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GO-CAM-like Models Report — Reactome

Model ID Title Date modified Contributors Pipeline result Result details Warnings 
R-HSA-9033807
 ABO blood group biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-156582
 Acetylation - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-399997
 Acetylcholine regulates insulin secretion - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-1482798
 Acyl chain remodeling of CL - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-1482883
 Acyl chain remodeling of DAG and TAG - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-1482788
 Acyl chain remodelling of PC - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
10 warnings
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has input' relationship to '1,2-diacyl-sn-glycero-3-phosphocholine [CHEBI:57643] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has input→ 1,2-diacyl-sn-glycero-3-phosphocholine [CHEBI:57643] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has output→ 1-O-acyl-sn-glycero-3-phosphocholine(1+) [CHEBI:17504] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has output→ long-chain fatty acid anion [CHEBI:57560] (chemical entity)
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has output' relationship to 'long-chain fatty acid anion [CHEBI:57560] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —occurs in→ extracellular region [GO:0005576] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —part of→ phosphatidylcholine acyl-chain remodeling [GO:0036151] (biological_process)
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has output' relationship to '1-O-acyl-sn-glycero-3-phosphocholine(1+) [CHEBI:17504] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-1482839
 Acyl chain remodelling of PE - imported from: Reactome 2026-07-02 Curators at Reactome success
10 warnings
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has output→ long-chain fatty acid anion [CHEBI:57560] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —part of→ phosphatidylethanolamine acyl-chain remodeling [GO:0036152] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —occurs in→ extracellular region [GO:0005576] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has output' relationship to 'long-chain fatty acid anion [CHEBI:57560] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has input→ phosphatidylethanolamine zwitterion [CHEBI:57613] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has output→ 1-acyl-sn-glycero-3-phosphoethanolamine [CHEBI:29017] (chemical entity)
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has output' relationship to '1-acyl-sn-glycero-3-phosphoethanolamine [CHEBI:29017] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has input' relationship to 'phosphatidylethanolamine zwitterion [CHEBI:57613] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-1482925
 Acyl chain remodelling of PG - imported from: Reactome 2026-07-02 Curators at Reactome success
10 warnings
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has output' relationship to '1-acyl-sn-glycero-3-phosphoglycerol [CHEBI:62747] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has output' relationship to 'long-chain fatty acid anion [CHEBI:57560] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —occurs in→ extracellular region [GO:0005576] (anatomical entity)
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has input' relationship to '1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) [CHEBI:64716] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —part of→ phosphatidylglycerol acyl-chain remodeling [GO:0036148] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has input→ 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) [CHEBI:64716] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has output→ 1-acyl-sn-glycero-3-phosphoglycerol [CHEBI:62747] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has output→ long-chain fatty acid anion [CHEBI:57560] (chemical entity) 
R-HSA-1482922
 Acyl chain remodelling of PI - imported from: Reactome 2026-07-02 Curators at Reactome success
10 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has output→ long-chain fatty acid anion [CHEBI:57560] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —occurs in→ extracellular region [GO:0005576] (anatomical entity)
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has input' relationship to '1-phosphatidyl-1D-myo-inositol(1-) [CHEBI:57880] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has output→ 1-acyl-sn-glycero-3-phospho-D-myo-inositol [CHEBI:28914] (chemical entity)
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has input→ 1-phosphatidyl-1D-myo-inositol(1-) [CHEBI:57880] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —part of→ phosphatidylinositol acyl-chain remodeling [GO:0036149] (biological_process)
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has output' relationship to 'long-chain fatty acid anion [CHEBI:57560] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has output' relationship to '1-acyl-sn-glycero-3-phospho-D-myo-inositol [CHEBI:28914] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-1482801
 Acyl chain remodelling of PS - imported from: Reactome 2026-07-02 Curators at Reactome success
10 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has input→ 3-sn-phosphatidyl-L-serine [CHEBI:11750] (chemical entity)
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has output→ long-chain fatty acid anion [CHEBI:57560] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —occurs in→ extracellular region [GO:0005576] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has output' relationship to 'long-chain fatty acid anion [CHEBI:57560] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has input' relationship to '3-sn-phosphatidyl-L-serine [CHEBI:11750] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —part of→ phosphatidylserine acyl-chain remodeling [GO:0036150] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has output→ 1-acyl-sn-glycero-3-phosphoserine [CHEBI:52603] (chemical entity)
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has output' relationship to '1-acyl-sn-glycero-3-phosphoserine [CHEBI:52603] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-400042
 Adrenaline,noradrenaline inhibits insulin secretion - imported from: Reactome 2026-07-02 Curators at Reactome success
6 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: guanyl-nucleotide exchange factor activity [GO:0005085] (molecular_function) —causally upstream of→ calcium channel inhibitor activity [GO:0019855] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: calcium channel inhibitor activity [GO:0019855] (molecular_function) —part of→ negative regulation of insulin secretion [GO:0046676] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase inhibitor activity [GO:0010855] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase inhibitor activity [GO:0010855] (molecular_function) —part of→ negative regulation of insulin secretion [GO:0046676] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: guanyl-nucleotide exchange factor activity [GO:0005085] (molecular_function) —provides input for→ adenylate cyclase inhibitor activity [GO:0010855] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: calcium channel inhibitor activity [GO:0019855] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity) 
R-HSA-5423646
 Aflatoxin activation and detoxification - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
38 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol dehydrogenase (NADP+) activity [GO:0008106] (molecular_function) —part of→ aflatoxin metabolic process [GO:0046222] (biological_process)
  • SKIPPED_FACT: Subject 'L-cysteine-S-conjugate N-acetyltransferase activity [GO:0047198] (molecular_function)' has 'has input' relationship to 'acetyl-CoA(4-) [CHEBI:57288] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'L-cysteine-S-conjugate N-acetyltransferase activity [GO:0047198] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-cysteine-S-conjugate N-acetyltransferase activity [GO:0047198] (molecular_function) —has input→ acetyl-CoA(4-) [CHEBI:57288] (chemical entity)
  • SKIPPED_FACT: Subject 'alcohol dehydrogenase (NADP+) activity [GO:0008106] (molecular_function)' has 'has output' relationship to 'NADP(3-) [CHEBI:58349] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'alcohol dehydrogenase (NADP+) activity [GO:0008106] (molecular_function)' has 'has input' relationship to 'aflatoxin B1 dialdehyde [CHEBI:53107] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function) —has output→ L-glutamate(1-) [CHEBI:29985] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol dehydrogenase (NADP+) activity [GO:0008106] (molecular_function) —has output→ aflatoxin B1 triol [CHEBI:53108] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol dehydrogenase (NADP+) activity [GO:0008106] (molecular_function) —has input→ aflatoxin B1 dialdehyde [CHEBI:53107] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: dipeptidase activity [GO:0016805] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione transferase activity [GO:0004364] (molecular_function) —has input→ glutathionate(1-) [CHEBI:57925] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —causally upstream of→ glutathione transferase activity [GO:0004364] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-cysteine-S-conjugate N-acetyltransferase activity [GO:0047198] (molecular_function) —part of→ aflatoxin metabolic process [GO:0046222] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione transferase activity [GO:0004364] (molecular_function) —part of→ aflatoxin metabolic process [GO:0046222] (biological_process)
  • SKIPPED_FACT: Subject 'alcohol dehydrogenase (NADP+) activity [GO:0008106] (molecular_function)' has 'has output' relationship to 'aflatoxin B1 triol [CHEBI:53108] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol dehydrogenase (NADP+) activity [GO:0008106] (molecular_function) —has input→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: dipeptidase activity [GO:0016805] (molecular_function) —part of→ aflatoxin metabolic process [GO:0046222] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-cysteine-S-conjugate N-acetyltransferase activity [GO:0047198] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol dehydrogenase (NADP+) activity [GO:0008106] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-cysteine-S-conjugate N-acetyltransferase activity [GO:0047198] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • SKIPPED_FACT: Subject 'alcohol dehydrogenase (NADP+) activity [GO:0008106] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function)' has 'has output' relationship to 'L-glutamate(1-) [CHEBI:29985] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'L-cysteine-S-conjugate N-acetyltransferase activity [GO:0047198] (molecular_function)' has 'has output' relationship to 'coenzyme A(4-) [CHEBI:57287] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'dipeptidase activity [GO:0016805] (molecular_function)' has 'has output' relationship to 'glycine zwitterion [CHEBI:57305] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'alcohol dehydrogenase (NADP+) activity [GO:0008106] (molecular_function)' has 'has input' relationship to 'NADPH(4-) [CHEBI:57783] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione transferase activity [GO:0004364] (molecular_function) —occurs in→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function) —part of→ aflatoxin metabolic process [GO:0046222] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: dipeptidase activity [GO:0016805] (molecular_function) —causally upstream of→ L-cysteine-S-conjugate N-acetyltransferase activity [GO:0047198] (molecular_function)
  • SKIPPED_FACT: Subject 'glutathione transferase activity [GO:0004364] (molecular_function)' has 'has input' relationship to 'glutathionate(1-) [CHEBI:57925] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —causally upstream of→ alcohol dehydrogenase (NADP+) activity [GO:0008106] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione transferase activity [GO:0004364] (molecular_function) —causally upstream of→ glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol dehydrogenase (NADP+) activity [GO:0008106] (molecular_function) —has input→ NADPH(4-) [CHEBI:57783] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol dehydrogenase (NADP+) activity [GO:0008106] (molecular_function) —has output→ NADP(3-) [CHEBI:58349] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: dipeptidase activity [GO:0016805] (molecular_function) —has output→ glycine zwitterion [CHEBI:57305] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-cysteine-S-conjugate N-acetyltransferase activity [GO:0047198] (molecular_function) —has output→ coenzyme A(4-) [CHEBI:57287] (chemical entity) 
R-HSA-351143
 Agmatine biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-8964540
 Alanine metabolism - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-2046106
 alpha-linolenic acid (ALA) metabolism - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-389599
 Alpha-oxidation of phytanate - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-163680
 AMPK inhibits chREBP transcriptional activation activity - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-193048
 Androgen biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success
12 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid Delta-isomerase activity [GO:0004769] (molecular_function) —occurs in→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid Delta-isomerase activity [GO:0004769] (molecular_function) —part of→ androgen biosynthetic process [GO:0006702] (biological_process)
  • SKIPPED_FACT: Subject 'steroid Delta-isomerase activity [GO:0004769] (molecular_function)' has 'has input' relationship to 'dehydroepiandrosterone [CHEBI:28689] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'steroid Delta-isomerase activity [GO:0004769] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid Delta-isomerase activity [GO:0004769] (molecular_function) —has input→ dehydroepiandrosterone [CHEBI:28689] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid Delta-isomerase activity [GO:0004769] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • SKIPPED_FACT: Subject 'steroid Delta-isomerase activity [GO:0004769] (molecular_function)' has 'has input' relationship to 'NAD(1-) [CHEBI:57540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid Delta-isomerase activity [GO:0004769] (molecular_function) —has output→ NADH(2-) [CHEBI:57945] (chemical entity)
  • SKIPPED_FACT: Subject 'steroid Delta-isomerase activity [GO:0004769] (molecular_function)' has 'has output' relationship to 'androst-4-ene-3,17-dione [CHEBI:16422] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid Delta-isomerase activity [GO:0004769] (molecular_function) —has input→ NAD(1-) [CHEBI:57540] (chemical entity)
  • SKIPPED_FACT: Subject 'steroid Delta-isomerase activity [GO:0004769] (molecular_function)' has 'has output' relationship to 'NADH(2-) [CHEBI:57945] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid Delta-isomerase activity [GO:0004769] (molecular_function) —has output→ androst-4-ene-3,17-dione [CHEBI:16422] (chemical entity) 
R-HSA-2142753
 Arachidonate metabolism - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-8963693
 Aspartate and asparagine metabolism - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
21 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • SKIPPED_FACT: Subject 'acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function)' has 'has output' relationship to 'L-glutamate(1-) [CHEBI:29985] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane transporter activity [GO:0022857] (molecular_function) —has input→ N-acetyl-L-aspartate(2-) [CHEBI:16953] (chemical entity)
  • SKIPPED_FACT: Subject 'acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function) —part of→ obsolete L-amino acid metabolic process [GO:0170033] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function) —has output→ L-glutamate(1-) [CHEBI:29985] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane transporter activity [GO:0022857] (molecular_function) —has output→ N-acetyl-L-aspartate(2-) [CHEBI:16953] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function) —occurs in→ mitochondrial inner membrane [GO:0005743] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function) —has input→ L-aspartate(1-) [CHEBI:29991] (chemical entity)
  • SKIPPED_FACT: Subject 'transmembrane transporter activity [GO:0022857] (molecular_function)' has 'has output' relationship to 'N-acetyl-L-aspartate(2-) [CHEBI:16953] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane transporter activity [GO:0022857] (molecular_function) —occurs in→ mitochondrial inner membrane [GO:0005743] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function) —causally upstream of→ carboxy-lyase activity [GO:0016831] (molecular_function)
  • SKIPPED_FACT: Subject 'acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane transporter activity [GO:0022857] (molecular_function) —part of→ obsolete L-amino acid metabolic process [GO:0170033] (biological_process)
  • SKIPPED_FACT: Subject 'acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function)' has 'has output' relationship to 'L-aspartate(1-) [CHEBI:29991] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function)' has 'has input' relationship to 'L-glutamate(1-) [CHEBI:29985] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function) —has input→ L-glutamate(1-) [CHEBI:29985] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function) —has input→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function) —has output→ L-aspartate(1-) [CHEBI:29991] (chemical entity)
  • SKIPPED_FACT: Subject 'transmembrane transporter activity [GO:0022857] (molecular_function)' has 'has input' relationship to 'N-acetyl-L-aspartate(2-) [CHEBI:16953] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function)' has 'has input' relationship to 'L-aspartate(1-) [CHEBI:29991] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-9859138
 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-77352
 Beta oxidation of butanoyl-CoA to acetyl-CoA - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-77346
 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-77350
 Beta oxidation of hexanoyl-CoA to butanoyl-CoA - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-77310
 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-77285
 Beta oxidation of myristoyl-CoA to lauroyl-CoA - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-77348
 Beta oxidation of octanoyl-CoA to hexanoyl-CoA - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-77305
 Beta oxidation of palmitoyl-CoA to myristoyl-CoA - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-389887
 Beta-oxidation of pristanoyl-CoA - imported from: Reactome 2026-07-02 Curators at Reactome success
10 warnings
  • SKIPPED_FACT: Subject 'pristanoyl-CoA oxidase activity [GO:0016402] (molecular_function)' has 'has output' relationship to 'hydrogen peroxide [CHEBI:16240] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: pristanoyl-CoA oxidase activity [GO:0016402] (molecular_function) —has input→ dioxygen [CHEBI:15379] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: pristanoyl-CoA oxidase activity [GO:0016402] (molecular_function) —occurs in→ peroxisomal matrix [GO:0005782] (anatomical entity)
  • SKIPPED_FACT: Subject 'pristanoyl-CoA oxidase activity [GO:0016402] (molecular_function)' has 'has input' relationship to '(2S)-pristanoyl-CoA(4-) [CHEBI:77099] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'pristanoyl-CoA oxidase activity [GO:0016402] (molecular_function)' has 'has output' relationship to '(E)-2,3-didehydropristanoyl-CoA(4-) [CHEBI:77293] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: pristanoyl-CoA oxidase activity [GO:0016402] (molecular_function) —has input→ (2S)-pristanoyl-CoA(4-) [CHEBI:77099] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: pristanoyl-CoA oxidase activity [GO:0016402] (molecular_function) —has output→ (E)-2,3-didehydropristanoyl-CoA(4-) [CHEBI:77293] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: pristanoyl-CoA oxidase activity [GO:0016402] (molecular_function) —part of→ fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540] (biological_process)
  • SKIPPED_FACT: Subject 'pristanoyl-CoA oxidase activity [GO:0016402] (molecular_function)' has 'has input' relationship to 'dioxygen [CHEBI:15379] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: pristanoyl-CoA oxidase activity [GO:0016402] (molecular_function) —has output→ hydrogen peroxide [CHEBI:16240] (chemical entity) 
R-HSA-390247
 Beta-oxidation of very long chain fatty acids - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
3 warnings
  • SKIPPED_FACT: 'malonyl-CoA decarboxylase activity [GO:0050080] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540] (biological_process)'
  • SKIPPED_FACT: 'fatty acyl-CoA hydrolase activity [GO:0047617] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540] (biological_process)'
  • SKIPPED_FACT: 'fatty acyl-CoA hydrolase activity [GO:0047617] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540] (biological_process)' 
R-HSA-9020265
 Biosynthesis of aspirin-triggered D-series resolvins - imported from: Reactome 2026-07-02 Curators at Reactome success
10 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —has output→ aspirin-triggered resolvin D5(1-) [CHEBI:747578] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —has output→ aspirin-triggered resolvin D6(1-) [CHEBI:747596] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —part of→ long-chain fatty acid biosynthetic process [GO:0042759] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —has input→ 7(S)-hydroperoxy-17(R)-hydroxydocosahexaenoate [CHEBI:747574] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'oxidoreductase activity [GO:0016491] (molecular_function)' has 'has output' relationship to 'aspirin-triggered resolvin D6(1-) [CHEBI:747596] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'oxidoreductase activity [GO:0016491] (molecular_function)' has 'has input' relationship to '7(S)-hydroperoxy-17(R)-hydroxydocosahexaenoate [CHEBI:747574] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —has input→ 4(S)-hydroperoxy-17(R)-hydroxydocosahexaenoate [CHEBI:747573] (chemical entity)
  • SKIPPED_FACT: Subject 'oxidoreductase activity [GO:0016491] (molecular_function)' has 'has output' relationship to 'aspirin-triggered resolvin D5(1-) [CHEBI:747578] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'oxidoreductase activity [GO:0016491] (molecular_function)' has 'has input' relationship to '4(S)-hydroperoxy-17(R)-hydroxydocosahexaenoate [CHEBI:747573] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-9018676
 Biosynthesis of D-series resolvins - imported from: Reactome 2026-07-02 Curators at Reactome success
10 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —has output→ resolvin D6(1-) [CHEBI:747593] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —has input→ 4(S)-hydroperoxy-17(S)-hydroxydocosahexaenoate [CHEBI:747595] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —part of→ long-chain fatty acid biosynthetic process [GO:0042759] (biological_process)
  • SKIPPED_FACT: Subject 'oxidoreductase activity [GO:0016491] (molecular_function)' has 'has input' relationship to '7(S)-hydroperoxy-17(S)-hydroxydocosahexaenoate [CHEBI:747594] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'oxidoreductase activity [GO:0016491] (molecular_function)' has 'has output' relationship to 'resolvin D6(1-) [CHEBI:747593] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —has input→ 7(S)-hydroperoxy-17(S)-hydroxydocosahexaenoate [CHEBI:747594] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —has output→ resolvin D5(1-) [CHEBI:140352] (chemical entity)
  • SKIPPED_FACT: Subject 'oxidoreductase activity [GO:0016491] (molecular_function)' has 'has input' relationship to '4(S)-hydroperoxy-17(S)-hydroxydocosahexaenoate [CHEBI:747595] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'oxidoreductase activity [GO:0016491] (molecular_function)' has 'has output' relationship to 'resolvin D5(1-) [CHEBI:140352] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-9018677
 Biosynthesis of DHA-derived SPMs - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-9026290
 Biosynthesis of DPAn-3-derived maresins - imported from: Reactome 2026-07-02 Curators at Reactome success
6 warnings
  • SKIPPED_FACT: Subject 'epoxide hydrolase activity [GO:0004301] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: epoxide hydrolase activity [GO:0004301] (molecular_function) —has input→ (7Z,9E,11E,16Z,19Z)-13,14-epoxydocosapentaenoate [CHEBI:140235] (chemical entity)
  • SKIPPED_FACT: Subject 'epoxide hydrolase activity [GO:0004301] (molecular_function)' has 'has input' relationship to '(7Z,9E,11E,16Z,19Z)-13,14-epoxydocosapentaenoate [CHEBI:140235] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: epoxide hydrolase activity [GO:0004301] (molecular_function) —part of→ lipoxygenase pathway [GO:0019372] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: epoxide hydrolase activity [GO:0004301] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: epoxide hydrolase activity [GO:0004301] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity) 
R-HSA-9026286
 Biosynthesis of DPAn-3-derived protectins and resolvins - imported from: Reactome 2026-07-02 Curators at Reactome success
15 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —has input→ (8E,10Z,13Z,15E,19Z)-7,17-bis(hydroperoxy)docosapentaenoate [CHEBI:140381] (chemical entity)
  • SKIPPED_FACT: Subject 'epoxide hydrolase activity [GO:0004301] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'epoxide hydrolase activity [GO:0004301] (molecular_function)' has 'has input' relationship to '(16S,17S)-epoxy-(7Z,10Z,12E,14E,19Z)-docosapentaenoate [CHEBI:140290] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: epoxide hydrolase activity [GO:0004301] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: epoxide hydrolase activity [GO:0004301] (molecular_function) —part of→ lipoxygenase pathway [GO:0019372] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —has output→ 7,17-dihydroxy-(8Z,15E,19Z)-docosa-8,10,13,15,19-pentaenoate [CHEBI:140419] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: epoxide hydrolase activity [GO:0004301] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: epoxide hydrolase activity [GO:0004301] (molecular_function) —has input→ 7,8-epoxy,17-hydroxy-(9E,11E,13Z,15E,19Z)-docosapentaenoate [CHEBI:140293] (chemical entity)
  • SKIPPED_FACT: Subject 'oxidoreductase activity [GO:0016491] (molecular_function)' has 'has input' relationship to '(8E,10Z,13Z,15E,19Z)-7,17-bis(hydroperoxy)docosapentaenoate [CHEBI:140381] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'oxidoreductase activity [GO:0016491] (molecular_function)' has 'has output' relationship to '7,17-dihydroxy-(8Z,15E,19Z)-docosa-8,10,13,15,19-pentaenoate [CHEBI:140419] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'epoxide hydrolase activity [GO:0004301] (molecular_function)' has 'has input' relationship to '7,8-epoxy,17-hydroxy-(9E,11E,13Z,15E,19Z)-docosapentaenoate [CHEBI:140293] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —part of→ lipoxygenase pathway [GO:0019372] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: epoxide hydrolase activity [GO:0004301] (molecular_function) —has input→ (16S,17S)-epoxy-(7Z,10Z,12E,14E,19Z)-docosapentaenoate [CHEBI:140290] (chemical entity)
  • SKIPPED_FACT: Subject 'epoxide hydrolase activity [GO:0004301] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-9023661
 Biosynthesis of E-series 18(R)-resolvins - imported from: Reactome 2026-07-02 Curators at Reactome success
12 warnings
  • SKIPPED_FACT: Subject 'NADPH dehydrogenase activity [GO:0003959] (molecular_function)' has 'has output' relationship to 'resolvin E2(1-) [CHEBI:133368] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: NADPH dehydrogenase activity [GO:0003959] (molecular_function) —has output→ resolvin E2(1-) [CHEBI:133368] (chemical entity)
  • SKIPPED_FACT: Subject 'NADPH dehydrogenase activity [GO:0003959] (molecular_function)' has 'has input' relationship to 'hydrogen donor [CHEBI:17499] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'NADPH dehydrogenase activity [GO:0003959] (molecular_function)' has 'has output' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: NADPH dehydrogenase activity [GO:0003959] (molecular_function) —has output→ hydrogen acceptor [CHEBI:13193] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: NADPH dehydrogenase activity [GO:0003959] (molecular_function) —has output→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: NADPH dehydrogenase activity [GO:0003959] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: NADPH dehydrogenase activity [GO:0003959] (molecular_function) —has input→ hydrogen donor [CHEBI:17499] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: NADPH dehydrogenase activity [GO:0003959] (molecular_function) —part of→ long-chain fatty acid biosynthetic process [GO:0042759] (biological_process)
  • SKIPPED_FACT: Subject 'NADPH dehydrogenase activity [GO:0003959] (molecular_function)' has 'has input' relationship to '5(S)-hydroperoxy-18(R)-hydroxy-(6E,8Z,11Z,14Z,16E)-icosapentaenoate [CHEBI:132218] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'NADPH dehydrogenase activity [GO:0003959] (molecular_function)' has 'has output' relationship to 'hydrogen acceptor [CHEBI:13193] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: NADPH dehydrogenase activity [GO:0003959] (molecular_function) —has input→ 5(S)-hydroperoxy-18(R)-hydroxy-(6E,8Z,11Z,14Z,16E)-icosapentaenoate [CHEBI:132218] (chemical entity) 
R-HSA-9018896
 Biosynthesis of E-series 18(S)-resolvins - imported from: Reactome 2026-07-02 Curators at Reactome success
26 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has input→ all-cis-5,8,11,14,17-icosapentaenoate [CHEBI:58562] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has input→ NADPH(4-) [CHEBI:57783] (chemical entity)
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has output' relationship to 'NADP(3-) [CHEBI:58349] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —occurs in→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: NADPH dehydrogenase activity [GO:0003959] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: NADPH dehydrogenase activity [GO:0003959] (molecular_function) —has output→ hydrogen acceptor [CHEBI:13193] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: NADPH dehydrogenase activity [GO:0003959] (molecular_function) —has input→ hydrogen donor [CHEBI:17499] (chemical entity)
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has input' relationship to 'NADPH(4-) [CHEBI:57783] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has output→ NADP(3-) [CHEBI:58349] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: NADPH dehydrogenase activity [GO:0003959] (molecular_function) —has input→ (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-icosapentaenoate [CHEBI:132091] (chemical entity)
  • SKIPPED_FACT: Subject 'NADPH dehydrogenase activity [GO:0003959] (molecular_function)' has 'has output' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'NADPH dehydrogenase activity [GO:0003959] (molecular_function)' has 'has output' relationship to 'hydrogen acceptor [CHEBI:13193] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has output→ (18S)-hydroperoxyicosapentaenoate [CHEBI:747601] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —part of→ long-chain fatty acid biosynthetic process [GO:0042759] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: NADPH dehydrogenase activity [GO:0003959] (molecular_function) —has output→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has output' relationship to '(18S)-hydroperoxyicosapentaenoate [CHEBI:747601] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has input' relationship to 'dioxygen [CHEBI:15379] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: NADPH dehydrogenase activity [GO:0003959] (molecular_function) —has output→ (18S)-resolvin E2(1-) [CHEBI:136056] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has input→ hydron [CHEBI:15378] (chemical entity)
  • SKIPPED_FACT: Subject 'NADPH dehydrogenase activity [GO:0003959] (molecular_function)' has 'has input' relationship to 'hydrogen donor [CHEBI:17499] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has input' relationship to 'all-cis-5,8,11,14,17-icosapentaenoate [CHEBI:58562] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'NADPH dehydrogenase activity [GO:0003959] (molecular_function)' has 'has input' relationship to '(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-icosapentaenoate [CHEBI:132091] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: NADPH dehydrogenase activity [GO:0003959] (molecular_function) —part of→ long-chain fatty acid biosynthetic process [GO:0042759] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has input→ dioxygen [CHEBI:15379] (chemical entity)
  • SKIPPED_FACT: Subject 'NADPH dehydrogenase activity [GO:0003959] (molecular_function)' has 'has output' relationship to '(18S)-resolvin E2(1-) [CHEBI:136056] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-2142700
 Biosynthesis of Lipoxins (LX) - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-9027307
 Biosynthesis of maresin-like SPMs - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
31 warnings
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has output' relationship to 'NADP(3-) [CHEBI:58349] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'oxidoreductase activity [GO:0016491] (molecular_function)' has 'has output' relationship to '(14S)-HDoHE(1-) [CHEBI:136526] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has output' relationship to 'NADP(3-) [CHEBI:58349] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —occurs in→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —part of→ long-chain fatty acid biosynthetic process [GO:0042759] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has output→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has input' relationship to 'NADPH(4-) [CHEBI:57783] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has input' relationship to 'NADPH(4-) [CHEBI:57783] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has output→ (4Z,7Z,10Z,12E,14R,16Z,19Z)-14,22-dihydroxydocosahexaenoate [CHEBI:136530] (chemical entity)
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has output' relationship to '(4Z,7Z,10Z,12E,14S,16Z,19Z)-14,22-dihydroxydocosahexaenoate [CHEBI:136529] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has input→ (14R)-HDoHE(1-) [CHEBI:136525] (chemical entity)
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has output→ NADP(3-) [CHEBI:58349] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —part of→ long-chain fatty acid biosynthetic process [GO:0042759] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'oxidoreductase activity [GO:0016491] (molecular_function)' has 'has input' relationship to '(4Z,8E,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosahexaenoate [CHEBI:140279] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has input' relationship to 'dioxygen [CHEBI:15379] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has output' relationship to '(4Z,7Z,10Z,12E,14R,16Z,19Z)-14,22-dihydroxydocosahexaenoate [CHEBI:136530] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has input' relationship to 'dioxygen [CHEBI:15379] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has input→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —has input→ (4Z,8E,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosahexaenoate [CHEBI:140279] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —has output→ (14S)-HDoHE(1-) [CHEBI:136526] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has output→ (4Z,7Z,10Z,12E,14S,16Z,19Z)-14,22-dihydroxydocosahexaenoate [CHEBI:136529] (chemical entity)
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has input' relationship to '(14S)-HDoHE(1-) [CHEBI:136526] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has input→ (14S)-HDoHE(1-) [CHEBI:136526] (chemical entity)
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has output' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has input→ NADPH(4-) [CHEBI:57783] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has input→ dioxygen [CHEBI:15379] (chemical entity)
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has output' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has input' relationship to '(14R)-HDoHE(1-) [CHEBI:136525] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-9018681
 Biosynthesis of protectins - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-196780
 Biotin transport and metabolism - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
10 warnings
  • SKIPPED_FACT: Subject 'peptidase activity [GO:0008233] (molecular_function)' has 'has output' relationship to 'biocytin zwitterion [CHEBI:195545] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'peptidase activity [GO:0008233] (molecular_function)' has 'has output' relationship to 'biocytin zwitterion [CHEBI:195545] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: peptidase activity [GO:0008233] (molecular_function) —causally upstream of→ biotinidase activity [GO:0047708] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: biotin--[biotin carboxyl-carrier protein] ligase activity [GO:0004077] (molecular_function) —causally upstream of→ peptidase activity [GO:0008233] (molecular_function)
  • SKIPPED_FACT: Subject 'peptidase activity [GO:0008233] (molecular_function)' has 'has output' relationship to 'biocytin zwitterion [CHEBI:195545] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: peptidase activity [GO:0008233] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: biotin--[biotin carboxyl-carrier protein] ligase activity [GO:0004077] (molecular_function) —provides input for→ peptidase activity [GO:0008233] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: peptidase activity [GO:0008233] (molecular_function) —occurs in→ mitochondrial matrix [GO:0005759] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: peptidase activity [GO:0008233] (molecular_function) —has output→ biocytin zwitterion [CHEBI:195545] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: peptidase activity [GO:0008233] (molecular_function) —part of→ biotin metabolic process [GO:0006768] (biological_process) 
R-HSA-70895
 Branched-chain amino acid catabolism - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
11 warnings
  • SKIPPED_FACT: Subject 'enoyl-CoA hydratase activity [GO:0004300] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: 'protein kinase activity [GO:0004672] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'branched-chain amino acid catabolic process [GO:0009083] (biological_process)'
  • SKIPPED_FACT: Subject 'enoyl-CoA hydratase activity [GO:0004300] (molecular_function)' has 'has output' relationship to '(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-) [CHEBI:57312] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: enoyl-CoA hydratase activity [GO:0004300] (molecular_function) —part of→ branched-chain amino acid catabolic process [GO:0009083] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: enoyl-CoA hydratase activity [GO:0004300] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: enoyl-CoA hydratase activity [GO:0004300] (molecular_function) —has output→ (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-) [CHEBI:57312] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: enoyl-CoA hydratase activity [GO:0004300] (molecular_function) —occurs in→ mitochondrial matrix [GO:0005759] (anatomical entity)
  • SKIPPED_FACT: '[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity [GO:0047385] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'branched-chain amino acid catabolic process [GO:0009083] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: enoyl-CoA hydratase activity [GO:0004300] (molecular_function) —has input→ 2-methylcrotonoyl-CoA(4-) [CHEBI:57337] (chemical entity)
  • SKIPPED_FACT: Subject 'enoyl-CoA hydratase activity [GO:0004300] (molecular_function)' has 'has input' relationship to '2-methylcrotonoyl-CoA(4-) [CHEBI:57337] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: 'branched-chain amino acid transmembrane transporter activity [GO:0015658] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'branched-chain amino acid transport [GO:0015803] (biological_process)' 
R-HSA-200425
 Carnitine shuttle - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
4 warnings
  • SKIPPED_FACT: 'carnitine transmembrane transporter activity [GO:0015226] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'carnitine transmembrane transport [GO:1902603] (biological_process)'
  • SKIPPED_FACT: 'acetyl-CoA carboxylase activity [GO:0003989] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'carnitine shuttle [GO:0006853] (biological_process)'
  • SKIPPED_FACT: 'AMP-activated protein kinase activity [GO:0004679] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'carnitine shuttle [GO:0006853] (biological_process)'
  • SKIPPED_FACT: 'acetyl-CoA carboxylase activity [GO:0003989] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid homeostasis [GO:0055089] (biological_process)' 
R-HSA-71262
 Carnitine synthesis - imported from: Reactome 2026-07-02 Curators at Reactome success
7 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carnitine transmembrane transporter activity [GO:0015226] (molecular_function) —part of→ carnitine biosynthetic process [GO:0045329] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carnitine transmembrane transporter activity [GO:0015226] (molecular_function) —part of→ carnitine transmembrane transport [GO:1902603] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carnitine transmembrane transporter activity [GO:0015226] (molecular_function) —has input→ (R)-carnitine [CHEBI:16347] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carnitine transmembrane transporter activity [GO:0015226] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity)
  • SKIPPED_FACT: Subject 'carnitine transmembrane transporter activity [GO:0015226] (molecular_function)' has 'has output' relationship to '(R)-carnitine [CHEBI:16347] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carnitine transmembrane transporter activity [GO:0015226] (molecular_function) —has output→ (R)-carnitine [CHEBI:16347] (chemical entity)
  • SKIPPED_FACT: Subject 'carnitine transmembrane transporter activity [GO:0015226] (molecular_function)' has 'has input' relationship to '(R)-carnitine [CHEBI:16347] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-209905
 Catecholamine biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-9969901
 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-6807047
 Cholesterol biosynthesis via desmosterol (Bloch pathway) - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-6798163
 Choline catabolism - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-71403
 Citric acid cycle (TCA cycle) - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-9759218
 Cobalamin (Cbl) metabolism - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
10 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —has output→ NADH(2-) [CHEBI:57945] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: transferase activity, transferring alkyl or aryl (other than methyl) groups [GO:0016765] (molecular_function) —provides input for→ oxidoreductase activity [GO:0016491] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —has input→ hydron [CHEBI:15378] (chemical entity)
  • SKIPPED_FACT: Subject 'oxidoreductase activity [GO:0016491] (molecular_function)' has 'has input' relationship to 'NAD(1-) [CHEBI:57540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'oxidoreductase activity [GO:0016491] (molecular_function)' has 'has output' relationship to 'NADH(2-) [CHEBI:57945] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —provides input for→ molecular carrier activity [GO:0140104] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —has input→ NAD(1-) [CHEBI:57540] (chemical entity)
  • SKIPPED_FACT: Subject 'oxidoreductase activity [GO:0016491] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —part of→ cobalamin metabolic process [GO:0009235] (biological_process) 
R-HSA-196783
 Coenzyme A biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-9865881
 Complex III assembly - imported from: Reactome 2026-07-02 Curators at Reactome success
6 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: iron chaperone activity [GO:0034986] (molecular_function) —causally upstream of→ endopeptidase activity [GO:0004175] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: endopeptidase activity [GO:0004175] (molecular_function) —part of→ mitochondrial respiratory chain complex III assembly [GO:0034551] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: endopeptidase activity [GO:0004175] (molecular_function) —part of→ protein processing [GO:0016485] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: protein binding [GO:0005515] (molecular_function) —causally upstream of→ endopeptidase activity [GO:0004175] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: endopeptidase activity [GO:0004175] (molecular_function) —occurs in→ mitochondrial inner membrane [GO:0005743] (anatomical entity)
  • SKIPPED_FACT: 'protein folding chaperone [GO:0044183] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'mitochondrial translation [GO:0032543] (biological_process)' 
R-HSA-9864848
 Complex IV assembly - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
1 warning
  • SKIPPED_FACT: 'copper chaperone activity [GO:0016531] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'mitochondrial respiratory chain complex IV assembly [GO:0033617] (biological_process)' 
R-HSA-177135
 Conjugation of benzoate with glycine - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-177128
 Conjugation of salicylate with glycine - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-140180
 COX reactions - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-71288
 Creatine metabolism - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
18 warnings
  • SKIPPED_FACT: Subject 'creatine kinase activity [GO:0004111] (molecular_function)' has 'has input' relationship to 'creatine zwitterion [CHEBI:57947] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'creatine kinase activity [GO:0004111] (molecular_function)' has 'has output' relationship to 'ADP(3-) [CHEBI:456216] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: creatine kinase activity [GO:0004111] (molecular_function) —has output→ ADP(3-) [CHEBI:456216] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: creatine kinase activity [GO:0004111] (molecular_function) —part of→ creatine metabolic process [GO:0006600] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: creatine kinase activity [GO:0004111] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: creatine kinase activity [GO:0004111] (molecular_function) —has input→ ATP(4-) [CHEBI:30616] (chemical entity)
  • SKIPPED_FACT: Subject 'creatine kinase activity [GO:0004111] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: creatine kinase activity [GO:0004111] (molecular_function) —has output→ N-phosphocreatinate(2-) [CHEBI:58092] (chemical entity)
  • SKIPPED_FACT: Subject 'creatine kinase activity [GO:0004111] (molecular_function)' has 'has output' relationship to 'N-phosphocreatinate(2-) [CHEBI:58092] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: creatine kinase activity [GO:0004111] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'creatine kinase activity [GO:0004111] (molecular_function)' has 'has input' relationship to 'ATP(4-) [CHEBI:30616] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'creatine kinase activity [GO:0004111] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'creatine kinase activity [GO:0004111] (molecular_function)' has 'has input' relationship to 'creatine zwitterion [CHEBI:57947] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'creatine kinase activity [GO:0004111] (molecular_function)' has 'has output' relationship to 'ADP(3-) [CHEBI:456216] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: creatine kinase activity [GO:0004111] (molecular_function) —occurs in→ mitochondrial inner membrane [GO:0005743] (anatomical entity)
  • SKIPPED_FACT: Subject 'creatine kinase activity [GO:0004111] (molecular_function)' has 'has output' relationship to 'N-phosphocreatinate(2-) [CHEBI:58092] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'creatine kinase activity [GO:0004111] (molecular_function)' has 'has input' relationship to 'ATP(4-) [CHEBI:30616] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: creatine kinase activity [GO:0004111] (molecular_function) —has input→ creatine zwitterion [CHEBI:57947] (chemical entity) 
R-HSA-2022870
 CS-GAG biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-2024101
 CS/DS degradation - imported from: Reactome 2026-07-02 Curators at Reactome success
19 warnings
  • SKIPPED_FACT: Subject 'hydrolase activity, acting on glycosyl bonds [GO:0016798] (molecular_function)' has 'has output' relationship to 'beta-D-GalNAc4S-(1->4)-beta-D-IdoA2S-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl(4-) [CHEBI:747399] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrolase activity, acting on glycosyl bonds [GO:0016798] (molecular_function) —part of→ proteoglycan catabolic process [GO:0030167] (biological_process)
  • SKIPPED_FACT: 'beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'proteoglycan catabolic process [GO:0030167] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrolase activity, acting on glycosyl bonds [GO:0016798] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrolase activity, acting on glycosyl bonds [GO:0016798] (molecular_function) —has output→ beta-D-GalNAc4S-(1->4)-beta-D-IdoA2S-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl(4-) [CHEBI:747399] (chemical entity)
  • SKIPPED_FACT: 'iduronate-2-sulfatase activity [GO:0004423] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'proteoglycan catabolic process [GO:0030167] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrolase activity, acting on glycosyl bonds [GO:0016798] (molecular_function) —part of→ dermatan sulfate proteoglycan catabolic process [GO:0030209] (biological_process)
  • SKIPPED_FACT: 'L-iduronidase activity [GO:0003940] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'dermatan sulfate proteoglycan catabolic process [GO:0030209] (biological_process)'
  • SKIPPED_FACT: 'N-acetylgalactosamine-4-sulfatase activity [GO:0003943] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'proteoglycan catabolic process [GO:0030167] (biological_process)'
  • SKIPPED_FACT: Subject 'hydrolase activity, acting on glycosyl bonds [GO:0016798] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: 'hyalurononglucosaminidase activity [GO:0004415] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'proteoglycan catabolic process [GO:0030167] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrolase activity, acting on glycosyl bonds [GO:0016798] (molecular_function) —part of→ chondroitin sulfate proteoglycan catabolic process [GO:0030207] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrolase activity, acting on glycosyl bonds [GO:0016798] (molecular_function) —causally upstream of→ hyalurononglucosaminidase activity [GO:0004415] (molecular_function)
  • SKIPPED_FACT: 'hyalurononglucosaminidase activity [GO:0004415] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'chondroitin sulfate proteoglycan catabolic process [GO:0030207] (biological_process)'
  • SKIPPED_FACT: 'hyalurononglucosaminidase activity [GO:0004415] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'chondroitin sulfate proteoglycan catabolic process [GO:0030207] (biological_process)'
  • SKIPPED_FACT: 'N-acetylgalactosamine-4-sulfatase activity [GO:0003943] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'chondroitin sulfate proteoglycan catabolic process [GO:0030207] (biological_process)'
  • SKIPPED_FACT: Subject 'hydrolase activity, acting on glycosyl bonds [GO:0016798] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrolase activity, acting on glycosyl bonds [GO:0016798] (molecular_function) —occurs in→ lysosomal lumen [GO:0043202] (anatomical entity)
  • SKIPPED_FACT: 'beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'dermatan sulfate proteoglycan catabolic process [GO:0030209] (biological_process)' 
R-HSA-211999
 CYP2E1 reactions - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
44 warnings
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'carbon tetrachloride metabolic process [GO:0018885] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'halogenated hydrocarbon metabolic process [GO:0042197] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'carbon tetrachloride metabolic process [GO:0018885] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'halogenated hydrocarbon metabolic process [GO:0042197] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'benzene metabolic process [GO:0018910] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'benzene metabolic process [GO:0018910] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'benzene metabolic process [GO:0018910] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'benzene metabolic process [GO:0018910] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'carbon tetrachloride metabolic process [GO:0018885] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'halogenated hydrocarbon metabolic process [GO:0042197] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'halogenated hydrocarbon metabolic process [GO:0042197] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'benzene metabolic process [GO:0018910] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'benzene metabolic process [GO:0018910] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'carbon tetrachloride metabolic process [GO:0018885] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'halogenated hydrocarbon metabolic process [GO:0042197] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)'
  • SKIPPED_FACT: 'monooxygenase activity [GO:0004497] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'xenobiotic metabolic process [GO:0006805] (biological_process)' 
R-HSA-1614603
 Cysteine formation from homocysteine - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-2564830
 Cytosolic iron-sulfur cluster assembly - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-156584
 Cytosolic sulfonation of small molecules - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
52 warnings
  • SKIPPED_FACT: Subject 'steroid sulfotransferase activity [GO:0050294] (molecular_function)' has 'has input' relationship to 'dehydroepiandrosterone [CHEBI:28689] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: estrone sulfotransferase activity [GO:0004304] (molecular_function) —has input→ estrone [CHEBI:17263] (chemical entity)
  • SKIPPED_FACT: Subject 'sulfotransferase activity [GO:0008146] (molecular_function)' has 'has output' relationship to '2-acetamidofluorene N-sulfate [CHEBI:35424] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid sulfotransferase activity [GO:0050294] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aryl sulfotransferase activity [GO:0004062] (molecular_function) —has output→ 3,3'-diiodo-L-thyronine sulfate [CHEBI:35431] (chemical entity)
  • SKIPPED_FACT: Subject 'aryl sulfotransferase activity [GO:0004062] (molecular_function)' has 'has output' relationship to '4-nitrophenyl hydrogen sulfate [CHEBI:35422] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'aryl sulfotransferase activity [GO:0004062] (molecular_function)' has 'has input' relationship to 'dopaminium(1+) [CHEBI:59905] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'steroid sulfotransferase activity [GO:0050294] (molecular_function)' has 'has input' relationship to 'pregnenolone [CHEBI:16581] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid sulfotransferase activity [GO:0050294] (molecular_function) —has output→ pregnenolone sulfate [CHEBI:35420] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: sulfotransferase activity [GO:0008146] (molecular_function) —has input→ N-hydroxy-2-acetamidofluorene [CHEBI:17931] (chemical entity)
  • SKIPPED_FACT: Subject 'aryl sulfotransferase activity [GO:0004062] (molecular_function)' has 'has input' relationship to '3,3'-diiodothyronine [CHEBI:35430] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid sulfotransferase activity [GO:0050294] (molecular_function) —causally upstream of→ 3'(2'),5'-bisphosphate nucleotidase activity [GO:0008441] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aryl sulfotransferase activity [GO:0004062] (molecular_function) —has input→ 3,3'-diiodothyronine [CHEBI:35430] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid sulfotransferase activity [GO:0050294] (molecular_function) —part of→ 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427] (biological_process)
  • SKIPPED_FACT: Subject 'steroid sulfotransferase activity [GO:0050294] (molecular_function)' has 'has output' relationship to 'dehydroepiandrosterone sulfate(1-) [CHEBI:57905] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid sulfotransferase activity [GO:0050294] (molecular_function) —has input→ pregnenolone [CHEBI:16581] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aryl sulfotransferase activity [GO:0004062] (molecular_function) —has output→ 4-nitrophenyl hydrogen sulfate [CHEBI:35422] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aryl sulfotransferase activity [GO:0004062] (molecular_function) —has input→ dopaminium(1+) [CHEBI:59905] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: estrone sulfotransferase activity [GO:0004304] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'steroid sulfotransferase activity [GO:0050294] (molecular_function)' has 'has output' relationship to 'pregnenolone sulfate [CHEBI:35420] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: estrone sulfotransferase activity [GO:0004304] (molecular_function) —part of→ 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol sulfotransferase activity [GO:0004027] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: estrone sulfotransferase activity [GO:0004304] (molecular_function) —has output→ estrone 3-sulfate(1-) [CHEBI:60050] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol sulfotransferase activity [GO:0004027] (molecular_function) —causally upstream of→ 3'(2'),5'-bisphosphate nucleotidase activity [GO:0008441] (molecular_function)
  • SKIPPED_FACT: Subject 'estrone sulfotransferase activity [GO:0004304] (molecular_function)' has 'has output' relationship to 'estrone 3-sulfate(1-) [CHEBI:60050] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aryl sulfotransferase activity [GO:0004062] (molecular_function) —has output→ dopamine 3-O-sulfate [CHEBI:37946] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aryl sulfotransferase activity [GO:0004062] (molecular_function) —causally upstream of→ 3'(2'),5'-bisphosphate nucleotidase activity [GO:0008441] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aryl sulfotransferase activity [GO:0004062] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid sulfotransferase activity [GO:0050294] (molecular_function) —has input→ dehydroepiandrosterone [CHEBI:28689] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: sulfotransferase activity [GO:0008146] (molecular_function) —causally upstream of→ 3'(2'),5'-bisphosphate nucleotidase activity [GO:0008441] (molecular_function)
  • SKIPPED_FACT: Subject 'aryl sulfotransferase activity [GO:0004062] (molecular_function)' has 'has output' relationship to 'dopamine 3-O-sulfate [CHEBI:37946] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: '3'(2'),5'-bisphosphate nucleotidase activity [GO:0008441] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to '3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aryl sulfotransferase activity [GO:0004062] (molecular_function) —has input→ 3,3',5-triiodo-L-thyronine zwitterion [CHEBI:533015] (chemical entity)
  • SKIPPED_FACT: Subject 'aryl sulfotransferase activity [GO:0004062] (molecular_function)' has 'has output' relationship to '3,3',5-triiodo-L-thyronine sulfate [CHEBI:35432] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'alcohol sulfotransferase activity [GO:0004027] (molecular_function)' has 'has input' relationship to '26-hydroxycholesterol [CHEBI:17703] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aryl sulfotransferase activity [GO:0004062] (molecular_function) —has output→ 3,3',5-triiodo-L-thyronine sulfate [CHEBI:35432] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol sulfotransferase activity [GO:0004027] (molecular_function) —has output→ 26-hydroxycholesterol 3-sulfate [CHEBI:35419] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol sulfotransferase activity [GO:0004027] (molecular_function) —part of→ 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427] (biological_process)
  • SKIPPED_FACT: Subject 'aryl sulfotransferase activity [GO:0004062] (molecular_function)' has 'has input' relationship to '3,3',5-triiodo-L-thyronine zwitterion [CHEBI:533015] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid sulfotransferase activity [GO:0050294] (molecular_function) —has output→ dehydroepiandrosterone sulfate(1-) [CHEBI:57905] (chemical entity)
  • SKIPPED_FACT: Subject 'aryl sulfotransferase activity [GO:0004062] (molecular_function)' has 'has input' relationship to '4-nitrophenol [CHEBI:16836] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'sulfotransferase activity [GO:0008146] (molecular_function)' has 'has input' relationship to 'N-hydroxy-2-acetamidofluorene [CHEBI:17931] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'aryl sulfotransferase activity [GO:0004062] (molecular_function)' has 'has output' relationship to '3,3'-diiodo-L-thyronine sulfate [CHEBI:35431] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'alcohol sulfotransferase activity [GO:0004027] (molecular_function)' has 'has output' relationship to '26-hydroxycholesterol 3-sulfate [CHEBI:35419] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: sulfotransferase activity [GO:0008146] (molecular_function) —part of→ 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aryl sulfotransferase activity [GO:0004062] (molecular_function) —part of→ 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: sulfotransferase activity [GO:0008146] (molecular_function) —has output→ 2-acetamidofluorene N-sulfate [CHEBI:35424] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: sulfotransferase activity [GO:0008146] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'estrone sulfotransferase activity [GO:0004304] (molecular_function)' has 'has input' relationship to 'estrone [CHEBI:17263] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aryl sulfotransferase activity [GO:0004062] (molecular_function) —has input→ 4-nitrophenol [CHEBI:16836] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol sulfotransferase activity [GO:0004027] (molecular_function) —has input→ 26-hydroxycholesterol [CHEBI:17703] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: estrone sulfotransferase activity [GO:0004304] (molecular_function) —causally upstream of→ 3'(2'),5'-bisphosphate nucleotidase activity [GO:0008441] (molecular_function) 
R-HSA-1614558
 Degradation of cysteine and homocysteine - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
1 warning
  • SKIPPED_FACT: 'cysteine dioxygenase activity [GO:0017172] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'sulfur amino acid catabolic process [GO:0000098] (biological_process)' 
R-HSA-2022923
 DS-GAG biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-2395516
 Electron transport from NADPH to Ferredoxin - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-211976
 Endogenous sterols - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-203615
 eNOS activation - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-193144
 Estrogen biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
1 warning
  • SKIPPED_FACT: 'estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'estrogen biosynthetic process [GO:0006703] (biological_process)' 
R-HSA-71384
 Ethanol oxidation - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
13 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol dehydrogenase (NAD+) activity [GO:0004022] (molecular_function) —has output→ NADH(2-) [CHEBI:57945] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol dehydrogenase (NAD+) activity [GO:0004022] (molecular_function) —has input→ NAD(1-) [CHEBI:57540] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol dehydrogenase (NAD+) activity [GO:0004022] (molecular_function) —has output→ acetaldehyde [CHEBI:15343] (chemical entity)
  • SKIPPED_FACT: Subject 'alcohol dehydrogenase (NAD+) activity [GO:0004022] (molecular_function)' has 'has output' relationship to 'NADH(2-) [CHEBI:57945] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'alcohol dehydrogenase (NAD+) activity [GO:0004022] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol dehydrogenase (NAD+) activity [GO:0004022] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol dehydrogenase (NAD+) activity [GO:0004022] (molecular_function) —has input→ ethanol [CHEBI:16236] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol dehydrogenase (NAD+) activity [GO:0004022] (molecular_function) —part of→ ethanol catabolic process [GO:0006068] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol dehydrogenase (NAD+) activity [GO:0004022] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'alcohol dehydrogenase (NAD+) activity [GO:0004022] (molecular_function)' has 'has input' relationship to 'NAD(1-) [CHEBI:57540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol dehydrogenase (NAD+) activity [GO:0004022] (molecular_function) —causally upstream of→ aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function)
  • SKIPPED_FACT: Subject 'alcohol dehydrogenase (NAD+) activity [GO:0004022] (molecular_function)' has 'has input' relationship to 'ethanol [CHEBI:16236] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'alcohol dehydrogenase (NAD+) activity [GO:0004022] (molecular_function)' has 'has output' relationship to 'acetaldehyde [CHEBI:15343] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-434316
 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-75105
 Fatty acyl-CoA biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-163210
 Formation of ATP by chemiosmotic coupling - imported from: Reactome 2026-07-02 Curators at Reactome success
2 warnings
  • SKIPPED_FACT: 'proton transmembrane transporter activity [GO:0015078] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'proton motive force-driven mitochondrial ATP synthesis [GO:0042776] (biological_process)'
  • SKIPPED_FACT: 'proton-transporting ATP synthase activity, rotational mechanism [GO:0046933] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'ATP biosynthetic process [GO:0006754] (biological_process)' 
R-HSA-173599
 Formation of the active cofactor, UDP-glucuronate - imported from: Reactome 2026-07-02 Curators at Reactome success
1 warning
  • SKIPPED_FACT: 'UDP-glucuronate transmembrane transporter activity [GO:0005461] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'UDP-glucuronate transmembrane transport [GO:0015787] (biological_process)' 
R-HSA-5661270
 Formation of xylulose-5-phosphate - imported from: Reactome 2026-07-02 Curators at Reactome success
8 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: dehydro-L-gulonate decarboxylase activity [GO:0047842] (molecular_function) —has input→ 3-dehydro-L-gulonate [CHEBI:57655] (chemical entity)
  • SKIPPED_FACT: Subject 'dehydro-L-gulonate decarboxylase activity [GO:0047842] (molecular_function)' has 'has input' relationship to '3-dehydro-L-gulonate [CHEBI:57655] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: dehydro-L-gulonate decarboxylase activity [GO:0047842] (molecular_function) —part of→ D-glucuronate catabolic process [GO:0042840] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: dehydro-L-gulonate decarboxylase activity [GO:0047842] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'dehydro-L-gulonate decarboxylase activity [GO:0047842] (molecular_function)' has 'has output' relationship to 'L-xylulose [CHEBI:17399] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'dehydro-L-gulonate decarboxylase activity [GO:0047842] (molecular_function)' has 'has output' relationship to 'carbon dioxide [CHEBI:16526] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: dehydro-L-gulonate decarboxylase activity [GO:0047842] (molecular_function) —has output→ carbon dioxide [CHEBI:16526] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: dehydro-L-gulonate decarboxylase activity [GO:0047842] (molecular_function) —has output→ L-xylulose [CHEBI:17399] (chemical entity) 
R-HSA-5652227
 Fructose biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-70350
 Fructose catabolism - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-70370
 Galactose catabolism - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-163359
 Glucagon signaling in metabolic regulation - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-381676
 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion - imported from: Reactome 2026-07-02 Curators at Reactome success
7 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: guanyl-nucleotide exchange factor activity [GO:0005085] (molecular_function) —has output→ GDP(3-) [CHEBI:58189] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: guanyl-nucleotide exchange factor activity [GO:0005085] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: cAMP binding [GO:0030552] (molecular_function) —causally upstream of→ guanyl-nucleotide exchange factor activity [GO:0005085] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: guanyl-nucleotide exchange factor activity [GO:0005085] (molecular_function) —has input→ GTP(4-) [CHEBI:37565] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: guanyl-nucleotide exchange factor activity [GO:0005085] (molecular_function) —part of→ positive regulation of insulin secretion [GO:0032024] (biological_process)
  • SKIPPED_FACT: Subject 'guanyl-nucleotide exchange factor activity [GO:0005085] (molecular_function)' has 'has input' relationship to 'GTP(4-) [CHEBI:37565] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'guanyl-nucleotide exchange factor activity [GO:0005085] (molecular_function)' has 'has output' relationship to 'GDP(3-) [CHEBI:58189] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-194002
 Glucocorticoid biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
18 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function) —has input→ 17alpha-hydroxypregnenolone [CHEBI:28750] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid Delta-isomerase activity [GO:0004769] (molecular_function) —has input→ 17alpha-hydroxypregn-5-ene-3,20-dione [CHEBI:63843] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function) —has output→ 17alpha-hydroxypregn-5-ene-3,20-dione [CHEBI:63843] (chemical entity)
  • SKIPPED_FACT: Subject '3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function)' has 'has input' relationship to '17alpha-hydroxypregnenolone [CHEBI:28750] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function) —has input→ NAD(1-) [CHEBI:57540] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function) —occurs in→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity)
  • SKIPPED_FACT: Subject '3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function)' has 'has output' relationship to 'NADH(2-) [CHEBI:57945] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject '3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'steroid Delta-isomerase activity [GO:0004769] (molecular_function)' has 'has input' relationship to '17alpha-hydroxypregn-5-ene-3,20-dione [CHEBI:63843] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid Delta-isomerase activity [GO:0004769] (molecular_function) —occurs in→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function) —part of→ glucocorticoid biosynthetic process [GO:0006704] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid Delta-isomerase activity [GO:0004769] (molecular_function) —part of→ glucocorticoid biosynthetic process [GO:0006704] (biological_process)
  • SKIPPED_FACT: Subject '3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function)' has 'has output' relationship to '17alpha-hydroxypregn-5-ene-3,20-dione [CHEBI:63843] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function) —has output→ NADH(2-) [CHEBI:57945] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid Delta-isomerase activity [GO:0004769] (molecular_function) —has output→ 17alpha-hydroxyprogesterone [CHEBI:17252] (chemical entity)
  • SKIPPED_FACT: Subject '3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function)' has 'has input' relationship to 'NAD(1-) [CHEBI:57540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'steroid Delta-isomerase activity [GO:0004769] (molecular_function)' has 'has output' relationship to '17alpha-hydroxyprogesterone [CHEBI:17252] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-70263
 Gluconeogenesis - imported from: Reactome 2026-07-02 Curators at Reactome success
3 warnings
  • SKIPPED_FACT: 'glucose 6-phosphate:phosphate antiporter activity [GO:0061513] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'glucose-6-phosphate transport [GO:0015760] (biological_process)'
  • SKIPPED_FACT: 'pyruvate carboxylase activity [GO:0004736] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gluconeogenesis [GO:0006094] (biological_process)'
  • SKIPPED_FACT: 'glucose 6-phosphate:phosphate antiporter activity [GO:0061513] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'glucose-6-phosphate transport [GO:0015760] (biological_process)' 
R-HSA-156588
 Glucuronidation - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
2 warnings
  • SKIPPED_FACT: 'glucuronosyltransferase activity [GO:0015020] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bilirubin conjugation [GO:0006789] (biological_process)'
  • SKIPPED_FACT: 'glucuronosyltransferase activity [GO:0015020] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bilirubin conjugation [GO:0006789] (biological_process)' 
R-HSA-8964539
 Glutamate and glutamine metabolism - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
29 warnings
  • SKIPPED_FACT: Subject 'glutaminase activity [GO:0004359] (molecular_function)' has 'has input' relationship to 'L-glutamine zwitterion [CHEBI:58359] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'delta1-pyrroline-5-carboxylate synthetase (NADP+) activity [GO:0017084] (molecular_function)' has 'has input' relationship to 'ATP(4-) [CHEBI:30616] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'delta1-pyrroline-5-carboxylate synthetase (NADP+) activity [GO:0017084] (molecular_function)' has 'has input' relationship to 'L-glutamate(1-) [CHEBI:29985] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: delta1-pyrroline-5-carboxylate synthetase (NADP+) activity [GO:0017084] (molecular_function) —occurs in→ mitochondrial inner membrane [GO:0005743] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: delta1-pyrroline-5-carboxylate synthetase (NADP+) activity [GO:0017084] (molecular_function) —has input→ ATP(4-) [CHEBI:30616] (chemical entity)
  • SKIPPED_FACT: Subject 'delta1-pyrroline-5-carboxylate synthetase (NADP+) activity [GO:0017084] (molecular_function)' has 'has input' relationship to 'NADPH(4-) [CHEBI:57783] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'delta1-pyrroline-5-carboxylate synthetase (NADP+) activity [GO:0017084] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: delta1-pyrroline-5-carboxylate synthetase (NADP+) activity [GO:0017084] (molecular_function) —has output→ L-glutamic 5-semialdehyde zwitterion [CHEBI:58066] (chemical entity)
  • SKIPPED_FACT: Subject 'glutaminase activity [GO:0004359] (molecular_function)' has 'has output' relationship to 'ammonium [CHEBI:28938] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: delta1-pyrroline-5-carboxylate synthetase (NADP+) activity [GO:0017084] (molecular_function) —has output→ NADP(3-) [CHEBI:58349] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: delta1-pyrroline-5-carboxylate synthetase (NADP+) activity [GO:0017084] (molecular_function) —has input→ hydron [CHEBI:15378] (chemical entity)
  • SKIPPED_FACT: Subject 'delta1-pyrroline-5-carboxylate synthetase (NADP+) activity [GO:0017084] (molecular_function)' has 'has output' relationship to 'ADP(3-) [CHEBI:456216] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'delta1-pyrroline-5-carboxylate synthetase (NADP+) activity [GO:0017084] (molecular_function)' has 'has output' relationship to 'NADP(3-) [CHEBI:58349] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutaminase activity [GO:0004359] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutaminase activity [GO:0004359] (molecular_function) —has output→ L-glutamate(1-) [CHEBI:29985] (chemical entity)
  • SKIPPED_FACT: Subject 'glutaminase activity [GO:0004359] (molecular_function)' has 'has output' relationship to 'L-glutamate(1-) [CHEBI:29985] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutaminase activity [GO:0004359] (molecular_function) —has output→ ammonium [CHEBI:28938] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutaminase activity [GO:0004359] (molecular_function) —part of→ obsolete L-amino acid metabolic process [GO:0170033] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: delta1-pyrroline-5-carboxylate synthetase (NADP+) activity [GO:0017084] (molecular_function) —part of→ obsolete L-amino acid metabolic process [GO:0170033] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutaminase activity [GO:0004359] (molecular_function) —has input→ L-glutamine zwitterion [CHEBI:58359] (chemical entity)
  • SKIPPED_FACT: Subject 'delta1-pyrroline-5-carboxylate synthetase (NADP+) activity [GO:0017084] (molecular_function)' has 'has output' relationship to 'hydrogenphosphate [CHEBI:43474] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: delta1-pyrroline-5-carboxylate synthetase (NADP+) activity [GO:0017084] (molecular_function) —has output→ hydrogenphosphate [CHEBI:43474] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutaminase activity [GO:0004359] (molecular_function) —occurs in→ mitochondrial matrix [GO:0005759] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: delta1-pyrroline-5-carboxylate synthetase (NADP+) activity [GO:0017084] (molecular_function) —causally upstream of→ pyrroline-5-carboxylate reductase activity [GO:0004735] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: delta1-pyrroline-5-carboxylate synthetase (NADP+) activity [GO:0017084] (molecular_function) —has output→ ADP(3-) [CHEBI:456216] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: delta1-pyrroline-5-carboxylate synthetase (NADP+) activity [GO:0017084] (molecular_function) —has input→ L-glutamate(1-) [CHEBI:29985] (chemical entity)
  • SKIPPED_FACT: Subject 'delta1-pyrroline-5-carboxylate synthetase (NADP+) activity [GO:0017084] (molecular_function)' has 'has output' relationship to 'L-glutamic 5-semialdehyde zwitterion [CHEBI:58066] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: delta1-pyrroline-5-carboxylate synthetase (NADP+) activity [GO:0017084] (molecular_function) —has input→ NADPH(4-) [CHEBI:57783] (chemical entity)
  • SKIPPED_FACT: Subject 'glutaminase activity [GO:0004359] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-174403
 Glutathione synthesis and recycling - imported from: Reactome 2026-07-02 Curators at Reactome success
12 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function) —has output→ L-glutamate(1-) [CHEBI:29985] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function) —has output→ L-cysteinylglycine zwitterion [CHEBI:61694] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity)
  • SKIPPED_FACT: Subject 'glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function)' has 'has output' relationship to 'L-glutamate(1-) [CHEBI:29985] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione synthase activity [GO:0004363] (molecular_function) —causally upstream of→ glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function)
  • SKIPPED_FACT: Subject 'glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function)' has 'has output' relationship to 'L-cysteinylglycine zwitterion [CHEBI:61694] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function) —causally upstream of→ carboxypeptidase activity [GO:0004180] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function) —part of→ glutathione metabolic process [GO:0006749] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function) —has input→ glutathione [CHEBI:16856] (chemical entity)
  • SKIPPED_FACT: Subject 'glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function)' has 'has input' relationship to 'glutathione [CHEBI:16856] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-6814848
 Glycerophospholipid catabolism - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-6783984
 Glycine degradation - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-70221
 Glycogen breakdown (glycogenolysis) - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
12 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphorylase kinase activity [GO:0004689] (molecular_function) —causally upstream of→ glycogen phosphorylase activity [GO:0008184] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: amylo-alpha-1,6-glucosidase activity [GO:0004135] (molecular_function) —causally upstream of→ glycogen phosphorylase activity [GO:0008184] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glycogen phosphorylase activity [GO:0008184] (molecular_function) —has input→ hydrogenphosphate [CHEBI:43474] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glycogen phosphorylase activity [GO:0008184] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glycogen phosphorylase activity [GO:0008184] (molecular_function) —has output→ alpha-D-glucose 1-phosphate(2-) [CHEBI:58601] (chemical entity)
  • SKIPPED_FACT: Subject 'glycogen phosphorylase activity [GO:0008184] (molecular_function)' has 'has input' relationship to 'hydrogenphosphate [CHEBI:43474] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glycogen phosphorylase activity [GO:0008184] (molecular_function) —part of→ glycogen catabolic process [GO:0005980] (biological_process)
  • SKIPPED_FACT: Subject 'glycogen phosphorylase activity [GO:0008184] (molecular_function)' has 'has output' relationship to 'alpha-D-glucose 1-phosphate(2-) [CHEBI:58601] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: AMP binding [GO:0016208] (molecular_function) —causally upstream of→ glycogen phosphorylase activity [GO:0008184] (molecular_function)
  • SKIPPED_FACT: Subject 'glycogen phosphorylase activity [GO:0008184] (molecular_function)' has 'has input' relationship to 'hydrogenphosphate [CHEBI:43474] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'glycogen phosphorylase activity [GO:0008184] (molecular_function)' has 'has output' relationship to 'alpha-D-glucose 1-phosphate(2-) [CHEBI:58601] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glycogen phosphorylase activity [GO:0008184] (molecular_function) —causally upstream of→ 4-alpha-glucanotransferase activity [GO:0004134] (molecular_function) 
R-HSA-3322077
 Glycogen synthesis - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-70171
 Glycolysis - imported from: Reactome 2026-07-02 Curators at Reactome success
5 warnings
  • SKIPPED_FACT: 'glucose-1,6-bisphosphate synthase activity [GO:0047933] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'glucose 6-phosphate metabolic process [GO:0051156] (biological_process)'
  • SKIPPED_FACT: 'glucosamine-6-phosphate deaminase activity [GO:0004342] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'canonical glycolysis [GO:0061621] (biological_process)'
  • SKIPPED_FACT: 'ADP-specific glucokinase activity [GO:0043843] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'canonical glycolysis [GO:0061621] (biological_process)'
  • SKIPPED_FACT: 'glucosamine-6-phosphate deaminase activity [GO:0004342] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'canonical glycolysis [GO:0061621] (biological_process)'
  • SKIPPED_FACT: 'bisphosphoglycerate mutase activity [GO:0004082] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'canonical glycolysis [GO:0061621] (biological_process)' 
R-HSA-1971475
 Glycosaminoglycan-protein linkage region biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success
12 warnings
  • SKIPPED_FACT: Subject 'galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018] (molecular_function)' has 'has output' relationship to 'UDP(3-) [CHEBI:58223] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018] (molecular_function) —occurs in→ Golgi membrane [GO:0000139] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018] (molecular_function) —has output→ UDP(3-) [CHEBI:58223] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018] (molecular_function) —provides input for→ phosphotransferase activity, alcohol group as acceptor [GO:0016773] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • SKIPPED_FACT: 'phosphatase activity [GO:0016791] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'positive regulation of proteoglycan biosynthetic process [GO:1902730] (biological_process)'
  • SKIPPED_FACT: 'phosphotransferase activity, alcohol group as acceptor [GO:0016773] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'negative regulation of proteoglycan biosynthetic process [GO:1902729] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018] (molecular_function) —has input→ UDP-alpha-D-glucuronate(3-) [CHEBI:58052] (chemical entity)
  • SKIPPED_FACT: Subject 'galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018] (molecular_function)' has 'has input' relationship to 'UDP-alpha-D-glucuronate(3-) [CHEBI:58052] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018] (molecular_function) —part of→ glycosaminoglycan-protein linkage region biosynthetic process [GO:0120532] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: galactosylxylosylprotein 3-beta-galactosyltransferase activity [GO:0047220] (molecular_function) —provides input for→ galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018] (molecular_function) 
R-HSA-9840309
 Glycosphingolipid biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
13 warnings
  • SKIPPED_FACT: Subject 'UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489] (molecular_function)' has 'has output' relationship to 'UDP(3-) [CHEBI:58223] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489] (molecular_function) —causally upstream of→ galactosylceramide sulfotransferase activity [GO:0001733] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489] (molecular_function) —has output→ beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-acylsphingosine [CHEBI:17950] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489] (molecular_function) —has output→ UDP(3-) [CHEBI:58223] (chemical entity)
  • SKIPPED_FACT: Subject 'UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489] (molecular_function)' has 'has output' relationship to 'beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-acylsphingosine [CHEBI:17950] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489] (molecular_function)' has 'has input' relationship to 'beta-D-glucosyl-N-acylsphingosine [CHEBI:22801] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489] (molecular_function) —has input→ beta-D-glucosyl-N-acylsphingosine [CHEBI:22801] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489] (molecular_function) —occurs in→ Golgi membrane [GO:0000139] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489] (molecular_function) —part of→ glycosphingolipid biosynthetic process [GO:0006688] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489] (molecular_function) —has input→ UDP-alpha-D-galactose(2-) [CHEBI:66914] (chemical entity)
  • SKIPPED_FACT: Subject 'UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489] (molecular_function)' has 'has input' relationship to 'UDP-alpha-D-galactose(2-) [CHEBI:66914] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-9840310
 Glycosphingolipid catabolism - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
22 warnings
  • SKIPPED_FACT: Subject 'beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function)' has 'has output' relationship to 'beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide(1-) [CHEBI:90163] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function)' has 'has output' relationship to 'N-acetyl-D-galactosamine [CHEBI:28037] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function) —part of→ glycosphingolipid catabolic process [GO:0046479] (biological_process)
  • SKIPPED_FACT: Subject 'beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function)' has 'has small molecule activator' relationship to '(S,S)-bis-(3-oleoylglycero)-1-phosphate(1-) [CHEBI:139150] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function) —causally upstream of→ beta-galactosidase activity [GO:0004565] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function) —provides input for→ sphingolipid activator protein activity [GO:0030290] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function) —has output→ beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide(1-) [CHEBI:90163] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-galactosidase activity [GO:0004565] (molecular_function) —provides input for→ beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function) —directly positively regulates→ sphingolipid activator protein activity [GO:0030290] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function) —has output→ N-acetyl-D-galactosamine [CHEBI:28037] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function) —has small molecule activator→ (S,S)-bis-(3-oleoylglycero)-1-phosphate(1-) [CHEBI:139150] (chemical entity)
  • SKIPPED_FACT: Subject 'beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function)' has 'has output' relationship to 'N-acetyl-D-galactosamine [CHEBI:28037] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: sphingolipid activator protein activity [GO:0030290] (molecular_function) —causally upstream of→ beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function)
  • SKIPPED_FACT: Subject 'beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function)' has 'has output' relationship to 'GM2A Hsap [UniProtKB:P17900] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function) —provides input for→ alpha-galactosidase activity [GO:0004557] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function) —occurs in→ lysosomal lumen [GO:0043202] (anatomical entity)
  • SKIPPED_FACT: Subject 'beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function)' has 'has output' relationship to 'N-acetyl-D-galactosamine [CHEBI:28037] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-N-acetylhexosaminidase activity [GO:0004563] (molecular_function) —has output→ GM2A Hsap [UniProtKB:P17900] (information biomacromolecule) 
R-HSA-389661
 Glyoxylate metabolism and glycine degradation - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
23 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane transporter activity [GO:0022857] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane transporter activity [GO:0022857] (molecular_function) —has output→ glyoxylate [CHEBI:36655] (chemical entity)
  • SKIPPED_FACT: 'proline dehydrogenase activity [GO:0004657] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'glyoxylate metabolic process [GO:0046487] (biological_process)'
  • SKIPPED_FACT: 'L-alanine:glyoxylate transaminase activity [GO:0008453] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'carboxylic acid metabolic process [GO:0019752] (biological_process)'
  • SKIPPED_FACT: Subject 'transmembrane transporter activity [GO:0022857] (molecular_function)' has 'has output' relationship to 'glyoxylate [CHEBI:36655] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-hydroxyproline transmembrane transporter activity [GO:0034590] (molecular_function) —occurs in→ mitochondrial inner membrane [GO:0005743] (anatomical entity)
  • SKIPPED_FACT: Subject 'transmembrane transporter activity [GO:0022857] (molecular_function)' has 'has input' relationship to 'glyoxylate [CHEBI:36655] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane transporter activity [GO:0022857] (molecular_function) —occurs in→ peroxisomal membrane [GO:0005778] (anatomical entity)
  • SKIPPED_FACT: 'L-glutamate gamma-semialdehyde dehydrogenase (NAD+) activity [GO:0003842] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'glyoxylate metabolic process [GO:0046487] (biological_process)'
  • SKIPPED_FACT: Subject 'L-hydroxyproline transmembrane transporter activity [GO:0034590] (molecular_function)' has 'has input' relationship to 'trans-4-hydroxy-L-proline zwitterion [CHEBI:58375] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: '(4S)-4-hydroxy-L-glutamate:2-oxoglutarate transaminase activity [GO:0047578] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'glyoxylate metabolic process [GO:0046487] (biological_process)'
  • SKIPPED_FACT: 'channel activity [GO:0015267] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'carboxylic acid metabolic process [GO:0019752] (biological_process)'
  • SKIPPED_FACT: Subject 'transmembrane transporter activity [GO:0022857] (molecular_function)' has 'has output' relationship to 'glyoxylate [CHEBI:36655] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'transmembrane transporter activity [GO:0022857] (molecular_function)' has 'has input' relationship to 'glyoxylate [CHEBI:36655] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'L-hydroxyproline transmembrane transporter activity [GO:0034590] (molecular_function)' has 'has output' relationship to 'trans-4-hydroxy-L-proline zwitterion [CHEBI:58375] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-hydroxyproline transmembrane transporter activity [GO:0034590] (molecular_function) —has input→ trans-4-hydroxy-L-proline zwitterion [CHEBI:58375] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane transporter activity [GO:0022857] (molecular_function) —part of→ monocarboxylic acid transport [GO:0015718] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-hydroxyproline transmembrane transporter activity [GO:0034590] (molecular_function) —has output→ trans-4-hydroxy-L-proline zwitterion [CHEBI:58375] (chemical entity)
  • SKIPPED_FACT: '(R,S)-4-hydroxy-2-oxoglutarate aldolase activity [GO:0008700] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'carboxylic acid metabolic process [GO:0019752] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane transporter activity [GO:0022857] (molecular_function) —part of→ carboxylic acid metabolic process [GO:0019752] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane transporter activity [GO:0022857] (molecular_function) —has input→ glyoxylate [CHEBI:36655] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-hydroxyproline transmembrane transporter activity [GO:0034590] (molecular_function) —part of→ carboxylic acid metabolic process [GO:0019752] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-hydroxyproline transmembrane transporter activity [GO:0034590] (molecular_function) —part of→ hydroxyproline transport [GO:0034589] (biological_process) 
R-HSA-189451
 Heme biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
17 warnings
  • SKIPPED_FACT: Subject '5-aminolevulinate synthase activity [GO:0003870] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 5-aminolevulinate synthase activity [GO:0003870] (molecular_function) —has output→ carbon dioxide [CHEBI:16526] (chemical entity)
  • SKIPPED_FACT: Subject '5-aminolevulinate synthase activity [GO:0003870] (molecular_function)' has 'has output' relationship to 'carbon dioxide [CHEBI:16526] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject '5-aminolevulinate synthase activity [GO:0003870] (molecular_function)' has 'has small molecule inhibitor' relationship to 'ferroheme b(2-) [CHEBI:60344] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 5-aminolevulinate synthase activity [GO:0003870] (molecular_function) —causally upstream of→ porphobilinogen synthase activity [GO:0004655] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 5-aminolevulinate synthase activity [GO:0003870] (molecular_function) —has input→ succinyl-CoA(5-) [CHEBI:57292] (chemical entity)
  • SKIPPED_FACT: Subject '5-aminolevulinate synthase activity [GO:0003870] (molecular_function)' has 'has output' relationship to '5-ammoniolevulinate [CHEBI:356416] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject '5-aminolevulinate synthase activity [GO:0003870] (molecular_function)' has 'has output' relationship to 'coenzyme A(4-) [CHEBI:57287] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 5-aminolevulinate synthase activity [GO:0003870] (molecular_function) —part of→ heme biosynthetic process [GO:0006783] (biological_process)
  • SKIPPED_FACT: Subject '5-aminolevulinate synthase activity [GO:0003870] (molecular_function)' has 'has input' relationship to 'succinyl-CoA(5-) [CHEBI:57292] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject '5-aminolevulinate synthase activity [GO:0003870] (molecular_function)' has 'has input' relationship to 'glycine zwitterion [CHEBI:57305] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 5-aminolevulinate synthase activity [GO:0003870] (molecular_function) —has input→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 5-aminolevulinate synthase activity [GO:0003870] (molecular_function) —has input→ glycine zwitterion [CHEBI:57305] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 5-aminolevulinate synthase activity [GO:0003870] (molecular_function) —occurs in→ mitochondrial matrix [GO:0005759] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 5-aminolevulinate synthase activity [GO:0003870] (molecular_function) —has output→ coenzyme A(4-) [CHEBI:57287] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 5-aminolevulinate synthase activity [GO:0003870] (molecular_function) —has small molecule inhibitor→ ferroheme b(2-) [CHEBI:60344] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 5-aminolevulinate synthase activity [GO:0003870] (molecular_function) —has output→ 5-ammoniolevulinate [CHEBI:356416] (chemical entity) 
R-HSA-189483
 Heme degradation - imported from: Reactome 2026-07-02 Curators at Reactome success
31 warnings
  • SKIPPED_FACT: 'glucuronosyltransferase activity [GO:0015020] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bilirubin conjugation [GO:0006789] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628] (molecular_function) —has output→ chemical entity [CHEBI:24431] (chemical entity)
  • SKIPPED_FACT: Subject 'oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628] (molecular_function)' has 'has input' relationship to 'chemical entity [CHEBI:24431] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627] (molecular_function) —has output→ urobilin [CHEBI:36378] (chemical entity)
  • SKIPPED_FACT: Subject 'oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627] (molecular_function)' has 'has output' relationship to 'urobilin [CHEBI:36378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628] (molecular_function) —has input→ D-Urobilinogen [CHEBI:4260] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: secondary active transmembrane transporter activity [GO:0015291] (molecular_function) —part of→ heme catabolic process [GO:0042167] (biological_process)
  • SKIPPED_FACT: Subject 'oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628] (molecular_function)' has 'has input' relationship to 'bilirubin(2-) [CHEBI:57977] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628] (molecular_function)' has 'has input' relationship to 'D-Urobilinogen [CHEBI:4260] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627] (molecular_function) —has input→ chemical entity [CHEBI:24431] (chemical entity)
  • SKIPPED_FACT: Subject 'oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627] (molecular_function)' has 'has input' relationship to 'chemical entity [CHEBI:24431] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628] (molecular_function) —has output→ stercobilin [CHEBI:26756] (chemical entity)
  • SKIPPED_FACT: Subject 'oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627] (molecular_function)' has 'has input' relationship to 'D-Urobilinogen [CHEBI:4260] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628] (molecular_function) —has input→ bilirubin(2-) [CHEBI:57977] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627] (molecular_function) —part of→ heme catabolic process [GO:0042167] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627] (molecular_function) —has input→ D-Urobilinogen [CHEBI:4260] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glucuronosyltransferase activity [GO:0015020] (molecular_function) —causally upstream of→ secondary active transmembrane transporter activity [GO:0015291] (molecular_function)
  • SKIPPED_FACT: Subject 'oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627] (molecular_function)' has 'has output' relationship to 'chemical entity [CHEBI:24431] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628] (molecular_function)' has 'has output' relationship to 'stercobilin [CHEBI:26756] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: 'glucuronosyltransferase activity [GO:0015020] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heme catabolic process [GO:0042167] (biological_process)'
  • SKIPPED_FACT: Subject 'oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628] (molecular_function)' has 'has output' relationship to 'chemical entity [CHEBI:24431] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627] (molecular_function) —has output→ chemical entity [CHEBI:24431] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627] (molecular_function) —occurs in→ extracellular region [GO:0005576] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: secondary active transmembrane transporter activity [GO:0015291] (molecular_function) —occurs in→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628] (molecular_function) —part of→ heme catabolic process [GO:0042167] (biological_process)
  • SKIPPED_FACT: Subject 'oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628] (molecular_function)' has 'has input' relationship to 'chemical entity [CHEBI:24431] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628] (molecular_function)' has 'has output' relationship to 'chemical entity [CHEBI:24431] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628] (molecular_function)' has 'has output' relationship to 'D-Urobilinogen [CHEBI:4260] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628] (molecular_function) —occurs in→ extracellular region [GO:0005576] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628] (molecular_function) —has output→ D-Urobilinogen [CHEBI:4260] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628] (molecular_function) —has input→ chemical entity [CHEBI:24431] (chemical entity) 
R-HSA-70921
 Histidine catabolism - imported from: Reactome 2026-07-02 Curators at Reactome success
11 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • SKIPPED_FACT: 'histidine decarboxylase activity [GO:0004398] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'histamine biosynthetic process [GO:0001694] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function)' has 'has input' relationship to '1-methylimidazole-4-acetaldehyde [CHEBI:28104] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function) —has input→ 1-methylimidazole-4-acetaldehyde [CHEBI:28104] (chemical entity)
  • SKIPPED_FACT: Subject 'aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function)' has 'has output' relationship to '1-methyl-4-imidazoleacetate [CHEBI:132918] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function) —has output→ 1-methyl-4-imidazoleacetate [CHEBI:132918] (chemical entity)
  • SKIPPED_FACT: Subject 'aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function) —part of→ L-histidine catabolic process [GO:0006548] (biological_process) 
R-HSA-2022928
 HS-GAG biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success
34 warnings
  • SKIPPED_FACT: 'N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity [GO:0050509] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • SKIPPED_FACT: 'nucleotide-sugar transmembrane transporter activity [GO:0005338] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'nucleotide-sugar transmembrane transport [GO:0015780] (biological_process)'
  • SKIPPED_FACT: '[heparan sulfate]-glucosamine 3-sulfotransferase activity [GO:0008467] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • SKIPPED_FACT: 'N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity [GO:0050509] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0001888] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • SKIPPED_FACT: '[heparan sulfate]-glucosamine 3-sulfotransferase activity [GO:0008467] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • SKIPPED_FACT: 'heparosan-N-sulfate-glucuronate 5-epimerase activity [GO:0047464] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • SKIPPED_FACT: 'heparan sulfate 2-sulfotransferase activity [GO:0004394] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0001888] (molecular_function) —part of→ heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)
  • SKIPPED_FACT: '[heparan sulfate]-glucosamine 3-sulfotransferase activity [GO:0008467] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • SKIPPED_FACT: 'heparan sulfate 6-sulfotransferase activity [GO:0017095] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0001888] (molecular_function) —has output→ UDP(3-) [CHEBI:58223] (chemical entity)
  • SKIPPED_FACT: 'glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0050508] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • SKIPPED_FACT: 'heparosan-N-sulfate-glucuronate 5-epimerase activity [GO:0047464] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • SKIPPED_FACT: '[heparan sulfate]-glucosamine 3-sulfotransferase activity [GO:0008467] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • SKIPPED_FACT: '[heparan sulfate]-glucosamine 3-sulfotransferase activity [GO:0008467] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • SKIPPED_FACT: 'heparan sulfate 6-sulfotransferase activity [GO:0017095] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • SKIPPED_FACT: 'N-acetylglucosamine deacetylase activity [GO:0050119] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • SKIPPED_FACT: 'heparan sulfate N-sulfotransferase activity [GO:0015016] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • SKIPPED_FACT: Subject 'glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0001888] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0001888] (molecular_function)' has 'has output' relationship to 'UDP(3-) [CHEBI:58223] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: 'heparan sulfate N-sulfotransferase activity [GO:0015016] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0001888] (molecular_function) —occurs in→ Golgi membrane [GO:0000139] (anatomical entity)
  • SKIPPED_FACT: Subject 'glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0001888] (molecular_function)' has 'has input' relationship to 'UDP-N-acetyl-alpha-D-glucosamine(2-) [CHEBI:57705] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: 'heparan sulfate N-sulfotransferase activity [GO:0015016] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0001888] (molecular_function) —provides input for→ N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity [GO:0050509] (molecular_function)
  • SKIPPED_FACT: 'heparan sulfate 6-sulfotransferase activity [GO:0017095] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • SKIPPED_FACT: 'N-acetylglucosamine deacetylase activity [GO:0050119] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • SKIPPED_FACT: 'N-acetylglucosamine deacetylase activity [GO:0050119] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • SKIPPED_FACT: 'N-acetylglucosamine deacetylase activity [GO:0050119] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • SKIPPED_FACT: 'heparan sulfate N-sulfotransferase activity [GO:0015016] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • SKIPPED_FACT: '[heparan sulfate]-glucosamine 3-sulfotransferase activity [GO:0008467] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0001888] (molecular_function) —has input→ UDP-N-acetyl-alpha-D-glucosamine(2-) [CHEBI:57705] (chemical entity)
  • SKIPPED_FACT: '[heparan sulfate]-glucosamine 3-sulfotransferase activity [GO:0008467] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparan sulfate proteoglycan biosynthetic process [GO:0015012] (biological_process)' 
R-HSA-2024096
 HS-GAG degradation - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
20 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] (molecular_function) —has output→ alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl(1-) [CHEBI:747401] (chemical entity)
  • SKIPPED_FACT: Subject 'heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] (molecular_function)' has 'has output' relationship to 'coenzyme A(4-) [CHEBI:57287] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] (molecular_function)' has 'has input' relationship to 'acetyl-CoA(4-) [CHEBI:57288] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] (molecular_function) —part of→ heparan sulfate proteoglycan catabolic process [GO:0030200] (biological_process)
  • SKIPPED_FACT: Subject 'heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] (molecular_function)' has 'has input' relationship to 'alpha-D-GlcN-(1->4)-beta-D-IdoA2S-(1->4)-alpha-D-GlcNS3S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group [CHEBI:63806] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • SKIPPED_FACT: 'cysteine-type endopeptidase activity [GO:0004197] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'zymogen activation [GO:0031638] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] (molecular_function) —has input→ alpha-D-GlcN-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group [CHEBI:63811] (chemical entity)
  • SKIPPED_FACT: Subject 'heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] (molecular_function)' has 'has input' relationship to 'alpha-D-GlcN-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group [CHEBI:63811] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] (molecular_function) —occurs in→ lysosomal membrane [GO:0005765] (anatomical entity)
  • SKIPPED_FACT: Subject 'heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] (molecular_function)' has 'has output' relationship to 'alpha-D-GlcNAc-(1->4)-beta-D-IdoA2S-(1->4)-alpha-D-GlcNS3S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group [CHEBI:63807] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] (molecular_function)' has 'has output' relationship to 'coenzyme A(4-) [CHEBI:57287] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] (molecular_function) —has input→ acetyl-CoA(4-) [CHEBI:57288] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] (molecular_function) —has output→ alpha-D-GlcNAc-(1->4)-beta-D-IdoA2S-(1->4)-alpha-D-GlcNS3S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group [CHEBI:63807] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] (molecular_function) —has input→ alpha-D-GlcN-(1->4)-beta-D-IdoA2S-(1->4)-alpha-D-GlcNS3S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group [CHEBI:63806] (chemical entity)
  • SKIPPED_FACT: Subject 'heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] (molecular_function)' has 'has input' relationship to 'acetyl-CoA(4-) [CHEBI:57288] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] (molecular_function)' has 'has output' relationship to 'alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl(1-) [CHEBI:747401] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] (molecular_function) —has output→ coenzyme A(4-) [CHEBI:57287] (chemical entity) 
R-HSA-2160916
 Hyaluronan degradation - imported from: Reactome 2026-07-02 Curators at Reactome success
2 warnings
  • SKIPPED_FACT: 'glucuronate transmembrane transporter activity [GO:0015135] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'hyaluronan catabolic process [GO:0030214] (biological_process)'
  • SKIPPED_FACT: 'hyalurononglucosaminidase activity [GO:0004415] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'hyaluronan catabolic process [GO:0030214] (biological_process)' 
R-HSA-2142845
 Hyaluronan metabolism - imported from: Reactome 2026-07-02 Curators at Reactome success
8 warnings
  • SKIPPED_FACT: 'cargo receptor activity [GO:0038024] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'hyaluronan metabolic process [GO:0030212] (biological_process)'
  • SKIPPED_FACT: 'cargo receptor activity [GO:0038024] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'carbohydrate derivative transport [GO:1901264] (biological_process)'
  • SKIPPED_FACT: 'hyaluronan synthase activity [GO:0050501] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'hyaluronan biosynthetic process [GO:0030213] (biological_process)'
  • SKIPPED_FACT: 'hyaluronan synthase activity [GO:0050501] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'hyaluronan biosynthetic process [GO:0030213] (biological_process)'
  • SKIPPED_FACT: 'cargo receptor activity [GO:0038024] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'hyaluronan metabolic process [GO:0030212] (biological_process)'
  • SKIPPED_FACT: 'cargo receptor activity [GO:0038024] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'hyaluronan metabolic process [GO:0030212] (biological_process)'
  • SKIPPED_FACT: 'transmembrane transporter activity [GO:0022857] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'carbohydrate derivative transport [GO:1901264] (biological_process)'
  • SKIPPED_FACT: 'hyaluronan synthase activity [GO:0050501] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'hyaluronan metabolic process [GO:0030212] (biological_process)' 
R-HSA-1483115
 Hydrolysis of LPC - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-1483152
 Hydrolysis of LPE - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-163754
 Insulin effects increased synthesis of Xylulose-5-Phosphate - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-880009
 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-499943
 Interconversion of nucleotide di- and triphosphates - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
12 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleoside diphosphate kinase activity [GO:0004550] (molecular_function) —has output→ ATP(4-) [CHEBI:30616] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleoside monophosphate kinase activity [GO:0050145] (molecular_function) —causally upstream of→ nucleoside diphosphate kinase activity [GO:0004550] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleoside diphosphate kinase activity [GO:0004550] (molecular_function) —has input→ ADP(3-) [CHEBI:456216] (chemical entity)
  • SKIPPED_FACT: Subject 'nucleoside diphosphate kinase activity [GO:0004550] (molecular_function)' has 'has output' relationship to 'ATP(4-) [CHEBI:30616] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleoside diphosphate kinase activity [GO:0004550] (molecular_function) —part of→ nucleobase-containing small molecule interconversion [GO:0015949] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleoside diphosphate kinase activity [GO:0004550] (molecular_function) —has output→ ADP(3-) [CHEBI:456216] (chemical entity)
  • SKIPPED_FACT: Subject 'nucleoside diphosphate kinase activity [GO:0004550] (molecular_function)' has 'has output' relationship to 'ADP(3-) [CHEBI:456216] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: GMP kinase activity [GO:0004385] (molecular_function) —causally upstream of→ nucleoside diphosphate kinase activity [GO:0004550] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleoside diphosphate kinase activity [GO:0004550] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'nucleoside diphosphate kinase activity [GO:0004550] (molecular_function)' has 'has input' relationship to 'ADP(3-) [CHEBI:456216] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleoside diphosphate kinase activity [GO:0004550] (molecular_function) —has input→ ATP(4-) [CHEBI:30616] (chemical entity)
  • SKIPPED_FACT: Subject 'nucleoside diphosphate kinase activity [GO:0004550] (molecular_function)' has 'has input' relationship to 'ATP(4-) [CHEBI:30616] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-351200
 Interconversion of polyamines - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-434313
 Intracellular metabolism of fatty acids regulates insulin secretion - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-2022854
 Keratan sulfate biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success
19 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831] (molecular_function) —provides input for→ beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831] (molecular_function) —provides input for→ beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836] (molecular_function)
  • SKIPPED_FACT: Subject 'beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831] (molecular_function)' has 'has input' relationship to 'UDP-alpha-D-galactose(2-) [CHEBI:66914] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532] (molecular_function) —provides input for→ beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831] (molecular_function)
  • SKIPPED_FACT: Subject 'beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831] (molecular_function)' has 'has input' relationship to 'UDP-alpha-D-galactose(2-) [CHEBI:66914] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831] (molecular_function) —has output→ UDP(3-) [CHEBI:58223] (chemical entity)
  • SKIPPED_FACT: Subject 'beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831] (molecular_function)' has 'has input' relationship to 'UDP-alpha-D-galactose(2-) [CHEBI:66914] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831] (molecular_function) —part of→ keratan sulfate proteoglycan biosynthetic process [GO:0018146] (biological_process)
  • SKIPPED_FACT: Subject 'beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831] (molecular_function)' has 'has output' relationship to 'UDP(3-) [CHEBI:58223] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: 'nucleotide-sugar transmembrane transporter activity [GO:0005338] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'keratan sulfate proteoglycan biosynthetic process [GO:0018146] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831] (molecular_function) —occurs in→ Golgi membrane [GO:0000139] (anatomical entity)
  • SKIPPED_FACT: Subject 'beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831] (molecular_function)' has 'has output' relationship to 'UDP(3-) [CHEBI:58223] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831] (molecular_function) —provides input for→ N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532] (molecular_function)
  • SKIPPED_FACT: Subject 'beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831] (molecular_function)' has 'has output' relationship to 'UDP(3-) [CHEBI:58223] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831] (molecular_function) —has input→ UDP-alpha-D-galactose(2-) [CHEBI:66914] (chemical entity) 
R-HSA-2022857
 Keratan sulfate degradation - imported from: Reactome 2026-07-02 Curators at Reactome success
6 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-galactosidase activity [GO:0004565] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-galactosidase activity [GO:0004565] (molecular_function) —has output→ beta-D-Galp6S-(1->4)-beta-D-GlcpNAc6S-(1->3)-beta-D-Galp-(1->4)-beta-D-GlcpNAc6S-(1->3)-D-Galp [CHEBI:63846] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-galactosidase activity [GO:0004565] (molecular_function) —occurs in→ lysosomal lumen [GO:0043202] (anatomical entity)
  • SKIPPED_FACT: Subject 'beta-galactosidase activity [GO:0004565] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'beta-galactosidase activity [GO:0004565] (molecular_function)' has 'has output' relationship to 'beta-D-Galp6S-(1->4)-beta-D-GlcpNAc6S-(1->3)-beta-D-Galp-(1->4)-beta-D-GlcpNAc6S-(1->3)-D-Galp [CHEBI:63846] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-galactosidase activity [GO:0004565] (molecular_function) —part of→ keratan sulfate proteoglycan catabolic process [GO:0042340] (biological_process) 
R-HSA-5653890
 Lactose synthesis - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-9969896
 Lanosterol biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-9037629
 Lewis blood group biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-2046105
 Linoleic acid (LA) metabolism - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-71064
 Lysine catabolism - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-8853383
 Lysosomal oligosaccharide catabolism - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-9856872
 Malate-aspartate shuttle - imported from: Reactome 2026-07-02 Curators at Reactome success
14 warnings
  • SKIPPED_FACT: Subject 'acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function)' has 'has output' relationship to 'L-aspartate(1-) [CHEBI:29991] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function)' has 'has input' relationship to 'L-glutamate(1-) [CHEBI:29985] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function) —has input→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function) —has output→ L-aspartate(1-) [CHEBI:29991] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function) —has input→ L-glutamate(1-) [CHEBI:29985] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function) —has output→ L-glutamate(1-) [CHEBI:29985] (chemical entity)
  • SKIPPED_FACT: Subject 'acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function)' has 'has output' relationship to 'L-glutamate(1-) [CHEBI:29985] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function) —occurs in→ mitochondrial inner membrane [GO:0005743] (anatomical entity)
  • SKIPPED_FACT: Subject 'acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function) —has input→ L-aspartate(1-) [CHEBI:29991] (chemical entity)
  • SKIPPED_FACT: Subject 'acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function)' has 'has input' relationship to 'L-aspartate(1-) [CHEBI:29991] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function) —part of→ malate-aspartate shuttle [GO:0043490] (biological_process)
  • SKIPPED_FACT: Subject 'acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acidic amino acid transmembrane transporter activity [GO:0015172] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity) 
R-HSA-9854311
 Maturation of TCA enzymes and regulation of TCA cycle - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-5662702
 Melanin biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-196757
 Metabolism of folate and pterines - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-2408550
 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
17 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3'-phosphoadenylylselenate reductase activity [GO:0098624] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject '3'-phosphoadenylylselenate reductase activity [GO:0098624] (molecular_function)' has 'has input' relationship to '3'-phosphoadenylyl selenate [CHEBI:28450] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3'-phosphoadenylylselenate reductase activity [GO:0098624] (molecular_function) —has output→ NADP(3-) [CHEBI:58349] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3'-phosphoadenylylselenate reductase activity [GO:0098624] (molecular_function) —has output→ adenosine 3',5'-bismonophosphate(4-) [CHEBI:58343] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3'-phosphoadenylylselenate reductase activity [GO:0098624] (molecular_function) —has input→ 3'-phosphoadenylyl selenate [CHEBI:28450] (chemical entity)
  • SKIPPED_FACT: Subject '3'-phosphoadenylylselenate reductase activity [GO:0098624] (molecular_function)' has 'has output' relationship to 'selenite(2-) [CHEBI:18212] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3'-phosphoadenylylselenate reductase activity [GO:0098624] (molecular_function) —has output→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3'-phosphoadenylylselenate reductase activity [GO:0098624] (molecular_function) —causally upstream of→ selenodiglutathione-disulfide reductase (NADPH) activity [GO:0098622] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3'-phosphoadenylylselenate reductase activity [GO:0098624] (molecular_function) —has output→ selenite(2-) [CHEBI:18212] (chemical entity)
  • SKIPPED_FACT: Subject '3'-phosphoadenylylselenate reductase activity [GO:0098624] (molecular_function)' has 'has input' relationship to 'NADPH(4-) [CHEBI:57783] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject '3'-phosphoadenylylselenate reductase activity [GO:0098624] (molecular_function)' has 'has output' relationship to 'NADP(3-) [CHEBI:58349] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject '3'-phosphoadenylylselenate reductase activity [GO:0098624] (molecular_function)' has 'has output' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3'-phosphoadenylylselenate reductase activity [GO:0098624] (molecular_function) —part of→ selenium compound metabolic process [GO:0001887] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3'-phosphoadenylylselenate reductase activity [GO:0098624] (molecular_function) —has input→ NADPH(4-) [CHEBI:57783] (chemical entity)
  • SKIPPED_FACT: Subject '3'-phosphoadenylylselenate reductase activity [GO:0098624] (molecular_function)' has 'has output' relationship to 'adenosine 3',5'-bismonophosphate(4-) [CHEBI:58343] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject '3'-phosphoadenylylselenate reductase activity [GO:0098624] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3'-phosphoadenylylselenate reductase activity [GO:0098624] (molecular_function) —has input→ hydron [CHEBI:15378] (chemical entity) 
R-HSA-5263617
 Metabolism of ingested MeSeO2H into MeSeH - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-2408508
 Metabolism of ingested SeMet, Sec, MeSec into H2Se - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
34 warnings
  • SKIPPED_FACT: Subject 'selenomethionine adenosyltransferase activity [GO:0098601] (molecular_function)' has 'has input' relationship to 'ATP(4-) [CHEBI:30616] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: selenomethionine adenosyltransferase activity [GO:0098601] (molecular_function) —has input→ L-selenomethionine zwitterion [CHEBI:62621] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: selenomethionine adenosyltransferase activity [GO:0098601] (molecular_function) —part of→ selenium compound metabolic process [GO:0001887] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: selenomethionine adenosyltransferase activity [GO:0098601] (molecular_function) —has output→ hydrogenphosphate [CHEBI:43474] (chemical entity)
  • SKIPPED_FACT: Subject 'selenomethionine adenosyltransferase activity [GO:0098601] (molecular_function)' has 'has output' relationship to 'L-adenosylselenomethionine zwitterion [CHEBI:62227] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrogen selenide methyltransferase activity [GO:0098614] (molecular_function) —has input→ S-adenosyl-L-methionine zwitterion [CHEBI:59789] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: selenomethionine adenosyltransferase activity [GO:0098601] (molecular_function) —has output→ diphosphate(3-) [CHEBI:33019] (chemical entity)
  • SKIPPED_FACT: Subject 'hydrogen selenide methyltransferase activity [GO:0098614] (molecular_function)' has 'has output' relationship to 'methylselenol [CHEBI:64685] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'selenomethionine adenosyltransferase activity [GO:0098601] (molecular_function)' has 'has output' relationship to 'diphosphate(3-) [CHEBI:33019] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrogen selenide methyltransferase activity [GO:0098614] (molecular_function) —has output→ methylselenol [CHEBI:64685] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: selenomethionine adenosyltransferase activity [GO:0098601] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methylselenol demethylase activity [GO:0098608] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'methylselenol demethylase activity [GO:0098608] (molecular_function)' has 'has output' relationship to 'selanide [CHEBI:29317] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: selenomethionine adenosyltransferase activity [GO:0098601] (molecular_function) —has output→ L-adenosylselenomethionine zwitterion [CHEBI:62227] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methylselenol demethylase activity [GO:0098608] (molecular_function) —part of→ selenium compound metabolic process [GO:0001887] (biological_process)
  • SKIPPED_FACT: Subject 'methylselenol demethylase activity [GO:0098608] (molecular_function)' has 'has output' relationship to 'methanol [CHEBI:17790] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrogen selenide methyltransferase activity [GO:0098614] (molecular_function) —part of→ selenium compound metabolic process [GO:0001887] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methylselenol demethylase activity [GO:0098608] (molecular_function) —has output→ methanol [CHEBI:17790] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrogen selenide methyltransferase activity [GO:0098614] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'selenomethionine adenosyltransferase activity [GO:0098601] (molecular_function)' has 'has input' relationship to 'L-selenomethionine zwitterion [CHEBI:62621] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'selenomethionine adenosyltransferase activity [GO:0098601] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'selenomethionine adenosyltransferase activity [GO:0098601] (molecular_function)' has 'has output' relationship to 'hydrogenphosphate [CHEBI:43474] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'hydrogen selenide methyltransferase activity [GO:0098614] (molecular_function)' has 'has input' relationship to 'selanide [CHEBI:29317] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'hydrogen selenide methyltransferase activity [GO:0098614] (molecular_function)' has 'has input' relationship to 'S-adenosyl-L-methionine zwitterion [CHEBI:59789] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrogen selenide methyltransferase activity [GO:0098614] (molecular_function) —has input→ selanide [CHEBI:29317] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methylselenol demethylase activity [GO:0098608] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'methylselenol demethylase activity [GO:0098608] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: selenomethionine adenosyltransferase activity [GO:0098601] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: selenomethionine adenosyltransferase activity [GO:0098601] (molecular_function) —has input→ ATP(4-) [CHEBI:30616] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrogen selenide methyltransferase activity [GO:0098614] (molecular_function) —has output→ S-adenosyl-L-homocysteine zwitterion [CHEBI:57856] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methylselenol demethylase activity [GO:0098608] (molecular_function) —has input→ methylselenol [CHEBI:64685] (chemical entity)
  • SKIPPED_FACT: Subject 'methylselenol demethylase activity [GO:0098608] (molecular_function)' has 'has input' relationship to 'methylselenol [CHEBI:64685] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methylselenol demethylase activity [GO:0098608] (molecular_function) —has output→ selanide [CHEBI:29317] (chemical entity)
  • SKIPPED_FACT: Subject 'hydrogen selenide methyltransferase activity [GO:0098614] (molecular_function)' has 'has output' relationship to 'S-adenosyl-L-homocysteine zwitterion [CHEBI:57856] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-351202
 Metabolism of polyamines - imported from: Reactome 2026-07-02 Curators at Reactome success
10 warnings
  • SKIPPED_FACT: Subject 'aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function) —has input→ 3-acetamidopropanal [CHEBI:30322] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function) —has output→ N-acetyl-beta-alaninate [CHEBI:57857] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function) —part of→ polyamine metabolic process [GO:0006595] (biological_process)
  • SKIPPED_FACT: Subject 'aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function)' has 'has input' relationship to '3-acetamidopropanal [CHEBI:30322] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'aldehyde dehydrogenase (NAD+) activity [GO:0004029] (molecular_function)' has 'has output' relationship to 'N-acetyl-beta-alaninate [CHEBI:57857] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-1237112
 Methionine salvage pathway - imported from: Reactome 2026-07-02 Curators at Reactome success
2 warnings
  • SKIPPED_FACT: 'methylthioribulose 1-phosphate dehydratase activity [GO:0046570] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'L-methionine salvage [GO:0071267] (biological_process)'
  • SKIPPED_FACT: 'transaminase activity [GO:0008483] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'L-methionine salvage [GO:0071267] (biological_process)' 
R-HSA-156581
 Methylation - imported from: Reactome 2026-07-02 Curators at Reactome success
24 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methionine adenosyltransferase activity [GO:0004478] (molecular_function) —has output→ hydrogenphosphate [CHEBI:43474] (chemical entity)
  • SKIPPED_FACT: Subject 'methionine adenosyltransferase activity [GO:0004478] (molecular_function)' has 'has output' relationship to 'hydrogenphosphate [CHEBI:43474] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: thiol S-methyltransferase activity [GO:0018708] (molecular_function) —has output→ S-adenosyl-L-homocysteine zwitterion [CHEBI:57856] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: thiol S-methyltransferase activity [GO:0018708] (molecular_function) —has input→ S-adenosyl-L-methionine zwitterion [CHEBI:59789] (chemical entity)
  • SKIPPED_FACT: Subject 'thiol S-methyltransferase activity [GO:0018708] (molecular_function)' has 'has output' relationship to 'S-adenosyl-L-homocysteine zwitterion [CHEBI:57856] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'methionine adenosyltransferase activity [GO:0004478] (molecular_function)' has 'has input' relationship to 'ATP(4-) [CHEBI:30616] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: thiol S-methyltransferase activity [GO:0018708] (molecular_function) —has input→ mercaptoethanol [CHEBI:41218] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: thiol S-methyltransferase activity [GO:0018708] (molecular_function) —has output→ 2-methylthioethanol [CHEBI:63861] (chemical entity)
  • SKIPPED_FACT: Subject 'methionine adenosyltransferase activity [GO:0004478] (molecular_function)' has 'has input' relationship to 'L-methionine zwitterion [CHEBI:57844] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methionine adenosyltransferase activity [GO:0004478] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: thiol S-methyltransferase activity [GO:0018708] (molecular_function) —part of→ methylation [GO:0032259] (biological_process)
  • SKIPPED_FACT: Subject 'thiol S-methyltransferase activity [GO:0018708] (molecular_function)' has 'has input' relationship to 'S-adenosyl-L-methionine zwitterion [CHEBI:59789] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methionine adenosyltransferase activity [GO:0004478] (molecular_function) —has input→ L-methionine zwitterion [CHEBI:57844] (chemical entity)
  • SKIPPED_FACT: Subject 'methionine adenosyltransferase activity [GO:0004478] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'methionine adenosyltransferase activity [GO:0004478] (molecular_function)' has 'has output' relationship to 'S-adenosyl-L-methionine zwitterion [CHEBI:59789] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methionine adenosyltransferase activity [GO:0004478] (molecular_function) —has output→ S-adenosyl-L-methionine zwitterion [CHEBI:59789] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methionine adenosyltransferase activity [GO:0004478] (molecular_function) —part of→ methylation [GO:0032259] (biological_process)
  • SKIPPED_FACT: Subject 'methionine adenosyltransferase activity [GO:0004478] (molecular_function)' has 'has output' relationship to 'diphosphate(3-) [CHEBI:33019] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methionine adenosyltransferase activity [GO:0004478] (molecular_function) —has output→ diphosphate(3-) [CHEBI:33019] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methionine adenosyltransferase activity [GO:0004478] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'thiol S-methyltransferase activity [GO:0018708] (molecular_function)' has 'has input' relationship to 'mercaptoethanol [CHEBI:41218] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'thiol S-methyltransferase activity [GO:0018708] (molecular_function)' has 'has output' relationship to '2-methylthioethanol [CHEBI:63861] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: thiol S-methyltransferase activity [GO:0018708] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methionine adenosyltransferase activity [GO:0004478] (molecular_function) —has input→ ATP(4-) [CHEBI:30616] (chemical entity) 
R-HSA-2408552
 Methylation of MeSeH for excretion - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-193993
 Mineralocorticoid biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success
18 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function) —has input→ pregnenolone [CHEBI:16581] (chemical entity)
  • SKIPPED_FACT: Subject 'steroid Delta-isomerase activity [GO:0004769] (molecular_function)' has 'has input' relationship to 'pregn-5-ene-3,20-dione [CHEBI:63837] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function) —occurs in→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity)
  • SKIPPED_FACT: Subject '3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function) —has output→ pregn-5-ene-3,20-dione [CHEBI:63837] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function) —has input→ NAD(1-) [CHEBI:57540] (chemical entity)
  • SKIPPED_FACT: Subject '3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function)' has 'has output' relationship to 'pregn-5-ene-3,20-dione [CHEBI:63837] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • SKIPPED_FACT: Subject '3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function)' has 'has input' relationship to 'NAD(1-) [CHEBI:57540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid Delta-isomerase activity [GO:0004769] (molecular_function) —has input→ pregn-5-ene-3,20-dione [CHEBI:63837] (chemical entity)
  • SKIPPED_FACT: Subject '3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function)' has 'has input' relationship to 'pregnenolone [CHEBI:16581] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid Delta-isomerase activity [GO:0004769] (molecular_function) —occurs in→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function) —has output→ NADH(2-) [CHEBI:57945] (chemical entity)
  • SKIPPED_FACT: Subject '3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function)' has 'has output' relationship to 'NADH(2-) [CHEBI:57945] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid Delta-isomerase activity [GO:0004769] (molecular_function) —part of→ mineralocorticoid biosynthetic process [GO:0006705] (biological_process)
  • SKIPPED_FACT: Subject 'steroid Delta-isomerase activity [GO:0004769] (molecular_function)' has 'has output' relationship to 'progesterone [CHEBI:17026] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854] (molecular_function) —part of→ mineralocorticoid biosynthetic process [GO:0006705] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid Delta-isomerase activity [GO:0004769] (molecular_function) —has output→ progesterone [CHEBI:17026] (chemical entity) 
R-HSA-77289
 Mitochondrial Fatty Acid Beta-Oxidation - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
11 warnings
  • SKIPPED_FACT: 'fatty acyl-CoA hydrolase activity [GO:0047617] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid beta-oxidation [GO:0006635] (biological_process)'
  • SKIPPED_FACT: 'fatty acyl-CoA hydrolase activity [GO:0047617] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'acyl-CoA metabolic process [GO:0006637] (biological_process)'
  • SKIPPED_FACT: 'fatty acyl-CoA hydrolase activity [GO:0047617] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid beta-oxidation [GO:0006635] (biological_process)'
  • SKIPPED_FACT: 'fatty acyl-CoA hydrolase activity [GO:0047617] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'acyl-CoA metabolic process [GO:0006637] (biological_process)'
  • SKIPPED_FACT: 'fatty acyl-CoA hydrolase activity [GO:0047617] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid beta-oxidation [GO:0006635] (biological_process)'
  • SKIPPED_FACT: 'fatty acyl-CoA hydrolase activity [GO:0047617] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid beta-oxidation [GO:0006635] (biological_process)'
  • SKIPPED_FACT: 'fatty acyl-CoA hydrolase activity [GO:0047617] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'acyl-CoA metabolic process [GO:0006637] (biological_process)'
  • SKIPPED_FACT: 'long-chain fatty acid-CoA ligase activity [GO:0004467] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'acyl-CoA metabolic process [GO:0006637] (biological_process)'
  • SKIPPED_FACT: 'fatty acyl-CoA hydrolase activity [GO:0047617] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'acyl-CoA metabolic process [GO:0006637] (biological_process)'
  • SKIPPED_FACT: 'fatty acyl-CoA hydrolase activity [GO:0047617] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid beta-oxidation [GO:0006635] (biological_process)'
  • SKIPPED_FACT: 'fatty acyl-CoA hydrolase activity [GO:0047617] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'acyl-CoA metabolic process [GO:0006637] (biological_process)' 
R-HSA-77288
 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids - imported from: Reactome 2026-07-02 Curators at Reactome success
3 warnings
  • SKIPPED_FACT: 'intramolecular oxidoreductase activity [GO:0016860] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid beta-oxidation [GO:0006635] (biological_process)'
  • SKIPPED_FACT: 'oxidoreductase activity, acting on NAD(P)H [GO:0016651] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid beta-oxidation [GO:0006635] (biological_process)'
  • SKIPPED_FACT: 'acyl-CoA dehydrogenase activity [GO:0003995] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid beta-oxidation [GO:0006635] (biological_process)' 
R-HSA-1362409
 Mitochondrial iron-sulfur cluster biogenesis - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-947581
 Molybdenum cofactor biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-389542
 NADPH regeneration - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
10 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —has output→ D-threo-isocitrate(3-) [CHEBI:15562] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —has input→ D-threo-isocitrate(3-) [CHEBI:15562] (chemical entity)
  • SKIPPED_FACT: Subject 'carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function)' has 'has input' relationship to '2-oxoglutarate(2-) [CHEBI:16810] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —has input→ 2-oxoglutarate(2-) [CHEBI:16810] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —has output→ 2-oxoglutarate(2-) [CHEBI:16810] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —occurs in→ peroxisomal membrane [GO:0005778] (anatomical entity)
  • SKIPPED_FACT: Subject 'carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function)' has 'has output' relationship to 'D-threo-isocitrate(3-) [CHEBI:15562] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —part of→ NADPH regeneration [GO:0006740] (biological_process)
  • SKIPPED_FACT: Subject 'carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function)' has 'has output' relationship to '2-oxoglutarate(2-) [CHEBI:16810] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function)' has 'has input' relationship to 'D-threo-isocitrate(3-) [CHEBI:15562] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-196807
 Nicotinate metabolism - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
5 warnings
  • SKIPPED_FACT: 'nicotinate-nucleotide adenylyltransferase activity [GO:0004515] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'nicotinate metabolic process [GO:1901847] (biological_process)'
  • SKIPPED_FACT: 'nicotinate-nucleotide diphosphorylase (carboxylating) activity [GO:0004514] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to ''de novo' NAD+ biosynthetic process from L-tryptophan [GO:0034354] (biological_process)'
  • SKIPPED_FACT: 'nicotinate transmembrane transporter activity [GO:0090416] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'NAD+ biosynthetic process via the salvage pathway [GO:0034355] (biological_process)'
  • SKIPPED_FACT: 'NAD+ synthase (glutamine-hydrolyzing) activity [GO:0003952] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to ''de novo' NAD+ biosynthetic process from L-tryptophan [GO:0034354] (biological_process)'
  • SKIPPED_FACT: 'nicotinate phosphoribosyltransferase activity [GO:0004516] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'nicotinate metabolic process [GO:1901847] (biological_process)' 
R-HSA-203754
 NOSIP mediated eNOS trafficking - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-203641
 NOSTRIN mediated eNOS trafficking - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-9858328
 OADH complex synthesizes glutaryl-CoA from 2-OA - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-9673163
 Oleoyl-phe metabolism - imported from: Reactome 2026-07-02 Curators at Reactome success
2 warnings
  • SKIPPED_FACT: 'hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'adaptive thermogenesis [GO:1990845] (biological_process)'
  • SKIPPED_FACT: 'hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'adaptive thermogenesis [GO:1990845] (biological_process)' 
R-HSA-9861559
 PDH complex synthesizes acetyl-CoA from PYR - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-71336
 Pentose phosphate pathway - imported from: Reactome 2026-07-02 Curators at Reactome success
23 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: D-ribulose-phosphate 3-epimerase activity [GO:0004750] (molecular_function) —has output→ D-xylulose 5-phosphate(2-) [CHEBI:57737] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: D-ribulose-phosphate 3-epimerase activity [GO:0004750] (molecular_function) —part of→ pentose-phosphate shunt [GO:0006098] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glucose-6-phosphate dehydrogenase activity [GO:0004345] (molecular_function) —has output→ 6-O-phosphonato-D-glucono-1,5-lactone(2-) [CHEBI:57955] (chemical entity)
  • SKIPPED_FACT: Subject 'glucose-6-phosphate dehydrogenase activity [GO:0004345] (molecular_function)' has 'has input' relationship to 'NADP(3-) [CHEBI:58349] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glucose-6-phosphate dehydrogenase activity [GO:0004345] (molecular_function) —has input→ alpha-D-glucose 6-phosphate(2-) [CHEBI:58225] (chemical entity)
  • SKIPPED_FACT: Subject 'glucose-6-phosphate dehydrogenase activity [GO:0004345] (molecular_function)' has 'has output' relationship to '6-O-phosphonato-D-glucono-1,5-lactone(2-) [CHEBI:57955] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glucose-6-phosphate dehydrogenase activity [GO:0004345] (molecular_function) —part of→ pentose-phosphate shunt [GO:0006098] (biological_process)
  • SKIPPED_FACT: Subject 'D-ribulose-phosphate 3-epimerase activity [GO:0004750] (molecular_function)' has 'has output' relationship to 'D-xylulose 5-phosphate(2-) [CHEBI:57737] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'glucose-6-phosphate dehydrogenase activity [GO:0004345] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: D-ribulose-phosphate 3-epimerase activity [GO:0004750] (molecular_function) —has input→ D-xylulose 5-phosphate(2-) [CHEBI:57737] (chemical entity)
  • SKIPPED_FACT: Subject 'glucose-6-phosphate dehydrogenase activity [GO:0004345] (molecular_function)' has 'has output' relationship to 'NADPH(4-) [CHEBI:57783] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: D-ribulose-phosphate 3-epimerase activity [GO:0004750] (molecular_function) —has input→ D-ribulose 5-phosphate(2-) [CHEBI:58121] (chemical entity)
  • SKIPPED_FACT: Subject 'D-ribulose-phosphate 3-epimerase activity [GO:0004750] (molecular_function)' has 'has input' relationship to 'D-ribulose 5-phosphate(2-) [CHEBI:58121] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glucose-6-phosphate dehydrogenase activity [GO:0004345] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glucose-6-phosphate dehydrogenase activity [GO:0004345] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: D-ribulose-phosphate 3-epimerase activity [GO:0004750] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'D-ribulose-phosphate 3-epimerase activity [GO:0004750] (molecular_function)' has 'has input' relationship to 'D-xylulose 5-phosphate(2-) [CHEBI:57737] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glucose-6-phosphate dehydrogenase activity [GO:0004345] (molecular_function) —has output→ NADPH(4-) [CHEBI:57783] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glucose-6-phosphate dehydrogenase activity [GO:0004345] (molecular_function) —has input→ NADP(3-) [CHEBI:58349] (chemical entity)
  • SKIPPED_FACT: 'phosphopentomutase activity [GO:0008973] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'pentose-phosphate shunt [GO:0006098] (biological_process)'
  • SKIPPED_FACT: Subject 'D-ribulose-phosphate 3-epimerase activity [GO:0004750] (molecular_function)' has 'has output' relationship to 'D-ribulose 5-phosphate(2-) [CHEBI:58121] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: D-ribulose-phosphate 3-epimerase activity [GO:0004750] (molecular_function) —has output→ D-ribulose 5-phosphate(2-) [CHEBI:58121] (chemical entity)
  • SKIPPED_FACT: Subject 'glucose-6-phosphate dehydrogenase activity [GO:0004345] (molecular_function)' has 'has input' relationship to 'alpha-D-glucose 6-phosphate(2-) [CHEBI:58225] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-8964208
 Phenylalanine metabolism - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-8850843
 Phosphate bond hydrolysis by NTPDase proteins - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-1483196
 PI and PC transport between ER and Golgi membranes - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-163358
 PKA-mediated phosphorylation of key metabolic factors - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
3 warnings
  • SKIPPED_FACT: 'cAMP-dependent protein kinase activity [GO:0004691] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'negative regulation of glycolytic process [GO:0045820] (biological_process)'
  • SKIPPED_FACT: 'cAMP-dependent protein kinase activity [GO:0004691] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'cAMP/PKA signal transduction [GO:0141156] (biological_process)'
  • SKIPPED_FACT: 'cAMP-dependent protein kinase activity [GO:0004691] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'negative regulation of glycolytic process [GO:0045820] (biological_process)' 
R-HSA-75896
 Plasmalogen biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-196108
 Pregnenolone biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-70688
 Proline catabolism - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-71032
 Propionyl-CoA catabolism - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-74259
 Purine catabolism - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-73817
 Purine ribonucleoside monophosphate biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
40 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylosuccinate synthase activity [GO:0004019] (molecular_function) —has small molecule inhibitor→ N(6)-(1,2-dicarboxylatoethyl)-AMP(4-) [CHEBI:57567] (chemical entity)
  • SKIPPED_FACT: Subject 'IMP dehydrogenase activity [GO:0003938] (molecular_function)' has 'has input' relationship to 'NAD(1-) [CHEBI:57540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylosuccinate synthase activity [GO:0004019] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: IMP dehydrogenase activity [GO:0003938] (molecular_function) —has small molecule inhibitor→ 5'-xanthylate(2-) [CHEBI:57464] (chemical entity)
  • SKIPPED_FACT: Subject 'adenylosuccinate synthase activity [GO:0004019] (molecular_function)' has 'has output' relationship to 'N(6)-(1,2-dicarboxylatoethyl)-AMP(4-) [CHEBI:57567] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'adenylosuccinate synthase activity [GO:0004019] (molecular_function)' has 'has output' relationship to 'GDP(3-) [CHEBI:58189] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: IMP dehydrogenase activity [GO:0003938] (molecular_function) —has output→ 5'-xanthylate(2-) [CHEBI:57464] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: IMP dehydrogenase activity [GO:0003938] (molecular_function) —has input→ NAD(1-) [CHEBI:57540] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: IMP dehydrogenase activity [GO:0003938] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: IMP dehydrogenase activity [GO:0003938] (molecular_function) —part of→ purine ribonucleoside monophosphate biosynthetic process [GO:0009168] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylosuccinate synthase activity [GO:0004019] (molecular_function) —has input→ IMP(2-) [CHEBI:58053] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylosuccinate synthase activity [GO:0004019] (molecular_function) —has output→ GDP(3-) [CHEBI:58189] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: IMP dehydrogenase activity [GO:0003938] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • SKIPPED_FACT: Subject 'adenylosuccinate synthase activity [GO:0004019] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'IMP dehydrogenase activity [GO:0003938] (molecular_function)' has 'has small molecule inhibitor' relationship to '5'-xanthylate(2-) [CHEBI:57464] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'adenylosuccinate synthase activity [GO:0004019] (molecular_function)' has 'has small molecule inhibitor' relationship to 'N(6)-(1,2-dicarboxylatoethyl)-AMP(4-) [CHEBI:57567] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylosuccinate synthase activity [GO:0004019] (molecular_function) —has input→ GTP(4-) [CHEBI:37565] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylosuccinate synthase activity [GO:0004019] (molecular_function) —has small molecule inhibitor→ guanosine 5'-monophosphate(2-) [CHEBI:58115] (chemical entity)
  • SKIPPED_FACT: Subject 'IMP dehydrogenase activity [GO:0003938] (molecular_function)' has 'has output' relationship to '5'-xanthylate(2-) [CHEBI:57464] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'IMP dehydrogenase activity [GO:0003938] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'adenylosuccinate synthase activity [GO:0004019] (molecular_function)' has 'has input' relationship to 'IMP(2-) [CHEBI:58053] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylosuccinate synthase activity [GO:0004019] (molecular_function) —has output→ hydrogenphosphate [CHEBI:43474] (chemical entity)
  • SKIPPED_FACT: Subject 'adenylosuccinate synthase activity [GO:0004019] (molecular_function)' has 'has small molecule inhibitor' relationship to 'guanosine 5'-monophosphate(2-) [CHEBI:58115] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'adenylosuccinate synthase activity [GO:0004019] (molecular_function)' has 'has input' relationship to 'GTP(4-) [CHEBI:37565] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: IMP dehydrogenase activity [GO:0003938] (molecular_function) —has input→ IMP(2-) [CHEBI:58053] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylosuccinate synthase activity [GO:0004019] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylosuccinate synthase activity [GO:0004019] (molecular_function) —part of→ purine ribonucleoside monophosphate biosynthetic process [GO:0009168] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: IMP dehydrogenase activity [GO:0003938] (molecular_function) —has output→ NADH(2-) [CHEBI:57945] (chemical entity)
  • SKIPPED_FACT: Subject 'IMP dehydrogenase activity [GO:0003938] (molecular_function)' has 'has input' relationship to 'IMP(2-) [CHEBI:58053] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'IMP dehydrogenase activity [GO:0003938] (molecular_function)' has 'has output' relationship to 'NADH(2-) [CHEBI:57945] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'IMP dehydrogenase activity [GO:0003938] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: IMP dehydrogenase activity [GO:0003938] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'adenylosuccinate synthase activity [GO:0004019] (molecular_function)' has 'has output' relationship to 'hydrogenphosphate [CHEBI:43474] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylosuccinate synthase activity [GO:0004019] (molecular_function) —has small molecule inhibitor→ beta-D-fructofuranose 1,6-bisphosphate(4-) [CHEBI:32966] (chemical entity)
  • SKIPPED_FACT: Subject 'adenylosuccinate synthase activity [GO:0004019] (molecular_function)' has 'has small molecule inhibitor' relationship to 'beta-D-fructofuranose 1,6-bisphosphate(4-) [CHEBI:32966] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'adenylosuccinate synthase activity [GO:0004019] (molecular_function)' has 'has input' relationship to 'L-aspartate(1-) [CHEBI:29991] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylosuccinate synthase activity [GO:0004019] (molecular_function) —has small molecule inhibitor→ GDP(3-) [CHEBI:58189] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylosuccinate synthase activity [GO:0004019] (molecular_function) —has input→ L-aspartate(1-) [CHEBI:29991] (chemical entity)
  • SKIPPED_FACT: Subject 'adenylosuccinate synthase activity [GO:0004019] (molecular_function)' has 'has small molecule inhibitor' relationship to 'GDP(3-) [CHEBI:58189] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylosuccinate synthase activity [GO:0004019] (molecular_function) —has output→ N(6)-(1,2-dicarboxylatoethyl)-AMP(4-) [CHEBI:57567] (chemical entity) 
R-HSA-500753
 Pyrimidine biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-73621
 Pyrimidine catabolism - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-70268
 Pyruvate metabolism - imported from: Reactome 2026-07-02 Curators at Reactome success
39 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function) —has output→ NAD(1-) [CHEBI:57540] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-alanine:2-oxoglutarate transaminase activity [GO:0004021] (molecular_function) —causally upstream of→ pyruvate transmembrane transporter activity [GO:0050833] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: 'pyruvate carboxylase activity [GO:0004736] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'pyruvate biosynthetic process [GO:0042866] (biological_process)'
  • SKIPPED_FACT: Subject 'pyruvate transmembrane transporter activity [GO:0050833] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function) —causally upstream of→ pyruvate transmembrane transporter activity [GO:0050833] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: pyruvate transmembrane transporter activity [GO:0050833] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • SKIPPED_FACT: Subject 'L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function)' has 'has output' relationship to '(S)-lactate [CHEBI:16651] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function) —part of→ pyruvate biosynthetic process [GO:0042866] (biological_process)
  • SKIPPED_FACT: Subject 'L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function)' has 'has input' relationship to 'NADH(2-) [CHEBI:57945] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function) —has input→ NADH(2-) [CHEBI:57945] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: pyruvate transmembrane transporter activity [GO:0050833] (molecular_function) —has input→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function) —has input→ (S)-lactate [CHEBI:16651] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: pyruvate transmembrane transporter activity [GO:0050833] (molecular_function) —has output→ pyruvate [CHEBI:15361] (chemical entity)
  • SKIPPED_FACT: Subject 'pyruvate transmembrane transporter activity [GO:0050833] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function) —has output→ (S)-lactate [CHEBI:16651] (chemical entity)
  • SKIPPED_FACT: Subject 'L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function)' has 'has input' relationship to '(S)-lactate [CHEBI:16651] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function) —has output→ pyruvate [CHEBI:15361] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: pyruvate transmembrane transporter activity [GO:0050833] (molecular_function) —part of→ pyruvate biosynthetic process [GO:0042866] (biological_process)
  • SKIPPED_FACT: 'lactoylglutathione lyase activity [GO:0004462] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'pyruvate biosynthetic process [GO:0042866] (biological_process)'
  • SKIPPED_FACT: Subject 'pyruvate transmembrane transporter activity [GO:0050833] (molecular_function)' has 'has input' relationship to 'pyruvate [CHEBI:15361] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function)' has 'has output' relationship to 'NADH(2-) [CHEBI:57945] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: pyruvate transmembrane transporter activity [GO:0050833] (molecular_function) —has input→ pyruvate [CHEBI:15361] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function) —has output→ NADH(2-) [CHEBI:57945] (chemical entity)
  • SKIPPED_FACT: Subject 'L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function)' has 'has output' relationship to 'pyruvate [CHEBI:15361] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: pyruvate transmembrane transporter activity [GO:0050833] (molecular_function) —occurs in→ mitochondrial inner membrane [GO:0005743] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function) —has input→ pyruvate [CHEBI:15361] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function) —has input→ NAD(1-) [CHEBI:57540] (chemical entity)
  • SKIPPED_FACT: Subject 'L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function)' has 'has input' relationship to 'NAD(1-) [CHEBI:57540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function) —has input→ hydron [CHEBI:15378] (chemical entity)
  • SKIPPED_FACT: Subject 'L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function)' has 'has input' relationship to 'pyruvate [CHEBI:15361] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'pyruvate transmembrane transporter activity [GO:0050833] (molecular_function)' has 'has output' relationship to 'pyruvate [CHEBI:15361] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: 'hydroxyacylglutathione hydrolase activity [GO:0004416] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'methylglyoxal catabolic process [GO:0051596] (biological_process)'
  • SKIPPED_FACT: 'L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'pyruvate biosynthetic process [GO:0042866] (biological_process)'
  • SKIPPED_FACT: Subject 'L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: pyruvate kinase activity [GO:0004743] (molecular_function) —causally upstream of→ pyruvate transmembrane transporter activity [GO:0050833] (molecular_function)
  • SKIPPED_FACT: Subject 'L-lactate dehydrogenase (NAD+) activity [GO:0004459] (molecular_function)' has 'has output' relationship to 'NAD(1-) [CHEBI:57540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-159418
 Recycling of bile acids and salts - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
1 warning
  • SKIPPED_FACT: 'acyltransferase activity [GO:0016746] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bile acid and bile salt transport [GO:0015721] (biological_process)' 
R-HSA-1655829
 Regulation of cholesterol biosynthesis by SREBP (SREBF) - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
3 warnings
  • SKIPPED_FACT: 'protein sequestering activity [GO:0140311] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of cholesterol biosynthetic process [GO:0045540] (biological_process)'
  • SKIPPED_FACT: 'protein sequestering activity [GO:0140311] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'maintenance of protein complex location [GO:0098544] (biological_process)'
  • SKIPPED_FACT: 'cargo adaptor activity [GO:0140312] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of cholesterol biosynthetic process [GO:0045540] (biological_process)' 
R-HSA-170822
 Regulation of Glucokinase by Glucokinase Regulatory Protein - imported from: Reactome 2026-07-02 Curators at Reactome success
8 warnings
  • SKIPPED_FACT: 'structural constituent of nuclear pore [GO:0017056] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of glycolytic process [GO:0006110] (biological_process)'
  • SKIPPED_FACT: 'structural constituent of nuclear pore [GO:0017056] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'protein import into nucleus [GO:0006606] (biological_process)'
  • SKIPPED_FACT: 'structural constituent of nuclear pore [GO:0017056] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of glycolytic process [GO:0006110] (biological_process)'
  • SKIPPED_FACT: 'structural constituent of nuclear pore [GO:0017056] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'protein import into nucleus [GO:0006606] (biological_process)'
  • SKIPPED_FACT: 'structural constituent of nuclear pore [GO:0017056] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of glycolytic process [GO:0006110] (biological_process)'
  • SKIPPED_FACT: 'structural constituent of nuclear pore [GO:0017056] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of glycolytic process [GO:0006110] (biological_process)'
  • SKIPPED_FACT: 'structural constituent of nuclear pore [GO:0017056] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of glycolytic process [GO:0006110] (biological_process)'
  • SKIPPED_FACT: 'structural constituent of nuclear pore [GO:0017056] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of glycolytic process [GO:0006110] (biological_process)' 
R-HSA-9634600
 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism - imported from: Reactome 2026-07-02 Curators at Reactome success
10 warnings
  • SKIPPED_FACT: 'cAMP-dependent protein kinase activity [GO:0004691] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'negative regulation of glycolytic process [GO:0045820] (biological_process)'
  • SKIPPED_FACT: '6-phosphofructo-2-kinase activity [GO:0003873] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of glycolytic process [GO:0006110] (biological_process)'
  • SKIPPED_FACT: 'fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of glycolytic process [GO:0006110] (biological_process)'
  • SKIPPED_FACT: 'protein serine/threonine phosphatase activity [GO:0004722] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of glycolytic process [GO:0006110] (biological_process)'
  • SKIPPED_FACT: 'cAMP-dependent protein kinase activity [GO:0004691] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'negative regulation of glycolytic process [GO:0045820] (biological_process)'
  • SKIPPED_FACT: 'cAMP-dependent protein kinase activity [GO:0004691] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'negative regulation of glycolytic process [GO:0045820] (biological_process)'
  • SKIPPED_FACT: '6-phosphofructo-2-kinase activity [GO:0003873] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of glycolytic process [GO:0006110] (biological_process)'
  • SKIPPED_FACT: 'protein serine/threonine phosphatase activity [GO:0004722] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of glycolytic process [GO:0006110] (biological_process)'
  • SKIPPED_FACT: '6-phosphofructo-2-kinase activity [GO:0003873] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'positive regulation of glycolytic process [GO:0045821] (biological_process)'
  • SKIPPED_FACT: '6-phosphofructo-2-kinase activity [GO:0003873] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of glycolytic process [GO:0006110] (biological_process)' 
R-HSA-400206
 Regulation of lipid metabolism by PPARalpha - imported from: Reactome 2026-07-02 Curators at Reactome success
6 warnings
  • SKIPPED_FACT: 'transcription corepressor activity [GO:0003714] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'negative regulation of transcription initiation by RNA polymerase II [GO:0060633] (biological_process)'
  • SKIPPED_FACT: 'transcription corepressor activity [GO:0003714] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of lipid metabolic process [GO:0019216] (biological_process)'
  • SKIPPED_FACT: 'transcription corepressor activity [GO:0003714] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of lipid metabolic process [GO:0019216] (biological_process)'
  • SKIPPED_FACT: 'transcription corepressor activity [GO:0003714] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of lipid metabolic process [GO:0019216] (biological_process)'
  • SKIPPED_FACT: 'nuclear receptor activity [GO:0004879] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of lipid metabolic process [GO:0019216] (biological_process)'
  • SKIPPED_FACT: 'transcription corepressor activity [GO:0003714] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of lipid metabolic process [GO:0019216] (biological_process)' 
R-HSA-350562
 Regulation of ornithine decarboxylase (ODC) - imported from: Reactome 2026-07-02 Curators at Reactome success
1 warning
  • SKIPPED_FACT: 'endopeptidase activity [GO:0004175] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'polyamine biosynthetic process [GO:0006596] (biological_process)' 
R-HSA-9861718
 Regulation of pyruvate metabolism - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-611105
 Respiratory electron transport - imported from: Reactome 2026-07-02 Curators at Reactome success
4 warnings
  • SKIPPED_FACT: 'NADH dehydrogenase (ubiquinone) activity [GO:0008137] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'respiratory electron transport chain [GO:0022904] (biological_process)'
  • SKIPPED_FACT: 'cytochrome-c oxidase activity [GO:0004129] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'mitochondrial electron transport, cytochrome c to oxygen [GO:0006123] (biological_process)'
  • SKIPPED_FACT: 'succinate dehydrogenase (quinone) activity [GO:0008177] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'mitochondrial electron transport, succinate to ubiquinone [GO:0006121] (biological_process)'
  • SKIPPED_FACT: 'quinol-cytochrome-c reductase activity [GO:0008121] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122] (biological_process)' 
R-HSA-975634
 Retinoid metabolism and transport - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
30 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —occurs in→ early endosome [GO:0005769] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'retinyl-palmitate esterase activity [GO:0050253] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: retinyl-palmitate esterase activity [GO:0050253] (molecular_function) —has input→ all-trans-retinyl ester [CHEBI:63410] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —part of→ retinoid metabolic process [GO:0001523] (biological_process)
  • SKIPPED_FACT: Subject 'all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function)' has 'has output' relationship to 'APOE Hsap [UniProtKB:P02649] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: retinyl-palmitate esterase activity [GO:0050253] (molecular_function) —part of→ retinoid metabolic process [GO:0001523] (biological_process)
  • SKIPPED_FACT: Subject 'retinyl-palmitate esterase activity [GO:0050253] (molecular_function)' has 'has input' relationship to 'all-trans-retinyl ester [CHEBI:63410] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: retinyl-palmitate esterase activity [GO:0050253] (molecular_function) —causally upstream of→ all-trans-retinol binding [GO:1904768] (molecular_function)
  • SKIPPED_FACT: Subject 'all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: retinyl-palmitate esterase activity [GO:0050253] (molecular_function) —has output→ all-trans-retinol [CHEBI:17336] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: retinyl-palmitate esterase activity [GO:0050253] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'retinyl-palmitate esterase activity [GO:0050253] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: low-density lipoprotein particle receptor activity [GO:0005041] (molecular_function) —provides input for→ all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: retinyl-palmitate esterase activity [GO:0050253] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —has output→ all-trans-retinol [CHEBI:17336] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: retinyl-palmitate esterase activity [GO:0050253] (molecular_function) —has output→ fatty acid anion [CHEBI:28868] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —has output→ fatty acid anion [CHEBI:28868] (chemical entity)
  • SKIPPED_FACT: Subject 'all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function)' has 'has output' relationship to 'all-trans-retinol [CHEBI:17336] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'retinyl-palmitate esterase activity [GO:0050253] (molecular_function)' has 'has output' relationship to 'all-trans-retinol [CHEBI:17336] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function)' has 'has output' relationship to 'fatty acid anion [CHEBI:28868] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —has output→ APOE Hsap [UniProtKB:P02649] (information biomacromolecule)
  • SKIPPED_FACT: Subject 'all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function)' has 'has output' relationship to 'fatty acid anion [CHEBI:28868] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: retinyl-palmitate esterase activity [GO:0050253] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'retinyl-palmitate esterase activity [GO:0050253] (molecular_function)' has 'has output' relationship to 'fatty acid anion [CHEBI:28868] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function)' has 'has output' relationship to 'all-trans-retinol [CHEBI:17336] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-1475029
 Reversible hydration of carbon dioxide - imported from: Reactome 2026-07-02 Curators at Reactome success
36 warnings
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has input' relationship to 'hydrogencarbonate [CHEBI:17544] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carbonate dehydratase activity [GO:0004089] (molecular_function) —has input→ carbon dioxide [CHEBI:16526] (chemical entity)
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has input' relationship to 'carbon dioxide [CHEBI:16526] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carbonate dehydratase activity [GO:0004089] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has output' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has output' relationship to 'hydrogencarbonate [CHEBI:17544] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carbonate dehydratase activity [GO:0004089] (molecular_function) —has output→ carbon dioxide [CHEBI:16526] (chemical entity)
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has output' relationship to 'carbon dioxide [CHEBI:16526] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has input' relationship to 'hydrogencarbonate [CHEBI:17544] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has input' relationship to 'carbon dioxide [CHEBI:16526] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carbonate dehydratase activity [GO:0004089] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carbonate dehydratase activity [GO:0004089] (molecular_function) —has output→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has output' relationship to 'hydrogencarbonate [CHEBI:17544] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has output' relationship to 'carbon dioxide [CHEBI:16526] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carbonate dehydratase activity [GO:0004089] (molecular_function) —has output→ hydrogencarbonate [CHEBI:17544] (chemical entity)
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has output' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has input' relationship to 'hydrogencarbonate [CHEBI:17544] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carbonate dehydratase activity [GO:0004089] (molecular_function) —occurs in→ mitochondrial matrix [GO:0005759] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carbonate dehydratase activity [GO:0004089] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carbonate dehydratase activity [GO:0004089] (molecular_function) —part of→ bicarbonate transport [GO:0015701] (biological_process)
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has output' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has input' relationship to 'carbon dioxide [CHEBI:16526] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carbonate dehydratase activity [GO:0004089] (molecular_function) —has input→ hydrogencarbonate [CHEBI:17544] (chemical entity)
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carbonate dehydratase activity [GO:0004089] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity)
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has output' relationship to 'hydrogencarbonate [CHEBI:17544] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carbonate dehydratase activity [GO:0004089] (molecular_function) —has input→ hydron [CHEBI:15378] (chemical entity)
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has output' relationship to 'carbon dioxide [CHEBI:16526] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'carbonate dehydratase activity [GO:0004089] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-2408557
 Selenocysteine synthesis - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-977347
 Serine metabolism - imported from: Reactome 2026-07-02 Curators at Reactome success
8 warnings
  • SKIPPED_FACT: Subject 'L-serine ammonia-lyase activity [GO:0003941] (molecular_function)' has 'has input' relationship to 'L-serine zwitterion [CHEBI:33384] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'L-serine ammonia-lyase activity [GO:0003941] (molecular_function)' has 'has output' relationship to 'ammonium [CHEBI:28938] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'L-serine ammonia-lyase activity [GO:0003941] (molecular_function)' has 'has output' relationship to 'pyruvate [CHEBI:15361] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-serine ammonia-lyase activity [GO:0003941] (molecular_function) —has input→ L-serine zwitterion [CHEBI:33384] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-serine ammonia-lyase activity [GO:0003941] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-serine ammonia-lyase activity [GO:0003941] (molecular_function) —has output→ ammonium [CHEBI:28938] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-serine ammonia-lyase activity [GO:0003941] (molecular_function) —part of→ proteinogenic amino acid metabolic process [GO:0170039] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-serine ammonia-lyase activity [GO:0003941] (molecular_function) —has output→ pyruvate [CHEBI:15361] (chemical entity) 
R-HSA-209931
 Serotonin and melatonin biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-9845614
 Sphingolipid catabolism - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-1660661
 Sphingolipid de novo biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
14 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: serine C-palmitoyltransferase activity [GO:0004758] (molecular_function) —part of→ sphingolipid biosynthetic process [GO:0030148] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: serine C-palmitoyltransferase activity [GO:0004758] (molecular_function) —has output→ coenzyme A(4-) [CHEBI:57287] (chemical entity)
  • SKIPPED_FACT: Subject 'serine C-palmitoyltransferase activity [GO:0004758] (molecular_function)' has 'has output' relationship to 'carbon dioxide [CHEBI:16526] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: serine C-palmitoyltransferase activity [GO:0004758] (molecular_function) —occurs in→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity)
  • SKIPPED_FACT: Subject 'serine C-palmitoyltransferase activity [GO:0004758] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: serine C-palmitoyltransferase activity [GO:0004758] (molecular_function) —has input→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: serine C-palmitoyltransferase activity [GO:0004758] (molecular_function) —has input→ L-serine zwitterion [CHEBI:33384] (chemical entity)
  • SKIPPED_FACT: Subject 'serine C-palmitoyltransferase activity [GO:0004758] (molecular_function)' has 'has output' relationship to 'coenzyme A(4-) [CHEBI:57287] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: serine C-palmitoyltransferase activity [GO:0004758] (molecular_function) —has input→ acyl-CoA(4-) [CHEBI:58342] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: serine C-palmitoyltransferase activity [GO:0004758] (molecular_function) —has output→ carbon dioxide [CHEBI:16526] (chemical entity)
  • SKIPPED_FACT: Subject 'serine C-palmitoyltransferase activity [GO:0004758] (molecular_function)' has 'has input' relationship to 'L-serine zwitterion [CHEBI:33384] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: serine C-palmitoyltransferase activity [GO:0004758] (molecular_function) —has output→ 3-dehydrosphingoid base(1+) [CHEBI:84411] (chemical entity)
  • SKIPPED_FACT: Subject 'serine C-palmitoyltransferase activity [GO:0004758] (molecular_function)' has 'has input' relationship to 'acyl-CoA(4-) [CHEBI:58342] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'serine C-palmitoyltransferase activity [GO:0004758] (molecular_function)' has 'has output' relationship to '3-dehydrosphingoid base(1+) [CHEBI:84411] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-9853506
 Succinyl-CoA Biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success
5 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: binding [GO:0005488] (molecular_function) —has input→ NADH(2-) [CHEBI:57945] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: binding [GO:0005488] (molecular_function) —part of→ succinyl-CoA biosynthetic process [GO:1901290] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: dihydrolipoyl dehydrogenase (NADH) activity [GO:0004148] (molecular_function) —provides input for→ binding [GO:0005488] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: binding [GO:0005488] (molecular_function) —directly positively regulates→ oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591] (molecular_function)
  • SKIPPED_FACT: Subject 'binding [GO:0005488] (molecular_function)' has 'has input' relationship to 'NADH(2-) [CHEBI:57945] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-1614517
 Sulfide oxidation to sulfate - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-1614635
 Sulfur amino acid metabolism - imported from: Reactome 2026-07-02 Curators at Reactome success
14 warnings
  • SKIPPED_FACT: Subject 'methionine adenosyltransferase activity [GO:0004478] (molecular_function)' has 'has input' relationship to 'L-methionine zwitterion [CHEBI:57844] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methionine adenosyltransferase activity [GO:0004478] (molecular_function) —has output→ diphosphate(3-) [CHEBI:33019] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methionine adenosyltransferase activity [GO:0004478] (molecular_function) —part of→ sulfur amino acid metabolic process [GO:0000096] (biological_process)
  • SKIPPED_FACT: Subject 'methionine adenosyltransferase activity [GO:0004478] (molecular_function)' has 'has output' relationship to 'diphosphate(3-) [CHEBI:33019] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'methionine adenosyltransferase activity [GO:0004478] (molecular_function)' has 'has output' relationship to 'hydrogenphosphate [CHEBI:43474] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methionine adenosyltransferase activity [GO:0004478] (molecular_function) —has input→ L-methionine zwitterion [CHEBI:57844] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methionine adenosyltransferase activity [GO:0004478] (molecular_function) —has input→ ATP(4-) [CHEBI:30616] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methionine adenosyltransferase activity [GO:0004478] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'methionine adenosyltransferase activity [GO:0004478] (molecular_function)' has 'has input' relationship to 'ATP(4-) [CHEBI:30616] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methionine adenosyltransferase activity [GO:0004478] (molecular_function) —has output→ S-adenosyl-L-methionine zwitterion [CHEBI:59789] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methionine adenosyltransferase activity [GO:0004478] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'methionine adenosyltransferase activity [GO:0004478] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'methionine adenosyltransferase activity [GO:0004478] (molecular_function)' has 'has output' relationship to 'S-adenosyl-L-methionine zwitterion [CHEBI:59789] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: methionine adenosyltransferase activity [GO:0004478] (molecular_function) —has output→ hydrogenphosphate [CHEBI:43474] (chemical entity) 
R-HSA-2142712
 Synthesis of 12-eicosatetraenoic acid derivatives - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
8 warnings
  • SKIPPED_FACT: Subject 'arachidonate 12(S)-lipoxygenase activity [GO:0004052] (molecular_function)' has 'has input' relationship to 'dioxygen [CHEBI:15379] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: arachidonate 12(S)-lipoxygenase activity [GO:0004052] (molecular_function) —has output→ 12(S)-HPETE(1-) [CHEBI:57444] (chemical entity)
  • SKIPPED_FACT: Subject 'arachidonate 12(S)-lipoxygenase activity [GO:0004052] (molecular_function)' has 'has output' relationship to '12(S)-HPETE(1-) [CHEBI:57444] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: arachidonate 12(S)-lipoxygenase activity [GO:0004052] (molecular_function) —has input→ dioxygen [CHEBI:15379] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: arachidonate 12(S)-lipoxygenase activity [GO:0004052] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: arachidonate 12(S)-lipoxygenase activity [GO:0004052] (molecular_function) —has input→ arachidonate [CHEBI:32395] (chemical entity)
  • SKIPPED_FACT: Subject 'arachidonate 12(S)-lipoxygenase activity [GO:0004052] (molecular_function)' has 'has input' relationship to 'arachidonate [CHEBI:32395] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: arachidonate 12(S)-lipoxygenase activity [GO:0004052] (molecular_function) —part of→ lipoxygenase pathway [GO:0019372] (biological_process) 
R-HSA-2142688
 Synthesis of 5-eicosatetraenoic acids - imported from: Reactome 2026-07-02 Curators at Reactome success
20 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007] (molecular_function) —part of→ lipoxygenase pathway [GO:0019372] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity [GO:0097265] (molecular_function) —has input→ NADP(3-) [CHEBI:58349] (chemical entity)
  • SKIPPED_FACT: Subject '5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity [GO:0097265] (molecular_function)' has 'has output' relationship to 'NADPH(4-) [CHEBI:57783] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007] (molecular_function)' has 'has output' relationship to '5-HETE(1-) [CHEBI:65341] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity [GO:0097265] (molecular_function) —has output→ 5-oxo-ETE(1-) [CHEBI:65342] (chemical entity)
  • SKIPPED_FACT: Subject '5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity [GO:0097265] (molecular_function)' has 'has input' relationship to '5(S)-HETE(1-) [CHEBI:90632] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007] (molecular_function) —has output→ 5-HETE(1-) [CHEBI:65341] (chemical entity)
  • SKIPPED_FACT: Subject '5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity [GO:0097265] (molecular_function)' has 'has output' relationship to '5-oxo-ETE(1-) [CHEBI:65342] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject '5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity [GO:0097265] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity [GO:0097265] (molecular_function) —has input→ 5(S)-HETE(1-) [CHEBI:90632] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007] (molecular_function) —occurs in→ extracellular region [GO:0005576] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity [GO:0097265] (molecular_function) —has output→ NADPH(4-) [CHEBI:57783] (chemical entity)
  • SKIPPED_FACT: Subject 'acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007] (molecular_function)' has 'has input' relationship to 'meadowlactone [CHEBI:132873] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007] (molecular_function) —has input→ meadowlactone [CHEBI:132873] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity [GO:0097265] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject '5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity [GO:0097265] (molecular_function)' has 'has input' relationship to 'NADP(3-) [CHEBI:58349] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity [GO:0097265] (molecular_function) —part of→ lipoxygenase pathway [GO:0019372] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity [GO:0097265] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity) 
R-HSA-192105
 Synthesis of bile acids and bile salts - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-193775
 Synthesis of bile acids and bile salts via 24-hydroxycholesterol - imported from: Reactome 2026-07-02 Curators at Reactome success
7 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol transmembrane transporter activity [GO:0015665] (molecular_function) —part of→ bile acid biosynthetic process [GO:0006699] (biological_process)
  • SKIPPED_FACT: Subject 'alcohol transmembrane transporter activity [GO:0015665] (molecular_function)' has 'has input' relationship to '(24S)-5beta-cholestane-3alpha,7alpha,24-triol [CHEBI:63831] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: 'ATPase-coupled transmembrane transporter activity [GO:0042626] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bile acid biosynthetic process [GO:0006699] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol transmembrane transporter activity [GO:0015665] (molecular_function) —has input→ (24S)-5beta-cholestane-3alpha,7alpha,24-triol [CHEBI:63831] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol transmembrane transporter activity [GO:0015665] (molecular_function) —occurs in→ mitochondrial inner membrane [GO:0005743] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol transmembrane transporter activity [GO:0015665] (molecular_function) —has output→ (24S)-5beta-cholestane-3alpha,7alpha,24-triol [CHEBI:63831] (chemical entity)
  • SKIPPED_FACT: Subject 'alcohol transmembrane transporter activity [GO:0015665] (molecular_function)' has 'has output' relationship to '(24S)-5beta-cholestane-3alpha,7alpha,24-triol [CHEBI:63831] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-193807
 Synthesis of bile acids and bile salts via 27-hydroxycholesterol - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
10 warnings
  • SKIPPED_FACT: Subject 'alcohol transmembrane transporter activity [GO:0015665] (molecular_function)' has 'has output' relationship to '5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol [CHEBI:17278] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol transmembrane transporter activity [GO:0015665] (molecular_function) —has output→ 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol [CHEBI:17278] (chemical entity)
  • SKIPPED_FACT: Subject 'alcohol transmembrane transporter activity [GO:0015665] (molecular_function)' has 'has input' relationship to '5beta-cholestane-3alpha,7alpha,26-triol [CHEBI:28540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'alcohol transmembrane transporter activity [GO:0015665] (molecular_function)' has 'has input' relationship to '5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol [CHEBI:17278] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol transmembrane transporter activity [GO:0015665] (molecular_function) —occurs in→ mitochondrial inner membrane [GO:0005743] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol transmembrane transporter activity [GO:0015665] (molecular_function) —has input→ 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol [CHEBI:17278] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol transmembrane transporter activity [GO:0015665] (molecular_function) —part of→ bile acid biosynthetic process [GO:0006699] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol transmembrane transporter activity [GO:0015665] (molecular_function) —has output→ 5beta-cholestane-3alpha,7alpha,26-triol [CHEBI:28540] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol transmembrane transporter activity [GO:0015665] (molecular_function) —has input→ 5beta-cholestane-3alpha,7alpha,26-triol [CHEBI:28540] (chemical entity)
  • SKIPPED_FACT: Subject 'alcohol transmembrane transporter activity [GO:0015665] (molecular_function)' has 'has output' relationship to '5beta-cholestane-3alpha,7alpha,26-triol [CHEBI:28540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-193368
 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - imported from: Reactome 2026-07-02 Curators at Reactome success
12 warnings
  • SKIPPED_FACT: Subject 'alcohol transmembrane transporter activity [GO:0015665] (molecular_function)' has 'has output' relationship to '5beta-cholestane-3alpha,7alpha-diol [CHEBI:28047] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol transmembrane transporter activity [GO:0015665] (molecular_function) —has output→ 5beta-cholestane-3alpha,7alpha,12alpha-triol [CHEBI:16496] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol transmembrane transporter activity [GO:0015665] (molecular_function) —has output→ 5beta-cholestane-3alpha,7alpha-diol [CHEBI:28047] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol transmembrane transporter activity [GO:0015665] (molecular_function) —occurs in→ mitochondrial inner membrane [GO:0005743] (anatomical entity)
  • SKIPPED_FACT: 'ATPase-coupled transmembrane transporter activity [GO:0042626] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bile acid biosynthetic process [GO:0006699] (biological_process)'
  • SKIPPED_FACT: Subject 'alcohol transmembrane transporter activity [GO:0015665] (molecular_function)' has 'has input' relationship to '5beta-cholestane-3alpha,7alpha,12alpha-triol [CHEBI:16496] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'alcohol transmembrane transporter activity [GO:0015665] (molecular_function)' has 'has output' relationship to '5beta-cholestane-3alpha,7alpha,12alpha-triol [CHEBI:16496] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol transmembrane transporter activity [GO:0015665] (molecular_function) —has input→ 5beta-cholestane-3alpha,7alpha-diol [CHEBI:28047] (chemical entity)
  • SKIPPED_FACT: 'ATPase-coupled transmembrane transporter activity [GO:0042626] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bile acid biosynthetic process [GO:0006699] (biological_process)'
  • SKIPPED_FACT: Subject 'alcohol transmembrane transporter activity [GO:0015665] (molecular_function)' has 'has input' relationship to '5beta-cholestane-3alpha,7alpha-diol [CHEBI:28047] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol transmembrane transporter activity [GO:0015665] (molecular_function) —part of→ bile acid biosynthetic process [GO:0006699] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: alcohol transmembrane transporter activity [GO:0015665] (molecular_function) —has input→ 5beta-cholestane-3alpha,7alpha,12alpha-triol [CHEBI:16496] (chemical entity) 
R-HSA-2142670
 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-1855183
 Synthesis of IP2, IP, and Ins in the cytosol - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
30 warnings
  • SKIPPED_FACT: Subject 'inositol monophosphate 1-phosphatase activity [GO:0008934] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol monophosphate 1-phosphatase activity [GO:0008934] (molecular_function) —has input→ 1D-myo-inositol 1-phosphate(2-) [CHEBI:58433] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol monophosphate 1-phosphatase activity [GO:0008934] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol monophosphate 3-phosphatase activity [GO:0052832] (molecular_function) —has input→ 1D-myo-inositol 3-phosphate(2-) [CHEBI:58401] (chemical entity)
  • SKIPPED_FACT: Subject 'inositol monophosphate 4-phosphatase activity [GO:0052833] (molecular_function)' has 'has input' relationship to '1D-myo-inositol 4-phosphate(2-) [CHEBI:58469] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol monophosphate 3-phosphatase activity [GO:0052832] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol monophosphate 4-phosphatase activity [GO:0052833] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol monophosphate 4-phosphatase activity [GO:0052833] (molecular_function) —part of→ inositol phosphate metabolic process [GO:0043647] (biological_process)
  • SKIPPED_FACT: Subject 'inositol monophosphate 3-phosphatase activity [GO:0052832] (molecular_function)' has 'has output' relationship to 'myo-inositol [CHEBI:17268] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'inositol monophosphate 3-phosphatase activity [GO:0052832] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'inositol monophosphate 4-phosphatase activity [GO:0052833] (molecular_function)' has 'has output' relationship to 'hydrogenphosphate [CHEBI:43474] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol monophosphate 1-phosphatase activity [GO:0008934] (molecular_function) —has output→ myo-inositol [CHEBI:17268] (chemical entity)
  • SKIPPED_FACT: Subject 'inositol monophosphate 3-phosphatase activity [GO:0052832] (molecular_function)' has 'has input' relationship to '1D-myo-inositol 3-phosphate(2-) [CHEBI:58401] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol monophosphate 3-phosphatase activity [GO:0052832] (molecular_function) —has output→ hydrogenphosphate [CHEBI:43474] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol monophosphate 4-phosphatase activity [GO:0052833] (molecular_function) —has output→ myo-inositol [CHEBI:17268] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol monophosphate 4-phosphatase activity [GO:0052833] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol monophosphate 4-phosphatase activity [GO:0052833] (molecular_function) —has output→ hydrogenphosphate [CHEBI:43474] (chemical entity)
  • SKIPPED_FACT: Subject 'inositol monophosphate 1-phosphatase activity [GO:0008934] (molecular_function)' has 'has input' relationship to '1D-myo-inositol 1-phosphate(2-) [CHEBI:58433] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol monophosphate 4-phosphatase activity [GO:0052833] (molecular_function) —has input→ 1D-myo-inositol 4-phosphate(2-) [CHEBI:58469] (chemical entity)
  • SKIPPED_FACT: Subject 'inositol monophosphate 3-phosphatase activity [GO:0052832] (molecular_function)' has 'has output' relationship to 'hydrogenphosphate [CHEBI:43474] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'inositol monophosphate 1-phosphatase activity [GO:0008934] (molecular_function)' has 'has output' relationship to 'hydrogenphosphate [CHEBI:43474] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'inositol monophosphate 4-phosphatase activity [GO:0052833] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol monophosphate 3-phosphatase activity [GO:0052832] (molecular_function) —has output→ myo-inositol [CHEBI:17268] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol monophosphate 3-phosphatase activity [GO:0052832] (molecular_function) —part of→ inositol phosphate metabolic process [GO:0043647] (biological_process)
  • SKIPPED_FACT: Subject 'inositol monophosphate 4-phosphatase activity [GO:0052833] (molecular_function)' has 'has output' relationship to 'myo-inositol [CHEBI:17268] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol monophosphate 1-phosphatase activity [GO:0008934] (molecular_function) —has output→ hydrogenphosphate [CHEBI:43474] (chemical entity)
  • SKIPPED_FACT: Subject 'inositol monophosphate 1-phosphatase activity [GO:0008934] (molecular_function)' has 'has output' relationship to 'myo-inositol [CHEBI:17268] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol monophosphate 3-phosphatase activity [GO:0052832] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol monophosphate 1-phosphatase activity [GO:0008934] (molecular_function) —part of→ inositol phosphate metabolic process [GO:0043647] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol monophosphate 1-phosphatase activity [GO:0008934] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity) 
R-HSA-1855204
 Synthesis of IP3 and IP4 in the cytosol - imported from: Reactome 2026-07-02 Curators at Reactome success
24 warnings
  • SKIPPED_FACT: Subject 'phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function)' has 'has output' relationship to '1,2-diacyl-sn-glycerol [CHEBI:17815] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function)' has 'has input' relationship to '1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) [CHEBI:58456] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function) —has output→ 1,2-diacyl-sn-glycerol [CHEBI:17815] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity)
  • SKIPPED_FACT: Subject 'phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function)' has 'has output' relationship to '1D-myo-inositol 1,4,5-trisphosphate(6-) [CHEBI:203600] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function)' has 'has output' relationship to '1,2-diacyl-sn-glycerol [CHEBI:17815] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function) —part of→ inositol phosphate metabolic process [GO:0043647] (biological_process)
  • SKIPPED_FACT: Subject 'phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function)' has 'has input' relationship to '1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) [CHEBI:58456] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function)' has 'has output' relationship to '1,2-diacyl-sn-glycerol [CHEBI:17815] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function)' has 'has input' relationship to '1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) [CHEBI:58456] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function) —has input→ 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) [CHEBI:58456] (chemical entity)
  • SKIPPED_FACT: Subject 'phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function) —has output→ 1D-myo-inositol 1,4,5-trisphosphate(6-) [CHEBI:203600] (chemical entity)
  • SKIPPED_FACT: Subject 'phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function)' has 'has output' relationship to '1D-myo-inositol 1,4,5-trisphosphate(6-) [CHEBI:203600] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function)' has 'has output' relationship to '1D-myo-inositol 1,4,5-trisphosphate(6-) [CHEBI:203600] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function) —occurs in→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity) 
R-HSA-1855231
 Synthesis of IPs in the ER lumen - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-1855191
 Synthesis of IPs in the nucleus - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-77111
 Synthesis of Ketone Bodies - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-2142691
 Synthesis of Leukotrienes (LT) and Eoxins (EX) - imported from: Reactome 2026-07-02 Curators at Reactome success
54 warnings
  • SKIPPED_FACT: Subject 'eoxin D4 synthase activity [GO:0097262] (molecular_function)' has 'has output' relationship to 'L-glutamate(1-) [CHEBI:29985] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'dipeptidase activity [GO:0016805] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: eoxin E4 synthase activity [GO:0097263] (molecular_function) —has output→ glycine zwitterion [CHEBI:57305] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: eoxin E4 synthase activity [GO:0097263] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject '20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259] (molecular_function)' has 'has output' relationship to '20-hydroxy-20-oxoleukotriene B4(2-) [CHEBI:90722] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function) —part of→ leukotriene metabolic process [GO:0006691] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259] (molecular_function) —has input→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: dipeptidase activity [GO:0016805] (molecular_function) —has output→ leukotriene E4(1-) [CHEBI:57462] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259] (molecular_function) —has input→ dioxygen [CHEBI:15379] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: eoxin D4 synthase activity [GO:0097262] (molecular_function) —part of→ leukotriene metabolic process [GO:0006691] (biological_process)
  • SKIPPED_FACT: Subject '20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259] (molecular_function)' has 'has input' relationship to 'NADPH(4-) [CHEBI:57783] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: dipeptidase activity [GO:0016805] (molecular_function) —part of→ leukotriene metabolic process [GO:0006691] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: eoxin E4 synthase activity [GO:0097263] (molecular_function) —has input→ eoxin D4(1-) [CHEBI:747583] (chemical entity)
  • SKIPPED_FACT: Subject 'glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function)' has 'has output' relationship to 'leukotriene D4(1-) [CHEBI:63166] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: dipeptidase activity [GO:0016805] (molecular_function) —has input→ leukotriene D4(1-) [CHEBI:63166] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function) —has output→ L-glutamate(1-) [CHEBI:29985] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: eoxin E4 synthase activity [GO:0097263] (molecular_function) —part of→ leukotriene metabolic process [GO:0006691] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: eoxin D4 synthase activity [GO:0097262] (molecular_function) —has output→ L-glutamate(1-) [CHEBI:29985] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity)
  • SKIPPED_FACT: Subject 'dipeptidase activity [GO:0016805] (molecular_function)' has 'has output' relationship to 'glycine zwitterion [CHEBI:57305] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'dipeptidase activity [GO:0016805] (molecular_function)' has 'has input' relationship to 'leukotriene D4(1-) [CHEBI:63166] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: eoxin E4 synthase activity [GO:0097263] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'eoxin E4 synthase activity [GO:0097263] (molecular_function)' has 'has output' relationship to 'glycine zwitterion [CHEBI:57305] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259] (molecular_function) —has output→ NADP(3-) [CHEBI:58349] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: dipeptidase activity [GO:0016805] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: dipeptidase activity [GO:0016805] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity)
  • SKIPPED_FACT: Subject '20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'eoxin D4 synthase activity [GO:0097262] (molecular_function)' has 'has output' relationship to 'eoxin D4(1-) [CHEBI:747583] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function) —has output→ leukotriene D4(1-) [CHEBI:63166] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259] (molecular_function) —has output→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259] (molecular_function) —has output→ 20-hydroxy-20-oxoleukotriene B4(2-) [CHEBI:90722] (chemical entity)
  • SKIPPED_FACT: Subject '20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259] (molecular_function)' has 'has output' relationship to 'NADP(3-) [CHEBI:58349] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259] (molecular_function) —part of→ leukotriene metabolic process [GO:0006691] (biological_process)
  • SKIPPED_FACT: Subject 'glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function)' has 'has output' relationship to 'L-glutamate(1-) [CHEBI:29985] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'eoxin E4 synthase activity [GO:0097263] (molecular_function)' has 'has output' relationship to 'eoxin E4(1-) [CHEBI:747194] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259] (molecular_function) —has input→ 20-oxoleukotriene B4(1-) [CHEBI:90720] (chemical entity)
  • SKIPPED_FACT: Subject 'dipeptidase activity [GO:0016805] (molecular_function)' has 'has output' relationship to 'leukotriene E4(1-) [CHEBI:57462] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259] (molecular_function) —has input→ NADPH(4-) [CHEBI:57783] (chemical entity)
  • SKIPPED_FACT: Subject '20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259] (molecular_function)' has 'has input' relationship to 'dioxygen [CHEBI:15379] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: eoxin E4 synthase activity [GO:0097263] (molecular_function) —has output→ eoxin E4(1-) [CHEBI:747194] (chemical entity)
  • SKIPPED_FACT: Subject 'eoxin E4 synthase activity [GO:0097263] (molecular_function)' has 'has input' relationship to 'eoxin D4(1-) [CHEBI:747583] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function)' has 'has input' relationship to 'leukotriene C4(2-) [CHEBI:57973] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function) —has input→ leukotriene C4(2-) [CHEBI:57973] (chemical entity)
  • SKIPPED_FACT: Subject 'glutathione gamma-glutamate hydrolase [GO:0036374] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'eoxin D4 synthase activity [GO:0097262] (molecular_function)' has 'has input' relationship to 'eoxin C4 [CHEBI:63984] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'eoxin E4 synthase activity [GO:0097263] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject '20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259] (molecular_function)' has 'has output' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: eoxin D4 synthase activity [GO:0097262] (molecular_function) —has input→ eoxin C4 [CHEBI:63984] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: eoxin D4 synthase activity [GO:0097262] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject '20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259] (molecular_function)' has 'has input' relationship to '20-oxoleukotriene B4(1-) [CHEBI:90720] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: dipeptidase activity [GO:0016805] (molecular_function) —has output→ glycine zwitterion [CHEBI:57305] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: eoxin D4 synthase activity [GO:0097262] (molecular_function) —has output→ eoxin D4(1-) [CHEBI:747583] (chemical entity) 
R-HSA-1483166
 Synthesis of PA - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
23 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [GO:0047952] (molecular_function) —has input→ glycerone phosphate(2-) [CHEBI:57642] (chemical entity)
  • SKIPPED_FACT: Subject 'glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [GO:0047952] (molecular_function)' has 'has output' relationship to 'NAD(1-) [CHEBI:57540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —occurs in→ extracellular region [GO:0005576] (anatomical entity)
  • SKIPPED_FACT: Subject 'glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [GO:0047952] (molecular_function)' has 'has output' relationship to 'sn-glycerol 3-phosphate(2-) [CHEBI:57597] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [GO:0047952] (molecular_function) —has output→ sn-glycerol 3-phosphate(2-) [CHEBI:57597] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [GO:0047952] (molecular_function) —has input→ hydron [CHEBI:15378] (chemical entity)
  • SKIPPED_FACT: Subject 'glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [GO:0047952] (molecular_function)' has 'has input' relationship to 'NADH(2-) [CHEBI:57945] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [GO:0047952] (molecular_function) —has input→ NADH(2-) [CHEBI:57945] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [GO:0047952] (molecular_function) —part of→ phosphatidic acid biosynthetic process [GO:0006654] (biological_process)
  • SKIPPED_FACT: Subject 'glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [GO:0047952] (molecular_function)' has 'has input' relationship to 'glycerone phosphate(2-) [CHEBI:57642] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: 'glycerol-3-phosphate dehydrogenase (quinone) activity [GO:0004368] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'phosphatidic acid biosynthetic process [GO:0006654] (biological_process)'
  • SKIPPED_FACT: Subject 'glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [GO:0047952] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has output' relationship to 'long-chain fatty acid anion [CHEBI:57560] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has input' relationship to 'phosphatidate(2-) [CHEBI:57739] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [GO:0047952] (molecular_function) —has output→ NAD(1-) [CHEBI:57540] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —part of→ phosphatidic acid biosynthetic process [GO:0006654] (biological_process)
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has output' relationship to '1-acyl-sn-glycerol 3-phosphate [CHEBI:16975] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'A2-type glycerophospholipase activity [GO:0004623] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has output→ long-chain fatty acid anion [CHEBI:57560] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has input→ phosphatidate(2-) [CHEBI:57739] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [GO:0047952] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: A2-type glycerophospholipase activity [GO:0004623] (molecular_function) —has output→ 1-acyl-sn-glycerol 3-phosphate [CHEBI:16975] (chemical entity) 
R-HSA-1483191
 Synthesis of PC - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
32 warnings
  • SKIPPED_FACT: Subject 'choline kinase activity [GO:0004103] (molecular_function)' has 'has output' relationship to 'phosphocholines [CHEBI:36700] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: choline-phosphate cytidylyltransferase activity [GO:0004105] (molecular_function) —has input→ CTP(4-) [CHEBI:37563] (chemical entity)
  • SKIPPED_FACT: Subject 'choline kinase activity [GO:0004103] (molecular_function)' has 'has input' relationship to 'choline [CHEBI:15354] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: 'acetylcholinesterase activity [GO:0003990] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'phosphatidylcholine biosynthetic process [GO:0006656] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidate phosphatase activity [GO:0008195] (molecular_function) —has input→ phosphatidate(2-) [CHEBI:57739] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidate phosphatase activity [GO:0008195] (molecular_function) —part of→ phosphatidylcholine biosynthetic process [GO:0006656] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidate phosphatase activity [GO:0008195] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'choline-phosphate cytidylyltransferase activity [GO:0004105] (molecular_function)' has 'has input' relationship to 'phosphocholines [CHEBI:36700] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: choline kinase activity [GO:0004103] (molecular_function) —part of→ phosphatidylcholine biosynthetic process [GO:0006656] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: choline kinase activity [GO:0004103] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: choline-phosphate cytidylyltransferase activity [GO:0004105] (molecular_function) —occurs in→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity)
  • SKIPPED_FACT: Subject 'choline-phosphate cytidylyltransferase activity [GO:0004105] (molecular_function)' has 'has output' relationship to 'CDP-choline [CHEBI:16436] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'phosphatidate phosphatase activity [GO:0008195] (molecular_function)' has 'has input' relationship to 'phosphatidate(2-) [CHEBI:57739] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: choline kinase activity [GO:0004103] (molecular_function) —has input→ ATP(4-) [CHEBI:30616] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidate phosphatase activity [GO:0008195] (molecular_function) —occurs in→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: choline-phosphate cytidylyltransferase activity [GO:0004105] (molecular_function) —has output→ diphosphate(3-) [CHEBI:33019] (chemical entity)
  • SKIPPED_FACT: Subject 'phosphatidate phosphatase activity [GO:0008195] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'choline-phosphate cytidylyltransferase activity [GO:0004105] (molecular_function)' has 'has input' relationship to 'CTP(4-) [CHEBI:37563] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: choline kinase activity [GO:0004103] (molecular_function) —has output→ ADP(3-) [CHEBI:456216] (chemical entity)
  • SKIPPED_FACT: Subject 'phosphatidate phosphatase activity [GO:0008195] (molecular_function)' has 'has output' relationship to '1,2-diacyl-sn-glycerol [CHEBI:17815] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidate phosphatase activity [GO:0008195] (molecular_function) —has output→ 1,2-diacyl-sn-glycerol [CHEBI:17815] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: choline-phosphate cytidylyltransferase activity [GO:0004105] (molecular_function) —has input→ phosphocholines [CHEBI:36700] (chemical entity)
  • SKIPPED_FACT: Subject 'phosphatidate phosphatase activity [GO:0008195] (molecular_function)' has 'has output' relationship to 'hydrogenphosphate [CHEBI:43474] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidate phosphatase activity [GO:0008195] (molecular_function) —has output→ hydrogenphosphate [CHEBI:43474] (chemical entity)
  • SKIPPED_FACT: Subject 'choline kinase activity [GO:0004103] (molecular_function)' has 'has output' relationship to 'ADP(3-) [CHEBI:456216] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: 'acetylcholinesterase activity [GO:0003990] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'acetylcholine catabolic process [GO:0006581] (biological_process)'
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: choline kinase activity [GO:0004103] (molecular_function) —has output→ phosphocholines [CHEBI:36700] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: choline kinase activity [GO:0004103] (molecular_function) —has input→ choline [CHEBI:15354] (chemical entity)
  • SKIPPED_FACT: Subject 'choline-phosphate cytidylyltransferase activity [GO:0004105] (molecular_function)' has 'has output' relationship to 'diphosphate(3-) [CHEBI:33019] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'choline kinase activity [GO:0004103] (molecular_function)' has 'has input' relationship to 'ATP(4-) [CHEBI:30616] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: choline-phosphate cytidylyltransferase activity [GO:0004105] (molecular_function) —has output→ CDP-choline [CHEBI:16436] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: choline-phosphate cytidylyltransferase activity [GO:0004105] (molecular_function) —part of→ phosphatidylcholine biosynthetic process [GO:0006656] (biological_process) 
R-HSA-1483213
 Synthesis of PE - imported from: Reactome 2026-07-02 Curators at Reactome success
23 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylserine decarboxylase activity [GO:0004609] (molecular_function) —causally upstream of→ phosphatidate phosphatase activity [GO:0008195] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: ethanolaminephosphotransferase activity [GO:0004307] (molecular_function) —part of→ phosphatidylethanolamine biosynthetic process [GO:0006646] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: ethanolaminephosphotransferase activity [GO:0004307] (molecular_function) —has output→ phosphatidylethanolamine zwitterion [CHEBI:57613] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: ethanolaminephosphotransferase activity [GO:0004307] (molecular_function) —has input→ 1,2-diacyl-sn-glycerol [CHEBI:17815] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidate phosphatase activity [GO:0008195] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'phosphatidate phosphatase activity [GO:0008195] (molecular_function)' has 'has input' relationship to 'phosphatidate(2-) [CHEBI:57739] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'ethanolaminephosphotransferase activity [GO:0004307] (molecular_function)' has 'has output' relationship to 'phosphatidylethanolamine zwitterion [CHEBI:57613] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: ethanolaminephosphotransferase activity [GO:0004307] (molecular_function) —has output→ cytidine 5'-monophosphate(2-) [CHEBI:60377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidate phosphatase activity [GO:0008195] (molecular_function) —occurs in→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity)
  • SKIPPED_FACT: Subject 'ethanolaminephosphotransferase activity [GO:0004307] (molecular_function)' has 'has input' relationship to 'CDP-ethanolamine(1-) [CHEBI:57876] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'phosphatidate phosphatase activity [GO:0008195] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'ethanolaminephosphotransferase activity [GO:0004307] (molecular_function)' has 'has output' relationship to 'cytidine 5'-monophosphate(2-) [CHEBI:60377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'phosphatidate phosphatase activity [GO:0008195] (molecular_function)' has 'has output' relationship to '1,2-diacyl-sn-glycerol [CHEBI:17815] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: ethanolaminephosphotransferase activity [GO:0004307] (molecular_function) —has input→ CDP-ethanolamine(1-) [CHEBI:57876] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidate phosphatase activity [GO:0008195] (molecular_function) —has output→ 1,2-diacyl-sn-glycerol [CHEBI:17815] (chemical entity)
  • SKIPPED_FACT: Subject 'phosphatidate phosphatase activity [GO:0008195] (molecular_function)' has 'has output' relationship to 'hydrogenphosphate [CHEBI:43474] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidate phosphatase activity [GO:0008195] (molecular_function) —has output→ hydrogenphosphate [CHEBI:43474] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidate phosphatase activity [GO:0008195] (molecular_function) —part of→ phosphatidylethanolamine biosynthetic process [GO:0006646] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: ethanolaminephosphotransferase activity [GO:0004307] (molecular_function) —causally upstream of→ phosphatidylserine decarboxylase activity [GO:0004609] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidate phosphatase activity [GO:0008195] (molecular_function) —causally upstream of→ phosphatidylserine decarboxylase activity [GO:0004609] (molecular_function)
  • SKIPPED_FACT: Subject 'ethanolaminephosphotransferase activity [GO:0004307] (molecular_function)' has 'has input' relationship to '1,2-diacyl-sn-glycerol [CHEBI:17815] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: ethanolaminephosphotransferase activity [GO:0004307] (molecular_function) —occurs in→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidate phosphatase activity [GO:0008195] (molecular_function) —has input→ phosphatidate(2-) [CHEBI:57739] (chemical entity) 
R-HSA-1483148
 Synthesis of PG - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-1483226
 Synthesis of PI - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-1660516
 Synthesis of PIPs at the early endosome membrane - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
10 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function) —has output→ 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-) [CHEBI:58088] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function) —has input→ 1-phosphatidyl-1D-myo-inositol(1-) [CHEBI:57880] (chemical entity)
  • SKIPPED_FACT: Subject '1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function)' has 'has input' relationship to '1-phosphatidyl-1D-myo-inositol(1-) [CHEBI:57880] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function) —has input→ ATP(4-) [CHEBI:30616] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject '1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function)' has 'has output' relationship to '1-phosphatidyl-1D-myo-inositol 3-phosphate(3-) [CHEBI:58088] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject '1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function)' has 'has input' relationship to 'ATP(4-) [CHEBI:30616] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject '1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function)' has 'has output' relationship to 'ADP(3-) [CHEBI:456216] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function) —part of→ phosphatidylinositol biosynthetic process [GO:0006661] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function) —has output→ ADP(3-) [CHEBI:456216] (chemical entity) 
R-HSA-1483248
 Synthesis of PIPs at the ER membrane - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-1660514
 Synthesis of PIPs at the Golgi membrane - imported from: Reactome 2026-07-02 Curators at Reactome success
15 warnings
  • SKIPPED_FACT: Subject '1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function)' has 'has output' relationship to '1-phosphatidyl-1D-myo-inositol 3-phosphate(3-) [CHEBI:58088] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject '1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function)' has 'has input' relationship to 'ATP(4-) [CHEBI:30616] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol 4-kinase activator activity [GO:0098744] (molecular_function) —directly positively regulates→ 1-phosphatidylinositol 4-kinase activity [GO:0004430] (molecular_function)
  • SKIPPED_FACT: Subject '1-phosphatidylinositol 4-kinase activator activity [GO:0098744] (molecular_function)' has 'has input' relationship to 'PI4KB Hsap [UniProtKB:Q9UBF8] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol 4-kinase activator activity [GO:0098744] (molecular_function) —part of→ phosphatidylinositol biosynthetic process [GO:0006661] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function) —part of→ phosphatidylinositol biosynthetic process [GO:0006661] (biological_process)
  • SKIPPED_FACT: Subject '1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function)' has 'has output' relationship to 'ADP(3-) [CHEBI:456216] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function) —has output→ ADP(3-) [CHEBI:456216] (chemical entity)
  • SKIPPED_FACT: Subject '1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function)' has 'has input' relationship to '1-phosphatidyl-1D-myo-inositol(1-) [CHEBI:57880] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol 4-kinase activator activity [GO:0098744] (molecular_function) —has input→ PI4KB Hsap [UniProtKB:Q9UBF8] (information biomacromolecule)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function) —has output→ 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-) [CHEBI:58088] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function) —has input→ 1-phosphatidyl-1D-myo-inositol(1-) [CHEBI:57880] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol 4-kinase activator activity [GO:0098744] (molecular_function) —occurs in→ Golgi membrane [GO:0000139] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function) —has input→ ATP(4-) [CHEBI:30616] (chemical entity) 
R-HSA-1660517
 Synthesis of PIPs at the late endosome membrane - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
10 warnings
  • SKIPPED_FACT: Subject '1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function)' has 'has input' relationship to '1-phosphatidyl-1D-myo-inositol(1-) [CHEBI:57880] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function) —part of→ phosphatidylinositol biosynthetic process [GO:0006661] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function) —has output→ ADP(3-) [CHEBI:456216] (chemical entity)
  • SKIPPED_FACT: Subject '1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function)' has 'has output' relationship to '1-phosphatidyl-1D-myo-inositol 3-phosphate(3-) [CHEBI:58088] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject '1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function)' has 'has input' relationship to 'ATP(4-) [CHEBI:30616] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function) —has output→ 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-) [CHEBI:58088] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function) —has input→ 1-phosphatidyl-1D-myo-inositol(1-) [CHEBI:57880] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function) —has input→ ATP(4-) [CHEBI:30616] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject '1-phosphatidylinositol-3-kinase activity [GO:0016303] (molecular_function)' has 'has output' relationship to 'ADP(3-) [CHEBI:456216] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-1660499
 Synthesis of PIPs at the plasma membrane - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
40 warnings
  • SKIPPED_FACT: Subject 'phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629] (molecular_function)' has 'has output' relationship to 'hydrogenphosphate [CHEBI:43474] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629] (molecular_function) —part of→ phosphatidylinositol biosynthetic process [GO:0006661] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629] (molecular_function)' has 'has input' relationship to '1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-) [CHEBI:57923] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject '1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934] (molecular_function)' has 'has input' relationship to 'ATP(4-) [CHEBI:30616] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629] (molecular_function) —has input→ 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-) [CHEBI:57923] (chemical entity)
  • SKIPPED_FACT: Subject 'phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438] (molecular_function)' has 'has input' relationship to '1-phosphatidyl-1D-myo-inositol 3-phosphate(3-) [CHEBI:58088] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438] (molecular_function) —has input→ 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-) [CHEBI:58088] (chemical entity)
  • SKIPPED_FACT: Subject 'phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject '1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934] (molecular_function)' has 'has input' relationship to '1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) [CHEBI:58456] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934] (molecular_function) —has output→ ADP(3-) [CHEBI:456216] (chemical entity)
  • SKIPPED_FACT: Subject 'phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438] (molecular_function)' has 'has output' relationship to 'hydrogenphosphate [CHEBI:43474] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: 'phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898] (biological_process)'
  • SKIPPED_FACT: Subject '1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309] (molecular_function)' has 'has input' relationship to 'ATP(4-) [CHEBI:30616] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309] (molecular_function) —has output→ 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) [CHEBI:58456] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309] (molecular_function) —part of→ phosphatidylinositol biosynthetic process [GO:0006661] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309] (molecular_function) —has input→ 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-) [CHEBI:57795] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629] (molecular_function) —has output→ hydrogenphosphate [CHEBI:43474] (chemical entity)
  • SKIPPED_FACT: Subject '1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309] (molecular_function)' has 'has output' relationship to '1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) [CHEBI:58456] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309] (molecular_function) —has output→ ADP(3-) [CHEBI:456216] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934] (molecular_function) —has output→ 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-) [CHEBI:57836] (chemical entity)
  • SKIPPED_FACT: Subject '1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309] (molecular_function)' has 'has input' relationship to '1-phosphatidyl-1D-myo-inositol 5-phosphate(3-) [CHEBI:57795] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934] (molecular_function) —part of→ phosphatidylinositol biosynthetic process [GO:0006661] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934] (molecular_function) —has input→ 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) [CHEBI:58456] (chemical entity)
  • SKIPPED_FACT: Subject '1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309] (molecular_function)' has 'has output' relationship to 'ADP(3-) [CHEBI:456216] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629] (molecular_function)' has 'has output' relationship to '1-phosphatidyl-1D-myo-inositol 5-phosphate(3-) [CHEBI:57795] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629] (molecular_function) —has output→ 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-) [CHEBI:57795] (chemical entity)
  • SKIPPED_FACT: Subject 'phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject '1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934] (molecular_function)' has 'has output' relationship to 'ADP(3-) [CHEBI:456216] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309] (molecular_function) —has input→ ATP(4-) [CHEBI:30616] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934] (molecular_function) —has input→ ATP(4-) [CHEBI:30616] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438] (molecular_function) —has output→ 1-phosphatidyl-1D-myo-inositol(1-) [CHEBI:57880] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438] (molecular_function) —has output→ hydrogenphosphate [CHEBI:43474] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438] (molecular_function) —part of→ phosphatidylinositol biosynthetic process [GO:0006661] (biological_process)
  • SKIPPED_FACT: Subject '1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934] (molecular_function)' has 'has output' relationship to '1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-) [CHEBI:57836] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438] (molecular_function)' has 'has output' relationship to '1-phosphatidyl-1D-myo-inositol(1-) [CHEBI:57880] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-2162123
 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
38 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 11-hydroxythromboxane B2 dehydrogenase activity [GO:0036133] (molecular_function) —has input→ thromboxane B2(1-) [CHEBI:90696] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydro-lyase activity [GO:0016836] (molecular_function) —part of→ prostanoid biosynthetic process [GO:0046457] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: intramolecular oxidoreductase activity, transposing C=C bonds [GO:0016863] (molecular_function) —has output→ 13,14-dihydro-Delta(12)-prostaglandin J2(1-) [CHEBI:133424] (chemical entity)
  • SKIPPED_FACT: Subject 'intramolecular oxidoreductase activity, transposing C=C bonds [GO:0016863] (molecular_function)' has 'has input' relationship to 'prostaglandin J2(1-) [CHEBI:133396] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: isomerase activity [GO:0016853] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: isomerase activity [GO:0016853] (molecular_function) —has output→ prostaglandin B2(1-) [CHEBI:133391] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 11-hydroxythromboxane B2 dehydrogenase activity [GO:0036133] (molecular_function) —has output→ 11-dehydro-thromboxane B2(1-) [CHEBI:136539] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydro-lyase activity [GO:0016836] (molecular_function) —has input→ prostaglandin E2(1-) [CHEBI:606564] (chemical entity)
  • SKIPPED_FACT: Subject 'isomerase activity [GO:0016853] (molecular_function)' has 'has output' relationship to 'prostaglandin B2(1-) [CHEBI:133391] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: isomerase activity [GO:0016853] (molecular_function) —part of→ prostanoid biosynthetic process [GO:0046457] (biological_process)
  • SKIPPED_FACT: Subject '11-hydroxythromboxane B2 dehydrogenase activity [GO:0036133] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'hydro-lyase activity [GO:0016836] (molecular_function)' has 'has output' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'intramolecular oxidoreductase activity, transposing C=C bonds [GO:0016863] (molecular_function)' has 'has output' relationship to '13,14-dihydro-Delta(12)-prostaglandin J2(1-) [CHEBI:133424] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: isomerase activity [GO:0016853] (molecular_function) —has input→ prostaglandin C2(1-) [CHEBI:133392] (chemical entity)
  • SKIPPED_FACT: Subject 'isomerase activity [GO:0016853] (molecular_function)' has 'has output' relationship to 'prostaglandin C2(1-) [CHEBI:133392] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 11-hydroxythromboxane B2 dehydrogenase activity [GO:0036133] (molecular_function) —part of→ prostanoid biosynthetic process [GO:0046457] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-D synthase activity [GO:0004667] (molecular_function) —causally upstream of→ intramolecular oxidoreductase activity, transposing C=C bonds [GO:0016863] (molecular_function)
  • SKIPPED_FACT: Subject '11-hydroxythromboxane B2 dehydrogenase activity [GO:0036133] (molecular_function)' has 'has input' relationship to 'NAD(1-) [CHEBI:57540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'isomerase activity [GO:0016853] (molecular_function)' has 'has input' relationship to 'prostaglandin A2(1-) [CHEBI:133370] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 11-hydroxythromboxane B2 dehydrogenase activity [GO:0036133] (molecular_function) —has output→ NADH(2-) [CHEBI:57945] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: isomerase activity [GO:0016853] (molecular_function) —has output→ prostaglandin C2(1-) [CHEBI:133392] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: intramolecular oxidoreductase activity, transposing C=C bonds [GO:0016863] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject '11-hydroxythromboxane B2 dehydrogenase activity [GO:0036133] (molecular_function)' has 'has output' relationship to '11-dehydro-thromboxane B2(1-) [CHEBI:136539] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydro-lyase activity [GO:0016836] (molecular_function) —has output→ prostaglandin A2(1-) [CHEBI:133370] (chemical entity)
  • SKIPPED_FACT: Subject 'isomerase activity [GO:0016853] (molecular_function)' has 'has input' relationship to 'prostaglandin C2(1-) [CHEBI:133392] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject '11-hydroxythromboxane B2 dehydrogenase activity [GO:0036133] (molecular_function)' has 'has input' relationship to 'thromboxane B2(1-) [CHEBI:90696] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydro-lyase activity [GO:0016836] (molecular_function) —has output→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: intramolecular oxidoreductase activity, transposing C=C bonds [GO:0016863] (molecular_function) —part of→ prostanoid biosynthetic process [GO:0046457] (biological_process)
  • SKIPPED_FACT: Subject 'hydro-lyase activity [GO:0016836] (molecular_function)' has 'has output' relationship to 'prostaglandin A2(1-) [CHEBI:133370] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: isomerase activity [GO:0016853] (molecular_function) —has input→ prostaglandin A2(1-) [CHEBI:133370] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydro-lyase activity [GO:0016836] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject '11-hydroxythromboxane B2 dehydrogenase activity [GO:0036133] (molecular_function)' has 'has output' relationship to 'NADH(2-) [CHEBI:57945] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'hydro-lyase activity [GO:0016836] (molecular_function)' has 'has input' relationship to 'prostaglandin E2(1-) [CHEBI:606564] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 11-hydroxythromboxane B2 dehydrogenase activity [GO:0036133] (molecular_function) —occurs in→ endoplasmic reticulum lumen [GO:0005788] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 11-hydroxythromboxane B2 dehydrogenase activity [GO:0036133] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: intramolecular oxidoreductase activity, transposing C=C bonds [GO:0016863] (molecular_function) —has input→ prostaglandin J2(1-) [CHEBI:133396] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 11-hydroxythromboxane B2 dehydrogenase activity [GO:0036133] (molecular_function) —has input→ NAD(1-) [CHEBI:57540] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: thromboxane-A synthase activity [GO:0004796] (molecular_function) —causally upstream of→ 11-hydroxythromboxane B2 dehydrogenase activity [GO:0036133] (molecular_function) 
R-HSA-1855167
 Synthesis of pyrophosphates in the cytosol - imported from: Reactome 2026-07-02 Curators at Reactome success
26 warnings
  • SKIPPED_FACT: Subject 'inositol bisdiphosphate tetrakisphosphate diphosphatase activity [GO:0052841] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol diphosphate pentakisphosphate diphosphatase activity [GO:0052842] (molecular_function) —part of→ inositol phosphate metabolic process [GO:0043647] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol bisdiphosphate tetrakisphosphate diphosphatase activity [GO:0052841] (molecular_function) —has output→ 5-diphospho-1D-myo-inositol pentakisphosphate(13-) [CHEBI:58628] (chemical entity)
  • SKIPPED_FACT: Subject 'inositol bisdiphosphate tetrakisphosphate diphosphatase activity [GO:0052841] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'inositol bisdiphosphate tetrakisphosphate diphosphatase activity [GO:0052841] (molecular_function)' has 'has output' relationship to '5-diphospho-1D-myo-inositol pentakisphosphate(13-) [CHEBI:58628] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol diphosphate pentakisphosphate diphosphatase activity [GO:0052842] (molecular_function) —has output→ hydrogenphosphate [CHEBI:43474] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol diphosphate pentakisphosphate diphosphatase activity [GO:0052842] (molecular_function) —has input→ 5-diphospho-1D-myo-inositol pentakisphosphate(13-) [CHEBI:58628] (chemical entity)
  • SKIPPED_FACT: Subject 'inositol diphosphate pentakisphosphate diphosphatase activity [GO:0052842] (molecular_function)' has 'has output' relationship to 'myo-inositol hexakisphosphate(12-) [CHEBI:58130] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol hexakisphosphate kinase activity [GO:0000828] (molecular_function) —causally upstream of→ inositol diphosphate pentakisphosphate diphosphatase activity [GO:0052842] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol diphosphate pentakisphosphate diphosphatase activity [GO:0052842] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'inositol diphosphate pentakisphosphate diphosphatase activity [GO:0052842] (molecular_function)' has 'has output' relationship to 'hydrogenphosphate [CHEBI:43474] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'inositol diphosphate pentakisphosphate diphosphatase activity [GO:0052842] (molecular_function)' has 'has input' relationship to '5-diphospho-1D-myo-inositol pentakisphosphate(13-) [CHEBI:58628] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'inositol diphosphate pentakisphosphate diphosphatase activity [GO:0052842] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'inositol bisdiphosphate tetrakisphosphate diphosphatase activity [GO:0052841] (molecular_function)' has 'has output' relationship to 'hydrogenphosphate [CHEBI:43474] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol bisdiphosphate tetrakisphosphate diphosphatase activity [GO:0052841] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'inositol bisdiphosphate tetrakisphosphate diphosphatase activity [GO:0052841] (molecular_function)' has 'has output' relationship to 'hydrogenphosphate [CHEBI:43474] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: diphosphoinositol pentakisphosphate kinase activity [GO:0000829] (molecular_function) —causally upstream of→ inositol bisdiphosphate tetrakisphosphate diphosphatase activity [GO:0052841] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol bisdiphosphate tetrakisphosphate diphosphatase activity [GO:0052841] (molecular_function) —causally upstream of→ diphosphoinositol pentakisphosphate kinase activity [GO:0000829] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol diphosphate pentakisphosphate diphosphatase activity [GO:0052842] (molecular_function) —has output→ myo-inositol hexakisphosphate(12-) [CHEBI:58130] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol bisdiphosphate tetrakisphosphate diphosphatase activity [GO:0052841] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'inositol diphosphate pentakisphosphate diphosphatase activity [GO:0052842] (molecular_function)' has 'has output' relationship to 'myo-inositol hexakisphosphate(12-) [CHEBI:58130] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'inositol diphosphate pentakisphosphate diphosphatase activity [GO:0052842] (molecular_function)' has 'has output' relationship to 'hydrogenphosphate [CHEBI:43474] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'inositol diphosphate pentakisphosphate diphosphatase activity [GO:0052842] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol diphosphate pentakisphosphate diphosphatase activity [GO:0052842] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol bisdiphosphate tetrakisphosphate diphosphatase activity [GO:0052841] (molecular_function) —has output→ hydrogenphosphate [CHEBI:43474] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol bisdiphosphate tetrakisphosphate diphosphatase activity [GO:0052841] (molecular_function) —part of→ inositol phosphate metabolic process [GO:0043647] (biological_process) 
R-HSA-75876
 Synthesis of very long-chain fatty acyl-CoAs - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-1474151
 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
6 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —part of→ tetrahydrobiopterin metabolic process [GO:0046146] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —has input→ dyspropterin [CHEBI:17804] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —has output→ L-sepiapterin [CHEBI:194527] (chemical entity)
  • SKIPPED_FACT: Subject 'oxidoreductase activity [GO:0016491] (molecular_function)' has 'has output' relationship to 'L-sepiapterin [CHEBI:194527] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'oxidoreductase activity [GO:0016491] (molecular_function)' has 'has input' relationship to 'dyspropterin [CHEBI:17804] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-209968
 Thyroxine biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success
1 warning
  • SKIPPED_FACT: 'NAD(P)H oxidase H2O2-forming activity [GO:0016174] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'hydrogen peroxide biosynthetic process [GO:0050665] (biological_process)' 
R-HSA-174362
 Transport and metabolism of PAPS - imported from: Reactome 2026-07-02 Curators at Reactome success
9 warnings
  • SKIPPED_FACT: 'adenylylsulfate kinase activity [GO:0004020] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to '3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428] (biological_process)'
  • SKIPPED_FACT: 'sulfate transmembrane transporter activity [GO:0015116] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'sulfate transmembrane transport [GO:1902358] (biological_process)'
  • SKIPPED_FACT: 'sulfate adenylyltransferase (ATP) activity [GO:0004781] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to '3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428] (biological_process)'
  • SKIPPED_FACT: '3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to '3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427] (biological_process)'
  • SKIPPED_FACT: 'sulfate adenylyltransferase (ATP) activity [GO:0004781] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to '3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427] (biological_process)'
  • SKIPPED_FACT: 'sulfate transmembrane transporter activity [GO:0015116] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'sulfate transmembrane transport [GO:1902358] (biological_process)'
  • SKIPPED_FACT: 'adenylylsulfate kinase activity [GO:0004020] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to '3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427] (biological_process)'
  • SKIPPED_FACT: '3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to '5'-adenylyl sulfate transmembrane transport [GO:1902558] (biological_process)'
  • SKIPPED_FACT: 'sulfate transmembrane transporter activity [GO:0015116] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'sulfate transmembrane transport [GO:1902358] (biological_process)' 
R-HSA-9758890
 Transport of RCbl within the body - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
5 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: peptidase activity [GO:0008233] (molecular_function) —has output→ R-cob(III)alamin [CHEBI:140785] (chemical entity)
  • SKIPPED_FACT: Subject 'peptidase activity [GO:0008233] (molecular_function)' has 'has output' relationship to 'R-cob(III)alamin [CHEBI:140785] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: peptidase activity [GO:0008233] (molecular_function) —occurs in→ lysosomal lumen [GO:0043202] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: cargo receptor activity [GO:0038024] (molecular_function) —provides input for→ peptidase activity [GO:0008233] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: peptidase activity [GO:0008233] (molecular_function) —part of→ cobalamin transport [GO:0015889] (biological_process) 
R-HSA-75109
 Triglyceride biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-163560
 Triglyceride catabolism - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
1 warning
  • SKIPPED_FACT: 'glycerol-3-phosphate dehydrogenase (quinone) activity [GO:0004368] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'glycerol-3-phosphate shuttle [GO:0006127] (biological_process)' 
R-HSA-71240
 Tryptophan catabolism - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
28 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: N-acetyltransferase activity [GO:0008080] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • SKIPPED_FACT: Subject 'N-acetyltransferase activity [GO:0008080] (molecular_function)' has 'has input' relationship to 'L-kynurenine zwitterion [CHEBI:57959] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'N-acetyltransferase activity [GO:0008080] (molecular_function)' has 'has input' relationship to 'acetyl-CoA(4-) [CHEBI:57288] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'N-acetyltransferase activity [GO:0008080] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function) —has input→ NAD(1-) [CHEBI:57540] (chemical entity)
  • SKIPPED_FACT: Subject 'aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function)' has 'has output' relationship to '(2Z,4E)-2-ammoniomuconate(1-) [CHEBI:77859] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: 'L-tryptophan transmembrane transporter activity [GO:0015196] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'L-tryptophan transmembrane transport [GO:1904556] (biological_process)'
  • SKIPPED_FACT: Subject 'N-acetyltransferase activity [GO:0008080] (molecular_function)' has 'has output' relationship to 'coenzyme A(4-) [CHEBI:57287] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: N-acetyltransferase activity [GO:0008080] (molecular_function) —has input→ L-kynurenine zwitterion [CHEBI:57959] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function) —has input→ 2-aminomuconic 6-semialdehyde zwitterion [CHEBI:77634] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: N-acetyltransferase activity [GO:0008080] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • SKIPPED_FACT: Subject 'aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function)' has 'has output' relationship to 'NADH(2-) [CHEBI:57945] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function)' has 'has input' relationship to '2-aminomuconic 6-semialdehyde zwitterion [CHEBI:77634] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: 'L-amino acid transmembrane transporter activity [GO:0015179] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'L-alpha-amino acid transmembrane transport [GO:1902475] (biological_process)'
  • SKIPPED_FACT: Subject 'N-acetyltransferase activity [GO:0008080] (molecular_function)' has 'has output' relationship to 'N-acetylkynureninate(1-) [CHEBI:746924] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: N-acetyltransferase activity [GO:0008080] (molecular_function) —has output→ N-acetylkynureninate(1-) [CHEBI:746924] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function) —has output→ NADH(2-) [CHEBI:57945] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function) —part of→ L-tryptophan catabolic process [GO:0006569] (biological_process)
  • SKIPPED_FACT: Subject 'aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function)' has 'has input' relationship to 'NAD(1-) [CHEBI:57540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: N-acetyltransferase activity [GO:0008080] (molecular_function) —has input→ acetyl-CoA(4-) [CHEBI:57288] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: N-acetyltransferase activity [GO:0008080] (molecular_function) —part of→ L-tryptophan catabolic process [GO:0006569] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function) —has output→ (2Z,4E)-2-ammoniomuconate(1-) [CHEBI:77859] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: N-acetyltransferase activity [GO:0008080] (molecular_function) —has output→ coenzyme A(4-) [CHEBI:57287] (chemical entity)
  • SKIPPED_FACT: Subject 'aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-8963684
 Tyrosine catabolism - imported from: Reactome 2026-07-02 Curators at Reactome success
12 warnings
  • SKIPPED_FACT: Subject 'L-2-hydroxycarboxylate dehydrogenase (NAD+) activity [GO:0102443] (molecular_function)' has 'has input' relationship to 'NADH(2-) [CHEBI:57945] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'L-2-hydroxycarboxylate dehydrogenase (NAD+) activity [GO:0102443] (molecular_function)' has 'has output' relationship to 'NAD(1-) [CHEBI:57540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-2-hydroxycarboxylate dehydrogenase (NAD+) activity [GO:0102443] (molecular_function) —has output→ (R)-3-(4-hydroxyphenyl)lactate [CHEBI:10980] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-2-hydroxycarboxylate dehydrogenase (NAD+) activity [GO:0102443] (molecular_function) —has input→ 3-(4-hydroxyphenyl)pyruvate [CHEBI:36242] (chemical entity)
  • SKIPPED_FACT: Subject 'L-2-hydroxycarboxylate dehydrogenase (NAD+) activity [GO:0102443] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'L-2-hydroxycarboxylate dehydrogenase (NAD+) activity [GO:0102443] (molecular_function)' has 'has input' relationship to '3-(4-hydroxyphenyl)pyruvate [CHEBI:36242] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-2-hydroxycarboxylate dehydrogenase (NAD+) activity [GO:0102443] (molecular_function) —has output→ NAD(1-) [CHEBI:57540] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-2-hydroxycarboxylate dehydrogenase (NAD+) activity [GO:0102443] (molecular_function) —part of→ L-tyrosine catabolic process [GO:0006572] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-2-hydroxycarboxylate dehydrogenase (NAD+) activity [GO:0102443] (molecular_function) —has input→ hydron [CHEBI:15378] (chemical entity)
  • SKIPPED_FACT: Subject 'L-2-hydroxycarboxylate dehydrogenase (NAD+) activity [GO:0102443] (molecular_function)' has 'has output' relationship to '(R)-3-(4-hydroxyphenyl)lactate [CHEBI:10980] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-2-hydroxycarboxylate dehydrogenase (NAD+) activity [GO:0102443] (molecular_function) —has input→ NADH(2-) [CHEBI:57945] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-2-hydroxycarboxylate dehydrogenase (NAD+) activity [GO:0102443] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity) 
R-HSA-2142789
 Ubiquinol biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
36 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxy-lyase activity [GO:0016831] (molecular_function) —occurs in→ mitochondrial matrix [GO:0005759] (anatomical entity)
  • SKIPPED_FACT: Subject '4-hydroxybenzaldehyde dehydrogenase (NAD+) activity [GO:0018484] (molecular_function)' has 'has output' relationship to 'NADH(2-) [CHEBI:57945] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'carboxy-lyase activity [GO:0016831] (molecular_function)' has 'has output' relationship to '4-hydroxybenzaldehyde [CHEBI:17597] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has input' relationship to '2-decaprenyl-6-methoxyphenol [CHEBI:50774] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 4-hydroxybenzaldehyde dehydrogenase (NAD+) activity [GO:0018484] (molecular_function) —has output→ 4-hydroxybenzoate [CHEBI:17879] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has output→ NADP(3-) [CHEBI:58349] (chemical entity)
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has output' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has output' relationship to 'NADP(3-) [CHEBI:58349] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has output' relationship to '2-decaprenyl-6-methoxyhydroquinone [CHEBI:64180] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject '4-hydroxybenzaldehyde dehydrogenase (NAD+) activity [GO:0018484] (molecular_function)' has 'has input' relationship to 'NAD(1-) [CHEBI:57540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject '4-hydroxybenzaldehyde dehydrogenase (NAD+) activity [GO:0018484] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxy-lyase activity [GO:0016831] (molecular_function) —part of→ ubiquinone biosynthetic process [GO:0006744] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 4-hydroxybenzaldehyde dehydrogenase (NAD+) activity [GO:0018484] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has input→ hydron [CHEBI:15378] (chemical entity)
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has input' relationship to 'NADPH(4-) [CHEBI:57783] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'carboxy-lyase activity [GO:0016831] (molecular_function)' has 'has input' relationship to '(S)-4-hydroxymandelate [CHEBI:17210] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxy-lyase activity [GO:0016831] (molecular_function) —has output→ 4-hydroxybenzaldehyde [CHEBI:17597] (chemical entity)
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject '4-hydroxybenzaldehyde dehydrogenase (NAD+) activity [GO:0018484] (molecular_function)' has 'has output' relationship to '4-hydroxybenzoate [CHEBI:17879] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 4-hydroxybenzaldehyde dehydrogenase (NAD+) activity [GO:0018484] (molecular_function) —has input→ NAD(1-) [CHEBI:57540] (chemical entity)
  • SKIPPED_FACT: Subject '4-hydroxybenzaldehyde dehydrogenase (NAD+) activity [GO:0018484] (molecular_function)' has 'has input' relationship to '4-hydroxybenzaldehyde [CHEBI:17597] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has output→ 2-decaprenyl-6-methoxyhydroquinone [CHEBI:64180] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has input→ 2-decaprenyl-6-methoxyphenol [CHEBI:50774] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —part of→ ubiquinone biosynthetic process [GO:0006744] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 4-hydroxybenzaldehyde dehydrogenase (NAD+) activity [GO:0018484] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 4-hydroxybenzaldehyde dehydrogenase (NAD+) activity [GO:0018484] (molecular_function) —has input→ 4-hydroxybenzaldehyde [CHEBI:17597] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 4-hydroxybenzaldehyde dehydrogenase (NAD+) activity [GO:0018484] (molecular_function) —part of→ ubiquinone biosynthetic process [GO:0006744] (biological_process)
  • SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has input' relationship to 'dioxygen [CHEBI:15379] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 4-hydroxybenzaldehyde dehydrogenase (NAD+) activity [GO:0018484] (molecular_function) —occurs in→ mitochondrial matrix [GO:0005759] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: 4-hydroxybenzaldehyde dehydrogenase (NAD+) activity [GO:0018484] (molecular_function) —has output→ NADH(2-) [CHEBI:57945] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has input→ NADPH(4-) [CHEBI:57783] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has input→ dioxygen [CHEBI:15379] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —occurs in→ mitochondrial matrix [GO:0005759] (anatomical entity)
  • SKIPPED_FACT: Subject '4-hydroxybenzaldehyde dehydrogenase (NAD+) activity [GO:0018484] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxy-lyase activity [GO:0016831] (molecular_function) —has input→ (S)-4-hydroxymandelate [CHEBI:17210] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has output→ water [CHEBI:15377] (chemical entity) 
R-HSA-9758881
 Uptake of dietary cobalamins into enterocytes - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
5 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: peptidase activity [GO:0008233] (molecular_function) —has output→ R-cob(III)alamin [CHEBI:140785] (chemical entity)
  • SKIPPED_FACT: Subject 'peptidase activity [GO:0008233] (molecular_function)' has 'has output' relationship to 'R-cob(III)alamin [CHEBI:140785] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: cargo receptor activity [GO:0038024] (molecular_function) —provides input for→ peptidase activity [GO:0008233] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: peptidase activity [GO:0008233] (molecular_function) —occurs in→ lysosomal lumen [GO:0043202] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: peptidase activity [GO:0008233] (molecular_function) —part of→ cobalamin transport [GO:0015889] (biological_process) 
R-HSA-70635
 Urea cycle - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
5 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: binding [GO:0005488] (molecular_function) —part of→ urea cycle [GO:0000050] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: L-glutamate N-acetyltransferase activity, acting on acetyl-CoA as donor [GO:0004042] (molecular_function) —provides input for→ binding [GO:0005488] (molecular_function)
  • SKIPPED_FACT: Subject 'binding [GO:0005488] (molecular_function)' has 'has input' relationship to 'N-acetyl-L-glutamate(2-) [CHEBI:44337] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: binding [GO:0005488] (molecular_function) —directly positively regulates→ carbamoyl-phosphate synthase (ammonia) activity [GO:0004087] (molecular_function)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: binding [GO:0005488] (molecular_function) —has input→ N-acetyl-L-glutamate(2-) [CHEBI:44337] (chemical entity) 
R-HSA-196819
 Vitamin B1 (thiamin) metabolism - imported from: Reactome 2026-07-02 Curators at Reactome success
10 warnings
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: thiamine-diphosphate kinase activity [GO:0050331] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: thiamine-diphosphate kinase activity [GO:0050331] (molecular_function) —has output→ thiamine(1+) triphosphate [CHEBI:9534] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: thiamine-diphosphate kinase activity [GO:0050331] (molecular_function) —has input→ ATP(4-) [CHEBI:30616] (chemical entity)
  • SKIPPED_FACT: Subject 'thiamine-diphosphate kinase activity [GO:0050331] (molecular_function)' has 'has input' relationship to 'thiamine(1+) diphosphate(3-) [CHEBI:58937] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: thiamine-diphosphate kinase activity [GO:0050331] (molecular_function) —has output→ ADP(3-) [CHEBI:456216] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: thiamine-diphosphate kinase activity [GO:0050331] (molecular_function) —part of→ thiamine-containing compound metabolic process [GO:0042723] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: thiamine-diphosphate kinase activity [GO:0050331] (molecular_function) —has input→ thiamine(1+) diphosphate(3-) [CHEBI:58937] (chemical entity)
  • SKIPPED_FACT: Subject 'thiamine-diphosphate kinase activity [GO:0050331] (molecular_function)' has 'has output' relationship to 'thiamine(1+) triphosphate [CHEBI:9534] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'thiamine-diphosphate kinase activity [GO:0050331] (molecular_function)' has 'has input' relationship to 'ATP(4-) [CHEBI:30616] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • SKIPPED_FACT: Subject 'thiamine-diphosphate kinase activity [GO:0050331] (molecular_function)' has 'has output' relationship to 'ADP(3-) [CHEBI:456216] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-196843
 Vitamin B2 (riboflavin) metabolism - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-199220
 Vitamin B5 (pantothenate) metabolism - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
10 warnings
  • SKIPPED_FACT: Subject 'hydrolase activity [GO:0016787] (molecular_function)' has 'has input' relationship to 'coenzyme A(4-) [CHEBI:57287] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrolase activity [GO:0016787] (molecular_function) —has output→ D-pantetheine 4'-phosphate(2-) [CHEBI:61723] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrolase activity [GO:0016787] (molecular_function) —has output→ adenosine 3',5'-bismonophosphate(4-) [CHEBI:58343] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrolase activity [GO:0016787] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity)
  • SKIPPED_FACT: Subject 'hydrolase activity [GO:0016787] (molecular_function)' has 'has output' relationship to 'D-pantetheine 4'-phosphate(2-) [CHEBI:61723] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrolase activity [GO:0016787] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity)
  • SKIPPED_FACT: Subject 'hydrolase activity [GO:0016787] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrolase activity [GO:0016787] (molecular_function) —part of→ pantothenate metabolic process [GO:0015939] (biological_process)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrolase activity [GO:0016787] (molecular_function) —has input→ coenzyme A(4-) [CHEBI:57287] (chemical entity)
  • SKIPPED_FACT: Subject 'hydrolase activity [GO:0016787] (molecular_function)' has 'has output' relationship to 'adenosine 3',5'-bismonophosphate(4-) [CHEBI:58343] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-964975
 Vitamin B6 activation to pyridoxal phosphate - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-196836
 Vitamin C (ascorbate) metabolism - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations
10 warnings
  • SKIPPED_FACT: Subject 'glutathione dehydrogenase (ascorbate) activity [GO:0045174] (molecular_function)' has 'has output' relationship to 'glutathione disulfide(2-) [CHEBI:58297] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione dehydrogenase (ascorbate) activity [GO:0045174] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione dehydrogenase (ascorbate) activity [GO:0045174] (molecular_function) —has input→ L-dehydroascorbate [CHEBI:58539] (chemical entity)
  • SKIPPED_FACT: Subject 'glutathione dehydrogenase (ascorbate) activity [GO:0045174] (molecular_function)' has 'has input' relationship to 'L-dehydroascorbate [CHEBI:58539] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione dehydrogenase (ascorbate) activity [GO:0045174] (molecular_function) —has output→ glutathione disulfide(2-) [CHEBI:58297] (chemical entity)
  • SKIPPED_FACT: Subject 'glutathione dehydrogenase (ascorbate) activity [GO:0045174] (molecular_function)' has 'has input' relationship to 'glutathionate(1-) [CHEBI:57925] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione dehydrogenase (ascorbate) activity [GO:0045174] (molecular_function) —has input→ glutathionate(1-) [CHEBI:57925] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione dehydrogenase (ascorbate) activity [GO:0045174] (molecular_function) —has output→ L-ascorbate [CHEBI:38290] (chemical entity)
  • UNHANDLED_FACT: Fact not representable in GO-CAM model: glutathione dehydrogenase (ascorbate) activity [GO:0045174] (molecular_function) —part of→ L-ascorbic acid metabolic process [GO:0019852] (biological_process)
  • SKIPPED_FACT: Subject 'glutathione dehydrogenase (ascorbate) activity [GO:0045174] (molecular_function)' has 'has output' relationship to 'L-ascorbate [CHEBI:38290] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association 
R-HSA-196791
 Vitamin D (calciferol) metabolism - imported from: Reactome 2026-07-02 Curators at Reactome success 
R-HSA-211916
 Vitamins - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-9640463
 Wax biosynthesis - imported from: Reactome 2026-07-02 Curators at Reactome filtered Model has at least one activity with no causal relations 
R-HSA-6807062
 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) - imported from: Reactome 2026-07-02 Curators at Reactome success
Release date
2026-08-28
Pipeline name
pipeline-from-goa
Pipeline branch
main
Generated on
2026-08-29T14:10:14+00:00
gocam-py version
0.12.0.post65.dev0+8382d25a