded organelle that prevent mRNA translation (Human) |
2025-08-21 |
Sylvain Poux |
success |
|
|
63c0ac2b00002148
|
IFFO1 immobilizes broken DNA for reparation (Human) |
2025-08-21 |
Lionel Breuza, Patrick Masson |
success |
|
2 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA double-strand break attachment to nuclear envelope [GO:1990683] (biological_process) —has input→ IFFO1 Hsap [UniProtKB:Q0D2I5] (information biomacromolecule)
-
SKIPPED_FACT: Subject 'DNA double-strand break attachment to nuclear envelope [GO:1990683] (biological_process)' has 'has input' relationship to 'IFFO1 Hsap [UniProtKB:Q0D2I5] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
|
63894f2500000826
|
Liquid-liquid phase separation of FXR1 drives spermatogenesis by activating translation of stored mRNAs (Human) |
2025-08-21 |
Sylvain Poux |
success |
|
|
63894f2500000788
|
Liquid-liquid phase separation of FXR1 drives spermatogenesis by activating translation of stored mRNAs (Mouse) |
2025-08-21 |
Sylvain Poux |
success |
|
|
63894f2500000870
|
Liquid-liquid phase separation of FXR1 drives translation of mRNAs and regulation of FXR1 by ubiquitination and phosphorylation (Human) |
2025-08-21 |
Sylvain Poux |
success |
|
|
6348a65d00002600
|
Negative regulation of white adipogenesis by OVOL2. (Human) |
2025-08-21 |
Cristina Casals, Sylvain Poux |
success |
|
|
6870555700001150
|
Perlecan interaction with post-translationally modified dystroglycan is required for acetylcholinesterase localization and accumulation at the neuromuscular junction(Human) |
2025-08-21 |
Livia Famiglietti |
success |
|
|
689e7a5d00000901
|
Post-translational modification-dependent alpha-dystroglycan interaction with pikachurin (EGFLAM) is required for ribbon synapse formation (Human) |
2025-08-21 |
Livia Famiglietti |
success |
|
|
684b6c8100000003
|
PRDM16 acts as a key chromatin adapter that mediates differentiation of beige adipocytes from white adipocytes (Human). |
2025-08-21 |
Sylvain Poux |
success |
|
|
682fbcd000003101
|
PRDM16 acts as a key chromatin adapter that mediates differentiation of brown adipocytes (Human). |
2025-08-21 |
Sylvain Poux |
success |
|
|
654d809000000053
|
Regulation of aggrephagy via acetylation and deacetylation of SQSTM1 by KAT5 and HDAC6, respectively (Human). |
2025-08-21 |
Sylvain Poux |
success |
|
|
654d809000000010
|
Regulation of aggrephagy via palmitoylation and depalmitoylation of SQSTM1 by ZDHHC19 and LYPLA1, respectively (Human). |
2025-08-21 |
Sylvain Poux |
success |
|
|
654d809000000248
|
Regulation of aggrephagy via phosphorylation of SQSTM1 by CK2 (Human). |
2025-08-21 |
Sylvain Poux |
success |
|
|
63894f2500001465
|
Regulation of CAPRIN1-mediated liquid-liquid phase separation by moderate level of ATP, glycosylation by OGT and mRNA-binding (Human) |
2025-08-21 |
Sylvain Poux |
success |
|
|
654d809000000112
|
SQSTM1 is involved in aggrephagy by mediating recruitment of ubiquitinated proteins to autophagosomes (Human). |
2025-08-21 |
Sylvain Poux |
success |
|
|
654d809000000171
|
SQSTM1 mediates retention of KEAP1 into p62 bodies (Human). |
2025-08-21 |
Sylvain Poux |
success |
|
|
682fbcd000004750
|
TLE3 acts as a chromatin adapter that mediates differentiation of white adipocytes and prevents browning of adipocytes (Human). |
2025-08-21 |
Sylvain Poux |
success |
|
|
6606056e00001722
|
TPK1 provides cofactor for pyruvate dehydrogenase (Human) |
2025-08-21 |
Lionel Breuza |
success |
|
|
63c0ac2b00000385
|
TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via SQSTM1 dependent selective autophagy (Human) |
2025-08-21 |
Sylvain Poux |
success |
|
|
635b1e3e00002404
|
Zar1 stores maternal mRNAs in oocytes by mediating formation of a non-membrane bound organelle (Human) |
2025-08-21 |
Sylvain Poux |
success |
|
|
635b1e3e00002287
|
Zar1 stores maternal mRNAs in oocytes by mediating formation of a non-membrane bound organelle (Mouse) |
2025-08-21 |
Sylvain Poux |
success |
|
|
6870555700001190
|
Alpha-dystroglycan is a laminin receptor involved in PI3K/AKT signaling activation in muscle (Human) |
2025-08-20 |
Livia Famiglietti |
success |
|
|
6870555700000153
|
HCAR3 inhibits lipolysis through activation of G-protein coupled receptor HCAR3 a receptor for 3-OH-octanoic acid. (Human) |
2025-08-19 |
Nadine Gruaz |
success |
|
|
689e7a5d00000567
|
Activation of XBP1 by IRE1 in UPR (Human) |
2025-08-18 |
Lionel Breuza |
success |
|
|
66187e4700000318
|
The CRL5(ASB11) complex mediates ubiquitination and degradation of BIK in response to endoplasmic reticulum stress (Human). |
2025-08-12 |
Sylvain Poux |
success |
|
|
65c57c3400002594
|
Heme catabolic process into urobilinogen (Human) |
2025-08-11 |
Sylvain Poux |
success |
|
|
6870555700001571
|
Laminin binding to alpha-dystroglycan activates Rac1 signaling via Src-Grb2-Sos1 (Human) |
2025-07-29 |
Livia Famiglietti |
success |
|
|
6882d2b800000346
|
JAK2 phosphorylates histone H3 at Tyr-41, promoting exclusion of CBX5/HP1 from chromatin (Human). |
2025-07-25 |
Sylvain Poux |
success |
|
|
6882d2b800000559
|
Phosphorylation of UHRF1 by CDK1 prevents UHRF1 deubiquitination by USP7, promoting autoubiquitination and degradation of UHRF1 (Human). |
2025-07-25 |
Sylvain Poux |
success |
|
|
6882d2b800000403
|
Phosphorylation of UHRF1 by PKA decreased UHRF1 binding to H3K9me3 (Human). |
2025-07-25 |
Sylvain Poux |
success |
|
|
6882d2b800000042
|
UHRF1 and SMARCA3 mediate histone H3 ubiquitination (H3K18ub and H3K23ub), promoting DNMT1 recruitment at hemimethylated DNA (Human). |
2025-07-25 |
Sylvain Poux |
success |
|
|
6882d2b800000491
|
USP7 mediates deubiquitination of UHRF1, preventing autoubiquitination and degradation of UHRF1 (Human). |
2025-07-25 |
Sylvain Poux |
success |
|
|
685de18700006327
|
ASB7 is a negative regulator of H3K9me3 homeostasis by mediating ubiquitination and degradation of SUV39H1 (Human). |
2025-07-24 |
Sylvain Poux |
success |
|
|
685de18700006415
|
CDK1 inhibits ASB7 ability to ubiquitinate SUV39H1 by mediating phosphorylation of ASB7 during mitosis (Human). |
2025-07-24 |
Sylvain Poux |
success |
|
|
6882d2b800000119
|
EHMT2 methylates histone H1-4 at Lys-26, creating a docking site for CBX5/HP1 (Human). |
2025-07-24 |
Sylvain Poux |
success |
|
|
6870555700004670
|
FBXO24 regulation of autophagy via ULK1 degradation (Human) |
2025-07-24 |
Patrick Masson |
success |
|
|
6870555700004574
|
FBXO24-mediated degradation of NME1(Human) |
2025-07-24 |
Patrick Masson |
success |
|
|
6870555700004614
|
FBXO24-mediated degradation of PRMT6 (Human) |
2025-07-24 |
Patrick Masson |
success |
|
|
6882d2b800000179
|
Histone H1-4 phosphorylation at Ser-27 prevents CBX5/HP1-binding to histone H1-4 (Human). |
2025-07-24 |
Sylvain Poux |
success |
|
|
6870555700002365
|
Linker histone H1.2 recognizes and binds H3K27me3 (Human). |
2025-07-24 |
Sylvain Poux |
success |
|
|
6882d2b800000215
|
Phosphorylation of histone H1-4 at Ser-35 by PKA during mitosis promotes histone H1 dissociation from mitotic chromosome (Human). |
2025-07-24 |
Sylvain Poux |
success |
|
|
685de18700006700
|
SUV39H1 phosphorylation by CDK2 inhibits its localization to heterochromatin (Human). |
2025-07-24 |
Sylvain Poux |
success |
|
|
6870555700002306
|
Transcription factor CRAMP1 specifically mediates expression of histone H1 genes, enabling Polycomb repression (Human). |
2025-07-24 |
Sylvain Poux |
success |
|
|
685de18700005131
|
Signaling by adrenaline mediated by ADRA1A receptor via G-alpha-q (phospholipase c-activating, IP3, DAG)_Cardiac hypertrophy (Human) |
2025-07-18 |
Lucille Pourcel |
success |
|
|
685de18700005822
|
Signaling by adrenaline mediated by ADRA1B receptor via G-alpha-q (phospholipase c-activating, IP3, DAG)_Cardiac hypertrophy (Human) |
2025-07-18 |
Lucille Pourcel |
success |
|
|
685de18700005944
|
Signaling by adrenaline mediated by ADRA1D receptor via G-alpha-q (phospholipase c-activating, IP3, DAG) (Human) |
2025-07-18 |
Lucille Pourcel |
success |
|
|
685de18700002943
|
Signaling by noradrenaline mediated by ADRA1A receptor via G-alpha-q (phospholipase c-activating, IP3, DAG)_Cardiac hypertrophy (Human) |
2025-07-18 |
Lucille Pourcel |
success |
|
|
685de18700005866
|
Signaling by noradrenaline mediated by ADRA1B receptor via G-alpha-q (phospholipase c-activating, IP3, DAG)_Cardiac hypertrophy (Human) |
2025-07-18 |
Lucille Pourcel |
success |
|
|
685de18700005336
|
Signaling by noradrenaline mediated by ADRA1D receptor via G-alpha-q (phospholipase c-activating, IP3, DAG) (Human) |
2025-07-18 |
Lucille Pourcel |
success |
|
|
685de18700006529
|
GMEB1 interacts with the deubiquitinase USP40 to stabilize CFLARL and inhibit apoptosis (Human) |
2025-07-10 |
Patrick Masson |
success |
|
|
685de18700001168
|
HPV E6 modulates MARCHF8 activity to down-regulate TRAIL-R1 and TRAIL-R2 (Human--HPV) |
2025-07-10 |
Patrick Masson |
success |
|
|
684b6c8100003917
|
PINK1-PRKN induction of mitophagy through VDAC1 Lys-27 ubiquitination (Human) |
2025-07-10 |
Patrick Masson |
success |
|
|
685de18700007432
|
Regulation of LRRK2 activity by TRIM1 (Human) |
2025-07-10 |
Patrick Masson |
success |
|
|
680ad14200006016
|
The SCF(FBXO312) complex mediates ubiquitination and stablization of CCND1(Human). |
2025-07-10 |
Patrick Masson |
success |
|
|
62f58d8800001680
|
Gut Microbiota tryptophan metabolism: Regulation of intestinal epithelial cell homesotasis by Indole-AhR (Human-E.coli) |
2025-07-09 |
Cristina Casals, Kimberly Van Auken |
success |
|
|
685de18700005328
|
TRIM48 promotes ASK1 activation and cell death through ubiquitination of PRMT1 (Human) |
2025-07-08 |
Patrick Masson |
success |
|
|
65f3ae5c00001022
|
UFL1 negatively regulates T-cell activation by mediating ufmylation of PDCD1/PD-1 (Human). |
2025-07-04 |
Sylvain Poux |
success |
|
|
685de18700001650
|
MRGPRD-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by beta-alanine (Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
684b6c8100000161
|
Acetylation of ZNF76 by EP300 prevents sumoylation of ZNF76 by PIAS1 (Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
682fbcd000004101
|
CBX4 promotes PRDM16 stability by preventing its ubiquitination and degradation (Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
662af8fa00002332
|
CD28/GRB2 axis leading to RAS activation (Human) |
2025-07-03 |
Patrick Masson |
success |
|
|
684b6c8100003865
|
Cholestatic itch via MRGPRX4-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by 3-sulfated bile acids(Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
684b6c8100003181
|
GPBAR1-mediated signaling via G-alpha-s ("stimulatory", activating adenylate cyclase) following activation by chenodeoxycholate (Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
684b6c8100003211
|
GPBAR1-mediated signaling via G-alpha-s ("stimulatory", activating adenylate cyclase) following activation by cholate (Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
684b6c8100003149
|
GPBAR1-mediated signaling via G-alpha-s ("stimulatory", activating adenylate cyclase) following activation by deoxycholate (Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
684b6c8100002980
|
GPBAR1-mediated signaling via G-alpha-s ("stimulatory", activating adenylate cyclase) following activation by lithocholate (Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
67c10cc400001896
|
GPR68-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by protons (Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
666b894f00001077
|
HTR2A-mediated serotonin signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) (Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
666b894f00001459
|
HTR2B-mediated serotonin signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) (Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
666b894f00001488
|
HTR2C-mediated serotonin signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) (Human) |
2025-07-03 |
Lionel Breuza, Sylvain Poux |
success |
|
|
685de18700001608
|
MRGPRD-mediated signaling via G-alpha-i (inhibitory) inhibiting adenylate cyclase) following activation by beta-alanine (Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
685de18700002069
|
MRGPRD-mediated signaling via G-alpha-i (inhibitory) inhibiting adenylate cyclase) following activation by beta-aminoisobutyrate (Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
685de18700002029
|
MRGPRD-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by allantoin (Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
685de18700002103
|
MRGPRD-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by beta-aminoisobutyrate (Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
685de18700000031
|
MRGPRX2-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by opioids (Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
675b862c00000237
|
OXGR1-mediated signaling via G-alpha-11 (phospholipase c-activating, IP3, DAG) following itaconate-binding (Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
684b6c8100003827
|
Perception of itch via MRGPRX4-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by chenodeoxycholate (Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
684b6c8100003781
|
Perception of itch via MRGPRX4-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by deoxycholate (Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
684b6c8100000137
|
Sumoylation of ZNF76 by PIAS1 inhibits ZNF76 ability to inhibit TATA-binding protein (TBP) (Human).
|
2025-07-03 |
Sylvain Poux |
success |
|
|
667dfe8d00000109
|
TAAR1-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by cyclohexylamine (Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
667dfe8d00000146
|
TAAR1-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by trimethylamine (Human). |
2025-07-03 |
Sylvain Poux |
success |
|
|
685de18700000473
|
ANGPT4 promotes angiogenesis via TIE2 signaling in endothelial cells (Human) |
2025-06-30 |
Livia Famiglietti |
success |
|
|
684b6c8100003650
|
SCF(Cyclin F) controls cell cycle-dependent execution of double-strand break repair through EXO1degradation (Human) |
2025-06-25 |
Patrick Masson |
success |
|
|
684b6c8100003601
|
SCF(Cyclin F) controls centrosome homeostasis through CP110 degradation (Human) |
2025-06-25 |
Patrick Masson |
success |
|
|
684b6c8100003714
|
SCF(Cyclin F) controls controls genome integrity and DNA repair through RRM2 degradation (Human) |
2025-06-25 |
Patrick Masson |
success |
|
|
680ad14200006794
|
Signaling by noradrenaline mediated by ADRB3 receptor via G-alpha-s (activatory)_Detrusor relaxation (Human) |
2025-06-25 |
Lucille Pourcel |
success |
|
|
680ad14200006651
|
Signaling by noradrenaline mediated by ADRB3 receptor via G-alpha-i (inhibititory)_Inotropic inhibition (Human) |
2025-06-25 |
Lucille Pourcel |
success |
|
|
680ad14200007287
|
Signaling by noradrenaline mediated by ADRB3 receptor via G-alpha-i (inhibititory)_Lipolysis (Human) |
2025-06-25 |
Lucille Pourcel |
success |
|
|
684b6c8100002169
|
ANGPT1 promotes angiogenesis via TIE2 signaling in endothelial cells (Human) |
2025-06-23 |
Livia Famiglietti |
success |
|
|
682fbcd000005208
|
ANGPT2 promotes angiogenesis via TIE2 signaling in endothelial progenitor cells (Human) |
2025-06-23 |
Livia Famiglietti |
success |
|
|
680ad14200006156
|
RAD51 and RAD54B cooperate in double-strand break repair via homologous recombination (Human) |
2025-06-23 |
Lionel Breuza |
success |
|
|
680ad14200006012
|
Negative regulation of signal transduction by p53 by RAD54B (Human) |
2025-06-20 |
Lionel Breuza |
success |
|
|
66c7d41500000080
|
Dolichol biosynthetic process (Human). |
2025-06-12 |
Sylvain Poux |
success |
|
|
682fbcd000004727
|
ANGPT2 does not promote angiogenesis via TIE2 signaling in differentiated blood vessel endothelial cells (i.e.humbelical vein endothelial cells HUVEC) (Human) |
2025-06-06 |
Livia Famiglietti |
success |
|
|
682fbcd000005285
|
ANGPT2 promotes angiogenesis via TIE2 signaling in lymphatic endothelial cells (Human) |
2025-06-06 |
Livia Famiglietti |
success |
|
|
682fbcd000005326
|
PTPRB abrogates ANGPT2-mediated activation of TIE2 signaling in blood vessel endothelial cells (Human) |
2025-06-06 |
Livia Famiglietti |
success |
|
|
682fbcd000000032
|
CTPS1 inhibits antiviral interferon induction by deamidating IRF3 (Human). |
2025-06-03 |
Sylvain Poux |
success |
|
|
680ad14200007201
|
GPX4 hydroxylation by EGLN3 prevents its degradation via chaperone-mediated autophagy, inhibiting ferroptosis (Human). |
2025-06-03 |
Sylvain Poux |
success |
|
|
680ad14200007162
|
GPX4 is degraded via chaperone-mediated autophagy (Human). |
2025-06-03 |
Sylvain Poux |
success |
|
|
682fbcd000000000
|
Histone H1 deamidation by CTSP1 promotes subsequent acetylation by EP300 and facilitates chromatin relaxation for DNA repair (Human). |
2025-06-03 |
Sylvain Poux |
success |
|
|
682fbcd000003724
|
RORgammaT, PRDM16 and ZBTB16 promote tolerance to gut microbiota by mediating differentiation of peripherally-induced regulatory T-cells (pTreg) (Human). |
2025-06-03 |
Sylvain Poux |
success |
|
|
680ad14200007142
|
SMURF2 promotes ferroptosis by mediating ubiquitination and degradation of GSTP1, thereby preventing detoxification of 4-hydroxynonenal (4-HNE) (Human). |
2025-06-03 |
Sylvain Poux |
success |
|
|
62f58d8800006008
|
EBV-BNLF2a inhibition of MHC class I peptide antigen assembly via TAP1/TAP2 (Human-Herpesvirus) |
2025-06-02 |
Patrick Masson |
success |
|
|
682fbcd000002112
|
SRCAP acts as transcription coactivator in cAMP/PKA signal transduction. (Human) |
2025-05-26 |
Cristina Casals |
success |
|
|
682fbcd000002020
|
Translesion synthesis (TLS) involving POLK-REV1(HUMAN) |
2025-05-26 |
Guilaine Argoud-Puy |
success |
|
|
680ad14200003422
|
Translesion synthesis (TLS) involving REV1-MAD2L2 (HUMAN) |
2025-05-26 |
Guilaine Argoud-Puy |
success |
|
|
680ad14200007896
|
ENPP3 is a cGAMP hydrolase involved in regulation of STING-mediated immune response (Human) |
2025-05-23 |
Livia Famiglietti |
success |
|
|
680ad14200003171
|
Signaling by adrenaline mediated by ADRB1 receptor via G-alpha-s (activatory) (Human) |
2025-05-23 |
Lucille Pourcel |
success |
|
|
680ad14200005774
|
Signaling by adrenaline mediated by ADRB2 receptor via G-alpha-s (activatory)_Cardiomyocyte contraction (Human) |
2025-05-23 |
Lucille Pourcel |
success |
|
|
680ad14200005738
|
Signaling by adrenaline mediated by ADRB2 receptor via G-alpha-i (inhibitory)_Cardioprotection (Human) |
2025-05-23 |
Lucille Pourcel |
success |
|
|
680ad14200003271
|
Signaling by noradrenaline mediated by ADRB1 receptor via G-alpha-s (activatory) (Human) |
2025-05-23 |
Lucille Pourcel |
success |
|
|
680ad14200005705
|
Signaling by noradrenaline mediated by ADRB2 receptor via G-alpha-s (activatory)_Cardiomyocyte contraction (Human) |
2025-05-23 |
Lucille Pourcel |
success |
|
|
680ad14200006397
|
ACSL4 activates ferroptosis following phosphorylation by isoform Beta-II of PRKCB (Human). |
2025-05-20 |
Sylvain Poux |
success |
|
|
680ad14200006442
|
ACSL4 activates ferroptosis following phosphorylation by PCK2 (Human). |
2025-05-20 |
Sylvain Poux |
success |
|
|
680ad14200003459
|
ALDH7A1 protects against ferroptosis by generating membrane NADH, thereby supporting AIFM2 activity (Human). |
2025-05-20 |
Sylvain Poux |
success |
|
|
680ad14200004334
|
FBXO7 mediates proteosomal degradation of UXT causing inhibition of the NF-KappaB signaling pathway. (Human) |
2025-05-20 |
Nadine Gruaz |
success |
|
|
680ad14200002857
|
GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by Kynurenic acid (Human). |
2025-05-20 |
Sylvain Poux |
success |
|
|
680ad14200002936
|
GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by lysophosphatidic acid (Human). |
2025-05-20 |
Sylvain Poux |
success |
|
|
680ad14200002791
|
GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) (Human). |
2025-05-20 |
Sylvain Poux |
success |
|
|
680ad14200002972
|
GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase promotes cardioprotection during ischemia following activation by kynurenic acid (Human). |
2025-05-20 |
Sylvain Poux |
success |
|
|
680ad14200005824
|
KIF12 involved in negative regulation of fatty acid biosynthesis via ACACA ubiquitination by COP1 (Human) |
2025-05-20 |
Livia Famiglietti |
success |
|
|
680ad14200000983
|
TNRC18 mediates silencing of endogenous retroviruses (ERV) by binding to H3K9me3 and mediating recruitment of Sin3-type complexes (Human). |
2025-05-20 |
Sylvain Poux |
success |
|
|
680ad14200004482
|
Inhibition of ADAR-mediated RNA editing by ADARB2/ADAR3 (Human). |
2025-05-16 |
Lionel Breuza |
success |
|
|
680ad14200003421
|
Inhibition of ADARB1-mediated RNA editing by ADARB2/ADAR3 (Human). |
2025-05-16 |
Lionel Breuza |
success |
|
|
65288b2200001166
|
TRIM55 and TRIM21-mediated inhibition of NFKB2 (Human) |
2025-05-15 |
Lucille Pourcel, Patrick Masson |
success |
|
|
646ff70100000239
|
Negative regulation of signal transduction by p53 class mediator by MORN3. (Human) |
2025-05-13 |
Cristina Casals |
success |
|
|
66c7d41500000427
|
Zika virus NS5 inhibition of STAT2 signaling via ZSWIM8 (Human-Zika virus) |
2025-05-12 |
Patrick Masson |
success |
|
|
63e5937500000106
|
Activation of the GCN2-mediated signaling by GCN1 in response to ribosome collisions and inhibition of GCN2 by HEL2 (S.cerevisiae) |
2025-05-02 |
Stacia Engel, Sylvain Poux |
success |
|
|
65bc474400000824
|
Acetylation of IRF3 by KAT8 inhibits type I interferon production (Human) |
2025-04-24 |
Sylvain Poux |
success |
|
|
653b0ce600000202
|
BRD3 and lncRNA DIGIT form phase-separated condensates to induce endoderm cell differentiation (Human). |
2025-04-24 |
Sylvain Poux |
success |
|
|
64e7eefa00000065
|
UAP1 catalyzes pyrophosphorylation of IRF3, promoting IRF3 activation (Human) |
2025-04-24 |
Sylvain Poux |
success |
|
|
666b894f00001059
|
PTGER2, prostaglandin E2 receptor. (Human) |
2025-04-22 |
Cristina Casals |
success |
|
|
666b894f00001139
|
PTGER4, prostaglandin E2 receptor involved in negative regulation of inflammatory response in macrophages. (Human) |
2025-04-22 |
Cristina Casals |
success |
|
|
666b894f00000604
|
PTGER4, prostaglandin E2 receptor via GNAS. (Human) |
2025-04-22 |
Cristina Casals |
success |
|
|
67f85f2b00000032
|
Negative regulation of RAB43 function in Golgi organization by USP6NL (Human) |
2025-04-16 |
Lucille Pourcel |
success |
|
|
67f85f2b00000104
|
Negative regulation of RAB5A function in endocytic trafficking by SGSM3 (Human) |
2025-04-16 |
Lucille Pourcel |
success |
|
|
67f85f2b00000958
|
RAB5A regulation of FERRY-mediated mRNA localization (Human) |
2025-04-16 |
Lucille Pourcel |
success |
|
1 warning
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: protein-macromolecule adaptor activity [GO:0030674] (molecular_function) —has part→ mRNA binding [GO:0003729] (molecular_function)
|
6796b94c00000576
|
Lanosterol biosynthesis (Human) |
2025-04-15 |
Patrick Masson |
success |
|
|
6796b94c00001105
|
Regulation of cholesterol biosynthesis by MARCH6 via SQLE degradation (Human) |
2025-04-15 |
Patrick Masson |
success |
|
|
6690711d00000596
|
NMDA glutamate receptor activity co-activated by glycine and involving GRIN1 and GRIN2A (human) |
2025-04-14 |
Guilaine Argoud-Puy |
success |
|
|
66c7d41500000672
|
NMDA glutamate receptor activity co-activated by glycine and involving GRIN1 and GRIN2B (Human) |
2025-04-14 |
Guilaine Argoud-Puy |
success |
|
|
666b894f00000352
|
CD70-CD27 ligand receptor in T cell activation (Human) |
2025-04-14 |
Guilaine Argoud-Puy |
success |
|
|
67e5e74400003294
|
EFNB2 ligand EPHB4 receptor in angiogenesis (Human) |
2025-04-14 |
Lionel Breuza |
success |
|
|
66c7d41500001953
|
glycine-gated cation channel activity involving GRIN1 and GRIN3A (Human) |
2025-04-14 |
Guilaine Argoud-Puy |
success |
|
|
66c7d41500003371
|
glycine-gated cation channel activity involving GRIN1 and GRIN3B (Human) |
2025-04-14 |
Guilaine Argoud-Puy |
success |
|
|
66e382fb00000049
|
NMDA glutamate receptor activity co-activated by D-serine and involving GRIN1 and GRIN2A (Human) |
2025-04-14 |
Guilaine Argoud-Puy |
success |
|
|
66c7d41500001120
|
NMDA glutamate receptor activity co-activated by glycine and involving GRIN1 and GRIN2C (Human) |
2025-04-14 |
Guilaine Argoud-Puy |
success |
|
|
66c7d41500003458
|
NMDA glutamate receptor activity co-activated by glycine and involving GRIN1 and GRIN2D (Human) |
2025-04-14 |
Guilaine Argoud-Puy |
success |
|
|
67e5e74400003200
|
PLD6-induced mitochondrial tethering through phosphatidic acid binding by NME3 (Human) |
2025-04-13 |
Guilaine Argoud-Puy |
success |
|
|
67b1629100000802
|
ADGRD1-mediated signaling G-alpha-s ("stimulatory", activating adenylate cyclase) following activation by 5alpha-dihydrotestosterone (Human). |
2025-04-10 |
Sylvain Poux |
success |
|
|
67b1629100003101
|
ADGRF1-mediated signaling G-alpha-s ("stimulatory", activating adenylate cyclase) following activation by N-docosahexaenoylethanolamine (synaptamide) (Human). |
2025-04-10 |
Sylvain Poux |
success |
|
|
67b1629100001260
|
ADGRG2-mediated signaling G-alpha-s ("stimulatory", activating adenylate cyclase) following activation by dehydroepiandrosterone (Human). |
2025-04-10 |
Sylvain Poux |
success |
|
|
67c10cc400001727
|
GPR4-mediated signaling via G-alpha-s ("stimulatory", activating adenylate cyclase) following activation by protons (Human). |
2025-04-10 |
Sylvain Poux |
success |
|
|
666b894f00001546
|
HTR4-mediated serotonin signaling G-alpha-s ("stimulatory", activating adenylate cyclase) (Human). |
2025-04-10 |
Sylvain Poux |
success |
|
|
666b894f00002018
|
HTR6-mediated serotonin signaling G-alpha-s ("stimulatory", activating adenylate cyclase) (Human). |
2025-04-10 |
Sylvain Poux |
success |
|
|
666b894f00002043
|
HTR7-mediated serotonin signaling G-alpha-s ("stimulatory", activating adenylate cyclase) (Human). |
2025-04-10 |
Sylvain Poux |
success |
|
|
667dfe8d00000012
|
TAAR1-mediated signaling G-alpha-s ("stimulatory", activating adenylate cyclase) following activation by beta-phenylethylamine (Human). |
2025-04-10 |
Sylvain Poux |
success |
|
|
667dfe8d00000211
|
TAAR1-mediated signaling G-alpha-s ("stimulatory", activating adenylate cyclase) following activation by trimethylamine (Human). |
2025-04-10 |
Sylvain Poux |
success |
|
|
67c10cc400006997
|
The ECS(RAB40B) complex mediates ubiquitination and degradation of LIMA1 during cell migration (Human) |
2025-04-04 |
Lucille Pourcel |
success |
|
|
67c10cc400007117
|
The ECS(RAB40B) complex mediates ubiquitination and degradation of RAP2A during cell migration (Human) |
2025-04-04 |
Lucille Pourcel |
success |
|
|
67c10cc400008763
|
CD59 inhibits formation of the membrane attack complex, protecting self-cells (Human). |
2025-04-01 |
Sylvain Poux |
success |
|
|
67c10cc400009046
|
Clusterin (CLU) inhibits formation of the membrane attack complex (Human). |
2025-04-01 |
Sylvain Poux |
success |
|
|
6494e2e900000134
|
Regulation of IRF7 activation by enterovirus D68 protein VP3 (Human-enterovirus) |
2025-04-01 |
Pascale Gaudet, Patrick Masson |
filtered |
Model has at least one activity with no causal relations |
|
67c10cc400002721
|
Mo-molybdopterin cofactor biosynthetic process (Human) |
2025-03-19 |
Antonia Lock |
success |
|
7 warnings
-
SKIPPED_FACT: Subject 'molybdopterin synthase activity [GO:0030366] (molecular_function)' has 'has input' relationship to 'precursor Z(1-) [CHEBI:59648] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
-
SKIPPED_FACT: Subject 'molybdopterin synthase activity [GO:0030366] (molecular_function)' has 'has output' relationship to 'molybdopterin(3-) [CHEBI:58698] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: molybdopterin synthase activity [GO:0030366] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: molybdopterin synthase activity [GO:0030366] (molecular_function) —has output→ molybdopterin(3-) [CHEBI:58698] (chemical entity)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: molybdopterin synthase activity [GO:0030366] (molecular_function) —has input→ precursor Z(1-) [CHEBI:59648] (chemical entity)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: molybdopterin-synthase sulfurtransferase activity [GO:0061604] (molecular_function) —provides input for→ molybdopterin synthase activity [GO:0030366] (molecular_function)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: molybdopterin synthase activity [GO:0030366] (molecular_function) —part of→ Mo-molybdopterin cofactor biosynthetic process [GO:0006777] (biological_process)
|
67c10cc400004900
|
Regulation of lipid droplet formation by RAB40C and DAB2IP (Human) |
2025-03-18 |
Lucille Pourcel |
success |
|
|
67c10cc400004918
|
The ECS(RAB40A) complex mediates ubiquitination and degradation of RHOU during cell migration (Human) |
2025-03-18 |
Lucille Pourcel |
success |
|
|
67c10cc400004816
|
The ECS(RAB40C) complex mediates ubiquitination and degradation of ANKRD28 during cell migration (Human) |
2025-03-18 |
Lucille Pourcel |
success |
|
|
67c10cc400005330
|
PARP12 activated GOLGA1 activity toward E-cadherin (Human) |
2025-03-17 |
Patrick Masson |
success |
|
|
675b862c00001470
|
Ubiquinone biosynthetic process (Human).
|
2025-02-28 |
Sylvain Poux |
success |
|
|
67b1629100003698
|
ADGRG6-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by 17alpha-hydroxyprogesterone (Human). |
2025-02-27 |
Sylvain Poux |
success |
|
|
67b1629100003733
|
ADGRG6-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by progesterone (Human). |
2025-02-27 |
Sylvain Poux |
success |
|
|
67b1629100003856
|
ARMC5 mediates RNA polymerase II transcription initiation surveillance by mediating ubiquitination and degradation of POLR2A (Human). |
2025-02-27 |
Sylvain Poux |
success |
|
|
6796b94c00003929
|
Cleavage of human TRMT1 by SARS-CoV-2 protease Nsp5, leading to perturb host cell translation (Human and SARS-CoV-2) |
2025-02-27 |
Sylvain Poux |
success |
|
|
6796b94c00006015
|
FBXO31 is ubiquitinated and degraded by the APC/C complex (Human). |
2025-02-27 |
Sylvain Poux |
success |
|
|
6796b94c00006250
|
MAP2K6 is ubiquitinated and degraded by the SCF(FBXO31) complex following DNA damage (Human). |
2025-02-27 |
Sylvain Poux |
success |
|
|
6796b94c00005540
|
MDM2 is ubiquitinated and degraded by the SCF(FBXO31) complex following DNA damage, promoting signal transduction by TP53/p53 (Human). |
2025-02-27 |
Sylvain Poux |
success |
|
|
67b1629100003765
|
Progesterone and cortisol biosynthetic pathway from cholesterol (Human). |
2025-02-27 |
Sylvain Poux |
success |
|
|
67b1629100003158
|
RAB39A and RAB2A-induced HOPS-mediated autophagosome-lysosome fusion (Human) |
2025-02-27 |
Lucille Pourcel |
success |
|
7 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: HOPS complex [GO:0030897] (cellular_component) —has part→ VPS16 Hsap [UniProtKB:Q9H269] (information biomacromolecule)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: HOPS complex [GO:0030897] (cellular_component) —has part→ VPS39 Hsap [UniProtKB:Q96JC1] (information biomacromolecule)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: SNAP receptor activity [GO:0005484] (molecular_function) —directly positively regulates→ autophagosome-lysosome fusion [GO:0061909] (biological_process)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: HOPS complex [GO:0030897] (cellular_component) —has part→ VPS41 Hsap [UniProtKB:P49754] (information biomacromolecule)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: HOPS complex [GO:0030897] (cellular_component) —has part→ VPS33A Hsap [UniProtKB:Q96AX1] (information biomacromolecule)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: HOPS complex [GO:0030897] (cellular_component) —has part→ VPS11 Hsap [UniProtKB:Q9H270] (information biomacromolecule)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: HOPS complex [GO:0030897] (cellular_component) —has part→ VPS18 Hsap [UniProtKB:Q9P253] (information biomacromolecule)
|
6796b94c00006325
|
The SCF(FBXO31) complex mediates ubiquitination and degradation of FBXO46 following DNA damage (Human). |
2025-02-27 |
Sylvain Poux |
success |
|
|
6796b94c00005197
|
The SCF(FBXO31) complex mediates ubiquitination of proteins amidated in response to oxidative stress (Human). |
2025-02-27 |
Sylvain Poux |
success |
|
|
6796b94c00006392
|
The SCF(FBXO46) complex mediates ubiquitination and degradation of FBXO31 in absence of stress (Human). |
2025-02-27 |
Sylvain Poux |
success |
|
|
6796b94c00002938
|
Transcription-coupled nucleotide-excision repair by ERRC6, ERCC8, ELOF1 and UVSSA (Human). |
2025-02-27 |
Sylvain Poux |
success |
|
|
6796b94c00002252
|
Transcription-pause release by the PNUTS-PP1 complex (Human). |
2025-02-27 |
Sylvain Poux |
success |
|
|
6796b94c00006045
|
Yersinia YopJ inhibits the MAPK cascade by mediating acetylation of MAP2K6, preventing phosphorylation and activation of MAP2K6 (Y.pseudotuberculosis and Human) |
2025-02-27 |
Sylvain Poux |
success |
|
|
66c7d41500000754
|
Dengue virus NS5 inhibition of STAT2 signaling via UBR4 (Human) |
2025-02-18 |
Patrick Masson |
success |
|
|
67b1629100000848
|
The ERK1/USP5 axis deubiquitinates and stabilizes PDCD1/PD-1 (Human). |
2025-02-18 |
Patrick Masson |
success |
|
|
646ff70100005033
|
Inhibition of FBXW7 by USP38 to prevent MYC degradation (Human) |
2025-02-17 |
Patrick Masson |
success |
|
|
67b1629100000368
|
Inhibition of FBXW7 by USP5 to prevent FOXM1 degradation (Human) |
2025-02-17 |
Patrick Masson |
success |
|
|
653b0ce600000432
|
TRIM32-TAX1BP1-dependent selective autophagic degradation of TICAM1 (Human) |
2025-02-11 |
Patrick Masson |
success |
|
|
63c0ac2b00001853
|
FBXO7-mediated degradation of SIRT7 leading to cell death in response to hydrogen peroxide (Human) |
2025-02-10 |
Patrick Masson |
success |
|
|
63c0ac2b00001613
|
FBXO9-mediated degradation of CARM1 leading to epithelial cell survival (Human) |
2025-02-10 |
Patrick Masson |
success |
|
|
6796b94c00004996
|
Sars-CoV2 entry into host cell (HUman-SARS-CoV-2) |
2025-02-10 |
Patrick Masson |
success |
|
2 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: viral transcription [GO:0019083] (biological_process) —causally upstream of→ viral translation [GO:0019081] (biological_process)
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: fusogenic activity [GO:0140522] (molecular_function) —causally upstream of→ viral translation [GO:0019081] (biological_process)
|
6796b94c00003233
|
HDAC3 positively regulates ferroptosis (Human) |
2025-02-07 |
Lionel Breuza |
success |
|
|
6796b94c00002691
|
SLC25A1 negatively regulates ferroptosis (Human) |
2025-02-07 |
Lionel Breuza, Patrick Masson |
success |
|
|
62900b6400002813
|
ZDHHC7 regulates androgen receptor activity at plasma membrane (Human) |
2025-02-07 |
Lionel Breuza |
success |
|
|
62900b6400002523
|
ZDHHC7 regulates estrogen receptor activity at plasma membrane (Human) |
2025-02-07 |
Kimberly Van Auken, Lionel Breuza |
success |
|
|
62900b6400002720
|
ZDHHC7 regulates progesterone receptor activity at plasma membrane (Human) |
2025-02-07 |
Lionel Breuza |
success |
|
|
61bcf0b700000585
|
tRNA methylation by METTL2A and regulation by threonylcarbamoylation of OSGEP (Human) |
2025-02-05 |
Sylvain Poux |
success |
|
|
6796b94c00001560
|
Cholesterol biosynthesis from lanosterol (Human) |
2025-02-03 |
Patrick Masson |
success |
|
|
6796b94c00001787
|
RAB33B recruitment of ATG16L1-ATG12-ATG5 complex to phagophore (Human) |
2025-01-31 |
Lucille Pourcel |
success |
|
2 warnings
-
SKIPPED_FACT: Subject 'protein localization to phagophore assembly site [GO:0034497] (biological_process)' has 'has primary input' relationship to 'ATG16L1 Hsap [UniProtKB:Q676U5] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: protein localization to phagophore assembly site [GO:0034497] (biological_process) —has primary input→ ATG16L1 Hsap [UniProtKB:Q676U5] (information biomacromolecule)
|
65692e7e00000578
|
Positive regulation of the Rab11-Rab8-Rabin8 cascade-mediated preciliary trafficking by FIP3 (Human) |
2025-01-23 |
Lionel Breuza, Lucille Pourcel |
success |
|
1 warning
-
SKIPPED_FACT: 'Golgi to plasma membrane protein transport [GO:0043001] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'protein localization to cilium [GO:0061512] (biological_process)'
|
675b862c00001535
|
Regulation of retinal function via autophogosome biogenesis by the RPGR-RAB37 association (Human) |
2025-01-23 |
Lucille Pourcel |
success |
|
|
63a86a8600001279
|
NF-kappa-B inhibition by TRIM15 sequestering of TRIM8 in the nucleus (Human) |
2025-01-22 |
Patrick Masson |
success |
|
|
678073a900001594
|
MARCHF5-mediated activation of cGAS-STING via K63 ubiquitination of STING1 (Human) |
2025-01-21 |
Patrick Masson |
success |
|
|
639bc18f00000054
|
NLRP3 'Lys-27'-linked ubiquitination by MARCHF5 leading to activation of inflammasome formation (Human) |
2025-01-21 |
Patrick Masson |
success |
|
|
678073a900001471
|
NLRP3 ubiquitination by TRIM65 leading to inhibition of inflammasome formation (Human) |
2025-01-21 |
Patrick Masson |
success |
|
|
678073a900001503
|
Ubiquitination of RIGI and MAVS by MARCHF5 leading to inhibition of cytosolic pattern recoognition pathway (Human) |
2025-01-21 |
Patrick Masson |
success |
|
|
613aae0000000011
|
Negative regulation of RIG-I-mediated innate antiviral signaling by SEC14L1 (Human) |
2025-01-14 |
Patrick Masson |
success |
|
|
614fa6f900000500
|
Regulation of RNA metabolism by SART3-mediated deubiquitination of TUT1 by USP15 (Human) |
2025-01-14 |
Patrick Masson |
success |
|
|
613aae0000000885
|
PTPRM role in glucose transport activity through inhibition of CTNND1 (Human) |
2025-01-08 |
Patrick Masson, Suzi Aleksander |
success |
|
|
62f58d8800004946
|
TBC1D31/PJA2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation (Human) |
2025-01-08 |
Lionel Breuza |
success |
|
|
62b4ffe300003074
|
Poxvirus-OPG029 inhibition of host TBK1 adaptor TANK (Human-Poxvirus) |
2024-12-12 |
Patrick Masson |
success |
|
|
62b4ffe300003321
|
Poxvirus-OPG062 inhibition of host mTOR/cGAS signaling (Human-Poxvirus) |
2024-12-12 |
Patrick Masson |
success |
|
|
62b4ffe300000784
|
Involvement of CASP7 in apoptosis, its activation by initiator caspases (CASP8, CASP9 and CASP10) and regulation by XIAP and PAK2 (Human) |
2024-12-09 |
Sylvain Poux |
success |
|
|
66e382fb00002662
|
mTORC1 and mTORC2 inhibit insulin receptor signaling by promoting ubiquitination and degradation of IRS1 by the CUL7(FBXW8) complex (Human). |
2024-12-09 |
Sylvain Poux |
success |
|
|
66a3e0bb00002723
|
MYH10 is the receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B (Human). |
2024-12-09 |
Sylvain Poux |
success |
|
|
66a3e0bb00002674
|
NECTIN1 is the receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein D (Human). |
2024-12-09 |
Sylvain Poux |
success |
|
|
66a3e0bb00002658
|
NECTIN1 is the receptor for herpes simplex virus 2/HHV-2 envelope glycoprotein D (Human). |
2024-12-09 |
Sylvain Poux |
success |
|
|
66a3e0bb00002690
|
NECTIN1 is the receptor for Pseudorabies virus envelope glycoprotein D (Human). |
2024-12-09 |
Sylvain Poux |
success |
|
|
627d95ee00001923
|
Regulation of PARP1 activity by XRCC1 (Human) |
2024-12-09 |
Sylvain Poux |
success |
|
|
66a3e0bb00002793
|
TMEFF1 restricts herpes simplex virus 1 (HHV-1) in the brain by blocking the association between MYH10 and the viral envelope glycoprotein B (Human). |
2024-12-09 |
Sylvain Poux |
success |
|
|
66a3e0bb00002776
|
TMEFF1 restricts herpes simplex virus 1 (HHV-1) in the brain by blocking the association between MYH9 and the viral envelope glycoprotein B (Human). |
2024-12-09 |
Sylvain Poux |
success |
|
|
66a3e0bb00002740
|
TMEFF1 restricts herpes simplex virus 1 (HHV-1) infection in the brain by blocking the association between NECTIN1 and the viral envelope glycoprotein D (Human). |
2024-12-09 |
Sylvain Poux |
success |
|
|
645d887900000624
|
Gamma-carboxylation of osteocalcin (bglap) by Ggcx promotes osteocalcin activity as structural constituent of bone and inhibits osteocalcin hormone activity (Mouse). |
2024-12-08 |
Sylvain Poux |
success |
|
|
645d887900000715
|
Osteocalcin (bglap) hormone produced by osteoblasts binds Gpr158 receptor and regulates brain development (Mouse). |
2024-12-08 |
Sylvain Poux |
success |
|
|
645d887900000671
|
Osteocalcin (bglap) hormone produced by osteoblasts binds Gprc6a receptor and regulates testosterone biosynthesis and male fertility (Mouse). |
2024-12-08 |
Sylvain Poux |
success |
|
|
627d95ee00001988
|
Regulation of Parp1 activity by Cgas, Setd7 and Riox1 (Mouse) |
2024-12-08 |
Sylvain Poux |
success |
|
|
633b013300001122
|
Gut Microbiota bile acid metabolism: Lithocholate increases intestinal phosphate absorption via VDR. (Human-Clostridium scindens) |
2024-12-05 |
Cristina Casals |
success |
|
|
645d887900001323
|
14-3-3 sequestering of ZNRF2 E3 ligase leading to ATP1A1 activity at plasma membrane (Human) |
2024-12-04 |
Patrick Masson |
success |
|
|
65a1f4f800002740
|
Regulation of TLR9 by palmitoylation (Human) |
2024-12-04 |
Patrick Masson |
success |
|
|
65c57c3400002054
|
Role of RPSA in antiviral proinflammatory cytokine production (Human) |
2024-12-04 |
Patrick Masson |
success |
|
|
65f3ae5c00001868
|
SLAMF1 acts as viral receptor for Measles virus protein H (Human-Measles virus) |
2024-12-04 |
Patrick Masson |
success |
|
|
641ce4dc00000586
|
UBL7/TRIM21-mediated ubiquitination of MAVS leading to type I interferon production (Human) |
2024-12-04 |
Patrick Masson |
success |
|
|
65a1f4f800000029
|
USP49 and SIRT7 inhibition of AKT1 via PHLPP1-mediated dephosphorylation of AKT1 (Human) |
2024-12-04 |
Patrick Masson |
success |
|
|
65bc474400000029
|
ZDHHC4-mediated palmitoylation of MAVS via CPT1A (Human) |
2024-12-04 |
Patrick Masson |
success |
|
|
67369e7600001439
|
(CHRNA7)3:(CHRNB2)2 acetylcholine receptor signaling pathway gated by amyloid beta complex, calcium transport. (Human) |
2024-12-03 |
Cristina Casals |
success |
|
|
62f58d8800003667
|
Gut Microbiota tryptophan metabolism: Activation of PXR by 3-indol-propanoate (Human-Clostridium sporogenes) |
2024-12-03 |
Cristina Casals |
success |
|
1 warning
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: cytoplasm [GO:0005737] (anatomical entity) —part of→ Clostridium sporogenes [NCBITaxon:1509] (anatomical entity)
|
671ae02600002262
|
Negative regulation of canonical NF-kappaB signal transduction by CHRNA7 in macrophages (Human). |
2024-12-03 |
Cristina Casals |
success |
|
|
671ae02600002661
|
Negative regulation of cytokine production involved in inflammatory response via STAT3 by CHRNA7 in macrophages (Human). |
2024-12-03 |
Cristina Casals |
success |
|
|
671ae02600002812
|
Negative regulation of cytokine production involved in inflammatory response via STAT3 by CHRNA7 in macrophages (Mouse). |
2024-12-03 |
Cristina Casals |
success |
|
|
671ae02600002382
|
Negative regulation of NF-kappaB signal transduction via STAT3 by CHRNA7 in macrophages (Human). |
2024-12-03 |
Cristina Casals |
success |
|
|
671ae02600000030
|
Regulation of CDH5 in cell migration involved sprouting angiogenesis. (Human) |
2024-12-03 |
Cristina Casals |
success |
|
|
67369e7600002892
|
Regulation of CDH5 in cell migration involved sprouting angiogenesis. (Mouse) |
2024-12-03 |
Cristina Casals |
success |
|
|
66a3e0bb00002971
|
SETDB1 activation through monoubiquitination by UBE2E3. (Human) |
2024-12-03 |
Cristina Casals, Suzi Aleksander |
success |
|
|
61e0e55600000900
|
TK1 in mitotic cell cycle phase transition (Human) |
2024-12-03 |
Cristina Casals |
success |
|
|
66c7d41500000016
|
Trans-synaptic complex NRXN1B-CBLN1-GRID2 regulates synaptogenesis. (Human) |
2024-12-03 |
Cristina Casals |
success |
|
|
671ae02600002752
|
BFAR modulation of the unfolded protein response (UPR) via TMBIM6 (Human) |
2024-12-02 |
Patrick Masson |
success |
|
|
67369e7600002467
|
LINCR amplifies the TLR-mediated signals through direct degradation of MKP1 (Human) |
2024-11-28 |
Patrick Masson |
success |
|
|
67369e7600001853
|
Negative role of BTLA in T cell proliferation upon binding to TNFRSF14 (Human) |
2024-11-28 |
Patrick Masson |
success |
|
|
64e7eefa00000034
|
QKI shuttle m7G-modified mRNAs into cytoplasmic stress granules (Human). |
2024-11-28 |
Sylvain Poux |
success |
|
|
646ff70100004973
|
USP38 Lys-33 to Lys-48 transition on TBK1 leading to its degratdation (Human) |
2024-11-19 |
Patrick Masson |
success |
|
|
6606056e00001184
|
17beta-estradiol binds and activates ESR1 nuclear receptor (human). |
2024-11-14 |
Sylvain Poux |
success |
|
|
632cf60a00000522
|
HHV1-US11 inhibition of autophagy via CASP8 cleavage (Human-Herpesvirus) |
2024-11-14 |
Patrick Masson |
success |
|
|
632cf60a00000478
|
HHV1-US11 inhibition of autophagy via TRIM23-TBK1 (Human-Herpesvirus) |
2024-11-14 |
Patrick Masson |
success |
|
|
6606056e00001223
|
Progesterone binds and activates PGR nuclear receptor (human). |
2024-11-14 |
Sylvain Poux |
success |
|
|
6606056e00001308
|
Retinoic acid binds and activates RARA and RXRA nuclear receptors (Human). |
2024-11-14 |
Sylvain Poux |
success |
|
|
6606056e00000678
|
UBR5 ubiquitinates ligand-bound ESR1 when ESR1 is not associated with Nuclear receptor coactivators (NCOAs) (Human).
|
2024-11-14 |
Sylvain Poux |
success |
|
|
6606056e00000637
|
UBR5 ubiquitinates ligand-bound PGR when PGR is not associated with Nuclear receptor coactivators (NCOAs) (Human). |
2024-11-14 |
Sylvain Poux |
success |
|
|
6606056e00000485
|
UBR5 ubiquitinates ligand-bound RARA and RXRA when RARA and RXRA are not associated with Nuclear receptor coactivators (NCOAs) (Human). |
2024-11-14 |
Sylvain Poux |
success |
|
|
6606056e00000576
|
UBR5 ubiquitinates ligand-bound VDR when VDR is not associated with Nuclear receptor coactivators (NCOAs) (Human). |
2024-11-14 |
Sylvain Poux |
success |
|
|
6606056e00001262
|
Vitamin-D3 binds and activates VDR nuclear receptor (human). |
2024-11-14 |
Sylvain Poux |
success |
|
|
63e5937500001279
|
Extraction of mRNA from stalled ribosomes by the SKI complex, leading to recruitment of the PELO-HBS1L complex that binds to stalled ribosomes, followed by ribosome dissociation by ABCE1 (Human) |
2024-11-12 |
Sylvain Poux |
success |
|
|
67086be200002981
|
Negative regulation of Amyloid-beta precursor protein/APP processing by SORL1 (Human) |
2024-11-12 |
Lucille Pourcel |
success |
|
|
623d156d00000817
|
Role of TONSL and MMS22L (TONSL-MMS22L complex) in promoting homologous recombination-mediated repair of DSBs (Human) |
2024-11-12 |
Sylvain Poux |
success |
|
|
671ae02600001961
|
RNF39-mediated activation of cGAS-STING via K63 ubiquitination of STING1 (Human) |
2024-11-07 |
Patrick Masson |
success |
|
|
671ae02600001912
|
RNF39-mediated inhibition of RLR signaling pathway via K48 ubiquitination of DDX3X (Human) |
2024-11-07 |
Patrick Masson |
success |
|
|
67086be200001601
|
Fertilization complex allows sperm-egg recognition during fertilization. (Human) |
2024-10-22 |
Cristina Casals |
success |
|
|
67086be200001578
|
Negative regulation of BNIP3 and BNIP3L via PPTC7 and FBXL4 (Human) |
2024-10-22 |
Patrick Masson |
success |
|
|
62b4ffe300001804
|
Cleavage and inactivation of PARP1 by CASP3 and/or CASP7 during the execution phase of apoptosis (Human) |
2024-10-10 |
Sylvain Poux |
success |
|
|
62b4ffe300002284
|
Phosphorylation of YY1 by CK2 (CSNK2A1) protects YY1 from CASP7-mediated degradation during apoptosis (Human) |
2024-10-10 |
Sylvain Poux |
success |
|
|
66e382fb00001468
|
EP300 activates the mTORC2 pathway by mediating acetylation of RICTOR (Human). |
2024-10-03 |
Sylvain Poux |
success |
|
|
66e382fb00001531
|
GSK3B inhibits the mTORC2 pathway by mediating phosphorylation of RICTOR in response to endoplasmic reticulum stress (Human). |
2024-10-03 |
Sylvain Poux |
success |
|
|
66e382fb00001913
|
mTORC1 inhibits mTORC2 signaling via phosphorylation of RICTOR and MAPKAP1 by RPS6KB1 (Human). |
2024-10-03 |
Sylvain Poux |
success |
|
|
66e382fb00001997
|
mTORC2 phosphorylates IMP1/IGF2BP1 to promote IGF2 production (Human). |
2024-10-03 |
Sylvain Poux |
success |
|
|
66e382fb00001412
|
mTORC2 signaling (Human). |
2024-10-03 |
Sylvain Poux |
success |
|
|
66f5faaa00000763
|
NSUN4 catalyzes RNA 5-methylcytosine mark on mitochondrial double-stranded RNAs, which are recognized by C1QBP, promoting RNA degradation by the mitochondrial degradosome complex (Human).
|
2024-10-03 |
Sylvain Poux |
success |
|
|
66e382fb00000012
|
Taurine metabolic process (Human). |
2024-10-03 |
Sylvain Poux |
filtered |
Model has at least one activity with no causal relations |
|
66e382fb00002599
|
TBK1 activates the mTORC2 signaling by mediating phosphorylation of MTOR (Human). |
2024-10-03 |
Sylvain Poux |
success |
|
|
66e382fb00001583
|
TRAF2 and OTUD7B regulate assembly and disassembly of mTORC1 and mTORC2 by mediating ubiquitination and deubiquitination of MLST8, respectively (Human). |
2024-10-03 |
Sylvain Poux |
success |
|
|
66f5faaa00000112
|
TRAF6 and HUWE1 catalyze branched-linked polyubiquitination that promote NF-kappa-B signaling (Human). |
2024-10-03 |
Sylvain Poux |
success |
|
|
66e382fb00002738
|
ZDHHC1 promotes activation of the NLRP3 inflammasome by mediating palmitoylation of NLRP3, leading to NLRP3 phosphorylation by LATS1 and activation of NLRP3 by NEK7 (Human) |
2024-10-03 |
Sylvain Poux |
success |
|
|
66c7d41500000715
|
CLEC12A acts as an inhibitor of neutrophil activation (Human). |
2024-09-12 |
Sylvain Poux |
success |
|
|
66c7d41500002513
|
DDX39A inhibition of immune related RNA export to the cytoplasm (Human) |
2024-09-10 |
Patrick Masson |
success |
|
|
66c7d41500002413
|
DDX41 activation of the cGAS-STING signaling (Human) |
2024-09-10 |
Patrick Masson |
success |
|
|
65a1f4f800001246
|
Lactylation of MRE11 by CREBBP and NBN by KAT5 in response to DNA damage promotes double-strand break repair via homologous recombination (Human). |
2024-09-03 |
Sylvain Poux |
success |
|
|
62b4ffe300004489
|
Regulation of the JAK-STAT pathway by calmodulin in response to interferon-gamma (Human) |
2024-08-26 |
Patrick Masson, Sylvain Poux |
success |
|
|
66b5638000002528
|
GRIM1 activates GRID1 via GNAQ in dopamine neurons (Mouse). |
2024-08-22 |
Cristina Casals |
success |
|
|
66b5638000002510
|
ICOSLG-ICOS pair activates T follicular helper cell differentiation (Human) |
2024-08-22 |
Patrick Masson |
success |
|
|
66b5638000000873
|
EIF2AK3/PERK phosphorylates NFE2L2/NRF2 in response to unfolded protein response, preventing the ubiquitination of NFE2L2/NRF2 by KEAP1 (Human). |
2024-08-21 |
Sylvain Poux |
success |
|
|
66b5638000000110
|
SMYD5 trimethylates the RPL40/eL40 subunit of the 60S ribosome, promoting translation elongation (Human). |
2024-08-21 |
Sylvain Poux |
success |
|
|
66b5638000000808
|
Ubiquitination and degradation of NFE2L2/NRF2 by KEAP1 in absence of stress (Human). |
2024-08-21 |
Sylvain Poux |
success |
|
|
66b5638000002031
|
NECTIN2-TIGIT pair inhibits NK cell mediated cytotoxicity (Human) |
2024-08-20 |
Patrick Masson |
success |
|
|
66b5638000002087
|
NECTIN4-TIGIT pair inhibits NK cell mediated cytotoxicity (Human) |
2024-08-20 |
Patrick Masson |
success |
|
|
66b5638000001968
|
PVR-TIGIT pair inhibits NK cell mediated cytotoxicity (Human) |
2024-08-20 |
Patrick Masson |
success |
|
|
66b5638000001291
|
NECTIN2-CD226 mediated NK-cell cytotoxicity (Human) |
2024-08-15 |
Patrick Masson |
success |
|
|
66b5638000000102
|
PVR-CD226 mediated NK-cell cytotoxicity (Human) |
2024-08-15 |
Patrick Masson |
success |
|
|
63f809ec00000152
|
TRIM25-mediated regulation of NRF2 signaling through activation by FOXO4 (Human) |
2024-08-14 |
Patrick Masson, Sylvain Poux |
success |
|
|
66b5638000000025
|
BSGT/GLUT1-mediated cone survival via NXNL1 ligand (Human) |
2024-08-13 |
Patrick Masson |
success |
|
|
62b4ffe300005623
|
HHV1-US3 inhibition of host TCR signaling via LAT (Human-Herpesvirus) |
2024-08-08 |
Patrick Masson |
success |
|
|
66a3e0bb00002939
|
SETDB1 activation through monoubiquitination by UBE2E1. (Human) |
2024-08-08 |
Cristina Casals |
success |
|
|
66a3e0bb00002955
|
SETDB1 activation through monoubiquitination by UBE2E2. (Human) |
2024-08-08 |
Cristina Casals |
success |
|
|
66a3e0bb00002104
|
ITPRIPL1 is a ligand of CD3E that negatively regulates TCR signaling pathway. (Human) |
2024-08-06 |
Cristina Casals |
success |
|
|
66a3e0bb00000989
|
ARID3C is a transcription factor involved in macrophage differentiation. (Human) |
2024-07-31 |
Cristina Casals |
success |
|
|
66a3e0bb00000922
|
PAQR3 mediates PPARG polyubiquitination by STUB1 in macrophages. (Human) |
2024-07-31 |
Cristina Casals |
success |
|
|
66a3e0bb00000525
|
PAQR3 mediates PPARA polyubiquitination by HUWE1 in hepatocytes. (Human) |
2024-07-30 |
Cristina Casals |
success |
|
|
6690711d00001696
|
AARS1 mediates lactylation and inactivation of p53/TP53 (Human). |
2024-07-25 |
Sylvain Poux |
success |
|
|
6690711d00001771
|
AARS1 mediates lactylation of YAP1 and TEAD1, promoting activation of Hippo signaling (Human). |
2024-07-25 |
Sylvain Poux |
success |
|
|
6690711d00001733
|
Beta-alanine inhibits the lactyltransferase activity of AARS1 (Human). |
2024-07-25 |
Sylvain Poux |
success |
|
|
6690711d00001806
|
SIRT1 mediates delactylation of YAP1 and TEAD1, promoting inactivation of Hippo signaling (Human). |
2024-07-25 |
Sylvain Poux |
success |
|
|
667dfe8d00000048
|
TAAR1-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by cadaverine (Human). |
2024-07-25 |
Sylvain Poux |
success |
|
|
667dfe8d00000179
|
TAAR1-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by trimethylamine (Human). |
2024-07-25 |
Sylvain Poux |
success |
|
|
666b894f00000484
|
HTR1A-mediated serotonin signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) (Human). |
2024-07-01 |
Sylvain Poux |
success |
|
|
666b894f00000518
|
HTR1D-mediated serotonin signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) (Human). |
2024-07-01 |
Sylvain Poux |
success |
|
|
666b894f00000542
|
HTR1E-mediated serotonin signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) (Human). |
2024-07-01 |
Sylvain Poux |
success |
|
|
666b894f00000566
|
HTR1F-mediated serotonin signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) (Human). |
2024-07-01 |
Sylvain Poux |
success |
|
|
666b894f00001836
|
HTR5A-mediated serotonin signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) (Human). |
2024-07-01 |
Sylvain Poux |
success |
|
|
60ad85f700000898
|
Futile creatine cycle (Mouse) |
2024-06-26 |
Sylvain Poux |
success |
|
|
666b894f00001912
|
PTGER4, prostaglandin E2 receptor via GNAI1. (Human) |
2024-06-21 |
Cristina Casals |
success |
|
|
65d7e4ac00002427
|
MICA-NKG2D mediated NK cell cytotoxicity (Human) |
2024-06-11 |
Patrick Masson |
success |
|
|
665912ed00002788
|
NK T cell activation by BAG6:NCR3 interaction. (Human) |
2024-06-11 |
Cristina Casals |
success |
|
|
665912ed00002806
|
NK T cell activation by NCR3LG1:NCR3 interaction. (Human) |
2024-06-11 |
Cristina Casals |
success |
|
|
662af8fa00000002
|
BTRC is ubiquitinated and degraded by a Cul5-RING ubiquitin ligase complex (Human). |
2024-05-16 |
Sylvain Poux |
success |
|
|
6606056e00000767
|
ITCH and UBR5 catalyzed branched-linked polyubiquitination of TXNIP (Human). |
2024-05-16 |
Sylvain Poux |
success |
|
|
663d668500001089
|
SELENOI is involved in ether lipid homeostasis and myelination (Human). |
2024-05-16 |
Sylvain Poux |
success |
|
|
65c57c3400002539
|
The CRL5(ASB11) complex mediates ubiquitination and degradation of DIRAS2 (Human). |
2024-05-16 |
Sylvain Poux |
success |
|
|
66187e4700000246
|
The CRL5(ASB9) complex mediates ubiquitination and degradation of CKB (Human). |
2024-05-16 |
Sylvain Poux |
success |
|
|
66187e4700001030
|
The ECS(SPSB3) complex mediates ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (Human). |
2024-05-16 |
Sylvain Poux |
success |
|
|
66187e4700001102
|
The SCF(FBXO11) complex mediates ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (Human). |
2024-05-16 |
Sylvain Poux |
success |
|
|
6606056e00000317
|
UBR4 and UBR5 catalyze branched-linked polyubiquitination of substrates, leading to proteasome-mediated degradation of substrates (Human). |
2024-05-16 |
Sylvain Poux |
success |
|
|
663d668500000226
|
VIF-mediated inhibition of STING by PTPN6 (Human-HIV) |
2024-05-14 |
Patrick Masson |
success |
|
|
65f3ae5c00000257
|
Ufmylation of RPL26 following ribosome stalling promotes 60S ribosomal subunit recycling (Human). |
2024-05-01 |
Sylvain Poux |
success |
|
|
65f3ae5c00000170
|
Ufmylation of RPL26 following translation termination promotes 60S ribosomal subunit recycling (Human). |
2024-05-01 |
Sylvain Poux |
success |
|
|
66187e4700000078
|
TREM2 activated by SEMA6D:PLXN1A in dendritic cell. (Human) |
2024-04-25 |
Cristina Casals, Suzi Aleksander |
success |
|
|
6205c24300000188
|
SP-PDE3A/SLFN12 intrinsic apoptotic signaling pathway (Human) |
2024-04-23 |
Lionel Breuza |
success |
|
|
6246724f00000025
|
PDE3B regulates angiogenesis (Human) |
2024-04-23 |
Lionel Breuza |
filtered |
Model has at least one activity with no causal relations |
|
65a1f4f800003990
|
Regulation of TORC1 signaling by the leucine sensor SAR1A (Human) |
2024-04-23 |
Lionel Breuza |
success |
|
|
65a1f4f800003346
|
Regulation of TORC1 signaling by the leucine sensor SAR1B (Human) |
2024-04-23 |
Lionel Breuza |
success |
|
|
6606056e00000282
|
LGALS1-CD69 pair involved in negative regulation of T-helper 17 cell lineage (Human) |
2024-04-22 |
Patrick Masson |
success |
|
|
65f3ae5c00000488
|
ULBP2-NKG2D mediated NK cell cytotoxicity on astrocytes during JCV infection (Human) |
2024-04-22 |
Patrick Masson |
success |
|
|
6606056e00001669
|
Acetylation of N-terminus by NAA30 prevents ubiquitination and degradation by UBR4 and KCMF1 (Human). |
2024-04-17 |
Sylvain Poux |
success |
|
|
6606056e00001890
|
Activation of mitophagy in response to mitochondrial damage via activation of EIF2AK1/HRI by DELE1 (Human). |
2024-04-17 |
Sylvain Poux |
success |
|
|
65d7e4ac00002910
|
AKT1 affect mitochondrial calcium uptake in response to rapamycin by mediating phosphorylation of MICU1 (Human). |
2024-04-17 |
Sylvain Poux |
success |
|
|
65c57c3400001115
|
Inhibition of SMDT1/EMRE and MCU following cleavage by the m-AAA protease complex (composed of AFG3L2 and SPG7) (Human). |
2024-04-17 |
Sylvain Poux |
success |
|
|
65d7e4ac00002808
|
MCUB inhibits mitochondrial calcium uptake by the uniplex complex (composed of SMDT1/EMRE, MICU1, MICU2 and MCU) to prevent calcium overload (Human). |
2024-04-17 |
Sylvain Poux |
success |
|
|
65d7e4ac00001584
|
MICU1 inhibits mitochondrial calcium uptake by occluding MCU in absence of calcium (Human). |
2024-04-17 |
Sylvain Poux |
success |
|
|
65d7e4ac00002435
|
MICU3 promotes mitochondrial calcium uptake by MCU in the central nervous system (Human). |
2024-04-17 |
Sylvain Poux |
success |
|
|
65d7e4ac00001363
|
Mitochondrial calcium uptake by the uniplex complex composed of SMDT1/EMRE, MICU1, MICU2 and MCU (Human). |
2024-04-17 |
Sylvain Poux |
success |
|
|
65f3ae5c00001692
|
STK38 recognizes ufmylated histone H4 in response to DNA damage, leading to ATM activation (Human). |
2024-04-17 |
Sylvain Poux |
success |
|
|
6606056e00001072
|
Ubiquitination by the SIFI complex composed of UBR4 and KCMF1 (Human). |
2024-04-17 |
Sylvain Poux |
success |
|
|
6606056e00001745
|
UBR4 and KCMF1 ubiquitinate arginylated proteins in response to oxidative stress, leading to degradation of ubiquitinated proteins in autophagosomes (Human) |
2024-04-17 |
Sylvain Poux |
success |
|
|
65f3ae5c00000111
|
Ufmylation pathway (Human). |
2024-04-17 |
Sylvain Poux |
success |
|
|
63894f2500001789
|
Fmr1 binds N6-methyladenosine (m6A)-containing mRNAs and promotes their nuclear export (Mouse) |
2024-03-28 |
David Hill, Sylvain Poux |
success |
|
|
63894f2500001748
|
FRM1 binds N6-methyladenosine (m6A)-containing mRNAs and promotes their nuclear export (Human) |
2024-03-28 |
Sylvain Poux |
success |
|
|
65f3ae5c00001388
|
LR-NK cell activation by the NKp80-AICL interaction (Human) |
2024-03-28 |
Patrick Masson |
success |
|
|
65f3ae5c00000420
|
ULBP1-NKG2D mediated NK cell cytotoxicity on hepatocytes during HCV infection (Human) |
2024-03-19 |
Patrick Masson |
success |
|
|
65d7e4ac00001771
|
Activation of CCR1 by PF4 leading to monocyte chemotaxis (Human) |
2024-03-05 |
Patrick Masson |
success |
|
|
65d7e4ac00001800
|
RUFY1 mediates early endosome to Golgi transport. (Human) |
2024-03-05 |
Cristina Casals |
success |
|
|
65d7e4ac00001282
|
Thrombospondin-1/CD36 inhibition of angiogenesis in endothelial cells (Human) |
2024-03-04 |
Patrick Masson |
success |
|
|
65a1f4f800003391
|
Hippo signaling core components (Human). |
2024-02-28 |
Cristina Casals |
success |
|
|
65c57c3400001478
|
Negative regulation of Hippo signaling by SLMAP-STRIPAK complex (Human). |
2024-02-28 |
Cristina Casals |
success |
|
|
65d7e4ac00000470
|
PTPN6 negatively regulates ROS1. (Human) |
2024-02-28 |
Cristina Casals |
success |
|
|
63894f2500001248
|
Regulation of cellular response to insulin stimulus by ubiquitin ligase-substrate adaptor KBTBD2. (Human) |
2024-02-28 |
Cristina Casals |
success |
|
|
65d7e4ac00000503
|
Regulation of Hippo signaling by PRP4K (Human). |
2024-02-28 |
Cristina Casals |
success |
|
|
65d7e4ac00000022
|
CARD9 regulation by TRIM62/USP15 (Human) |
2024-02-23 |
Patrick Masson |
success |
|
|
65d7e4ac00000082
|
DUSP22 inhibition of TCR signaling via UBR2 inhibition (Human) |
2024-02-23 |
Patrick Masson |
success |
|
|
65c57c3400002666
|
Role of CD53 in T-cell receptor signaling pathway (Human) |
2024-02-22 |
Patrick Masson |
success |
|
|
653b0ce600001283
|
KSHV-ORF57 inhibition of host P-body formation (Human-HHV8) |
2024-02-20 |
Patrick Masson |
success |
|
|
657ba49f00000136
|
PINK1 role in mitophagy (Human) |
2024-02-20 |
Patrick Masson |
success |
|
|
62b4ffe300005283
|
Poxvirus-OPG058 inhibition of host NF-kappa-B via CBP (Human-Poxvirus) |
2024-02-20 |
Patrick Masson |
success |
|
|
65bc474400001349
|
Acetylation and deacetylation of PAX7 by KAT8 and SIRT2, respectively, regulate asymmetric division in muscle stem cells (Human). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65a1f4f800002335
|
C1QBP inhibits the activity of MRE11 (Human). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65c57c3400000359
|
Dosage compensation in male Drosophila by the MSL complex (composed of mle- msl-1, msl-2, msl-3 and mof) (D.melanogaster). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65a1f4f800002142
|
DYNLL1 binds to MRE11 to limit DNA end resection (Human). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65a1f4f800000855
|
Initiation of double-strand break repair via homologous recombination by the MRN complex (MRE11-RAD50-NBN) (Human). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65bc474400001510
|
KDM1A acetylation by KAT8 inhibits epithelial to mesenchymal transition (Human). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65a1f4f800001566
|
Methylation of MRE11 by PRMT1 in response to DNA damage promotes double-strand break repair via homologous recombination (Human). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65a1f4f800001668
|
Methylation of TP53BP1 by PRMT1 in response to DNA damage promotes double-strand break repair via nonhomologous end joining (Human). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65a1f4f800002442
|
MRE11 phosphorylation by ATM dissociates MRE11 from C1QBP inhibitor (Human). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65a1f4f800000487
|
Phosphorylation of H2AX by ATM or ATR promotes recruitment of NBN and MRN complex to DNA damage sites (Human).
|
2024-02-14 |
Sylvain Poux |
success |
|
|
65a1f4f800000428
|
Phosphorylation of MDC1 by CK2 promotes recruitment of NBN and MRN complex to DNA damage sites (Human). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65a1f4f800001740
|
Phosphorylation of MRE11 by PLK1 and CK2 inhibits double-strand break repair via homologous recombination (Human).
|
2024-02-14 |
Sylvain Poux |
success |
|
|
65a1f4f800002884
|
Phosphorylation of NBN regulates DNA repair choice at telomes (Human). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65a1f4f800000391
|
Phosphorylation of RAD17 by ATM promotes recruitment of NBN and MRN complex to DNA damage sites (Human). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65a1f4f800001380
|
RBBP8/CtIP stimulates the endonuclease activity of MRE11 following phosphorylation by ATR and CDK1 (Human). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65c57c3400001018
|
Regulation of SLC25A39 by AFG3L2 and iron-sulfur-binding (Human). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65c57c3400000100
|
Resolution of protein-DNA cross-links by HMCES, BRIP1/FANCJ and SPRTN (Human). |
2024-02-14 |
Sylvain Poux |
success |
|
|
657ba49f00001093
|
resolution of RNA-protein cross-links by GCN1, RNF14 and RNF25, leading to K6-linked ubiquitination and degradation of RNA-protein cross-links (Human) |
2024-02-14 |
Sylvain Poux |
success |
|
|
65a1f4f800001029
|
SKP2 mediates 'Lys-63'-linked ubiquitination of NBN, promoting double-strand break repair via homologous recombination (Human). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65a1f4f800002665
|
Sumoylation of MRE11 by PIAS1 promotes retention of the MRN complex (MRE11-RAD50-NBN) to DNA damage sites (Human). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65c57c3400000270
|
Sxl and Unr inhibit translation of msl-2 transcripts in females (D.melanogaster). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65a1f4f800002022
|
Ubiquitination of MRE11 by RNF126 promotes its exonuclease activity (Human). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65a1f4f800000553
|
Ubiquitination of NBN by PELI1 promotes double-strand break repair via homologous recombination (Human). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65a1f4f800001127
|
Ubiquitination of NBN by RNF8 promotes double-strand break repair via homologous recombination (Human). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65a1f4f800002560
|
Ufmylation of MRE11 promotes ATM activation by the MRN complex (MRE11-RAD50-NBN) (Human). |
2024-02-14 |
Sylvain Poux |
success |
|
|
65a1f4f800002257
|
ZDHHC5-mediated palmitoylation of NLRP3 activates inflammasome assembly (Human) |
2024-02-13 |
Patrick Masson |
success |
|
|
653b0ce600000780
|
ATR promotes nuclear envelope rupture by mediating phosphorylation of LMNA in response to DNA damage (Human). |
2024-02-08 |
Sylvain Poux |
success |
|
|
65a1f4f800000922
|
PELI1 negative regulation of MTOR pathway via TSC1 ubiquitination (Human) |
2024-02-06 |
Patrick Masson |
success |
|
|
65bc474400000069
|
Regulation of GSK3B phosphorylation by ZDHHC4-mediated palmitoylation (Human) |
2024-02-06 |
Patrick Masson |
success |
|
|
65bc474400000537
|
Regulation of Hippo signaling by MAP4K4 (Human). |
2024-02-06 |
Cristina Casals |
success |
|
|
65bc474400000269
|
Hippo signaling core components, WWC2 variant (Human). |
2024-02-05 |
Cristina Casals |
success |
|
|
65bc474400000403
|
Hippo signaling core components, WWC3 variant (Human). |
2024-02-05 |
Cristina Casals |
success |
|
|
63e5937500001029
|
Inhibition of IFNB1 translation initiation by EIF4E2 in response to viral infection. (Human/Sars-CoV-2) |
2024-02-01 |
Cristina Casals, Patrick Masson |
success |
|
2 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of translational initiation [GO:0045947] (biological_process) —has input→ IFNB1 Hsap [UniProtKB:P01574] (information biomacromolecule)
-
SKIPPED_FACT: Subject 'negative regulation of translational initiation [GO:0045947] (biological_process)' has 'has input' relationship to 'IFNB1 Hsap [UniProtKB:P01574] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
|
65039e8700000967
|
Kaposi herpesvirus vIRF-1 inhibition of SIRT6 by preventing its deubiquitination (Human-Herpesvirus) |
2024-02-01 |
Patrick Masson |
success |
|
|
62b4ffe300003618
|
Poxvirus-OPG045 inhibition of host BAK-mediated apoptosis (Human-Poxvirus) |
2024-02-01 |
Patrick Masson |
success |
|
|
654d809000001692
|
Activation of autophagosome assembly by ATM-CHK2-TRIM32-ATG7 axis (Human) |
2024-01-25 |
Lucille Pourcel |
success |
|
|
65a1f4f800000673
|
Role of USP51 in DNA damage response via DGCR8 deubiquitination (Human) |
2024-01-19 |
Patrick Masson |
success |
|
|
62b4ffe300005953
|
HHV1-US3 inhibition of host NF-kappa-B signaling via RELA (Human-Herpesvirus) |
2024-01-11 |
Patrick Masson |
success |
|
2 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of protein localization to nucleus [GO:1900181] (biological_process) —has input→ RELA Hsap [UniProtKB:Q04206] (information biomacromolecule)
-
SKIPPED_FACT: Subject 'negative regulation of protein localization to nucleus [GO:1900181] (biological_process)' has 'has input' relationship to 'RELA Hsap [UniProtKB:Q04206] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
|
62b4ffe300005181
|
Poxvirus-OPG003 inhibition of host NF-kappa-B pathway via NFKB1 (Human-Poxvirus) |
2024-01-11 |
Patrick Masson |
success |
|
|
62b4ffe300005342
|
Poxvirus-OPG179 inhibition of host NF-kappa-B via BTRC (Human-Poxvirus) |
2024-01-11 |
Patrick Masson |
success |
|
|
62b4ffe300005506
|
Poxvirus-OPG182 inhibition of host NF-kappa-B via IRAK2 (Human-Poxvirus) |
2024-01-11 |
Patrick Masson |
success |
|
|
62b4ffe300005389
|
Poxvirus-OPG184 inhibition of host NF-kappa-B via KPNA2 (Human-Poxvirus) |
2024-01-11 |
Patrick Masson |
success |
|
|
62b4ffe300003679
|
Poxvirus-OPG200 inhibition of host IKBKE-mediated NF-Kappa-B (Human-Poxvirus) |
2024-01-11 |
Patrick Masson |
success |
|
|
62b4ffe300004589
|
USP22 activation of IRF3 via KPNA2 stabilization (Human) |
2024-01-11 |
Patrick Masson |
success |
|
|
65692e7e00001822
|
RNF115 inhibition of TLR transport to cell surface (Human) |
2023-12-18 |
Patrick Masson |
success |
|
|
65692e7e00001784
|
USP25-mediated stabilization of KEAP1 leading to NRF2 degradation (Human) |
2023-12-13 |
Patrick Masson |
success |
|
|
653b0ce600000721
|
A checkpoint mediated by ATR that restricts activation of CDK1 during S-phase (Human). |
2023-12-05 |
Sylvain Poux |
success |
|
|
65692e7e00000049
|
GBP1 GTPase promotes assembly of the non-canonical inflammasome via association with lipopolysaccharide (Human). |
2023-12-05 |
Sylvain Poux |
success |
|
|
654d809000002692
|
Maturation and inactivation following cleavage by various caspases (Human). |
2023-12-05 |
Sylvain Poux |
success |
|
|
65692e7e00000115
|
PIM1 inhibits the innate immune response by promoting cytosolic retention of GBP1 (Human). |
2023-12-05 |
Sylvain Poux |
success |
|
|
65288b2200000496
|
Regulation of CGAS activity via palmitoylation and depalmitoylation by ZDHHC9 and LYPLAL1, respectively (Human). |
2023-12-05 |
Sylvain Poux |
success |
|
|
653b0ce600000330
|
Triglyceride biosynthesis via canonical (DGAT1 and DGAT2) and alternative (DIESL/TMEM68) triglyceride biosynthesis pathways (Human). |
2023-12-05 |
Sylvain Poux |
filtered |
Model has at least one activity with no causal relations |
|
645d887900001077
|
Cell type specific, p53-independent mitotic G2 DNA damage checkpoint signaling mediated by CREB3L1 in astrocytes. (Mouse) |
2023-12-04 |
Cristina Casals |
success |
|
|
63c0ac2b00000331
|
IpaH9.8 effector protein from S.flexneri ubiquitinate host GBP1, leading to its degradation and inhibition of innate immunity (Human and S.flexneri) |
2023-11-30 |
Sylvain Poux |
success |
|
|
646ff70100000049
|
Antibacterial innate immune response to muramyl dipeptide. (Human) |
2023-11-23 |
Cristina Casals |
success |
|
|
654d809000001411
|
RNF144A-mediated K6-linked ubiquitination of STING(Human) |
2023-11-22 |
Patrick Masson |
success |
|
|
63d320cd00001733
|
Response to ribosome stalling by RNF14 and RNF25, leading to ubiquitination and degradation of ETF1 (Human) |
2023-11-16 |
Sylvain Poux |
success |
|
|
653b0ce600001230
|
KSHV-ORF57 inhibition of host PKR (Human-HHV8) |
2023-11-09 |
Patrick Masson |
success |
|
|
62b4ffe300002896
|
Poxvirus-OPG043 inhibition of host PKR (Human-Poxvirus) |
2023-11-09 |
Kimberly Van Auken, Patrick Masson |
success |
|
|
653b0ce600000382
|
TAX1BP1-mediated degradation of MAVS by E3 ligase ITCH (Human) |
2023-11-02 |
Patrick Masson |
success |
|
|
6413ac9800000654
|
MYD88-independent TLR4 signaling pathway leading to interferon production (Human) |
2023-10-26 |
Patrick Masson |
success |
|
|
6413ac9800000138
|
p62/SQSTM1 inhibition of TLR4-mediated signaling via ECSIT (Human) |
2023-10-26 |
Patrick Masson |
success |
|
|
65288b2200001218
|
USP9X-TRIM32 modulation of IQCB1 during G1-S (Human) |
2023-10-26 |
Patrick Masson |
success |
|
|
65288b2200001267
|
USP9X-TRIM32 modulation of IQCB1 during G2-M (Human) |
2023-10-26 |
Patrick Masson |
success |
|
|
63f809ec00001892
|
TRIM26 activation of TAK1/MAP3K7 via TAB1-K11-linked ubiquitination (Human) |
2023-10-20 |
Patrick Masson |
success |
|
|
65039e8700001188
|
KIF11 ubiquitination leading to mitotic spindle assembly (Human) |
2023-09-26 |
Patrick Masson |
success |
|
|
65039e8700001110
|
TRIM69 activation of STK3 by ubiquitination leading to centrosome separation (Human) |
2023-09-26 |
Patrick Masson |
success |
|
|
64e7eefa00001978
|
ALKBH5 is involved in paraspeckle assembly and is regulated by acetylation and deacetylation by KAT8 and HDAC7, respectively (Human). |
2023-09-19 |
Sylvain Poux |
success |
|
|
65039e8700000123
|
ATR autophosphorylation leads to interaction with TOPBP1 and ATR activation (Human). |
2023-09-19 |
Sylvain Poux |
success |
|
|
65039e8700000196
|
HTATSF1 and TOPBP1 promote RPA-RAD51 exchange in double-strand break repair via homologous recombination (Human). |
2023-09-19 |
Sylvain Poux |
success |
|
|
64e7eefa00001258
|
Inhibition of ALKBH5 RNA demethylase activity by sumoylation in response to reactive oxygen species (Human) |
2023-09-19 |
Sylvain Poux |
success |
|
|
65039e8700000055
|
Phosphorylation-mediated interactions with TOPBP1 couples TP53BP1 and 9-1-1 in DNA damage checkpoint (Human). |
2023-09-19 |
Sylvain Poux |
success |
|
|
64e7eefa00001299
|
RBM33 binds N6-methyladenosine (m6A)-containing mRNAs and promotes their demethylation by ALKBH5 RNA demethylase (Human) |
2023-09-19 |
Sylvain Poux |
success |
|
|
65039e8700000010
|
Recruitment of TOPBP1 to DNA damage sites by MDC1 during mitosis (Human) |
2023-09-19 |
Sylvain Poux |
success |
|
|
64e7eefa00000404
|
TOPBP1 and RHNO1 mediate POLQ recruitment to DNA damage sites during mitosis to promote microhomology-mediated end-joining (MMEJ) (Human). |
2023-09-14 |
Sylvain Poux |
success |
|
|
63c0ac2b00000593
|
TRIM6 activation of antiviral response via unanchored K48-linked polyubiquitin (Human) |
2023-09-14 |
Patrick Masson, Sylvain Poux |
success |
|
|
64b9cb1500000331
|
Inhibition of G3BP1 ability to undergo liquid-liquid phase separation for the formation of stress granules following ubiquitination by TRIM21 (Human) |
2023-09-04 |
Sylvain Poux |
success |
|
|
6494e2e900001496
|
MPEG1/perforin-2 forms a pore for to deliver antigens for cross-presentation (Human) |
2023-09-04 |
Sylvain Poux |
success |
|
|
64d5781900002111
|
KDM4D stabilization by TRIM14-USP14 (Human) |
2023-08-24 |
Patrick Masson |
success |
|
|
64d5781900001969
|
Role of 14-3-3epsilon (YWHAE) in RIGI signaling pathway (Human) |
2023-08-24 |
Patrick Masson |
success |
|
|
6482692800001739
|
Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by AMPK in response to glucose starvation (Human) |
2023-08-11 |
Sylvain Poux |
success |
|
|
64d5781900000111
|
Activation of cGAS-STING signaling following acetylation by KAT5 (Human) |
2023-08-10 |
Sylvain Poux |
success |
|
|
64c3044100002015
|
Inhibition of cGAS-STING signaling by PRKDC (Human) |
2023-08-10 |
Sylvain Poux |
success |
|
|
64d5781900000443
|
Inhibition of cGAS-STING signaling in the cytosol by TREX1 (Human) |
2023-08-10 |
Sylvain Poux |
success |
|
|
64c3044100001568
|
Positive regulation of cGAS-STING signaling by TRIM56 (Human) |
2023-08-10 |
Sylvain Poux |
success |
|
|
627d95ee00000909
|
Regulation of CGAS by PCBP2 (Human) |
2023-08-10 |
Sylvain Poux |
success |
|
|
63894f2500001048
|
Regulation of cellular response to glucocorticoid by the transcription coregulator ZNF764. (Human) |
2023-07-26 |
Cristina Casals |
success |
|
|
63c0ac2b00001634
|
DCAF13 supports the spindle assembly and chromosome condensation during oocyte meiotic division by targeting PTEN polyubiquitination and degradation. (Human) |
2023-07-24 |
Cristina Casals |
success |
|
|
632cf60a00000028
|
mRNA editing enabled by APOBEC1 (Human) |
2023-07-20 |
Lionel Breuza, Suzi Aleksander |
success |
|
|
62183af000000586
|
Activation of SIRT6 histone deacetylase activity upon nucleosome and chromatin-binding (Human) |
2023-06-30 |
Sylvain Poux |
success |
|
|
617b481400000793
|
KAT5 autoacetylation and deacetylation by HDAC3 and SIRT1 (Human) |
2023-06-30 |
Sylvain Poux |
success |
|
|
6494e2e900000187
|
TRAF7 modulation of NF-kappa-B via IKBKG and NEMO K-29 ubquitination (Human) |
2023-06-29 |
Patrick Masson |
success |
|
|
648d0dc100001547
|
Epstein-Barr BILF1 inhibition of NLRP3 inflammasome via MAVS UFMylation (Human-EBV) |
2023-06-27 |
Patrick Masson, Suzi Aleksander |
success |
|
1 warning
-
UNKNOWN_ENABLED_BY_TYPE: 'UniProtKB:P03208' is used in enabled by relationship, but it is not of type protein-containing complex [GO:0032991] or information biomacromolecule [CHEBI:33695]; assuming information biomacromolecule / gene product.
|
646ff70100003516
|
Activation of mTORC1 signaling following phosphorylation of MTOR by TBK1 (Human) |
2023-06-22 |
Sylvain Poux |
success |
|
|
646ff70100004848
|
Activation of the canonical mTORC1 signaling in response to insulin via phosphorylation and inhibition of TSC2 (Human) |
2023-06-22 |
Sylvain Poux |
success |
|
2 warnings
-
SKIPPED_FACT: Subject 'positive regulation of protein localization to membrane [GO:1905477] (biological_process)' has 'has primary input' relationship to 'AKT1 Hsap [UniProtKB:P31749] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of protein localization to membrane [GO:1905477] (biological_process) —has primary input→ AKT1 Hsap [UniProtKB:P31749] (information biomacromolecule)
|
646ff70100001795
|
Activation of the mTORC1 signaling by phosphorylation of GATOR1 subunit DEPDC5 by AKT1 and PIM1 (Human) |
2023-06-22 |
Sylvain Poux |
success |
|
|
63f809ec00000635
|
Activity of the RQC complex via ubiquitination and degradation of incompletely synthesized nascent proteins (by RQC2 and RKR1/LTN1) following ribosome dissociation (S.cerevisiae)
|
2023-06-22 |
Sylvain Poux |
success |
|
|
648d0dc100000266
|
Inhibition of DEPTOR by phosphatidic acid (Human) |
2023-06-22 |
Sylvain Poux |
success |
|
|
646ff70100004606
|
Inhibition of the canonical mTORC1 signaling by TSC2 in response to starvation (Human) |
2023-06-22 |
Sylvain Poux |
success |
|
|
646ff70100004220
|
Inhibition of the canonical mTORC1 signaling by AKT1S1/PRAS40 in absence of insulin (Human) |
2023-06-22 |
Sylvain Poux |
success |
|
|
6482692800001813
|
Inhibition of the canonical mTORC1 signaling following phosphorylation of TSC2 by AMPK in response to glucose starvation (Human) |
2023-06-22 |
Sylvain Poux |
success |
|
|
646ff70100003362
|
Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by PKA (PRKACA and PRKACB) (Human) |
2023-06-22 |
Sylvain Poux |
success |
|
|
646ff70100003456
|
Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by TBK1 (Human) |
2023-06-22 |
Sylvain Poux |
success |
|
|
646ff70100002094
|
Negative regulation of the canonical mTORC1 signaling via phosphorylation of LAMTOR4 by PKA (Human) |
2023-06-22 |
Sylvain Poux |
success |
|
|
646ff70100004457
|
Phosphorylation of AKT1S1/PRAS40 in response to insulin, relieving AKT1S1/PRAS40 inhibitor activity (Human) |
2023-06-22 |
Sylvain Poux |
success |
|
|
648d0dc100000867
|
Phosphorylation of DEPTOR by MAPK3/ERK1 promotes DEPTOR deubiquitination by USP7 and enhanced protein stability (Human). |
2023-06-22 |
Sylvain Poux |
success |
|
|
648d0dc100000710
|
Phosphorylation of DEPTOR by SYK impairs its ability to associate with MTOR (Human). |
2023-06-22 |
Sylvain Poux |
success |
|
|
648d0dc100000321
|
Phosphorylation of DEPTOR in response to nutrients leads to its ubiquitination and degradation by the SCF(BTRC) complex (Human). |
2023-06-22 |
Sylvain Poux |
success |
|
|
648d0dc100000075
|
Positive regulation of autophagy via inhibition of MTOR by DEPTOR (Human) |
2023-06-22 |
Sylvain Poux |
success |
|
|
646ff70100002802
|
Positive regulation of canonical mTORC1 signaling via acetylation of RPTOR by EP300 (Human) |
2023-06-22 |
Sylvain Poux |
success |
|
|
6482692800000330
|
Regulation of the canonical mTORC1 signaling via deubiquitination of RHEB by ATXN3 in response to starvation (Human) |
2023-06-22 |
Sylvain Poux |
success |
|
|
646ff70100005032
|
HCMV UL138 substains STAT1 activation during viral latency (Human-Cytomegalovirus) |
2023-06-18 |
Patrick Masson |
success |
|
|
633b013300001197
|
TRIM27-mediated ubiquitination and degradation of TBK1 (Human) |
2023-06-18 |
Patrick Masson |
success |
|
|
645d887900001414
|
ZNFR1-mediated TLR4 signaling pathway via CAV1 ubiquitination and degradation (Human) |
2023-06-18 |
Patrick Masson |
success |
|
|
63f809ec00001779
|
SLC17A9 regulates P2RX4 (Mouse) |
2023-06-13 |
Lionel Breuza, Pascale Gaudet |
success |
|
|
63e5937500000284
|
18S rRNA degradation in response to ribosome collision by HEL2, leading to ubiquitination of RPS3/uS3 by MAG2, RSP5 and HEL2 and rRNA degradation (S.cerevisiae). |
2023-06-08 |
Sylvain Poux |
success |
|
|
63e5937500000215
|
Activation of the No-Go decay (NGD) pathway in response to ribosome collision by HEL2, leading to ubiquitination of RPS7/eS7, recruitment of CUE2 and mRNA degradation (S.cerevisiae). |
2023-06-08 |
Sylvain Poux |
success |
|
|
63e5937500000160
|
Activation of the ribosome quality control by HEL2 in response to ribosome collisions, leading to ubiquitination of RPS20/us10 and ribosome dissociation by the RQT complex, composed of CUE3, RQT4 and SLH1 (S.cerevisiae) |
2023-06-08 |
Sylvain Poux |
success |
|
|
63f809ec00000512
|
Activity of the RQC complex via ubiquitination and degradation of incompletely synthesized nascent proteins (by NEMF and LTN1) following ribosome dissociation (Human) |
2023-06-08 |
Sylvain Poux |
success |
|
|
63a86a8600001812
|
Gbp4 inhibits Irf7 ubiquitination by Traf6 (Mouse) |
2023-06-08 |
Sylvain Poux |
success |
|
|
63f809ec00000560
|
Non-canonical activity of the RQC complex via CAT-tailing by NEMF that promotes degradation of incompletely synthesized nascent proteins by the DesCEND pathway (Human) |
2023-06-08 |
Sylvain Poux |
success |
|
|
6438950a00000714
|
Regulation of ion transport in the distal nephron by WNK4 (Human) |
2023-06-08 |
Sylvain Poux |
success |
|
|
63e5937500000950
|
RNF10 and USP10 mediate monoubiquitination and deubiquitination of RPS2/us5 and RPS3/us3 in response to ribosome stalling, respectively (Human) |
2023-06-08 |
Sylvain Poux |
success |
|
|
63f809ec00000611
|
The CRL2(KLHDC10) complex catalyzes ubiquitination via the DesCEND (destruction via C-end degrons) pathway (Human) |
2023-06-08 |
Sylvain Poux |
success |
|
|
63f809ec00000701
|
tRNA repair and recycling by ANKZF1, ELAC1 and TRNT1 following activity of the RQC complex in response to stalled ribosomes (Human) |
2023-06-08 |
Sylvain Poux |
success |
|
|
63f809ec00000307
|
TRIM45-mediated degradation of TAB2 leading to inflammatory response inhibition (Human) |
2023-06-01 |
Patrick Masson |
success |
|
|
636d9ce800001444
|
XAF1 prevents hyperproduction of type I interferon by targeting IRF7 (Human) |
2023-06-01 |
Patrick Masson |
success |
|
|
645d887900001502
|
Src-ZNRF1 axis controls TLR3 trafficking (Human) |
2023-05-24 |
Patrick Masson |
success |
|
|
63a86a8600001248
|
TRIM3-mediated ubiquitination of TLR3 leading to TLR3 activation (Human) |
2023-04-20 |
Patrick Masson |
success |
|
|
6438950a00000074
|
Human metapneumovirus M2-2 inhibition of RIGI-MAVS signaling (Human-Metapneumovirus) |
2023-04-19 |
Patrick Masson |
filtered |
Model has at least one activity with no causal relations |
|
6438950a00000032
|
Human metapneumovirus M2-2 inhibition of IRF7 (Human-Metapneumovirus) |
2023-04-17 |
Patrick Masson |
success |
|
|
62900b6400001836
|
Activation of METAP1 activity by zinc chaperone ZNG1 (Human) |
2023-04-04 |
Sylvain Poux |
success |
|
|
62900b6400001815
|
Activation of Metap1 activity by zinc chaperone Zng1 (Mouse) |
2023-04-04 |
Sylvain Poux |
success |
|
|
61e0e55600000624
|
Cyclin-D ubiquitination and degradation by AMBRA1 (Human) |
2023-03-30 |
Sylvain Poux |
success |
|
|
62900b6400000602
|
Differentiation of iTreg cells following ubiquitination and degradation of ACLY by KLHL25 (Human) |
2023-03-30 |
Sylvain Poux |
success |
|
|
62900b6400000462
|
Regulation of translation initiation by EIF4EBP1 via phosphorylation by MTOR and ubiquitination by KLHL25 (Human) |
2023-03-30 |
Sylvain Poux |
success |
|
|
63d320cd00001588
|
FBXL19-mediated degradation of IL1R1 via GSK3B (Human) |
2023-03-28 |
Patrick Masson |
success |
|
|
63f809ec00001358
|
ARKL1 negatively negulates Epstein-Barr virus reactivation by inhibiting JUN-mediated transcription. (Human-Epstein-Barr virus) |
2023-03-27 |
Cristina Casals |
success |
|
|
63f809ec00001308
|
EBNA1 hijacks the host kinase CK2 to disrupt PML nuclear bodies. (Human-Epstein-Barr virus) |
2023-03-27 |
Cristina Casals |
success |
|
|
62f58d8800006555
|
Gut Microbiota bile acid metabolism: Cholate 7-dehydroxylation to produce deoxycholate (DCA) by bai operon. (Human-Clostridium scindens) update with CHEBI:193152 |
2023-03-27 |
Cristina Casals |
success |
|
|
63e5937500000997
|
Inhibition of translation initiation of defective mRNAs by GIGYF2 and EIF4E2 to assist ribosome-associated quality control. (Human) |
2023-03-27 |
Cristina Casals |
success |
|
|
63f809ec00001167
|
Regulation of nucleolar liquid-liquid phase separation by LIAT1. (Human) |
2023-03-27 |
Cristina Casals, Patrick Masson |
success |
|
|
63f809ec00001147
|
Regulation of nucleolar liquid-liquid phase separation by LIAT1. (Mouse) |
2023-03-27 |
Cristina Casals, Patrick Masson |
success |
|
|
6197061700001469
|
Acetylation of MAPRE1/EB1 by PCAF (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
62b4ffe300001832
|
Activation of CASP7 by CASP1 in response to lipopolysaccharide, leading to cleavage and degradation of PARP1 by CASP7 (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
627d95ee00001943
|
Activation of PARP1 activity by HPF1 during DNA repair (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
627d95ee00002030
|
Activation of PARP2 activity by HPF1 during DNA repair (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
635b1e3e00002004
|
Activation of the NLRP3 inflammasome by MAPK8/JNK1 and BRCC3 (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
63894f2500001894
|
ARRDC4-mediated activation of MDA5 through K63-ubiquitination by TRIM65 (Human) |
2023-03-16 |
Patrick Masson |
success |
|
|
635b1e3e00002327
|
CSNK1A1 inhibits formation of the NLRP3 inflammasome by mediating phosphorylation of NLRP3, inhibiting interaction betweeN NLRP3 and NEK7 (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
62b4ffe300003746
|
CXCR4 desensitization by ENTREP1 and ITCH (Human) |
2023-03-16 |
Lionel Breuza |
success |
|
|
63a86a8600001202
|
DHX16-mediated viral RNA recognition and activation of RIGI (Human) |
2023-03-16 |
Patrick Masson |
success |
|
|
635b1e3e00002360
|
Dual role of TRIM31 that inhibits the NLRP3 inflammasome and indirectly activates it via MAVS (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
63894f2500001337
|
FMR1 undergoes liquid-liquid phase separation upon mRNA-binding, leading to formation of neuronal ribonucleoprotein granules that repress mRNA translation (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
62183af000001095
|
GLYR1-KDM1B complex involved in epigenetic maintenance of chromatin in transcription-competent conformation (Human) |
2023-03-16 |
Cristina Casals |
success |
|
|
62f58d8800001022
|
HBV-HBX inhibition of Smad5/6 via DDB1/CUL4A (Human-Hepadnavirus) |
2023-03-16 |
Patrick Masson |
success |
|
|
62f58d8800000464
|
HCMV-UL145 inhibition of STAT2 via DDB1/CUL4A (Human-Herpesvirus) |
2023-03-16 |
Patrick Masson |
success |
|
|
62f58d8800005908
|
HCMV-US6 inhibition of MHC class I peptide antigen assembly via inhibition of TAP1 ATP-binding (Human-Herpesvirus) |
2023-03-16 |
Patrick Masson |
success |
|
|
62f58d8800005854
|
HHV1-ICP47 inhibition of MHC class I peptide antigen assembly via TAP1/TAP2 (Human-Herpesvirus) |
2023-03-16 |
Patrick Masson |
success |
|
|
62b4ffe300006258
|
HHV1-UL36 inhibition of host cGAS-STING pathway via STING (Human-Herpesvirus) |
2023-03-16 |
Patrick Masson |
success |
|
|
62b4ffe300006335
|
HHV1-UL37 inhibition of host cGAS-STING pathway via cGAS deamidation (Human-Herpesvirus) |
2023-03-16 |
Patrick Masson |
success |
|
|
62b4ffe300006376
|
HHV1-UL37 inhibition of host RIG-I signaling via RIG-I deamidation (Human-Herpesvirus) |
2023-03-16 |
Patrick Masson |
success |
|
|
62b4ffe300006001
|
HHV1-US3 inhibition of host IRF3 (Human-Herpesvirus) |
2023-03-16 |
Patrick Masson |
success |
|
4 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: protein import into nucleus [GO:0006606] (biological_process) —has input→ IRF3 Hsap [UniProtKB:Q14653] (information biomacromolecule)
-
SKIPPED_FACT: Subject 'protein import into nucleus [GO:0006606] (biological_process)' has 'has input' relationship to 'IRF3 Hsap [UniProtKB:Q14653] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of protein import into nucleus [GO:0042308] (biological_process) —has input→ IRF3 Hsap [UniProtKB:Q14653] (information biomacromolecule)
-
SKIPPED_FACT: Subject 'negative regulation of protein import into nucleus [GO:0042308] (biological_process)' has 'has input' relationship to 'IRF3 Hsap [UniProtKB:Q14653] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
|
62b4ffe300005697
|
HHV1-US3 inhibition of host RIG-I signaling (Human-Herpesvirus) |
2023-03-16 |
Patrick Masson |
success |
|
|
62f58d8800005377
|
Histidine methylation of RPL3 by METTL18 that regulates translation elongation (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
62900b6400000103
|
Histone poly-ADP-ribosylation of histone H2B at Glu-35 by PARP1 that prevents phosphorylation at of histone H2B at Ser-36 by PRKAA1 (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
62900b6400000076
|
Histone poly-ADP-ribosylation of histone H2B at Glu-35 by Parp1 that prevents phosphorylation at of histone H2B at Ser-36 by Prkaa1 (Mouse) |
2023-03-16 |
Sylvain Poux |
success |
|
|
62f58d8800000934
|
HIV1-Vpr inhibition of UNG2 via DDB1/CUL4A (Human-Lentivrus) |
2023-03-16 |
Patrick Masson |
success |
|
|
59cc772c00000000
|
IL1beta-mediated signaling pathway (Human) |
2023-03-16 |
Patrick Masson |
success |
|
|
62b4ffe300002544
|
Ilicicolin H (Neonectria sp. strain DH2) |
2023-03-16 |
Marc Feuermann |
success |
|
|
62b4ffe300002596
|
Ilicicolin H (Talaromyces variabilis) |
2023-03-16 |
Marc Feuermann |
success |
|
|
639bc18f00000768
|
Inhibition of the CARD8 inflammasome by DPP8 and DPP9 and indirect inhibition by PEPD and XPNPEP1 (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
62b4ffe300005467
|
Inhibition of the JAK-STAT pathway by S.flexneri OspC1 that blocks calcium-binding to calmodulin (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
62b4ffe300005437
|
Inhibition of the JAK-STAT pathway by S.flexneri OspC3 that blocks calcium-binding to calmodulin (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
63c0ac2b00000267
|
IRGM governs the core autophagy machinery to conduct antimicrobial defense (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
639bc18f00000090
|
Isg12a K6-ubiquitination by TRIM21 leading to pyroptosis (Human) |
2023-03-16 |
Patrick Masson |
success |
|
|
62b4ffe300003513
|
Lovastatin biosynthesis (Aspergillus terreus) |
2023-03-16 |
Marc Feuermann |
success |
|
|
63c0ac2b00002078
|
m7G tRNA methylation by METTL1 and WDR4 (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
62183af000000874
|
miRNA maturation by TRUB1 (Human) |
2023-03-16 |
Paul Thomas, Sylvain Poux |
success |
|
|
62900b6400000022
|
Mono-ADP-ribosylation of ribosome subunits by PARP16 (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
62f58d8800001368
|
Mumps-V inhibition of STAT3 via DDB1/CUL4A (Human-Paramyxovirus) |
2023-03-16 |
Patrick Masson |
success |
|
|
635b1e3e00001969
|
NEK9 activates NEK7 kinase activity and inhibits ability of NEK7 to activate NLRP3 inflammasome during mitosis (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
62b4ffe300000335
|
Perforin maturation leading to granzyme-mediated programmed cell death signaling pathway (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
62f58d8800001316
|
PIV5-V inhibition of STAT1 via DDB1/CUL4A (Human-Paramyxovirus) |
2023-03-16 |
Patrick Masson |
success |
|
|
636d9ce800000749
|
Positive regulation of cold-induced thermogenesis in brown adipose tissue by LETMD1. (Human) |
2023-03-16 |
Cristina Casals, Kimberly Van Auken |
success |
|
|
62b4ffe300000418
|
Poxvirus-CRMA inhibition of cGAS-STING signaling (Human-Poxvirus) |
2023-03-16 |
Patrick Masson |
success |
|
|
62b4ffe300003248
|
Poxvirus-OPG029 inhibition of host HDAC4_STAT2 (Human-Poxvirus) |
2023-03-16 |
Patrick Masson |
success |
|
|
62b4ffe300000067
|
Poxvirus-OPG044 inhibition of interferon beta induction (Human-Poxvirus) |
2023-03-16 |
Patrick Masson |
success |
|
|
62b4ffe300000504
|
Poxvirus-OPG065 inhibition of ZBP1-mediated necroptosis (Human-Poxvirus) |
2023-03-16 |
Patrick Masson |
success |
|
|
62f58d8800002742
|
Quality control leading to polyubiquitination and degradation of PEX5 receptor by PEX10 and PEX12 when PEX5 recycling is compromised (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
62f58d8800002875
|
Quality control leading to polyubiquitination and degradation of PEX5 receptor by PEX10 and PEX12 when PEX5 recycling is compromised (S.cerevisiae) |
2023-03-16 |
Sylvain Poux |
success |
|
|
62900b6400000500
|
Regulation of ACLY by acetylation by PCAF/KAT2B and ubiquitination (by UBR4) (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
627d95ee00001189
|
Regulation of PARP1 activity by BANF1 and SPINDOC (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
627d95ee00001902
|
Regulation of poly-ADP-ribosyltransferase activity of Parp1 by MACROH2A1 (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
627d95ee00001881
|
Regulation of poly-ADP-ribosyltransferase activity of Parp1 by Macroh2a1 (Mouse) |
2023-03-16 |
Sylvain Poux |
success |
|
|
62b4ffe300004525
|
Regulation of the JAK-STAT pathway by calmodulin in response to interferon-beta (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
627d95ee00001209
|
Regulation of tyrosyl-tRNA aminoacylation by resveratrol-binding to YARS1 and regulatin of PARP1 activity (Human) |
2023-03-16 |
Sylvain Poux |
success |
|
|
61e0e55600000321
|
SP_ RNF186on BNIP1 |
2023-03-16 |
Patrick Masson |
success |
|
|
5fadbcf000001646
|
SP_SIK2-actvity-on-P300 |
2023-03-16 |
Patrick Masson |
success |
|
1 warning
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: lipid biosynthetic process [GO:0008610] (biological_process) —occurs in→ liver [UBERON:0002107] (anatomical entity)
|
5fadbcf000001101
|
SPModule IFIH1-MAVS |
2023-03-16 |
Patrick Masson |
success |
|
|
5f46c3b700002102
|
SPModule-TIRAP-MYDDOSOME |
2023-03-16 |
Patrick Masson |
success |
|
|
63c0ac2b00000547
|
Staphylococcal HlgB activation of NF-kappa-B via AMFR and TAB3 (Human-Staphylococcus Aureus) |
2023-03-16 |
Patrick Masson |
success |
|
|
5f46c3b700001407
|
TBK1 activation via TRAF3 autoubiquitination (Human) |
2023-03-16 |
Patrick Masson |
success |
|
|
63c0ac2b00000088
|
The AIM2 inflammasome (Mouse) |
2023-03-16 |
Sylvain Poux |
success |
|
|
63a86a8600000489
|
TRIM22-NT5C2 regulation of RIGI via ubiquitination (Human) |
2023-03-16 |
Patrick Masson |
success |
|
|
633b013300001722
|
TRIM27-mediated inhibition of starvation-induced autophagy via ubiquitination of STK38L and ULK1 (Human) |
2023-03-16 |
Patrick Masson |
success |
|
|
63a86a8600001314
|
TRIM56 activation of NK-kappa-B signaling via MAP3K7 (Human) |
2023-03-16 |
Patrick Masson |
success |
|
|
6348a65d00000093
|
USP20 inhibition of NF-kappa-B signaling via TRAF6 deubiquitination (Human) |
2023-03-16 |
Patrick Masson |
success |
|
|
632cf60a00000788
|
USP20-mediated STING deubiquitination leading to STING stabilisation (Human) |
2023-03-16 |
Patrick Masson |
success |
|
|
6348a65d00000136
|
USP20-mediated ULK1 stabilisation for autophagy initiation (Human) |
2023-03-16 |
Patrick Masson |
success |
|
|
6348a65d00002206
|
USP44-mediated stabilization of DDB2 to Facilitate Nucleotide Excision Repair (Human) |
2023-03-16 |
Patrick Masson |
success |
|
|
6348a65d00002142
|
USP44-mediated STING deubiquitination leading to antiviral innate immune response (Human) |
2023-03-16 |
Patrick Masson |
success |
|
|
639bc18f00000028
|
VCAM1 ubiquitination by TRIM65 leading to inflammation inhibition (Human) |
2023-03-16 |
Patrick Masson |
success |
|
|
62f58d8800000841
|
Zdhhc2 in regulation of long-term synaptic potentiation via Akap5 (Mouse) |
2023-03-16 |
Lionel Breuza, Sylvain Poux |
success |
|
|
62b4ffe300003655
|
Zearalenone biosynthesis (Gibberella zeae) |
2023-03-16 |
Marc Feuermann |
success |
|
|
63c0ac2b00000464
|
Zika virus inhibition of TBK1 via CEP63 binding and centrosome disorganization (Human-Zika virus) |
2023-03-16 |
Patrick Masson |
success |
|
|
63e5937500000370
|
Regulation of SLC46A3 by AHR in response to 2,3,7,8-tetrachlorodibenzodioxine |
2023-03-03 |
Cristina Casals, Patrick Masson |
success |
|
|
63d320cd00000317
|
Activation of the AIM2 inflammasome in neural cells shapes neurodevelopment (Mouse) |
2023-03-02 |
Sylvain Poux |
success |
|
|
63d320cd00000225
|
Activation of the AIM2 inflammasome in response to DNA damage (Mouse) |
2023-03-02 |
Sylvain Poux |
success |
|
|
63e5937500000591
|
Activation of the ribosome quality control by ZNF598 in response to ribosome collisions, leading to ubiquitination of RPS20/us10 and ribosome dissociation by the RQT complex, composed of ASCC2 and ASCC3 (Human)
|
2023-03-02 |
Sylvain Poux |
success |
|
|
63d320cd00000399
|
Negative regulation of the AIM2 inflammasome by Ifi202 (Mouse) |
2023-03-02 |
Sylvain Poux |
success |
|
|
63e5937500001319
|
Translation termination by the eRF1-eRF3 complex, followed by ribosome dissociation by ABCE1 (Human) |
2023-03-02 |
Sylvain Poux |
success |
|
|
63f809ec00000347
|
TRIM60-mediated inhibition of NF-kappa-B signaling via TAB2 SUMOylation (Human) |
2023-03-02 |
Patrick Masson |
success |
|
|
63e5937500000838
|
G3BP1 ability to undergo liquid-liquid phase separation for the formation of stress granules is activated by CAPRIN1 and inhibited by USP10 (Human) |
2023-02-23 |
Sylvain Poux |
success |
|
|
63e5937500000738
|
Inhibition of the ribosome quality control by OTUD3 and USP21 that deubiquitinate RSP20/us10 and antagonize ZNF598 activity (Human)
|
2023-02-23 |
Sylvain Poux |
success |
|
|
63d320cd00001536
|
FBXL19-mediated degradation of RAC1 (Human) |
2023-02-08 |
Patrick Masson |
success |
|
4 warnings
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] (biological_process) —has input→ RAC1 Hsap [UniProtKB:P63000] (information biomacromolecule)
-
SKIPPED_FACT: Subject 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436] (biological_process)' has 'has input' relationship to 'RAC1 Hsap [UniProtKB:P63000] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
-
UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436] (biological_process) —has input→ RAC1 Hsap [UniProtKB:P63000] (information biomacromolecule)
-
SKIPPED_FACT: Subject 'proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] (biological_process)' has 'has input' relationship to 'RAC1 Hsap [UniProtKB:P63000] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
|
636d9ce800000719
|
Positive regulation of cold-induced thermogenesis in brown adipose tissue by LETMD1. (Mouse) |
2023-02-08 |
Cristina Casals, Sylvain Poux |
success |
|
|
62f58d8800005413
|
Inhibition of vitamin K metabolic process via inhibition of VKORC1 by warfarin; antidotal effect of AIFM2/FSP1 that suppresses ferroptosis (Human) |
2023-01-24 |
Sylvain Poux |
success |
|
|
633b013300000887
|
Gut Microbiota tryptophan metabolism: Regulation of mucus release by tryptamine (Mouse-Bacteroides thetaiotaomicron) |
2022-12-12 |
Cristina Casals |
success |
|
|
6246724f00000886
|
Regulation of lysosome position by ubiquitination of ARL8B by RNF167 (Human) |
2022-09-22 |
Sylvain Poux |
success |
|
|
62f58d8800000065
|
Carotenoid biosynthesis (N. crassa) |
2022-08-12 |
Marc Feuermann |
success |
|
|
62b4ffe300003703
|
(M)-viriditoxin biosynthesis (Byssochlamys spectabilis) |
2022-07-29 |
Marc Feuermann |
success |
|
|
62b4ffe300002959
|
Aflaroxin (Aspergillus parasiticus) |
2022-07-29 |
Marc Feuermann |
success |
|
|
62b4ffe300004264
|
kotanin biosynthesis (Aspergillus niger) |
2022-07-29 |
Marc Feuermann, Patrick Masson |
success |
|
|
62900b6400001631
|
Mycophenolic acid - Penicillium brevicompactum |
2022-07-29 |
Marc Feuermann |
success |
|
|
62b4ffe300003754
|
Novofumigatonin biosynthesis (Aspergillus novofumigatus) |
2022-07-29 |
Marc Feuermann |
success |
|
|
62b4ffe300002512
|
Ochratoxin biosynthesis in A. carbonarius |
2022-07-29 |
Marc Feuermann |
success |
|
|
6258b8f300000816
|
Patulin biosynthesis by Penicillium expansum |
2022-07-29 |
Marc Feuermann |
success |
|
|
62b4ffe300002470
|
Ochratoxin A biosynthesis & catabolism (A. niger) |
2022-07-07 |
Marc Feuermann |
success |
|
|
62b4ffe300002340
|
Penicillin G from Penicillium chrysogenum |
2022-07-07 |
Marc Feuermann, Pascale Gaudet |
success |
|
|
62b4ffe300002925
|
psilocybin (Psilocybe cubensis) |
2022-07-07 |
Marc Feuermann |
success |
|
|
613aae0000000591
|
CASP6 palmitoylation (Human) |
2022-07-01 |
Sylvain Poux |
success |
|
|
61f34dd300000000
|
Nuclear import of the proteasome by AKIRIN2 (Human) |
2022-07-01 |
Sylvain Poux |
success |
|
|
6197061700001429
|
Crotonylation and decrotonylation of EB1/MAPRE1 by KAT5 and HDAC3 (Human) |
2022-03-18 |
Sylvain Poux |
success |
|
|
617b481400000672
|
KAT5 chromatin localization (Human) |
2022-03-18 |
Sylvain Poux |
success |
|
|
617b481400000648
|
KAT5 involvement in triglyceride biosynthetic process (Human) |
2022-03-18 |
Sylvain Poux |
success |
|
|
617b481400000389
|
KAT5 regulation of the cytoskeleton by acetylation of proteins (Human) |
2022-03-18 |
Sylvain Poux |
success |
|
|
62183af000000536
|
DNA damage sensor activity of SIRT6 and its regulation by SIRT1 (Human) |
2022-03-16 |
Sylvain Poux |
success |
|
|
62183af000000520
|
p53 deacetylation by SIRT6 (Human) |
2022-03-16 |
Sylvain Poux |
success |
|
|
6205c24300000794
|
Ubiquitination and stablization of SIRT6 by STUB1/CHIP (Human) |
2022-03-16 |
Sylvain Poux |
success |
|
|
5f46c3b700001570
|
SPModule TBK1-IRF3 |
2022-01-26 |
Patrick Masson, Sylvain Poux |
success |
|
|
6168d1e000000007
|
SP_RNF26ubiquinatesSQSTM1 |
2022-01-17 |
Patrick Masson |
success |
|
|
60ad85f700000612
|
TRIM47-activity-on-ILF3 |
2022-01-17 |
Patrick Masson |
success |
|
|