GO-CAM-like Models Report — MGI

339 models
277 success
62 filtered
0 error

Model ID	Title	Date modified	Contributors	Pipeline result	Result details	Warnings
668d5f2700000201	CMP-N-acetylneuraminate biosynthetic process (Mouse)	2026-08-14	David Hill, Li Ni	success		10 warnings SKIPPED_FACT: Subject 'biosynthetic process [GO:0009058] (biological_process)' has 'has primary output' relationship to 'CMP-N-acetyl-beta-neuraminate(2-) [CHEBI:57812] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'transporter activity [GO:0005215] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'biosynthetic process [GO:0009058] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: biosynthetic process [GO:0009058] (biological_process) —has primary output→ CMP-N-acetyl-beta-neuraminate(2-) [CHEBI:57812] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target start location→ nucleoplasm [GO:0005654] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target end location→ Golgi lumen [GO:0005796] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: biosynthetic process [GO:0009058] (biological_process) —has primary output→ N-acetylneuraminate [CHEBI:35418] (chemical entity) SKIPPED_FACT: Subject 'biosynthetic process [GO:0009058] (biological_process)' has 'has primary output' relationship to 'N-acetylneuraminate [CHEBI:35418] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target end location→ nucleoplasm [GO:0005654] (anatomical entity)
623d156d00000975	Glycophagy (Mouse)	2026-08-10	David Hill, Li Ni	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: glycophagy [GO:0061723] (biological_process) —occurs in→ phagophore [GO:0061908] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: autophagosome-lysosome fusion [GO:0061909] (biological_process) —causally upstream of positive effect→ alpha-1,4-glucosidase activity [GO:0004558] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: autophagosome-lysosome fusion [GO:0061909] (biological_process) —part of→ glycophagy [GO:0061723] (biological_process)
YeastPathways_GLYCOLYSIS	glycolysis I (from glucose 6-phosphate) - imported from: Saccharomyces Genome Database	2026-07-30	Curators at SGD, David Hill, Stacia Engel, Suzi Aleksander	success
5c4605cc00002010	PMID:19644500LN	2026-07-17	Li Ni	filtered	Model has at least one activity with no causal relations	11 warnings SKIPPED_FACT: 'DNA-binding transcription factor activity [GO:0003700] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of transcription by RNA polymerase II [GO:0006357] (biological_process)' SKIPPED_FACT: Subject 'regulation of transcription by RNA polymerase II [GO:0006357] (biological_process)' has 'has input' relationship to 'Ercc1 Mmus [MGI:MGI:95412] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'regulation of transcription by RNA polymerase II [GO:0006357] (biological_process)' has 'has input' relationship to 'mXPC Mmus [PR:P51612] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: UV-damage excision repair [GO:0070914] (biological_process) —causally upstream of positive effect→ molecular_function [GO:0003674] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of transcription by RNA polymerase II [GO:0006357] (biological_process) —has input→ mXPC Mmus [PR:P51612] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'UV-damage excision repair [GO:0070914] (biological_process)' SKIPPED_FACT: Subject 'positive regulation of gene expression [GO:0010628] (biological_process)' has 'has input' relationship to 'Xpc Mmus [MGI:MGI:103557] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of transcription by RNA polymerase II [GO:0006357] (biological_process) —has input→ Ercc1 Mmus [MGI:MGI:95412] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of gene expression [GO:0010628] (biological_process) —causally upstream of positive effect→ molecular_function [GO:0003674] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within positive effect→ positive regulation of gene expression [GO:0010628] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of gene expression [GO:0010628] (biological_process) —has input→ Xpc Mmus [MGI:MGI:103557] (information biomacromolecule)
622aace900000962	Pentose-phosphate shunt 1 (Mouse)	2026-07-15	David Hill, Li Ni	success		4 warnings SKIPPED_FACT: 'glucose-6-phosphate dehydrogenase activity [GO:0004345] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'pentose-phosphate shunt, oxidative branch [GO:0009051] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: pentose-phosphate shunt [GO:0006098] (biological_process) —has primary output→ beta-D-fructofuranose 6-phosphate(2-) [CHEBI:57634] (chemical entity) SKIPPED_FACT: 'phosphogluconate dehydrogenase (decarboxylating) activity [GO:0004616] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'NADPH regeneration [GO:0006740] (biological_process)' SKIPPED_FACT: Subject 'pentose-phosphate shunt [GO:0006098] (biological_process)' has 'has primary output' relationship to 'beta-D-fructofuranose 6-phosphate(2-) [CHEBI:57634] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
6a18a9ba00001344	Polyuridylation-dependent mRNA catabolic process (Mouse)	2026-06-22	David Hill	success
682fbcd000004876	Cholesterol biosynthetic process via lathosterol (Mouse)	2026-06-16	David Hill, Li Ni	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: sterol transfer activity [GO:0120015] (molecular_function) —has target start location→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity)
68b0f0d000003768	Geranylgeranyl diphosphate biosynthetic process (Mouse)	2026-06-16	David Hill, Li Ni	success		2 warnings SKIPPED_FACT: Subject 'geranylgeranyl diphosphate biosynthetic process [GO:0033386] (biological_process)' has 'has output' relationship to '2-trans,6-trans,10-trans-geranylgeranyl diphosphate(3-) [CHEBI:58756] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: geranylgeranyl diphosphate biosynthetic process [GO:0033386] (biological_process) —has output→ 2-trans,6-trans,10-trans-geranylgeranyl diphosphate(3-) [CHEBI:58756] (chemical entity)
6516135700000380	Heme A biosynthetic process (Mouse)	2026-06-16	David Hill, Li Ni	filtered	Model has at least one activity with no causal relations	21 warnings SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has primary input' relationship to 'coproporphyrinogen III(4-) [CHEBI:57309] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'organophosphate biosynthetic process [GO:0090407] (biological_process)' has 'has primary output' relationship to '2-trans,6-trans-farnesyl diphosphate(3-) [CHEBI:175763] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target start location→ mitochondrial matrix [GO:0005759] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has primary input→ coproporphyrinogen III(4-) [CHEBI:57309] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target end location→ mitochondrial matrix [GO:0005759] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —part of→ heme A biosynthetic process [GO:0006784] (biological_process) SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has primary input' relationship to 'protoporphyrin(2-) [CHEBI:57306] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has primary input→ 5-ammoniolevulinate [CHEBI:356416] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has primary input→ protoporphyrin(2-) [CHEBI:57306] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target start location→ mitochondrial intermembrane space [GO:0005758] (anatomical entity) SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has output' relationship to 'protoporphyrin(2-) [CHEBI:57306] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has output→ coproporphyrinogen III(4-) [CHEBI:57309] (chemical entity) SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has primary input' relationship to '5-ammoniolevulinate [CHEBI:356416] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: organophosphate biosynthetic process [GO:0090407] (biological_process) —has primary output→ 2-trans,6-trans-farnesyl diphosphate(3-) [CHEBI:175763] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target end location→ mitochondrial intermembrane space [GO:0005758] (anatomical entity) SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has output' relationship to 'coproporphyrinogen III(4-) [CHEBI:57309] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has output→ protoporphyrin(2-) [CHEBI:57306] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has output' relationship to '5-ammoniolevulinate [CHEBI:356416] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has output→ 5-ammoniolevulinate [CHEBI:356416] (chemical entity)
67369e7600006071	Ubiquinone biosynthetic process 1 (Mouse)	2026-06-16	David Hill, Li Ni	success		20 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has input→ hydron [CHEBI:15378] (chemical entity) SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has input' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has output→ 2-methoxy-6-all-trans-nonaprenylhydroquinone [CHEBI:84529] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —part of→ ubiquinone biosynthetic process [GO:0006744] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has input→ 2-methoxy-6-(all-trans-nonaprenyl)phenol [CHEBI:84522] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —provides input for→ 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity [GO:0008425] (molecular_function) SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has input' relationship to 'dioxygen [CHEBI:15379] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has input' relationship to '2-methoxy-6-(all-trans-nonaprenyl)phenol [CHEBI:84522] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —occurs in→ mitochondrial matrix [GO:0005759] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has input→ dioxygen [CHEBI:15379] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has input→ NADPH [CHEBI:16474] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has output→ NADP(+) [CHEBI:18009] (chemical entity) SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has output' relationship to 'NADP(+) [CHEBI:18009] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: monooxygenase activity [GO:0004497] (molecular_function) —has output→ water [CHEBI:15377] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxy-lyase activity [GO:0016831] (molecular_function) —provides input for→ monooxygenase activity [GO:0004497] (molecular_function) SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has output' relationship to '2-methoxy-6-all-trans-nonaprenylhydroquinone [CHEBI:84529] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: organophosphate biosynthetic process [GO:0090407] (biological_process) —has primary output→ 2-trans,6-trans-farnesyl diphosphate(3-) [CHEBI:175763] (chemical entity) SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has output' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'monooxygenase activity [GO:0004497] (molecular_function)' has 'has input' relationship to 'NADPH [CHEBI:16474] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'organophosphate biosynthetic process [GO:0090407] (biological_process)' has 'has primary output' relationship to '2-trans,6-trans-farnesyl diphosphate(3-) [CHEBI:175763] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
63a86a8600000221	positive regulation of transcription from RNA polymerase II promoter by glucose 1 (Mouse)	2026-06-15	David Hill	success		4 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —positively regulates→ glycolytic process [GO:0006096] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: glycolytic process [GO:0006096] (biological_process) —occurs in→ hepatocyte [CL:0000182] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —occurs in→ hepatocyte [CL:0000182] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of transcription by RNA polymerase II [GO:0000122] (biological_process) —negatively regulates→ glycolytic process [GO:0006096] (biological_process)
63a86a8600000288	positive regulation of transcription from RNA polymerase II promoter by glucose 2 (Mouse)	2026-06-15	David Hill	success		4 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of transcription by RNA polymerase II [GO:0000122] (biological_process) —negatively regulates→ lipid biosynthetic process [GO:0008610] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: lipid biosynthetic process [GO:0008610] (biological_process) —occurs in→ hepatocyte [CL:0000182] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —occurs in→ hepatocyte [CL:0000182] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —positively regulates→ lipid biosynthetic process [GO:0008610] (biological_process)
63a86a8600000805	Positive regulation of transcription from RNA polymerase II promoter by glucose 3 (Mouse)	2026-06-15	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —occurs in→ hepatocyte [CL:0000182] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: lipid biosynthetic process [GO:0008610] (biological_process) —occurs in→ hepatocyte [CL:0000182] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —positively regulates→ lipid biosynthetic process [GO:0008610] (biological_process)
6a18a9ba00001160	Nuclear-transcribed mRNA poly(A) tail shortening (Mouse)	2026-06-04	David Hill	filtered	Model has at least one activity with no causal relations	3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: nuclear export signal receptor activity [GO:0005049] (molecular_function) —causally upstream of positive effect→ enzyme-substrate adaptor activity [GO:0140767] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: nuclear export signal receptor activity [GO:0005049] (molecular_function) —part of→ poly(A)+ mRNA export from nucleus [GO:0016973] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: CCR4-NOT complex [GO:0030014] (cellular_component) —part of→ P-body [GO:0000932] (anatomical entity)
693b3c0900005348	Tryptophan catabolic process 1 (Mouse)	2026-06-04	David Hill	success		18 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function) —part of→ L-tryptophan catabolic process [GO:0006569] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxy-lyase activity [GO:0016831] (molecular_function) —provides input for→ aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity) SKIPPED_FACT: Subject 'aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function)' has 'has output' relationship to '(2Z,4E)-2-ammoniomuconate(1-) [CHEBI:77859] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function) —has output→ (2Z,4E)-2-ammoniomuconate(1-) [CHEBI:77859] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function) —has output→ NADH(2-) [CHEBI:57945] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: L-tryptophan transmembrane transporter activity [GO:0015196] (molecular_function) —has target start location→ extracellular region [GO:0005576] (anatomical entity) SKIPPED_FACT: Subject 'aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function)' has 'has input' relationship to 'NAD(1-) [CHEBI:57540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function) —has input→ NAD(1-) [CHEBI:57540] (chemical entity) SKIPPED_FACT: 'L-tryptophan transmembrane transporter activity [GO:0015196] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'L-tryptophan transmembrane transport [GO:1904556] (biological_process)' SKIPPED_FACT: Subject 'aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function)' has 'has output' relationship to 'NADH(2-) [CHEBI:57945] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function)' has 'has input' relationship to '2-aminomuconic 6-semialdehyde zwitterion [CHEBI:77634] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function) —has input→ 2-aminomuconic 6-semialdehyde zwitterion [CHEBI:77634] (chemical entity) SKIPPED_FACT: Subject 'aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'aminomuconate-semialdehyde dehydrogenase (NAD+) activity [GO:0047102] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: L-tryptophan transmembrane transporter activity [GO:0015196] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity)
69ea894900004473	7-methylguanosine mRNA capping (Mouse)	2026-06-02	David Hill	success
67c10cc400008232	Cholesterol biosynthetic process via desmosterol (Mouse)	2026-05-28	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: sterol transfer activity [GO:0120015] (molecular_function) —has target start location→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity) SKIPPED_FACT: '3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity [GO:0000253] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'cholesterol biosynthetic process [GO:0006695] (biological_process)'
622aace900000413	fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate (Mouse)	2026-05-28	David Hill	success
6246724f00000078	Glucuronate catabolic process to xylulose 5-phosphate (Mouse)	2026-05-28	David Hill	success		4 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: L-gulonate 3-dehydrogenase activity [GO:0050104] (molecular_function) —provides input for→ dehydro-L-gulonate decarboxylase activity [GO:0047842] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: dehydro-L-gulonate decarboxylase activity [GO:0047842] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: dehydro-L-gulonate decarboxylase activity [GO:0047842] (molecular_function) —provides input for→ L-xylulose reductase (NADPH) activity [GO:0050038] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: dehydro-L-gulonate decarboxylase activity [GO:0047842] (molecular_function) —part of→ D-glucuronate catabolic process [GO:0042840] (biological_process)
60418ffa00000790	GMP catabolic process to guanine (Mouse)	2026-05-28	David Hill	success
69ea894900003185	Negative regulation of nitric oxide synthase activity (Mouse)	2026-05-11	David Hill	filtered	Model has at least one activity with no causal relations	2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: GTPase activity [GO:0003924] (molecular_function) —has target end location→ endocytic vesicle membrane [GO:0030666] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: GTPase activity [GO:0003924] (molecular_function) —has target start location→ plasma membrane [GO:0005886] (anatomical entity)
69729a3800008215	5-hydroxylysine catabolic process 1 (Mouse)	2026-05-06	David Hill, Li Ni	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: non-proteinogenic amino acid catabolic process [GO:0170044] (biological_process) —has primary input→ 5-hydroxylysine [CHEBI:60175] (chemical entity) SKIPPED_FACT: Subject 'non-proteinogenic amino acid catabolic process [GO:0170044] (biological_process)' has 'has primary input' relationship to '5-hydroxylysine [CHEBI:60175] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
69c59f8a00002841	Nitric oxide biosynthetic process 1 (Mouse)	2026-05-06	David Hill	filtered	Model has at least one activity with no causal relations	1 warning SKIPPED_FACT: 'dimethylargininase activity [GO:0016403] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'positive regulation of nitric oxide-cGMP mediated signal transduction [GO:0141150] (biological_process)'
63a86a8600001865	Irgb10/Gm12250 mediates disruption of the pathogen membrane, liberating ligands that are detected by inflammasomes (Mouse)	2026-04-17	David Hill, Sylvain Poux	success
69c59f8a00001593	Selenium compound metabolic process 2 (Mouse)	2026-04-09	David Hill	success
5941cdbd00000947	PMID:23913272-KRC Plekha8	2026-04-06	Karen Christie, Li Ni	filtered	Model has at least one activity with no causal relations	3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: glycosphingolipid binding [GO:0043208] (molecular_function) —RO:0002400→ glucosylceramide [CHEBI:36500] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: sphingolipid transfer activity [GO:0120016] (molecular_function) —provides input for→ globoside biosynthetic process [GO:0001576] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: globoside biosynthetic process [GO:0001576] (biological_process) —occurs in→ trans-Golgi network [GO:0005802] (anatomical entity)
60d5209a00001519	'de novo' CTP biosynthesis, mouse	2026-04-05	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: 'de novo' CTP biosynthetic process [GO:0044210] (biological_process) —RO:0002224→ carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: 'de novo' CTP biosynthetic process [GO:0044210] (biological_process) —ends with→ CTP synthase activity [GO:0003883] (molecular_function)
69729a3800008790	D-Lysine catabolic process (Mouse)	2026-04-05	David Hill	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: amino acid catabolic process [GO:0009063] (biological_process) —occurs in→ brain [EMAPA:16894] (anatomical entity)
69729a3800008054	L-Lysine catabolic process 2 (Mouse)	2026-04-05	David Hill	success		6 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: L-amino-acid oxidase activity [GO:0001716] (molecular_function) —causally upstream of positive effect→ delta1-piperideine-2-carboxylate reductase activity [GO:0047125] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: L-amino-acid oxidase activity [GO:0001716] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: L-lysine catabolic process [GO:0019477] (biological_process) —occurs in→ brain [EMAPA:16894] (anatomical entity) SKIPPED_FACT: Subject 'L-amino-acid oxidase activity [GO:0001716] (molecular_function)' has 'has input' relationship to 'D-lysinium(1+) [CHEBI:32557] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: L-amino-acid oxidase activity [GO:0001716] (molecular_function) —part of→ L-lysine catabolic process [GO:0019477] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: L-amino-acid oxidase activity [GO:0001716] (molecular_function) —has input→ D-lysinium(1+) [CHEBI:32557] (chemical entity)
66e382fb00003045	Protein lipoylation 1 (Mouse)	2026-04-03	David Hill, Li Ni	success
69c59f8a00001158	Selenium compound metabolic process 1 (Mouse)	2026-04-01	David Hill	success
69b3372b00003391	Selenocysteine metabolic process 2 (Mouse)	2026-03-31	David Hill	success
68d5ebd600002976	Gamma-aminobutyric acid catabolic process (Mouse)	2026-03-26	David Hill	success
68d5ebd600002604	Oxoglutarate metabolic process (Mouse)	2026-03-26	David Hill	success		4 warnings SKIPPED_FACT: Subject 'biosynthetic process [GO:0009058] (biological_process)' has 'has primary output' relationship to '2-oxoglutarate(2-) [CHEBI:16810] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: biosynthetic process [GO:0009058] (biological_process) —has primary output→ 2-oxoglutarate(2-) [CHEBI:16810] (chemical entity) SKIPPED_FACT: Subject 'catabolic process [GO:0009056] (biological_process)' has 'has primary input' relationship to '4-hydroxybutyrate [CHEBI:16724] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: catabolic process [GO:0009056] (biological_process) —has primary input→ 4-hydroxybutyrate [CHEBI:16724] (chemical entity)
MGI_MGI_1278344	Nipsnap1 (MGI:MGI:1278344)	2026-03-23	David Hill, Dmitry Sitnikov, Harold Drabkin	filtered	Model has at least one activity with no causal relations	8 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: Nipsnap1 Mmus [MGI:MGI:1278344] (information biomacromolecule) —located in→ membrane [GO:0016020] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: mitochondrion [GO:0005739] (anatomical entity) —part of→ heart [EMAPA:16105] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Nipsnap1 Mmus [MGI:MGI:1278344] (information biomacromolecule) —located in→ mitochondrion [GO:0005739] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Nipsnap1 Mmus [MGI:MGI:1278344] (information biomacromolecule) —located in→ mitochondrial inner membrane [GO:0005743] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: mitochondrion [GO:0005739] (anatomical entity) —part of→ liver [EMAPA:16846] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: neuron-neuron synaptic transmission [GO:0007270] (biological_process) —occurs in→ spinal cord [EMAPA:17577] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: mitochondrion [GO:0005739] (anatomical entity) —part of→ metanephros [EMAPA:17373] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: mitochondrion [GO:0005739] (anatomical entity) —part of→ brain [EMAPA:16894] (anatomical entity)
69b3372b00002132	Selenium compound metabolic process (Mouse)	2026-03-23	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: selenium compound metabolic process [GO:0001887] (biological_process) —has primary output→ trimethylselenonium [CHEBI:77058] (chemical entity) SKIPPED_FACT: Subject 'selenium compound metabolic process [GO:0001887] (biological_process)' has 'has primary output' relationship to 'trimethylselenonium [CHEBI:77058] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
60ad85f700002009	Enpp1 mouse	2026-03-19	David Hill, Dmitry Sitnikov, Harold Drabkin, Li Ni, Pascale Gaudet	filtered	Model has at least one activity with no causal relations	282 warnings SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Ank Mmus [MGI:MGI:3045421] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'calcium ion homeostasis [GO:0055074] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'artery development [GO:0060840] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Enpp1 Mmus [MGI:MGI:97370] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Runx2 Mmus [MGI:MGI:99829] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Alpl Mmus [MGI:MGI:87983] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: inhibition of non-skeletal tissue mineralization [GO:0140928] (biological_process) —occurs in→ vibrissa epithelium [EMAPA:17530] (anatomical entity) SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Ngfr Mmus [MGI:MGI:97323] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: bone mineralization [GO:0030282] (biological_process) —occurs in→ lumbar vertebra [EMAPA:18007] (anatomical entity) SKIPPED_FACT: 'gene expression [GO:0010467] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'bone development [GO:0060348] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: mRNA transcription by RNA polymerase II [GO:0042789] (biological_process) —has input→ Slc2a4 Mmus [MGI:MGI:95758] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bone mineralization [GO:0030282] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bone development [GO:0060348] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Mapk1 Mmus [MGI:MGI:1346858] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'biomineral tissue development [GO:0031214] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'phosphate ion homeostasis [GO:0055062] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'aorta development [GO:0035904] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'vascular associated smooth muscle cell migration [GO:1904738] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bone remodeling [GO:0046849] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Spp1 Mmus [MGI:MGI:98389] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —occurs in→ calvarial osteoblast [CL:2000058] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: bone mineralization involved in bone maturation [GO:0035630] (biological_process) —occurs in→ femur [EMAPA:19143] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'skin development [GO:0043588] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'inorganic diphosphate transport [GO:0030505] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Enpp1 Mmus [MGI:MGI:97370] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: D-glucose import across plasma membrane [GO:0098708] (biological_process) —occurs in→ plasma cell [CL:0000786] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'metabolic process [GO:0008152] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: calcium ion homeostasis [GO:0055074] (biological_process) —occurs in→ metanephros [EMAPA:17373] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: inhibition of non-skeletal tissue mineralization [GO:0140928] (biological_process) —occurs in→ connective tissue [EMAPA:35251] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'immunoglobulin production involved in immunoglobulin-mediated immune response [GO:0002381] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bone growth [GO:0098868] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'vasculogenesis [GO:0001570] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: glycolytic process [GO:0006096] (biological_process) —occurs in→ plasma cell [CL:0000786] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bone mineralization [GO:0030282] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: bone morphogenesis [GO:0060349] (biological_process) —occurs in→ trabecular bone [EMAPA:35873] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: calcium ion homeostasis [GO:0055074] (biological_process) —occurs in→ renal artery [EMAPA:28373] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'calcium ion homeostasis [GO:0055074] (biological_process)' SKIPPED_FACT: 'calcium ion homeostasis [GO:0055074] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'response to sodium phosphate [GO:1904383] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid metabolic process [GO:0006631] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Fas Mmus [MGI:MGI:95484] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: long-term synaptic potentiation [GO:0060291] (biological_process) —occurs in→ hippocampus [EMAPA:32845] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Enpp1 Mmus [MGI:MGI:97370] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: mRNA transcription by RNA polymerase II [GO:0042789] (biological_process) —occurs in→ subcutaneous adipocyte [CL:0002521] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: inhibition of non-skeletal tissue mineralization [GO:0140928] (biological_process) —occurs in→ stapedial artery [EMAPA:17313] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: bone mineralization involved in bone maturation [GO:0035630] (biological_process) —occurs in→ tibia [EMAPA:19142] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: ossification [GO:0001503] (biological_process) —occurs in→ cochlea [EMAPA:17597] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: bone mineralization [GO:0030282] (biological_process) —occurs in→ femur [EMAPA:19143] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: bone remodeling [GO:0046849] (biological_process) —occurs in→ lumbar region of vertebral column [UBERON:0006074] (anatomical entity) SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Ddit3 Mmus [MGI:MGI:109247] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'response to sodium phosphate [GO:1904383] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'response to sodium phosphate [GO:1904383] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'morphogenesis of an epithelium [GO:0002009] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'determination of adult lifespan [GO:0008340] (biological_process)' SKIPPED_FACT: Subject 'mRNA transcription by RNA polymerase II [GO:0042789] (biological_process)' has 'has input' relationship to 'Sost Mmus [MGI:MGI:1921749] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'calcium ion homeostasis [GO:0055074] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Mapk3 Mmus [MGI:MGI:1346859] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: hormone metabolic process [GO:0042445] (biological_process) —occurs in→ plasma [EMAPA:35690] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bone morphogenesis [GO:0060349] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: mRNA transcription by RNA polymerase II [GO:0042789] (biological_process) —has input→ Fgf23 Mmus [MGI:MGI:1891427] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: biomineral tissue development [GO:0031214] (biological_process) —occurs in→ ear [EMAPA:16193] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'osteoclast differentiation [GO:0030316] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Kl Mmus [MGI:MGI:1101771] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'long-term synaptic potentiation [GO:0060291] (biological_process)' SKIPPED_FACT: 'response to magnesium ion [GO:0032026] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'phosphate ion homeostasis [GO:0055062] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'hematopoietic stem cell migration to bone marrow [GO:0097241] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'mRNA transcription by RNA polymerase II [GO:0042789] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Kl Mmus [MGI:MGI:1101771] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'adult walking behavior [GO:0007628] (biological_process)' SKIPPED_FACT: Subject 'mRNA transcription by RNA polymerase II [GO:0042789] (biological_process)' has 'has input' relationship to 'Sost Mmus [MGI:MGI:1921749] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Entpd5 Mmus [MGI:MGI:1321385] (information biomacromolecule) SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Mapk1 Mmus [MGI:MGI:1346858] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: bone mineralization [GO:0030282] (biological_process) —occurs in→ tibia [EMAPA:19142] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'ligamentous ossification [GO:0036076] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: fatty acid metabolic process [GO:0006631] (biological_process) —occurs in→ serum [EMAPA:35770] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'inhibition of non-skeletal tissue mineralization [GO:0140928] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'calcium ion homeostasis [GO:0055074] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Ngfr Mmus [MGI:MGI:97323] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: bone remodeling [GO:0046849] (biological_process) —occurs in→ humerus [EMAPA:19106] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'multicellular organism growth [GO:0035264] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'endochondral ossification [GO:0001958] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'glucose homeostasis [GO:0042593] (biological_process)' SKIPPED_FACT: 'calcium ion homeostasis [GO:0055074] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'response to sodium phosphate [GO:1904383] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'response to dietary excess [GO:0002021] (biological_process)' SKIPPED_FACT: 'gene expression [GO:0010467] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'ligamentous ossification [GO:0036076] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: bone mineralization involved in bone maturation [GO:0035630] (biological_process) —occurs in→ vertebra [EMAPA:32740] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: mRNA transcription by RNA polymerase II [GO:0042789] (biological_process) —occurs in→ fat pad [EMAPA:35340] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of gene expression [GO:0010628] (biological_process) —has output→ Ibsp Mmus [MGI:MGI:96389] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: bone mineralization [GO:0030282] (biological_process) —occurs in→ carpal bone [EMAPA:25056] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: calcium ion homeostasis [GO:0055074] (biological_process) —occurs in→ arcuate artery [EMAPA:28215] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Ddit3 Mmus [MGI:MGI:109247] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bone mineralization [GO:0030282] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'adult locomotory behavior [GO:0008344] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Alpl Mmus [MGI:MGI:87983] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'interleukin-10 production [GO:0032613] (biological_process)' SKIPPED_FACT: 'response to sodium phosphate [GO:1904383] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'determination of adult lifespan [GO:0008340] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'sensory perception of mechanical stimulus [GO:0050954] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'post-embryonic forelimb morphogenesis [GO:0035128] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bone mineralization involved in bone maturation [GO:0035630] (biological_process)' SKIPPED_FACT: 'calcium ion homeostasis [GO:0055074] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'response to magnesium ion [GO:0032026] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'cementum mineralization [GO:0071529] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: biomineral tissue development [GO:0031214] (biological_process) —occurs in→ vibrissa follicle [UBERON:0010419] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'calcium ion homeostasis [GO:0055074] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bone mineralization [GO:0030282] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Fas Mmus [MGI:MGI:95484] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: bone mineralization [GO:0030282] (biological_process) —occurs in→ osteoblast [CL:0000062] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: mRNA transcription by RNA polymerase II [GO:0042789] (biological_process) —has input→ Fndc5 Mmus [MGI:MGI:1917614] (information biomacromolecule) SKIPPED_FACT: 'plasma cell differentiation [GO:0002317] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'defense response to protozoan [GO:0042832] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Fas Mmus [MGI:MGI:95484] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'macrophage differentiation [GO:0030225] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'determination of adult lifespan [GO:0008340] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'lymphocyte migration [GO:0072676] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Tnfrsf1a Mmus [MGI:MGI:1314884] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'kidney development [GO:0001822] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'phosphate ion homeostasis [GO:0055062] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Sp7 Mmus [MGI:MGI:2153568] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'vascular associated smooth muscle cell proliferation [GO:1990874] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'mRNA transcription by RNA polymerase II [GO:0042789] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: calcium ion homeostasis [GO:0055074] (biological_process) —occurs in→ medullary tubule [EMAPA:35557] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'cartilage development [GO:0051216] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'inhibition of non-skeletal tissue mineralization [GO:0140928] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'phosphate ion homeostasis [GO:0055062] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: mRNA transcription by RNA polymerase II [GO:0042789] (biological_process) —has input→ Sost Mmus [MGI:MGI:1921749] (information biomacromolecule) SKIPPED_FACT: 'gene expression [GO:0010467] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'smoothened signaling pathway [GO:0007224] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Ank Mmus [MGI:MGI:3045421] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: Subject 'mRNA transcription by RNA polymerase II [GO:0042789] (biological_process)' has 'has input' relationship to 'Fgf23 Mmus [MGI:MGI:1891427] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: calcium ion homeostasis [GO:0055074] (biological_process) —occurs in→ plasma [EMAPA:35690] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: plasma cell differentiation [GO:0002317] (biological_process) —occurs in→ bone marrow [EMAPA:32760] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphoric diester hydrolase activity [GO:0008081] (molecular_function) —causally upstream of or within negative effect→ protein poly-ADP-ribosylation [GO:0070212] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: morphogenesis of an epithelium [GO:0002009] (biological_process) —occurs in→ middle ear [EMAPA:17000] (anatomical entity) SKIPPED_FACT: 'calcium ion homeostasis [GO:0055074] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'bone mineralization [GO:0030282] (biological_process)' SKIPPED_FACT: 'response to magnesium ion [GO:0032026] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'inhibition of non-skeletal tissue mineralization [GO:0140928] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Kl Mmus [MGI:MGI:1101771] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Entpd5 Mmus [MGI:MGI:1321385] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'plasma cell differentiation [GO:0002317] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: mRNA transcription by RNA polymerase II [GO:0042789] (biological_process) —occurs in→ osteoblast [CL:0000062] (anatomical entity) SKIPPED_FACT: 'gene expression [GO:0010467] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'collagen-activated signaling pathway [GO:0038065] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fat cell differentiation [GO:0045444] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: calcium ion homeostasis [GO:0055074] (biological_process) —occurs in→ skin [EMAPA:17525] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: bone mineralization involved in bone maturation [GO:0035630] (biological_process) —occurs in→ compact bone [EMAPA:35250] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: biomineral tissue development [GO:0031214] (biological_process) —occurs in→ vertebra [EMAPA:32740] (anatomical entity) SKIPPED_FACT: 'vascular associated smooth muscle cell proliferation [GO:1990874] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'response to platelet-derived growth factor [GO:0036119] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bone mineralization [GO:0030282] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'calcium ion homeostasis [GO:0055074] (biological_process)' SKIPPED_FACT: 'bone trabecula formation [GO:0060346] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'endochondral bone morphogenesis [GO:0060350] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: bone mineralization [GO:0030282] (biological_process) —occurs in→ hindlimb [EMAPA:17458] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: bone remodeling [GO:0046849] (biological_process) —occurs in→ tibia [EMAPA:19142] (anatomical entity) SKIPPED_FACT: 'neuron apoptotic process [GO:0051402] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'axon regeneration [GO:0031103] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'multicellular organism growth [GO:0035264] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphate ion homeostasis [GO:0055062] (biological_process) —occurs in→ plasma [EMAPA:35690] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of positive effect→ cell morphogenesis [GO:0000902] (biological_process) SKIPPED_FACT: 'calcium ion homeostasis [GO:0055074] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'inhibition of non-skeletal tissue mineralization [GO:0140928] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: cartilage development [GO:0051216] (biological_process) —occurs in→ skeletal joint [EMAPA:35456] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: ligamentous ossification [GO:0036076] (biological_process) —occurs in→ knee joint [EMAPA:19137] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Runx2 Mmus [MGI:MGI:99829] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'inhibition of non-skeletal tissue mineralization [GO:0140928] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Spp1 Mmus [MGI:MGI:98389] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bone trabecula formation [GO:0060346] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: bone mineralization involved in bone maturation [GO:0035630] (biological_process) —occurs in→ bone marrow [EMAPA:32760] (anatomical entity) SKIPPED_FACT: 'calcium ion homeostasis [GO:0055074] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'cell population proliferation [GO:0008283] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: inhibition of non-skeletal tissue mineralization [GO:0140928] (biological_process) —occurs in→ metanephros [EMAPA:17373] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'ligamentous ossification [GO:0036076] (biological_process)' SKIPPED_FACT: 'chromatin DNA binding [GO:0031490] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'positive regulation of gene expression [GO:0010628] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —occurs in→ aorta [EMAPA:18601] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'vitamin D3 metabolic process [GO:0070640] (biological_process)' SKIPPED_FACT: 'bone trabecula formation [GO:0060346] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'bone mineralization involved in bone maturation [GO:0035630] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'phosphate ion homeostasis [GO:0055062] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fat cell proliferation [GO:0070341] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —occurs in→ spinal cord [EMAPA:17577] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —occurs in→ cartilage [EMAPA:32730] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cartilage development [GO:0051216] (biological_process) —occurs in→ intervertebral disc [EMAPA:32739] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'response to sodium phosphate [GO:1904383] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'vascular associated smooth muscle cell proliferation [GO:1990874] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: biomineral tissue development [GO:0031214] (biological_process) —occurs in→ trachea [EMAPA:16853] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: mucus secretion [GO:0070254] (biological_process) —occurs in→ goblet cell [CL:0000160] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'diphosphate metabolic process [GO:0071344] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: mRNA transcription by RNA polymerase II [GO:0042789] (biological_process) —has input→ Ppargc1a Mmus [MGI:MGI:1342774] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fat cell differentiation [GO:0045444] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'biomineral tissue development [GO:0031214] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Tnfrsf1a Mmus [MGI:MGI:1314884] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'mRNA transcription by RNA polymerase II [GO:0042789] (biological_process)' has 'has input' relationship to 'Fndc5 Mmus [MGI:MGI:1917614] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'oligodendrocyte apoptotic process [GO:0097252] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'axon regeneration [GO:0031103] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bone mineralization [GO:0030282] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'determination of adult lifespan [GO:0008340] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Ank Mmus [MGI:MGI:3045421] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Enpp1 Mmus [MGI:MGI:97370] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: inhibition of non-skeletal tissue mineralization [GO:0140928] (biological_process) —occurs in→ skin [EMAPA:17525] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: lymphocyte migration [GO:0072676] (biological_process) —occurs in→ peritoneum [EMAPA:16139] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Mapk14 Mmus [MGI:MGI:1346865] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: bone remodeling [GO:0046849] (biological_process) —occurs in→ trabecular bone [EMAPA:35873] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: inorganic diphosphate transport [GO:0030505] (biological_process) —occurs in→ plasma [EMAPA:35690] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: calcium ion homeostasis [GO:0055074] (biological_process) —occurs in→ aorta [EMAPA:18601] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'response to vitamin B6 [GO:0034516] (biological_process)' SKIPPED_FACT: Subject 'mRNA transcription by RNA polymerase II [GO:0042789] (biological_process)' has 'has input' relationship to 'Ppargc1a Mmus [MGI:MGI:1342774] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: calcium ion homeostasis [GO:0055074] (biological_process) —occurs in→ heart [EMAPA:16105] (anatomical entity) SKIPPED_FACT: 'gene expression [GO:0010467] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'Wnt signaling pathway [GO:0016055] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'calcium ion homeostasis [GO:0055074] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'response to vitamin B6 [GO:0034516] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'phosphate ion homeostasis [GO:0055062] (biological_process)' SKIPPED_FACT: 'calcium ion homeostasis [GO:0055074] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'response to sodium phosphate [GO:1904383] (biological_process)' SKIPPED_FACT: 'vascular associated smooth muscle cell migration [GO:1904738] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'artery development [GO:0060840] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: adipose tissue development [GO:0060612] (biological_process) —occurs in→ epididymal fat pad [EMAPA:35316] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Ngfr Mmus [MGI:MGI:97323] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'microglial cell migration [GO:1904124] (biological_process)' SKIPPED_FACT: 'diphosphate metabolic process [GO:0071344] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'phosphate ion homeostasis [GO:0055062] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: mRNA transcription by RNA polymerase II [GO:0042789] (biological_process) —occurs in→ osteocyte [CL:0000137] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: inhibition of non-skeletal tissue mineralization [GO:0140928] (biological_process) —occurs in→ aortic smooth muscle cell [CL:0002539] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'middle ear morphogenesis [GO:0042474] (biological_process)' SKIPPED_FACT: Subject 'positive regulation of gene expression [GO:0010628] (biological_process)' has 'has output' relationship to 'Ibsp Mmus [MGI:MGI:96389] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: calcium ion homeostasis [GO:0055074] (biological_process) —occurs in→ growth plate cartilage chondrocyte [CL:1000217] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'mRNA transcription by RNA polymerase II [GO:0042789] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'B-1 B cell homeostasis [GO:0001922] (biological_process)' SKIPPED_FACT: Subject 'mRNA transcription by RNA polymerase II [GO:0042789] (biological_process)' has 'has input' relationship to 'Slc2a4 Mmus [MGI:MGI:95758] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'glycolytic process [GO:0006096] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'calcium ion homeostasis [GO:0055074] (biological_process)' SKIPPED_FACT: 'bone remodeling [GO:0046849] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'bone remodeling [GO:0046849] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: inhibition of non-skeletal tissue mineralization [GO:0140928] (biological_process) —occurs in→ aorta [EMAPA:18601] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: inorganic diphosphate transport [GO:0030505] (biological_process) —occurs in→ urine [EMAPA:36554] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'articular cartilage development [GO:0061975] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Fgf23 Mmus [MGI:MGI:1891427] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'response to Gram-positive bacterium [GO:0140459] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Fgf23 Mmus [MGI:MGI:1891427] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Tnfrsf1a Mmus [MGI:MGI:1314884] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell morphogenesis [GO:0000902] (biological_process) —part of→ osteoblast differentiation [GO:0001649] (biological_process) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'adipose tissue development [GO:0060612] (biological_process)' SKIPPED_FACT: 'response to magnesium ion [GO:0032026] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'calcium ion homeostasis [GO:0055074] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bone mineralization involved in bone maturation [GO:0035630] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'ossification [GO:0001503] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —occurs in→ artery [EMAPA:35147] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: calcium ion homeostasis [GO:0055074] (biological_process) —occurs in→ skeletal joint [EMAPA:35456] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell population proliferation [GO:0008283] (biological_process) —occurs in→ skeletal ligament [EMAPA:37004] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'calcium ion homeostasis [GO:0055074] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: mRNA transcription by RNA polymerase II [GO:0042789] (biological_process) —has input→ Cpt1a Mmus [MGI:MGI:1098296] (information biomacromolecule) SKIPPED_FACT: 'calcium ion homeostasis [GO:0055074] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'inorganic diphosphate transport [GO:0030505] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'inhibition of non-skeletal tissue mineralization [GO:0140928] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: cartilage development [GO:0051216] (biological_process) —occurs in→ stromal cell of bone marrow [CL:0010001] (anatomical entity) SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Sp7 Mmus [MGI:MGI:2153568] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'mRNA transcription by RNA polymerase II [GO:0042789] (biological_process)' has 'has input' relationship to 'Cpt1a Mmus [MGI:MGI:1098296] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'microglia differentiation [GO:0014004] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: ligamentous ossification [GO:0036076] (biological_process) —occurs in→ spinal cord [EMAPA:17577] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'articular cartilage development [GO:0061975] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: inhibition of non-skeletal tissue mineralization [GO:0140928] (biological_process) —occurs in→ skeletal joint [EMAPA:35456] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Mapk3 Mmus [MGI:MGI:1346859] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'hormone metabolic process [GO:0042445] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Mapk14 Mmus [MGI:MGI:1346865] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: bone remodeling [GO:0046849] (biological_process) —occurs in→ compact bone [EMAPA:35250] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —occurs in→ oligodendrocyte [CL:0000128] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'adipose tissue development [GO:0060612] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: bone remodeling [GO:0046849] (biological_process) —occurs in→ parietal bone [EMAPA:18715] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bone mineralization [GO:0030282] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'calcium ion homeostasis [GO:0055074] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: vasculogenesis [GO:0001570] (biological_process) —occurs in→ compact bone [EMAPA:35250] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: osteoblast differentiation [GO:0001649] (biological_process) —causally upstream of positive effect→ bone mineralization [GO:0030282] (biological_process) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'osteoblast differentiation [GO:0001649] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: calcium ion homeostasis [GO:0055074] (biological_process) —occurs in→ spinal cord [EMAPA:17577] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'bone mineralization [GO:0030282] (biological_process)' SKIPPED_FACT: 'response to magnesium ion [GO:0032026] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'determination of adult lifespan [GO:0008340] (biological_process)' SKIPPED_FACT: 'calcium ion homeostasis [GO:0055074] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'ligamentous ossification [GO:0036076] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —occurs in→ cementum [EMAPA:35203] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'inorganic diphosphate transport [GO:0030505] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Alpl Mmus [MGI:MGI:87983] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: bone mineralization [GO:0030282] (biological_process) —occurs in→ calvarial osteoblast [CL:2000058] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'odontogenesis [GO:0042476] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —occurs in→ neuron [CL:0000540] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'cartilage development [GO:0051216] (biological_process)' SKIPPED_FACT: 'organic phosphonate metabolic process [GO:0019634] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'calcium ion homeostasis [GO:0055074] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'response to magnesium ion [GO:0032026] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphate ion homeostasis [GO:0055062] (biological_process) —occurs in→ extracellular region [GO:0005576] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'response to insulin [GO:0032868] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: ATP metabolic process [GO:0046034] (biological_process) —occurs in→ extracellular region [GO:0005576] (anatomical entity)
5fce9b7300002524	Traf3ip2 mouse	2026-03-19	David Hill, Dmitry Sitnikov	filtered	Model has at least one activity with no causal relations	74 warnings SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Gata3 Mmus [MGI:MGI:95663] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'response to cytokine [GO:0034097] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'inflammatory response [GO:0006954] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Gfi1 Mmus [MGI:MGI:103170] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —part of→ interleukin-17A-mediated signaling pathway [GO:0038173] (biological_process) SKIPPED_FACT: 'interleukin-17-mediated signaling pathway [GO:0097400] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'mRNA metabolic process [GO:0016071] (biological_process)' SKIPPED_FACT: Subject 'peptidyl-serine phosphorylation [GO:0018105] (biological_process)' has 'has input' relationship to 'Traf3ip2 Mmus [MGI:MGI:2143599] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Il5 Mmus [MGI:MGI:96557] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Il6 Mmus [MGI:MGI:96559] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein localization to P-body [GO:0110012] (biological_process) —has input→ Traf3ip2 Mmus [MGI:MGI:2143599] (information biomacromolecule) SKIPPED_FACT: 'protein binding [GO:0005515] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'interleukin-17-mediated signaling pathway [GO:0097400] (biological_process)' SKIPPED_FACT: Subject 'protein polyubiquitination [GO:0000209] (biological_process)' has 'has input' relationship to 'Traf6 Mmus [MGI:MGI:108072] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'skin development [GO:0043588] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'interleukin-17-mediated signaling pathway [GO:0097400] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'interleukin-17-mediated signaling pathway [GO:0097400] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Gfi1 Mmus [MGI:MGI:103170] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Cxcl1 Mmus [MGI:MGI:108068] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Ccl24 Mmus [MGI:MGI:1928953] (information biomacromolecule) SKIPPED_FACT: 'interleukin-17-mediated signaling pathway [GO:0097400] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'neutrophil activation [GO:0042119] (biological_process)' SKIPPED_FACT: 'protein binding [GO:0005515] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'interleukin-17-mediated signaling pathway [GO:0097400] (biological_process)' SKIPPED_FACT: 'interleukin-17-mediated signaling pathway [GO:0097400] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'inflammatory response [GO:0006954] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'interleukin-17A-mediated signaling pathway [GO:0038173] (biological_process)' SKIPPED_FACT: Subject 'protein localization to P-body [GO:0110012] (biological_process)' has 'has input' relationship to 'Traf3ip2 Mmus [MGI:MGI:2143599] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Il13 Mmus [MGI:MGI:96541] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: cellular response to cytokine stimulus [GO:0071345] (biological_process) —has input→ Il25 Mmus [MGI:MGI:2155888] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Cxcl1 Mmus [MGI:MGI:108068] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'immunoglobulin production [GO:0002377] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'tumor necrosis factor-mediated signaling pathway [GO:0033209] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: protein localization to nucleus [GO:0034504] (biological_process) —has input→ Traf3ip2 Mmus [MGI:MGI:2143599] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: peptidyl-serine phosphorylation [GO:0018105] (biological_process) —has input→ Traf3ip2 Mmus [MGI:MGI:2143599] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'spleen development [GO:0048536] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: establishment of T cell polarity [GO:0001768] (biological_process) —has input→ T-helper 2 cell [CL:0000546] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'B cell differentiation [GO:0030183] (biological_process)' SKIPPED_FACT: 'cellular response to cytokine stimulus [GO:0071345] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'establishment of T cell polarity [GO:0001768] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: protein polyubiquitination [GO:0000209] (biological_process) —has input→ Traf6 Mmus [MGI:MGI:108072] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'mRNA stabilization [GO:0048255] (biological_process)' SKIPPED_FACT: 'interleukin-17-mediated signaling pathway [GO:0097400] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'protein-containing complex assembly [GO:0065003] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of protein-containing complex assembly [GO:0043254] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'response to xenobiotic stimulus [GO:0009410] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'kidney development [GO:0001822] (biological_process)' SKIPPED_FACT: 'response to cytokine [GO:0034097] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'eosinophil homeostasis [GO:1990959] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'T cell activation [GO:0042110] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Il13 Mmus [MGI:MGI:96541] (information biomacromolecule) SKIPPED_FACT: 'interleukin-17-mediated signaling pathway [GO:0097400] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'immune response [GO:0006955] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'B cell affinity maturation [GO:0002344] (biological_process)' SKIPPED_FACT: Subject 'protein localization to nucleus [GO:0034504] (biological_process)' has 'has input' relationship to 'Traf3ip2 Mmus [MGI:MGI:2143599] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'protein catabolic process [GO:0030163] (biological_process)' has 'has input' relationship to 'Notch1 Mmus [MGI:MGI:97363] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'transitional two stage B cell differentiation [GO:0002334] (biological_process)' SKIPPED_FACT: 'interleukin-17A-mediated signaling pathway [GO:0038173] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'eosinophil mediated immunity [GO:0002447] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Il5 Mmus [MGI:MGI:96557] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: cytokine production [GO:0001816] (biological_process) —has input→ T cell [CL:0000084] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'lymph node development [GO:0048535] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'immunoglobulin production [GO:0002377] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'cytokine-mediated signaling pathway [GO:0019221] (biological_process)' SKIPPED_FACT: 'interleukin-17-mediated signaling pathway [GO:0097400] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'I-kappaB phosphorylation [GO:0007252] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Il6 Mmus [MGI:MGI:96559] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'mRNA stabilization [GO:0048255] (biological_process)' has 'has input' relationship to 'Cxcl1 Mmus [MGI:MGI:108068] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Ccl24 Mmus [MGI:MGI:1928953] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: mRNA stabilization [GO:0048255] (biological_process) —has input→ Cxcl1 Mmus [MGI:MGI:108068] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'CD40 signaling pathway [GO:0023035] (biological_process)' SKIPPED_FACT: 'protein binding [GO:0005515] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'interleukin-17-mediated signaling pathway [GO:0097400] (biological_process)' SKIPPED_FACT: 'interleukin-17-mediated signaling pathway [GO:0097400] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'cytokine production [GO:0001816] (biological_process)' SKIPPED_FACT: 'cellular response to interleukin-17 [GO:0097398] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'protein localization to nucleus [GO:0034504] (biological_process)' SKIPPED_FACT: Subject 'establishment of T cell polarity [GO:0001768] (biological_process)' has 'has input' relationship to 'T-helper 2 cell [CL:0000546] (anatomical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'interleukin-17-mediated signaling pathway [GO:0097400] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'chemokine production [GO:0032602] (biological_process)' SKIPPED_FACT: Subject 'cytokine production [GO:0001816] (biological_process)' has 'has input' relationship to 'T cell [CL:0000084] (anatomical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Gata3 Mmus [MGI:MGI:95663] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein catabolic process [GO:0030163] (biological_process) —has input→ Notch1 Mmus [MGI:MGI:97363] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'protein binding [GO:0005515] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'protein catabolic process [GO:0030163] (biological_process)' SKIPPED_FACT: 'ubiquitin protein ligase activity [GO:0061630] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'ubiquitin protein ligase activity [GO:0061630] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'interleukin-17-mediated signaling pathway [GO:0097400] (biological_process)' SKIPPED_FACT: Subject 'cellular response to cytokine stimulus [GO:0071345] (biological_process)' has 'has input' relationship to 'Il25 Mmus [MGI:MGI:2155888] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
60ad85f700000058	Atf2 mouse	2026-03-18	David Hill, Dmitry Sitnikov	filtered	Model has at least one activity with no causal relations	106 warnings SKIPPED_FACT: 'RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Mapk8 Mmus [MGI:MGI:1346861] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'in utero embryonic development [GO:0001701] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Mki67 Mmus [MGI:MGI:106035] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'mRNA transcription by RNA polymerase II [GO:0042789] (biological_process)' SKIPPED_FACT: Subject 'protein phosphorylation [GO:0006468] (biological_process)' has 'has input' relationship to 'Mapk8 Mmus [MGI:MGI:1346861] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: cAMP response element binding [GO:0035497] (molecular_function) —causally upstream of or within→ DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within positive effect→ positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within positive effect→ gene expression [GO:0010467] (biological_process) SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Jun Mmus [MGI:MGI:96646] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'hematopoietic progenitor cell differentiation [GO:0002244] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Mitf Mmus [MGI:MGI:104554] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Rbl1 Mmus [MGI:MGI:103300] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'p38MAPK cascade [GO:0038066] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'cellular response to anisomycin [GO:0072740] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: protein binding [GO:0005515] (molecular_function) —causally upstream of or within→ cAMP response element binding [GO:0035497] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein phosphorylation [GO:0006468] (biological_process) —has input→ Mapk14 Mmus [MGI:MGI:1346865] (information biomacromolecule) SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Ccnd1 Mmus [MGI:MGI:88313] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Col10a1 Mmus [MGI:MGI:88445] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'motor neuron apoptotic process [GO:0097049] (biological_process)' SKIPPED_FACT: 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'JNK cascade [GO:0007254] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Nefm Mmus [MGI:MGI:97314] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'type B pancreatic cell differentiation [GO:0003309] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ cAMP response element binding [GO:0035497] (molecular_function) SKIPPED_FACT: 'motor neuron apoptotic process [GO:0097049] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'hypoglossal nucleus development [GO:0021743] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'hematopoietic progenitor cell differentiation [GO:0002244] (biological_process)' SKIPPED_FACT: 'brown fat cell proliferation [GO:0070342] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'temperature homeostasis [GO:0001659] (biological_process)' SKIPPED_FACT: Subject 'mRNA transcription by RNA polymerase II [GO:0042789] (biological_process)' has 'has input' relationship to 'Rb1 Mmus [MGI:MGI:97874] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heart development [GO:0007507] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228] (molecular_function) —has input→ Ppargc1a Mmus [MGI:MGI:1342774] (information biomacromolecule) SKIPPED_FACT: 'motor neuron apoptotic process [GO:0097049] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'abducens nucleus development [GO:0021742] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Col10a1 Mmus [MGI:MGI:88445] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Jun Mmus [MGI:MGI:96646] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Rb1 Mmus [MGI:MGI:97874] (information biomacromolecule) SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Pparg Mmus [MGI:MGI:97747] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: protein phosphorylation [GO:0006468] (biological_process) —part of→ p38MAPK cascade [GO:0038066] (biological_process) SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Foxp3 Mmus [MGI:MGI:1891436] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'positive regulation of protein phosphorylation [GO:0001934] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'cellular response to virus [GO:0098586] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within negative effect→ regulation of transcription by RNA polymerase II [GO:0006357] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Mapk14 Mmus [MGI:MGI:1346865] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heart development [GO:0007507] (biological_process)' SKIPPED_FACT: Subject 'protein phosphorylation [GO:0006468] (biological_process)' has 'has input' relationship to 'Mapk14 Mmus [MGI:MGI:1346865] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Mki67 Mmus [MGI:MGI:106035] (information biomacromolecule) SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Rbl1 Mmus [MGI:MGI:103300] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228] (molecular_function) —has input→ Ucp1 Mmus [MGI:MGI:98894] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: Subject 'DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228] (molecular_function)' has 'has input' relationship to 'Ucp1 Mmus [MGI:MGI:98894] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'hepatocyte apoptotic process [GO:0097284] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'BMP signaling pathway [GO:0030509] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'neurofilament cytoskeleton organization [GO:0060052] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Foxp3 Mmus [MGI:MGI:1891436] (information biomacromolecule) SKIPPED_FACT: Subject 'positive regulation of protein phosphorylation [GO:0001934] (biological_process)' has 'has input' relationship to 'Rb1 Mmus [MGI:MGI:97874] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228] (molecular_function) —part of→ protein import into nucleus [GO:0006606] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within positive effect→ regulation of transcription by RNA polymerase II [GO:0006357] (biological_process) SKIPPED_FACT: 'phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'pancreas regeneration [GO:1990798] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of protein phosphorylation [GO:0001934] (biological_process) —has input→ Atf2 Mmus [MGI:MGI:109349] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'brown fat cell proliferation [GO:0070342] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Pparg Mmus [MGI:MGI:97747] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —has input→ Il23a Mmus [MGI:MGI:1932410] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'motor neuron apoptotic process [GO:0097049] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'facial nucleus development [GO:0021754] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —has input→ Ddit3 Mmus [MGI:MGI:109247] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Sox10 Mmus [MGI:MGI:98358] (information biomacromolecule) SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Mapk14 Mmus [MGI:MGI:1346865] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'protein import into nucleus [GO:0006606] (biological_process)' has 'has input' relationship to 'Atf2 Mmus [MGI:MGI:109349] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'positive regulation of protein phosphorylation [GO:0001934] (biological_process)' has 'has input' relationship to 'Atf2 Mmus [MGI:MGI:109349] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: protein phosphorylation [GO:0006468] (biological_process) —part of→ JNK cascade [GO:0007254] (biological_process) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'lipid metabolic process [GO:0006629] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Nefh Mmus [MGI:MGI:97309] (information biomacromolecule) SKIPPED_FACT: Subject 'protein phosphorylation [GO:0006468] (biological_process)' has 'has input' relationship to 'Atf2 Mmus [MGI:MGI:109349] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: Cebpz Mmus [MGI:MGI:109386] (information biomacromolecule) —part of→ CCAAT-binding factor complex [GO:0016602] (cellular_component) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'liver development [GO:0001889] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: protein binding [GO:0005515] (molecular_function) —causally upstream of or within→ DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein import into nucleus [GO:0006606] (biological_process) —has input→ Atf2 Mmus [MGI:MGI:109349] (information biomacromolecule) SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Sox10 Mmus [MGI:MGI:98358] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Nefh Mmus [MGI:MGI:97309] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Il23a Mmus [MGI:MGI:1932410] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'detection of cell density [GO:0060245] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Sox10 Mmus [MGI:MGI:98358] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'hepatocyte apoptotic process [GO:0097284] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Ccnd1 Mmus [MGI:MGI:88313] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within positive effect→ cellular response to leucine starvation [GO:1990253] (biological_process) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'liver development [GO:0001889] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: protein phosphorylation [GO:0006468] (biological_process) —has input→ Atf2 Mmus [MGI:MGI:109349] (information biomacromolecule) SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Rb1 Mmus [MGI:MGI:97874] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'gene expression [GO:0010467] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'JNK cascade [GO:0007254] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: Atf2 Mmus [MGI:MGI:109349] (information biomacromolecule) —part of→ CCAAT-binding factor complex [GO:0016602] (cellular_component) SKIPPED_FACT: Subject 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' has 'has input' relationship to 'Ddit3 Mmus [MGI:MGI:109247] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Mapk8 Mmus [MGI:MGI:1346861] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within positive effect→ tumor necrosis factor production [GO:0032640] (biological_process) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'p38MAPK cascade [GO:0038066] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Nefm Mmus [MGI:MGI:97314] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Mitf Mmus [MGI:MGI:104554] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: protein binding [GO:0005515] (molecular_function) —causally upstream of or within→ RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: mRNA transcription by RNA polymerase II [GO:0042789] (biological_process) —has input→ Rb1 Mmus [MGI:MGI:97874] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of protein phosphorylation [GO:0001934] (biological_process) —has input→ Rb1 Mmus [MGI:MGI:97874] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228] (molecular_function) —part of→ brown fat cell proliferation [GO:0070342] (biological_process) SKIPPED_FACT: Subject 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' has 'has input' relationship to 'Il23a Mmus [MGI:MGI:1932410] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'cellular response to virus [GO:0098586] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: protein phosphorylation [GO:0006468] (biological_process) —has input→ Mapk8 Mmus [MGI:MGI:1346861] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Il23a Mmus [MGI:MGI:1932410] (information biomacromolecule) SKIPPED_FACT: Subject 'DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228] (molecular_function)' has 'has input' relationship to 'Ppargc1a Mmus [MGI:MGI:1342774] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
69a0c46f00001390	Branched-chain amino acid catabolic process 2(Mouse)	2026-03-18	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: branched-chain amino acid transmembrane transporter activity [GO:0015658] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: branched-chain amino acid transmembrane transporter activity [GO:0015658] (molecular_function) —has target end location→ mitochondrial matrix [GO:0005759] (anatomical entity)
60e7989d00000855	Ednra mouse	2026-03-18	David Hill, Dmitry Sitnikov, Karen Christie, Li Ni	filtered	Model has at least one activity with no causal relations	159 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: face development [GO:0060324] (biological_process) —occurs in→ upper jaw [EMAPA:17924] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'angiogenesis [GO:0001525] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Edn1 Mmus [MGI:MGI:95283] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'smooth muscle tissue development [GO:0048745] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'axon extension [GO:0048675] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Ednra Mmus [MGI:MGI:105923] (information biomacromolecule) SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Dlx5 Mmus [MGI:MGI:101926] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'meiotic cell cycle process involved in oocyte maturation [GO:1903537] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'canonical Wnt signaling pathway [GO:0060070] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'specification of segmental identity, maxillary segment [GO:0007382] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —occurs in→ sympathetic neuron [CL:0011103] (anatomical entity) SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Dlx6 Mmus [MGI:MGI:101927] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: blood vessel remodeling [GO:0001974] (biological_process) —occurs in→ sympathetic neuron [CL:0011103] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'axonogenesis involved in innervation [GO:0060385] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Tbx2 Mmus [MGI:MGI:98494] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: axon extension [GO:0048675] (biological_process) —occurs in→ sympathetic neuron [CL:0011103] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'protein phosphorylation [GO:0006468] (biological_process)' SKIPPED_FACT: Subject 'protein phosphorylation [GO:0006468] (biological_process)' has 'has input' relationship to 'Tnk2 Mmus [MGI:MGI:1858308] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'endothelin receptor signaling pathway [GO:0086100] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'cranial skeletal system development [GO:1904888] (biological_process)' SKIPPED_FACT: 'heparin proteoglycan metabolic process [GO:0030202] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'establishment of endothelial barrier [GO:0061028] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'axon guidance [GO:0007411] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Tbx5 Mmus [MGI:MGI:102541] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of blood pressure [GO:0008217] (biological_process) —occurs in→ smooth muscle cell [CL:0000192] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Tbx5 Mmus [MGI:MGI:102541] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of protein localization to cell leading edge [GO:1905871] (biological_process) —has input→ Cdc42 Mmus [MGI:MGI:106211] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: endothelin receptor signaling pathway [GO:0086100] (biological_process) —occurs in→ podocyte [CL:0000653] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: muscle structure development [GO:0061061] (biological_process) —occurs in→ facial muscle [EMAPA:25133] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'endothelin receptor signaling pathway [GO:0086100] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'aorta development [GO:0035904] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'axonogenesis involved in innervation [GO:0060385] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of blood pressure [GO:0008217] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Tbx2 Mmus [MGI:MGI:98494] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'cardiac chamber formation [GO:0003207] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'cell tip growth [GO:0009932] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of positive effect→ podocyte differentiation [GO:0072112] (biological_process) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'neuron projection development [GO:0031175] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'vasculature development [GO:0001944] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'cellular response to follicle-stimulating hormone stimulus [GO:0071372] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of protein localization to cell leading edge [GO:1905871] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'vascular associated smooth muscle cell development [GO:0097084] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'neuron remodeling [GO:0016322] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'neural crest cell differentiation [GO:0014033] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'response to amphetamine [GO:0001975] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'response to sodium phosphate [GO:1904383] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Plxna4 Mmus [MGI:MGI:2179061] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: endothelin receptor signaling pathway [GO:0086100] (biological_process) —positively regulates→ canonical NF-kappaB signal transduction [GO:0007249] (biological_process) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'podocyte apoptotic process [GO:1903210] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Mef2c Mmus [MGI:MGI:99458] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'neuron projection development [GO:0031175] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Tbx5 Mmus [MGI:MGI:102541] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —occurs in→ sympathetic ganglion [EMAPA:17157] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'branching involved in blood vessel morphogenesis [GO:0001569] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'embryonic skeletal system development [GO:0048706] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of positive effect→ renal albumin absorption [GO:0097018] (biological_process) SKIPPED_FACT: Subject 'positive regulation of cation channel activity [GO:2001259] (biological_process)' has 'has input' relationship to 'Trpa1 Mmus [MGI:MGI:3522699] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Tbx3 Mmus [MGI:MGI:98495] (information biomacromolecule) SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Ednra Mmus [MGI:MGI:105923] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'intracellular calcium ion homeostasis [GO:0006874] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: protein phosphorylation [GO:0006468] (biological_process) —has input→ Tnk2 Mmus [MGI:MGI:1858308] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'cAMP/PKA signal transduction [GO:0141156] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Plxna4 Mmus [MGI:MGI:2179061] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —occurs in→ migratory neural crest cell [CL:0000333] (anatomical entity) SKIPPED_FACT: 'response to wounding [GO:0009611] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'norepinephrine metabolic process [GO:0042415] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'mesenchymal cell apoptotic process [GO:0097152] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'meiotic cell cycle process involved in oocyte maturation [GO:1903537] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: cellular response to luteinizing hormone stimulus [GO:0071373] (biological_process) —occurs in→ ovary [EMAPA:17962] (anatomical entity) SKIPPED_FACT: 'response to wounding [GO:0009611] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'sympathetic nervous system development [GO:0048485] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'specification of segmental identity, maxillary segment [GO:0007382] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Plxna4 Mmus [MGI:MGI:2179061] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'neural crest cell differentiation [GO:0014033] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: cellular response to follicle-stimulating hormone stimulus [GO:0071372] (biological_process) —occurs in→ ovary [EMAPA:17962] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —occurs in→ vascular associated smooth muscle cell [CL:0000359] (anatomical entity) SKIPPED_FACT: 'gene expression [GO:0010467] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'semaphorin-plexin signaling pathway [GO:0071526] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heart contraction [GO:0060047] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: axonogenesis involved in innervation [GO:0060385] (biological_process) —occurs in→ sympathetic ganglion [EMAPA:17157] (anatomical entity) SKIPPED_FACT: 'glomerular endothelium development [GO:0072011] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'glomerular filtration [GO:0003094] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: renal sodium ion absorption [GO:0070294] (biological_process) —occurs in→ cortical collecting duct [EMAPA:28130] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: face development [GO:0060324] (biological_process) —occurs in→ lower jaw [EMAPA:17906] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Epas1 Mmus [MGI:MGI:109169] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] (molecular_function) —causally upstream of positive effect→ mRNA transcription by RNA polymerase II [GO:0042789] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Dlx5 Mmus [MGI:MGI:101926] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of cation channel activity [GO:2001259] (biological_process) —has input→ Trpa1 Mmus [MGI:MGI:3522699] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of blood pressure [GO:0008217] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: protein transmembrane transport [GO:0071806] (biological_process) —has input→ Alb Mmus [MGI:MGI:87991] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: endothelial cell migration [GO:0043542] (biological_process) —occurs in→ retina [EMAPA:17168] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'neural crest cell fate commitment [GO:0014034] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'mitotic cell cycle [GO:0000278] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'endothelin receptor signaling pathway [GO:0086100] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Jag1 Mmus [MGI:MGI:1095416] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of positive effect→ heparin proteoglycan metabolic process [GO:0030202] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Edn1 Mmus [MGI:MGI:95283] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of heart rate [GO:0002027] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Edn1 Mmus [MGI:MGI:95283] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Dlx6 Mmus [MGI:MGI:101927] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'face development [GO:0060324] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'pharyngeal arch artery morphogenesis [GO:0061626] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of blood pressure [GO:0008217] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Mef2c Mmus [MGI:MGI:99458] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: response to acetylcholine [GO:1905144] (biological_process) —occurs in→ mesenteric artery [EMAPA:17312] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'mitochondrion organization [GO:0007005] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'glomerulus development [GO:0032835] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'sympathetic neuron axon guidance [GO:0097492] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'renin secretion into blood stream [GO:0002001] (biological_process)' SKIPPED_FACT: Subject 'protein transmembrane transport [GO:0071806] (biological_process)' has 'has input' relationship to 'Alb Mmus [MGI:MGI:87991] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'neural crest cell differentiation [GO:0014033] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'neural crest cell differentiation [GO:0014033] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: transcription by RNA polymerase II [GO:0006366] (biological_process) —has input→ Hpse Mmus [MGI:MGI:1343124] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'pharyngeal system development [GO:0060037] (biological_process)' SKIPPED_FACT: Subject 'transcription by RNA polymerase II [GO:0006366] (biological_process)' has 'has input' relationship to 'Hpse Mmus [MGI:MGI:1343124] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'intracellular calcium ion homeostasis [GO:0006874] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'cellular response to hydrogen peroxide [GO:0070301] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'neuron projection development [GO:0031175] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Jag1 Mmus [MGI:MGI:1095416] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'canonical Wnt signaling pathway [GO:0060070] (biological_process)' SKIPPED_FACT: 'response to sodium phosphate [GO:1904383] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'renal sodium excretion [GO:0035812] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: axonogenesis involved in innervation [GO:0060385] (biological_process) —occurs in→ sympathetic neuron [CL:0011103] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'cellular response to human chorionic gonadotropin stimulus [GO:0044751] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical NF-kappaB signal transduction [GO:0007249] (biological_process) —occurs in→ podocyte [CL:0000653] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'axonogenesis involved in innervation [GO:0060385] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'left ventricular cardiac muscle tissue morphogenesis [GO:0003220] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'embryonic heart tube development [GO:0035050] (biological_process)' SKIPPED_FACT: 'renal albumin absorption [GO:0097018] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'podocyte differentiation [GO:0072112] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: cellular response to human chorionic gonadotropin stimulus [GO:0044751] (biological_process) —occurs in→ ovary [EMAPA:17962] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: mRNA transcription by RNA polymerase II [GO:0042789] (biological_process) —part of→ gene expression [GO:0010467] (biological_process) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'heparanase activity [GO:0030305] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heparin proteoglycan metabolic process [GO:0030202] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'embryonic skeletal system development [GO:0048706] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Epas1 Mmus [MGI:MGI:109169] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'cellular response to human chorionic gonadotropin stimulus [GO:0044751] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'cellular response to oxidative stress [GO:0034599] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Tbx3 Mmus [MGI:MGI:98495] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Edn1 Mmus [MGI:MGI:95283] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: neuron projection development [GO:0031175] (biological_process) —occurs in→ sympathetic ganglion [EMAPA:17157] (anatomical entity) SKIPPED_FACT: Subject 'regulation of protein localization to cell leading edge [GO:1905871] (biological_process)' has 'has input' relationship to 'Cdc42 Mmus [MGI:MGI:106211] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'calcium ion transmembrane transport [GO:0070588] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'glomerular endothelium development [GO:0072011] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'cellular response to follicle-stimulating hormone stimulus [GO:0071372] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'protein phosphorylation [GO:0006468] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Ednra Mmus [MGI:MGI:105923] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'MAPK cascade [GO:0000165] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Edn1 Mmus [MGI:MGI:95283] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: angiogenesis [GO:0001525] (biological_process) —occurs in→ retina [EMAPA:17168] (anatomical entity) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'embryonic heart tube development [GO:0035050] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'gene expression [GO:0010467] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'calcium ion transmembrane transport [GO:0070588] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: cell tip growth [GO:0009932] (biological_process) —occurs in→ retina [EMAPA:17168] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: axon guidance [GO:0007411] (biological_process) —occurs in→ carotid artery [EMAPA:18609] (anatomical entity)
69a0c46f00000571	Branched-chain amino acid catabolic process 1(Mouse)	2026-03-16	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: branched-chain amino acid transmembrane transporter activity [GO:0015658] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: branched-chain amino acid transmembrane transporter activity [GO:0015658] (molecular_function) —has target end location→ mitochondrial matrix [GO:0005759] (anatomical entity)
63894f2500001874	Acetate metabolic process 1 (Mouse)	2026-03-12	David Hill	filtered	Model has at least one activity with no causal relations	16 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —provides input for→ carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) SKIPPED_FACT: Subject 'carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function)' has 'has primary input' relationship to 'N-acetyl-L-aspartic acid [CHEBI:21547] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: L-aspartate N-acetyltransferase activity [GO:0017188] (molecular_function) —provides input for→ carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: organic acid:sodium symporter activity [GO:0005343] (molecular_function) —has target start location→ extracellular region [GO:0005576] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —has primary input→ N-acetyl-L-aspartic acid [CHEBI:21547] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: organic acid:sodium symporter activity [GO:0005343] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —has target end location→ extracellular region [GO:0005576] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cytosol [GO:0005829] (anatomical entity) —part of→ neuron [CL:0000540] (anatomical entity) SKIPPED_FACT: Subject 'carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function)' has 'has primary input' relationship to 'N-acetyl-L-aspartic acid [CHEBI:21547] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —has target start location→ mitochondrial matrix [GO:0005759] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —provides input for→ organic acid:sodium symporter activity [GO:0005343] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: acetate metabolic process [GO:0006083] (biological_process) —has primary output→ acetate [CHEBI:30089] (chemical entity) SKIPPED_FACT: Subject 'acetate metabolic process [GO:0006083] (biological_process)' has 'has primary output' relationship to 'acetate [CHEBI:30089] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —part of→ carboxylic acid transport [GO:0046942] (biological_process)
63894f2500001094	Aspartate metabolic process 1 (Mouse)	2026-03-12	David Hill	filtered	Model has at least one activity with no causal relations	14 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —provides input for→ organic acid:sodium symporter activity [GO:0005343] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —has primary input→ N-acetyl-L-aspartic acid [CHEBI:21547] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —part of→ carboxylic acid transport [GO:0046942] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —provides input for→ carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cytosol [GO:0005829] (anatomical entity) —part of→ neuron [CL:0000540] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: L-aspartate N-acetyltransferase activity [GO:0017188] (molecular_function) —provides input for→ carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —has target end location→ extracellular region [GO:0005576] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: organic acid:sodium symporter activity [GO:0005343] (molecular_function) —has target start location→ extracellular region [GO:0005576] (anatomical entity) SKIPPED_FACT: Subject 'carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function)' has 'has primary input' relationship to 'N-acetyl-L-aspartic acid [CHEBI:21547] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: organic acid:sodium symporter activity [GO:0005343] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) SKIPPED_FACT: Subject 'carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function)' has 'has primary input' relationship to 'N-acetyl-L-aspartic acid [CHEBI:21547] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: carboxylic acid transmembrane transporter activity [GO:0046943] (molecular_function) —has target start location→ mitochondrial matrix [GO:0005759] (anatomical entity)
617b481400001334	cell surface receptor signaling pathway 1 (Mouse)	2026-03-12	David Hill	success
627d95ee00000955	Chondroitin sulfate catabolic process (Mouse)	2026-03-12	David Hill, Kimberly Van Auken	success		12 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553] (molecular_function) —occurs in→ lysosome [GO:0005764] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553] (molecular_function) —provides input for→ N-acetylgalactosamine-6-sulfatase activity [GO:0043890] (molecular_function) SKIPPED_FACT: Subject 'hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553] (molecular_function)' has 'has input' relationship to 'chondroitin sulfate [CHEBI:37397] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transport [GO:0006810] (biological_process) —has primary input→ chondroitin sulfate [CHEBI:37397] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transport [GO:0006810] (biological_process) —causally upstream of positive effect→ chondroitin sulfate proteoglycan catabolic process [GO:0030207] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553] (molecular_function) —has input→ chondroitin sulfate [CHEBI:37397] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: chondroitin sulfate [CHEBI:37397] (chemical entity) —part of→ proteoglycan [CHEBI:37396] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: transport [GO:0006810] (biological_process) —has target end location→ lysosome [GO:0005764] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553] (molecular_function) —part of→ chondroitin sulfate proteoglycan catabolic process [GO:0030207] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553] (molecular_function) —provides input for→ N-acetylgalactosamine-4-sulfatase activity [GO:0003943] (molecular_function) SKIPPED_FACT: Subject 'transport [GO:0006810] (biological_process)' has 'has primary input' relationship to 'chondroitin sulfate [CHEBI:37397] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transport [GO:0006810] (biological_process) —has target start location→ extracellular region [GO:0005576] (anatomical entity)
613aae0000000500	cobalamin metabolic process 3, methylation of cobalamin (Mouse)	2026-03-12	David Hill	success		6 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: lysosomal lumen [GO:0043202] (anatomical entity) —part of→ intestinal epithelial cell [CL:0002563] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: extracellular region [GO:0005576] (anatomical entity) —part of→ stomach [EMAPA:17021] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: extracellular region [GO:0005576] (anatomical entity) —part of→ esophagus lumen [EMAPA:18380] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: external side of apical plasma membrane [GO:0098591] (anatomical entity) —part of→ intestinal epithelial cell [CL:0002563] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: microvillus membrane [GO:0031528] (anatomical entity) —part of→ intestinal epithelial cell [CL:0002563] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: lysosomal membrane [GO:0005765] (anatomical entity) —part of→ intestinal epithelial cell [CL:0002563] (anatomical entity)
613aae0000000341	cobalamin transport 2, distribution to tissues (Mouse)	2026-03-12	David Hill	success		7 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: cytosol [GO:0005829] (anatomical entity) —part of→ enterocyte [CL:0000584] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: ABC-type vitamin B12 transporter activity [GO:0015420] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: peptidase activity [GO:0008233] (molecular_function) —occurs in→ lysosomal lumen [GO:0043202] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cargo receptor activity [GO:0038024] (molecular_function) —provides input for→ peptidase activity [GO:0008233] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: ABC-type vitamin B12 transporter activity [GO:0015420] (molecular_function) —has target end location→ extracellular region [GO:0005576] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: lysosomal lumen [GO:0043202] (anatomical entity) —part of→ enterocyte [CL:0000584] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: peptidase activity [GO:0008233] (molecular_function) —part of→ cobalamin transport [GO:0015889] (biological_process)
62900b6400002552	Cobalamin transport, into enterocytes (Mouse)	2026-03-12	David Hill, Li Ni	success		11 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: ABC-type vitamin B12 transporter activity [GO:0015420] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: peptidase activity [GO:0008233] (molecular_function) —provides input for→ ABC-type vitamin B12 transporter activity [GO:0015420] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: peptidase activity [GO:0008233] (molecular_function) —occurs in→ lysosomal lumen [GO:0043202] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cargo receptor activity [GO:0038024] (molecular_function) —provides input for→ peptidase activity [GO:0008233] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: ABC-type vitamin B12 transporter activity [GO:0015420] (molecular_function) —has target start location→ lysosomal lumen [GO:0043202] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: lysosomal lumen [GO:0043202] (anatomical entity) —part of→ lysosome [GO:0005764] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: lysosome [GO:0005764] (anatomical entity) —part of→ enterocyte [CL:0000584] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: vitamin transmembrane transporter activity [GO:0090482] (molecular_function) —has target end location→ lysosome [GO:0005764] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular carrier activity [GO:0140104] (molecular_function) —has part→ cobalamin binding [GO:0031419] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: cytosol [GO:0005829] (anatomical entity) —part of→ enterocyte [CL:0000584] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: vitamin transmembrane transporter activity [GO:0090482] (molecular_function) —has target start location→ endoplasmic reticulum [GO:0005783] (anatomical entity)
645d887900001551	Coenzyme A catabolic process 2 (Mouse)	2026-03-12	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: coenzyme A catabolic process [GO:0015938] (biological_process) —occurs in→ extracellular region [GO:0005576] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: extracellular region [GO:0005576] (anatomical entity) —part of→ epithelial cell [CL:0000066] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: epithelial cell [CL:0000066] (anatomical entity) —part of→ intestine [EMAPA:32874] (anatomical entity)
62900b6400002879	Dermatan sulfate catabolic process (Mouse)	2026-03-12	David Hill	success		9 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: transport [GO:0006810] (biological_process) —has primary input→ dermatan sulfate [CHEBI:18376] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553] (molecular_function) —provides input for→ N-acetylgalactosamine-6-sulfatase activity [GO:0043890] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553] (molecular_function) —has input→ dermatan sulfate [CHEBI:18376] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transport [GO:0006810] (biological_process) —causally upstream of positive effect→ dermatan sulfate proteoglycan catabolic process [GO:0030209] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: transport [GO:0006810] (biological_process) —has target end location→ lysosome [GO:0005764] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: dermatan sulfate [CHEBI:18376] (chemical entity) —part of→ proteoglycan [CHEBI:37396] (information biomacromolecule) SKIPPED_FACT: Subject 'hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553] (molecular_function)' has 'has input' relationship to 'dermatan sulfate [CHEBI:18376] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transport [GO:0006810] (biological_process) —has target start location→ extracellular region [GO:0005576] (anatomical entity) SKIPPED_FACT: Subject 'transport [GO:0006810] (biological_process)' has 'has primary input' relationship to 'dermatan sulfate [CHEBI:18376] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
617b481400000995	Epidermal growth factor receptor signaling pathway 1 (Mouse)	2026-03-12	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] (molecular_function) —part of→ epidermal growth factor receptor signaling pathway [GO:0007173] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: epidermal growth factor receptor activity [GO:0005006] (molecular_function) —directly positively regulates→ transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] (molecular_function)
61e0e55600000239	Epidermal growth factor receptor signaling pathway 10 (Mouse)	2026-03-12	David Hill	success
61e0e55600000430	Epidermal growth factor receptor signaling pathway 11 (Mouse)	2026-03-12	David Hill	success
6197061700001622	Epidermal growth factor receptor signaling pathway 2 (Mouse)	2026-03-12	David Hill	success
6197061700001643	Epidermal growth factor receptor signaling pathway 3 (Mouse)	2026-03-12	David Hill	success
6197061700001725	Epidermal growth factor receptor signaling pathway 4 (Mouse)	2026-03-12	David Hill	success
6197061700001879	Epidermal growth factor receptor signaling pathway 5 (Mouse)	2026-03-12	David Hill	success
6197061700002061	Epidermal growth factor receptor signaling pathway 6 (Mouse)	2026-03-12	David Hill	success
6197061700002460	Epidermal growth factor receptor signaling pathway 7 (Mouse)	2026-03-12	David Hill	success
6197061700000593	ERBB2-EGFR signaling pathway 1 (Mouse)	2026-03-12	David Hill	success
6197061700002298	ERBB2-EGFR signaling pathway 2 (Mouse)	2026-03-12	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: metallopeptidase activity [GO:0008237] (molecular_function) —causally upstream of positive effect→ receptor ligand activity [GO:0048018] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: metallopeptidase activity [GO:0008237] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: metallopeptidase activity [GO:0008237] (molecular_function) —part of→ signaling receptor ligand precursor processing [GO:0140448] (biological_process)
6197061700002519	ERBB2-EGFR signaling pathway 3 (Mouse)	2026-03-12	David Hill	filtered	Model has at least one activity with no causal relations
6197061700003490	ERBB2-EGFR signaling pathway 4 (Mouse)	2026-03-12	David Hill	success
61b2b68300000303	ERBB2-EGFR signaling pathway 5 (Mouse)	2026-03-12	David Hill	success
61b2b68300000408	ERBB2-EGFR signaling pathway 6 (Mouse)	2026-03-12	David Hill	success
61b2b68300000617	ERBB2-ERBB3 receptor signaling pathway involved in myelination 1 (Mouse)	2026-03-12	David Hill	success
6197061700003523	ERBB2-ERBB3 signaling pathway 1 (Mouse)	2026-03-12	David Hill	success
61b2b68300000015	ERBB2-ERBB3 signaling pathway 2 (Mouse)	2026-03-12	David Hill	success
6197061700000616	ERBB2-ERBB4 signaling pathway 1 (Mouse)	2026-03-12	David Hill	success
6197061700002226	ERBB2-ERBB4 signaling pathway 2 (Mouse)	2026-03-12	David Hill	success
61b2b68300000203	ERBB2-ERBB4 signaling pathway 3 (Mouse)	2026-03-12	David Hill	success
617b481400002516	ERBB4 signaling pathway 1 (Mouse)	2026-03-12	David Hill	success
617b481400002743	ERBB4 signaling pathway 2 (Mouse)	2026-03-12	David Hill	success
617b481400002881	ERBB4 signaling pathway 4 (Mouse)	2026-03-12	David Hill	success
6197061700003709	ERBB4-ERBB4 signaling pathway 1 (Mouse)	2026-03-12	David Hill	success
617b481400001986	ERBB4-ERBB4 signaling pathway 2 (Mouse)	2026-03-12	David Hill	success
6197061700002320	ERBB4-ERBB4 signaling pathway 4 (Mouse)	2026-03-12	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: metallopeptidase activity [GO:0008237] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: metallopeptidase activity [GO:0008237] (molecular_function) —part of→ signaling receptor ligand precursor processing [GO:0140448] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: metallopeptidase activity [GO:0008237] (molecular_function) —causally upstream of positive effect→ receptor ligand activity [GO:0048018] (molecular_function)
61b2b68300000390	ERBB4-ERBB4 signaling pathway 5 (Mouse)	2026-03-12	David Hill	success
617b481400002844	ERBB4-ERBB4 signaling pathway 6 (Mouse)	2026-03-12	David Hill	success
617b481400002254	ERBB4-ERRB4 signaling pathway 3 (Mouse)	2026-03-12	David Hill	success
68b0f0d000007538	Glucocorticoid biosynthetic process 2 (Mouse)	2026-03-12	David Hill	success		8 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —part of→ glucocorticoid biosynthetic process [GO:0006704] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: progesterone 21-hydroxylase activity [GO:0106309] (molecular_function) —causally upstream of→ transporter activity [GO:0005215] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —causally upstream of→ steroid 11-beta-monooxygenase activity [GO:0004507] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: glucocorticoid catabolic process [GO:0006713] (biological_process) —has primary input→ corticosterone [CHEBI:16827] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: pregnenolone [CHEBI:16581] (chemical entity) —part of→ C21-steroid hormone biosynthetic process [GO:0006700] (biological_process) SKIPPED_FACT: Subject 'glucocorticoid catabolic process [GO:0006713] (biological_process)' has 'has primary input' relationship to 'corticosterone [CHEBI:16827] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'glucocorticoid biosynthetic process [GO:0006704] (biological_process)' has 'has primary output' relationship to 'corticosterone [CHEBI:16827] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: glucocorticoid biosynthetic process [GO:0006704] (biological_process) —has primary output→ corticosterone [CHEBI:16827] (chemical entity)
6348a65d00000394	Gut Microbiota lactate metabolism: Improvement of glucose tolerance by induction of REG3G. (Mouse-Lactobacillus)	2026-03-12	Cristina Casals, David Hill, Suzi Aleksander	success
5716c41300000389	Human-CXCL17-Macrophage chemotaxis	2026-03-12	David Hill	filtered	Model has at least one activity with no causal relations	4 warnings SKIPPED_FACT: 'chemokine receptor activity [GO:0004950] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'monocyte chemotaxis [GO:0002548] (biological_process)' SKIPPED_FACT: 'chemokine activity [GO:0008009] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'monocyte chemotaxis [GO:0002548] (biological_process)' INDIVIDUAL_HAS_MULTIPLE_TYPES: Individual has multiple types; using the first type for translation UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of cytosolic calcium ion concentration [GO:0007204] (biological_process) —occurs in→ monocyte [CL:0000576] (anatomical entity)
62b4ffe300004795	Insulin receptor signaling pathway 1 (Mouse)	2026-03-12	David Hill	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: MAP kinase kinase activity [GO:0004708] (molecular_function) —causally upstream of positive effect→ type B pancreatic cell proliferation [GO:0044342] (biological_process)
6796b94c00004574	NAD salvage 6 (mouse)	2026-03-12	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: nicotinate transmembrane transporter activity [GO:0090416] (molecular_function) —has target start location→ extracellular region [GO:0005576] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: nicotinate transmembrane transporter activity [GO:0090416] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Nmnat2 Mmus [MGI:MGI:2444155] (information biomacromolecule) —located in→ transport vesicle [GO:0030133] (anatomical entity)
64c3044100000125	Positive regulation of acetylcholine receptor transcription (Mouse)	2026-03-12	David Hill	success		16 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: protein-membrane adaptor activity [GO:0043495] (molecular_function) —part of→ Ras protein signal transduction [GO:0007265] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein tyrosine kinase activity [GO:0004713] (molecular_function) —directly positively regulates→ transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: guanyl-nucleotide exchange factor activity [GO:0005085] (molecular_function) —directly positively regulates→ protein-membrane adaptor activity [GO:0043495] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —occurs in→ nucleus [GO:0005634] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] (molecular_function) —causally upstream of positive effect→ guanyl-nucleotide exchange factor activity [GO:0005085] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: ERBB signaling pathway [GO:0038127] (biological_process) —positively regulates→ positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) SKIPPED_FACT: 'DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'ERBB signaling pathway [GO:0038127] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —has input→ Chrne Mmus [MGI:MGI:87894] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: guanyl-nucleotide exchange factor activity [GO:0005085] (molecular_function) —part of→ Ras protein signal transduction [GO:0007265] (biological_process) SKIPPED_FACT: Subject 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' has 'has input' relationship to 'Chrne Mmus [MGI:MGI:87894] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ myotube [CL:0002372] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] (molecular_function) —part of→ positive regulation of JNK cascade [GO:0046330] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ras protein signal transduction [GO:0007265] (biological_process) —part of→ ERBB signaling pathway [GO:0038127] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —causally upstream of positive effect→ synaptic transmission, cholinergic [GO:0007271] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: ERBB signaling pathway [GO:0038127] (biological_process) —occurs in→ myotube [CL:0002372] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein-membrane adaptor activity [GO:0043495] (molecular_function) —directly positively regulates→ MAP kinase kinase kinase activity [GO:0004709] (molecular_function)
62f58d8800003012	Positive regulation of insulin secretion 2 (Mouse)	2026-03-12	David Hill	success		5 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: store-operated calcium channel activity [GO:0015279] (molecular_function) —has target start location→ extracellular region [GO:0005576] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol 1,4,5-trisphosphate-gated calcium channel activity [GO:0005220] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol 1,4,5-trisphosphate-gated calcium channel activity [GO:0005220] (molecular_function) —has target start location→ endoplasmic reticulum [GO:0005783] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: store-operated calcium channel activity [GO:0015279] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200] (biological_process) —positively regulates→ insulin secretion [GO:0030073] (biological_process)
62f58d8800003672	Positive regulation of insulin secretion 3 (Mouse)	2026-03-12	David Hill	success		8 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol 1,4,5-trisphosphate-gated calcium channel activity [GO:0005220] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: insulin secretion [GO:0030073] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol 1,4,5-trisphosphate-gated calcium channel activity [GO:0005220] (molecular_function) —has target start location→ endoplasmic reticulum [GO:0005783] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: store-operated calcium channel activity [GO:0015279] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: GTPase-dependent fusogenic activity [GO:0140523] (molecular_function) —causally upstream of or within positive effect→ phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207] (biological_process) —positively regulates→ insulin secretion [GO:0030073] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: store-operated calcium channel activity [GO:0015279] (molecular_function) —has target start location→ extracellular region [GO:0005576] (anatomical entity)
62f58d8800002184	positive regulation of insulin secretion involved in cellular response to glucose stimulus (Mouse)	2026-03-12	David Hill	success		21 warnings SKIPPED_FACT: Subject 'phosphoglycerate kinase activity [GO:0004618] (molecular_function)' has 'has output' relationship to 'ATP(4-) [CHEBI:30616] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: pyruvate decarboxylation to acetyl-CoA [GO:0006086] (biological_process) —part of→ positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774] (biological_process) SKIPPED_FACT: Subject 'oxidative phosphorylation [GO:0006119] (biological_process)' has 'has output' relationship to 'ATP(4-) [CHEBI:30616] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: glucokinase activity [GO:0004340] (molecular_function) —causally upstream of positive effect→ phosphoglycerate kinase activity [GO:0004618] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: tricarboxylic acid cycle [GO:0006099] (biological_process) —causally upstream of positive effect→ oxidative phosphorylation [GO:0006119] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: pyruvate kinase activity [GO:0004743] (molecular_function) —causally upstream of positive effect→ pyruvate decarboxylation to acetyl-CoA [GO:0006086] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: pyruvate decarboxylation to acetyl-CoA [GO:0006086] (biological_process) —causally upstream of positive effect→ tricarboxylic acid cycle [GO:0006099] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: D-glucose transmembrane transporter activity [GO:0055056] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: tricarboxylic acid cycle [GO:0006099] (biological_process) —part of→ positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774] (biological_process) SKIPPED_FACT: Subject 'pyruvate kinase activity [GO:0004743] (molecular_function)' has 'has output' relationship to 'ATP(4-) [CHEBI:30616] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: pyruvate kinase activity [GO:0004743] (molecular_function) —has output→ ATP(4-) [CHEBI:30616] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphoglycerate kinase activity [GO:0004618] (molecular_function) —part of→ canonical glycolysis [GO:0061621] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: D-glucose transmembrane transporter activity [GO:0055056] (molecular_function) —transports or maintains localization of→ alpha-D-glucose [CHEBI:17925] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: D-glucose transmembrane transporter activity [GO:0055056] (molecular_function) —has target start location→ extracellular region [GO:0005576] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidative phosphorylation [GO:0006119] (biological_process) —has output→ ATP(4-) [CHEBI:30616] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphoglycerate kinase activity [GO:0004618] (molecular_function) —has output→ ATP(4-) [CHEBI:30616] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphoglycerate kinase activity [GO:0004618] (molecular_function) —causally upstream of positive effect→ pyruvate kinase activity [GO:0004743] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: pyruvate kinase activity [GO:0004743] (molecular_function) —part of→ canonical glycolysis [GO:0061621] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidative phosphorylation [GO:0006119] (biological_process) —part of→ positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidative phosphorylation [GO:0006119] (biological_process) —causally upstream of positive effect→ ATP binding [GO:0005524] (molecular_function)
6348a65d00000724	Regulation by IL22 and Reg3g of allergic airway inflammation. (Mouse)	2026-03-12	Cristina Casals, David Hill	success
64c3044100000089	Skeletal muscle acetylcholine-gated channel clustering 1 (Mouse)	2026-03-12	David Hill	filtered	Model has at least one activity with no causal relations	7 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: postsynaptic specialization membrane [GO:0099634] (anatomical entity) —part of→ neuromuscular junction [GO:0031594] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: G protein activity [GO:0003925] (molecular_function) —positively regulates→ molecular_function [GO:0003674] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: skeletal muscle acetylcholine-gated channel clustering [GO:0071340] (biological_process) —occurs in→ postsynaptic membrane [GO:0045211] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: enzyme-linked receptor protein signaling pathway [GO:0007167] (biological_process) —positively regulates→ skeletal muscle acetylcholine-gated channel clustering [GO:0071340] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —part of→ postsynaptic actin cytoskeleton organization [GO:0098974] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: skeletal muscle acetylcholine-gated channel clustering [GO:0071340] (biological_process) —occurs in→ postsynaptic specialization membrane [GO:0099634] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: postsynaptic actin cytoskeleton organization [GO:0098974] (biological_process) —part of→ skeletal muscle acetylcholine-gated channel clustering [GO:0071340] (biological_process)
6516135700000211	Tumor necrosis factor-mediated signaling pathway 2 (Mouse)	2026-03-12	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: ceramide metabolic process [GO:0006672] (biological_process) —has primary output→ ceramide [CHEBI:17761] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: tumor necrosis factor-mediated signaling pathway [GO:0033209] (biological_process) —positively regulates→ ceramide metabolic process [GO:0006672] (biological_process) SKIPPED_FACT: Subject 'ceramide metabolic process [GO:0006672] (biological_process)' has 'has primary output' relationship to 'ceramide [CHEBI:17761] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
69a0c46f00001542	Branched-chain amino acid catabolic process 3(Mouse)	2026-03-05	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: branched-chain amino acid transmembrane transporter activity [GO:0015658] (molecular_function) —has target end location→ mitochondrial matrix [GO:0005759] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: branched-chain amino acid transmembrane transporter activity [GO:0015658] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity)
6994852c00006698	Glutamine catabolic process 5 (Mouse)	2026-03-02	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: L-glutamine catabolic process [GO:0006543] (biological_process) —has primary input→ L-glutamine zwitterion [CHEBI:58359] (chemical entity) SKIPPED_FACT: Subject 'L-glutamine catabolic process [GO:0006543] (biological_process)' has 'has primary input' relationship to 'L-glutamine zwitterion [CHEBI:58359] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
6994852c00006613	Glutamine catabolic process 6 (Mouse)	2026-02-26	David Hill	success		2 warnings SKIPPED_FACT: Subject 'L-glutamine catabolic process [GO:0006543] (biological_process)' has 'has primary input' relationship to 'L-glutamine zwitterion [CHEBI:58359] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: L-glutamine catabolic process [GO:0006543] (biological_process) —has primary input→ L-glutamine zwitterion [CHEBI:58359] (chemical entity)
6994852c00000452	L-glutamate catabolic process (Mouse)	2026-02-26	David Hill	filtered	Model has at least one activity with no causal relations
6994852c00001989	Glutamine catabolic process 4 (Mouse)	2026-02-25	David Hill	success		2 warnings SKIPPED_FACT: Subject 'L-glutamine catabolic process [GO:0006543] (biological_process)' has 'has primary input' relationship to 'L-glutamine zwitterion [CHEBI:58359] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: L-glutamine catabolic process [GO:0006543] (biological_process) —has primary input→ L-glutamine zwitterion [CHEBI:58359] (chemical entity)
6994852c00000686	Glutamine catabolic process 1 (Mouse)	2026-02-19	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: L-glutamine catabolic process [GO:0006543] (biological_process) —has primary input→ L-glutamine zwitterion [CHEBI:58359] (chemical entity) SKIPPED_FACT: Subject 'L-glutamine catabolic process [GO:0006543] (biological_process)' has 'has primary input' relationship to 'L-glutamine zwitterion [CHEBI:58359] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
6994852c00001950	Glutamine catabolic process 2 (Mouse)	2026-02-19	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: L-glutamine catabolic process [GO:0006543] (biological_process) —has primary input→ L-glutamine zwitterion [CHEBI:58359] (chemical entity) SKIPPED_FACT: Subject 'L-glutamine catabolic process [GO:0006543] (biological_process)' has 'has primary input' relationship to 'L-glutamine zwitterion [CHEBI:58359] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
6994852c00001892	Glutamine catabolic process 3 (Mouse)	2026-02-19	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: L-glutamine catabolic process [GO:0006543] (biological_process) —has primary input→ L-glutamine zwitterion [CHEBI:58359] (chemical entity) SKIPPED_FACT: Subject 'L-glutamine catabolic process [GO:0006543] (biological_process)' has 'has primary input' relationship to 'L-glutamine zwitterion [CHEBI:58359] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
69729a3800005274	L-Lysine catabolic process (Mouse)	2026-02-11	David Hill	success
69729a3800001853	Asparagine biosynthetic process 1 (Mouse)	2026-02-02	David Hill	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: L-aspartate biosynthetic process [GO:0006532] (biological_process) —causally upstream of positive effect→ L-asparagine biosynthetic process [GO:0070981] (biological_process)
69729a3800004816	Asparagine biosynthetic process 2 (Mouse)	2026-02-02	David Hill	success
693b3c0900004487	L-serine biosynthetic process (Mouse)	2026-01-22	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular carrier activity [GO:0140104] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular carrier activity [GO:0140104] (molecular_function) —has target end location→ plasma membrane [GO:0005886] (anatomical entity)
693b3c0900003746	Proline catabolic process (Mouse)	2026-01-22	David Hill	success		4 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: L-proline catabolic process [GO:0006562] (biological_process) —has primary output→ L-glutamate(1-) [CHEBI:29985] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: L-proline catabolic process [GO:0006562] (biological_process) —has primary input→ L-proline zwitterion [CHEBI:60039] (chemical entity) SKIPPED_FACT: Subject 'L-proline catabolic process [GO:0006562] (biological_process)' has 'has primary input' relationship to 'L-proline zwitterion [CHEBI:60039] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'L-proline catabolic process [GO:0006562] (biological_process)' has 'has primary output' relationship to 'L-glutamate(1-) [CHEBI:29985] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
693b3c0900005466	Tryptophan catabolic process 2 (Mouse)	2026-01-16	David Hill, Li Ni	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: L-tryptophan transmembrane transporter activity [GO:0015196] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: L-tryptophan transmembrane transporter activity [GO:0015196] (molecular_function) —has target start location→ extracellular region [GO:0005576] (anatomical entity)
60ad85f700003288	'de novo' UMP biosynthetic process (Mouse)	2026-01-08	David Hill	success
60418ffa00000414	Adenosine catabolic process (Mouse)	2026-01-08	David Hill	success		2 warnings SKIPPED_FACT: Subject 'adenosine catabolic process [GO:0006154] (biological_process)' has 'has primary output' relationship to 'allantoin [CHEBI:15676] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: adenosine catabolic process [GO:0006154] (biological_process) —has primary output→ allantoin [CHEBI:15676] (chemical entity)
5f46c3b700003884	AMP catabolic process to allantoin (Mouse)	2026-01-08	David Hill	success		2 warnings SKIPPED_FACT: Subject 'AMP catabolic process [GO:0006196] (biological_process)' has 'has primary output' relationship to 'allantoin [CHEBI:15676] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: AMP catabolic process [GO:0006196] (biological_process) —has primary output→ allantoin [CHEBI:15676] (chemical entity)
60ff660000001341	AMP salvage 2b, from adenosine (Mouse)	2026-01-08	David Hill	success
5fadbcf000002042	CMP catabolic process (Mouse)	2026-01-08	David Hill	success
5fadbcf000002236	dCMP catabolic process (Mouse)	2026-01-08	David Hill	success
60418ffa00001258	Deoxyadenosine catabolic process (Mouse)	2026-01-08	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: deoxyadenosine catabolic process [GO:0006157] (biological_process) —has primary output→ allantoin [CHEBI:15676] (chemical entity) SKIPPED_FACT: Subject 'deoxyadenosine catabolic process [GO:0006157] (biological_process)' has 'has primary output' relationship to 'allantoin [CHEBI:15676] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
60418ffa00001536	Deoxyguanosine catabolic process (Mouse)	2026-01-08	David Hill	success
60418ffa00001643	Deoxyinosine catabolic process (Mouse)	2026-01-08	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: deoxyinosine catabolic process [GO:0006149] (biological_process) —has primary output→ allantoin [CHEBI:15676] (chemical entity) SKIPPED_FACT: Subject 'deoxyinosine catabolic process [GO:0006149] (biological_process)' has 'has primary output' relationship to 'allantoin [CHEBI:15676] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
5f46c3b700003802	dGMP catabolic process to allantoin (Mouse)	2026-01-08	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: dGMP catabolic process [GO:0046055] (biological_process) —has primary output→ allantoin [CHEBI:15676] (chemical entity) SKIPPED_FACT: Subject 'dGMP catabolic process [GO:0046055] (biological_process)' has 'has primary output' relationship to 'allantoin [CHEBI:15676] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
60e7989d00000165	dTMP biosynthetic process1A (Mouse)	2026-01-08	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: Rrm2 Mmus [MGI:MGI:98181] (information biomacromolecule) —part of→ ribonucleoside-diphosphate reductase complex [GO:0005971] (cellular_component) UNHANDLED_FACT: Fact not representable in GO-CAM model: Rrm1 Mmus [MGI:MGI:98180] (information biomacromolecule) —part of→ ribonucleoside-diphosphate reductase complex [GO:0005971] (cellular_component)
5fadbcf000000942	dTMP catabolic process (Mouse)	2026-01-08	David Hill	filtered	Model has at least one activity with no causal relations	2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-ureidopropionase activity [GO:0003837] (molecular_function) —provides input for→ transporter activity [GO:0005215] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —provides input for→ (R)-3-amino-2-methylpropionate:pyruvate transaminase activity [GO:0047305] (molecular_function)
5fadbcf000000868	dUMP catabolic process (Mouse)	2026-01-08	David Hill	filtered	Model has at least one activity with no causal relations	2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-ureidopropionase activity [GO:0003837] (molecular_function) —provides input for→ transporter activity [GO:0005215] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —provides input for→ beta-alanine:pyruvate transaminase activity [GO:0016223] (molecular_function)
662af8fa00000138	GDP-mannose biosynthetic process from mannose (Mouse)	2026-01-08	David Hill	success		4 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: GDP-mannose biosynthetic process [GO:0009298] (biological_process) —has primary output→ GDP-alpha-D-mannose(2-) [CHEBI:57527] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: GDP-mannose biosynthetic process [GO:0009298] (biological_process) —has primary input→ mannose [CHEBI:37684] (chemical entity) SKIPPED_FACT: Subject 'GDP-mannose biosynthetic process [GO:0009298] (biological_process)' has 'has primary input' relationship to 'mannose [CHEBI:37684] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'GDP-mannose biosynthetic process [GO:0009298] (biological_process)' has 'has primary output' relationship to 'GDP-alpha-D-mannose(2-) [CHEBI:57527] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
5fa76ad400000110	GMP catabolic process to allantoin (Mouse)	2026-01-08	David Hill	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: GMP catabolic process [GO:0046038] (biological_process) —RO:0002224→ 5'-nucleotidase activity [GO:0008253] (molecular_function)
60ff660000000882	GMP salvage 2a, from adenosine (Mouse)	2026-01-08	David Hill	success
60ff660000000897	GMP salvage 2b, from adenosine (Mouse)	2026-01-08	David Hill, Harold Drabkin	success
60ff660000000917	GMP salvage 3, from adenine (Mouse)	2026-01-08	David Hill	success
60418ffa00001200	Guanine catabolic process (Mouse)	2026-01-08	David Hill	success		2 warnings SKIPPED_FACT: Subject 'guanine catabolic process [GO:0006147] (biological_process)' has 'has primary output' relationship to 'allantoin [CHEBI:15676] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: guanine catabolic process [GO:0006147] (biological_process) —has primary output→ allantoin [CHEBI:15676] (chemical entity)
60418ffa00001124	Hypoxanthine catabolic process (Mouse)	2026-01-08	David Hill, Li Ni	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: hypoxanthine catabolic process [GO:0009114] (biological_process) —has primary output→ allantoin [CHEBI:15676] (chemical entity) SKIPPED_FACT: Subject 'hypoxanthine catabolic process [GO:0009114] (biological_process)' has 'has primary output' relationship to 'allantoin [CHEBI:15676] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
5fa76ad400000374	IMP catabolic process to allantoin (Mouse)	2026-01-08	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: IMP catabolic process [GO:0006204] (biological_process) —has primary output→ allantoin [CHEBI:15676] (chemical entity) SKIPPED_FACT: Subject 'IMP catabolic process [GO:0006204] (biological_process)' has 'has primary output' relationship to 'allantoin [CHEBI:15676] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
60418ffa00000811	Inosine catabolic process (Mouse)	2026-01-08	David Hill	success		2 warnings SKIPPED_FACT: Subject 'inosine catabolic process [GO:0006148] (biological_process)' has 'has primary output' relationship to 'allantoin [CHEBI:15676] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: inosine catabolic process [GO:0006148] (biological_process) —has primary output→ allantoin [CHEBI:15676] (chemical entity)
5fadbcf000000480	UMP catabolic process (Mouse)	2026-01-08	David Hill	filtered	Model has at least one activity with no causal relations	2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: beta-ureidopropionase activity [GO:0003837] (molecular_function) —provides input for→ transporter activity [GO:0005215] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —provides input for→ beta-alanine:pyruvate transaminase activity [GO:0016223] (molecular_function)
60418ffa00000327	Xanthine catabolic process (Mouse)	2026-01-08	David Hill	success		2 warnings SKIPPED_FACT: Subject 'xanthine catabolic process [GO:0009115] (biological_process)' has 'has primary output' relationship to 'allantoin [CHEBI:15676] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: xanthine catabolic process [GO:0009115] (biological_process) —has primary output→ allantoin [CHEBI:15676] (chemical entity)
693b3c0900003926	Proline biosynthetic process (Mouse)	2025-12-31	David Hill	success
693b3c0900004089	Proline biosynthetic process 2 (Mouse)	2025-12-31	David Hill	success
693b3c0900003788	Trans-4-hydroxy-L-proline catabolic process (Mouse)	2025-12-30	David Hill	success
6882d2b800003495	Negative Regulation of Triglyceride Catabolic Process 1 (Mouse)	2025-12-19	David Hill	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of triglyceride catabolic process [GO:0010897] (biological_process) —negatively regulates→ triglyceride catabolic process [GO:0019433] (biological_process)
6882d2b800003605	Negative Regulation of Triglyceride Catabolic Process 2 (Mouse)	2025-12-19	David Hill	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of triglyceride catabolic process [GO:0010897] (biological_process) —negatively regulates→ triglyceride catabolic process [GO:0019433] (biological_process)
67c10cc400005077	Cyclooxygenase pathway 10 (Mouse)	2025-12-17	David Hill	filtered	Model has at least one activity with no causal relations	10 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has primary input→ prostaglandin H2(1-) [CHEBI:57405] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cyclooxygenase pathway [GO:0019371] (biological_process) —has primary output→ prostaglandin D2(1-) [CHEBI:57406] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —has part→ peroxidase activity [GO:0004601] (molecular_function) SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has primary output' relationship to 'prostaglandin H2(1-) [CHEBI:57405] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —part of→ cyclooxygenase pathway [GO:0019371] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has primary output→ prostaglandin H2(1-) [CHEBI:57405] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —occurs in→ endoplasmic reticulum lumen [GO:0005788] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —has part→ oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705] (molecular_function) SKIPPED_FACT: Subject 'cyclooxygenase pathway [GO:0019371] (biological_process)' has 'has primary output' relationship to 'prostaglandin D2(1-) [CHEBI:57406] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has primary input' relationship to 'prostaglandin H2(1-) [CHEBI:57405] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
67c10cc400001632	Cyclooxygenase pathway 6 (Mouse)	2025-12-17	David Hill	filtered	Model has at least one activity with no causal relations	11 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —has part→ peroxidase activity [GO:0004601] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: lipid transmembrane transporter activity [GO:0170055] (molecular_function) —has primary input→ prostaglandin H2(1-) [CHEBI:57405] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cyclooxygenase pathway [GO:0019371] (biological_process) —has primary output→ prostaglandin E2(1-) [CHEBI:606564] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —occurs in→ endoplasmic reticulum lumen [GO:0005788] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —part of→ cyclooxygenase pathway [GO:0019371] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: lipid transmembrane transporter activity [GO:0170055] (molecular_function) —has primary output→ prostaglandin H2(1-) [CHEBI:57405] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —has part→ oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705] (molecular_function) SKIPPED_FACT: Subject 'lipid transmembrane transporter activity [GO:0170055] (molecular_function)' has 'has primary input' relationship to 'prostaglandin H2(1-) [CHEBI:57405] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: Ptges Mmus [MGI:MGI:1927593] (information biomacromolecule) —located in→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity) SKIPPED_FACT: Subject 'lipid transmembrane transporter activity [GO:0170055] (molecular_function)' has 'has primary output' relationship to 'prostaglandin H2(1-) [CHEBI:57405] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'cyclooxygenase pathway [GO:0019371] (biological_process)' has 'has primary output' relationship to 'prostaglandin E2(1-) [CHEBI:606564] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
67c10cc400002461	Cyclooxygenase pathway 7 (Mouse)	2025-12-17	David Hill	success		6 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —has part→ peroxidase activity [GO:0004601] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —part of→ cyclooxygenase pathway [GO:0019371] (biological_process) SKIPPED_FACT: Subject 'cyclooxygenase pathway [GO:0019371] (biological_process)' has 'has primary output' relationship to 'prostaglandin E2(1-) [CHEBI:606564] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: cyclooxygenase pathway [GO:0019371] (biological_process) —has primary output→ prostaglandin E2(1-) [CHEBI:606564] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —occurs in→ endoplasmic reticulum lumen [GO:0005788] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —has part→ oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705] (molecular_function)
67c10cc400002481	Cyclooxygenase pathway 8 (Mouse)	2025-12-17	David Hill	success		6 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —has part→ peroxidase activity [GO:0004601] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —occurs in→ endoplasmic reticulum lumen [GO:0005788] (anatomical entity) SKIPPED_FACT: Subject 'cyclooxygenase pathway [GO:0019371] (biological_process)' has 'has primary output' relationship to 'prostaglandin E2(1-) [CHEBI:606564] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —part of→ cyclooxygenase pathway [GO:0019371] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: cyclooxygenase pathway [GO:0019371] (biological_process) —has primary output→ prostaglandin E2(1-) [CHEBI:606564] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —has part→ oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705] (molecular_function)
67c10cc400005143	Heme catabolic process 1 (Mouse)	2025-12-17	David Hill	filtered	Model has at least one activity with no causal relations	19 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular carrier activity [GO:0140104] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ugt1a1 Mmus [MGI:MGI:98898] (information biomacromolecule) —located in→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane transporter activity [GO:0022857] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular carrier activity [GO:0140104] (molecular_function) —has input→ bilirubin(2-) [CHEBI:57977] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane transporter activity [GO:0022857] (molecular_function) —has primary input→ bis(beta-glucosyluronate)bilirubin [CHEBI:58471] (chemical entity) SKIPPED_FACT: Subject 'molecular carrier activity [GO:0140104] (molecular_function)' has 'has output' relationship to 'bilirubin(2-) [CHEBI:57977] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'transmembrane transporter activity [GO:0022857] (molecular_function)' has 'has primary input' relationship to 'bis(beta-glucosyluronate)bilirubin [CHEBI:58471] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular carrier activity [GO:0140104] (molecular_function) —has output→ bilirubin(2-) [CHEBI:57977] (chemical entity) SKIPPED_FACT: Subject 'transmembrane transporter activity [GO:0022857] (molecular_function)' has 'has output' relationship to 'bis(beta-glucosyluronate)bilirubin [CHEBI:58471] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'glucuronosyltransferase activity [GO:0015020] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heme catabolic process [GO:0042167] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: secondary active transmembrane transporter activity [GO:0015291] (molecular_function) —has target start location→ extracellular region [GO:0005576] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: ABC-type transporter activity [GO:0140359] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) SKIPPED_FACT: Subject 'molecular carrier activity [GO:0140104] (molecular_function)' has 'has input' relationship to 'bilirubin(2-) [CHEBI:57977] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane transporter activity [GO:0022857] (molecular_function) —has output→ bis(beta-glucosyluronate)bilirubin [CHEBI:58471] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: ABC-type transporter activity [GO:0140359] (molecular_function) —has target end location→ extracellular region [GO:0005576] (anatomical entity) SKIPPED_FACT: 'glucuronosyltransferase activity [GO:0015020] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'heme catabolic process [GO:0042167] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular carrier activity [GO:0140104] (molecular_function) —part of→ bilirubin transport [GO:0015723] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane transporter activity [GO:0022857] (molecular_function) —has target start location→ endoplasmic reticulum lumen [GO:0005788] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: secondary active transmembrane transporter activity [GO:0015291] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity)
67c10cc400003329	Prostanoid biosynthetic process 1 (Mouse)	2025-12-17	David Hill	success		6 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —part of→ prostanoid biosynthetic process [GO:0046457] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —has part→ peroxidase activity [GO:0004601] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —occurs in→ endoplasmic reticulum lumen [GO:0005788] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostanoid biosynthetic process [GO:0046457] (biological_process) —has primary output→ thromboxane A2(1-) [CHEBI:57445] (chemical entity) SKIPPED_FACT: Subject 'prostanoid biosynthetic process [GO:0046457] (biological_process)' has 'has primary output' relationship to 'thromboxane A2(1-) [CHEBI:57445] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —has part→ oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705] (molecular_function)
67c10cc400003560	Prostanoid biosynthetic process 2 (Mouse)	2025-12-17	David Hill	success		6 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: prostanoid biosynthetic process [GO:0046457] (biological_process) —has primary output→ 12(S)-HHTrE(1-) [CHEBI:90694] (chemical entity) SKIPPED_FACT: Subject 'prostanoid biosynthetic process [GO:0046457] (biological_process)' has 'has primary output' relationship to '12(S)-HHTrE(1-) [CHEBI:90694] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —has part→ peroxidase activity [GO:0004601] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —occurs in→ endoplasmic reticulum lumen [GO:0005788] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —has part→ oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —part of→ prostanoid biosynthetic process [GO:0046457] (biological_process)
67c10cc400003706	Prostanoid biosynthetic process 3 (Mouse)	2025-12-17	David Hill	success		6 warnings SKIPPED_FACT: Subject 'prostanoid biosynthetic process [GO:0046457] (biological_process)' has 'has primary output' relationship to 'thromboxane A2(1-) [CHEBI:57445] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —part of→ prostanoid biosynthetic process [GO:0046457] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —has part→ peroxidase activity [GO:0004601] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —occurs in→ endoplasmic reticulum lumen [GO:0005788] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostaglandin-endoperoxide synthase activity [GO:0004666] (molecular_function) —has part→ oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: prostanoid biosynthetic process [GO:0046457] (biological_process) —has primary output→ thromboxane A2(1-) [CHEBI:57445] (chemical entity)
67b1629100001160	Blvra, Gsk3b, Ppara mouse PMID:27738106	2025-12-16	David Hill, Dmitry Sitnikov	filtered	Model has at least one activity with no causal relations	19 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: glycogen metabolic process [GO:0005977] (biological_process) —occurs in→ liver [EMAPA:16846] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ protein metabolic process [GO:0019538] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ lipid metabolic process [GO:0006629] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ insulin metabolic process [GO:1901142] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ glucose homeostasis [GO:0042593] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ peptidyl-serine phosphorylation [GO:0018105] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: peptidyl-serine phosphorylation [GO:0018105] (biological_process) —has input→ Gsk3b Mmus [MGI:MGI:1861437] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ regulation of catalytic activity [GO:0050790] (biological_process) SKIPPED_FACT: Subject 'peptidyl-serine phosphorylation [GO:0018105] (biological_process)' has 'has input' relationship to 'Gsk3b Mmus [MGI:MGI:1861437] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: lipid metabolic process [GO:0006629] (biological_process) —occurs in→ liver [EMAPA:16846] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ protein ubiquitination [GO:0016567] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: insulin receptor signaling pathway [GO:0008286] (biological_process) —occurs in→ liver [EMAPA:16846] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ protein phosphorylation [GO:0006468] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ insulin receptor signaling pathway [GO:0008286] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ glycogen metabolic process [GO:0005977] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: insulin metabolic process [GO:1901142] (biological_process) —occurs in→ plasma [EMAPA:35690] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ gene expression [GO:0010467] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: glucose homeostasis [GO:0042593] (biological_process) —occurs in→ plasma [EMAPA:35690] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of catalytic activity [GO:0050790] (biological_process) —occurs in→ liver [EMAPA:16846] (anatomical entity)
67b1629100003590	Cyclooxygenase pathway 1 (Mouse)	2025-12-16	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: cyclooxygenase pathway [GO:0019371] (biological_process) —has primary output→ prostaglandin I2(1-) [CHEBI:57403] (chemical entity) SKIPPED_FACT: Subject 'cyclooxygenase pathway [GO:0019371] (biological_process)' has 'has primary output' relationship to 'prostaglandin I2(1-) [CHEBI:57403] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: NAD+ catabolic process [GO:0019677] (biological_process) —positively regulates→ cyclooxygenase pathway [GO:0019371] (biological_process)
67c10cc400000716	Cyclooxygenase pathway 2 (Mouse)	2025-12-16	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: cyclooxygenase pathway [GO:0019371] (biological_process) —has primary output→ prostaglandin I2(1-) [CHEBI:57403] (chemical entity) SKIPPED_FACT: Subject 'cyclooxygenase pathway [GO:0019371] (biological_process)' has 'has primary output' relationship to 'prostaglandin I2(1-) [CHEBI:57403] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
671ae02600001531	Gpr108, Smurf1, Irf3 mouse PMID:37330913	2025-12-16	David Hill, Dmitry Sitnikov, Li Ni	filtered	Model has at least one activity with no causal relations	6 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ type I interferon-mediated signaling pathway [GO:0060337] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ defense response to virus [GO:0051607] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ autophagy [GO:0006914] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ cytokine production [GO:0001816] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ protein K63-linked ubiquitination [GO:0070534] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ protein catabolic process [GO:0030163] (biological_process)
67086be200002592	Retinoid Metabolic Process 3 (Mouse)	2025-12-16	David Hill	filtered	Model has at least one activity with no causal relations	20 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —part of→ retinoid metabolic process [GO:0001523] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: low-density lipoprotein particle receptor activity [GO:0005041] (molecular_function) —causally upstream of→ all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) SKIPPED_FACT: Subject 'all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: retinoid binding [GO:0005501] (molecular_function) —causally upstream of→ molecular_function [GO:0003674] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —has output→ all-trans-retinol [CHEBI:17336] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —provides input for→ all-trans-retinol 13,14-reductase activity [GO:0051786] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —part of→ secretion [GO:0046903] (biological_process) SKIPPED_FACT: Subject 'molecular_function [GO:0003674] (molecular_function)' has 'has input' relationship to 'all-trans-retinyl ester [CHEBI:63410] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —part of→ chylomicron remodeling [GO:0034371] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —provides input for→ lipoprotein lipase activity [GO:0004465] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl ester [CHEBI:63410] (chemical entity) —part of→ chylomicron [GO:0042627] (cellular_component) SKIPPED_FACT: Subject 'all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function)' has 'has output' relationship to 'all-trans-retinol [CHEBI:17336] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of→ molecular_function [GO:0003674] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —has input→ all-trans-retinyl ester [CHEBI:63410] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —occurs in→ early endosome [GO:0005769] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: early endosome [GO:0005769] (anatomical entity) —part of→ hepatocyte [CL:0000182] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —occurs in→ extracellular region [GO:0005576] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity)
67086be200002705	Retinoid Metabolic Process 4 (Mouse)	2025-12-16	David Hill	success		34 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: low-density lipoprotein particle receptor activity [GO:0005041] (molecular_function) —causally upstream of→ all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) SKIPPED_FACT: Subject 'molecular_function [GO:0003674] (molecular_function)' has 'has primary input' relationship to 'all-trans-retinyl ester [CHEBI:63410] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function)' has 'has output' relationship to 'all-trans-retinol [CHEBI:17336] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular carrier activity [GO:0140104] (molecular_function) —part of→ retinol transport [GO:0034633] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: retinoid binding [GO:0005501] (molecular_function) —causally upstream of→ molecular_function [GO:0003674] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: retinal dehydrogenase (NAD+) activity [GO:0001758] (molecular_function) —has input→ NAD(1-) [CHEBI:57540] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: lipid storage [GO:0019915] (biological_process) —occurs in→ hepatic stellate cell [CL:0000632] (anatomical entity) SKIPPED_FACT: Subject 'all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinol binding [GO:1904768] (molecular_function) —provides input for→ molecular carrier activity [GO:0140104] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: retinol transport [GO:0034633] (biological_process) —has primary input→ all-trans-retinol [CHEBI:17336] (chemical entity) SKIPPED_FACT: Subject 'retinal dehydrogenase (NAD+) activity [GO:0001758] (molecular_function)' has 'has input' relationship to 'NAD(1-) [CHEBI:57540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —provides input for→ all-trans-retinol binding [GO:1904768] (molecular_function) SKIPPED_FACT: Subject 'retinal dehydrogenase (NAD+) activity [GO:0001758] (molecular_function)' has 'has primary input' relationship to 'all-trans-retinal [CHEBI:17898] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —part of→ secretion [GO:0046903] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —has output→ all-trans-retinol [CHEBI:17336] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —part of→ chylomicron remodeling [GO:0034371] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: lipid storage [GO:0019915] (biological_process) —has primary input→ all-trans-retinyl ester [CHEBI:63410] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —provides input for→ lipoprotein lipase activity [GO:0004465] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular carrier activity [GO:0140104] (molecular_function) —provides input for→ all-trans-retinol binding [GO:1904768] (molecular_function) SKIPPED_FACT: Subject 'all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl ester [CHEBI:63410] (chemical entity) —part of→ chylomicron [GO:0042627] (cellular_component) SKIPPED_FACT: Subject 'lipid storage [GO:0019915] (biological_process)' has 'has primary input' relationship to 'all-trans-retinyl ester [CHEBI:63410] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —has primary input→ all-trans-retinyl ester [CHEBI:63410] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: retinal dehydrogenase (NAD+) activity [GO:0001758] (molecular_function) —part of→ retinoic acid biosynthetic process [GO:0002138] (biological_process) SKIPPED_FACT: Subject 'retinol transport [GO:0034633] (biological_process)' has 'has primary input' relationship to 'all-trans-retinol [CHEBI:17336] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of→ molecular_function [GO:0003674] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —occurs in→ early endosome [GO:0005769] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: retinal dehydrogenase (NAD+) activity [GO:0001758] (molecular_function) —has primary input→ all-trans-retinal [CHEBI:17898] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: enzyme-substrate adaptor activity [GO:0140767] (molecular_function) —directly negatively regulates→ retinal dehydrogenase (NAD+) activity [GO:0001758] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: early endosome [GO:0005769] (anatomical entity) —part of→ hepatocyte [CL:0000182] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —occurs in→ extracellular region [GO:0005576] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —part of→ retinoid metabolic process [GO:0001523] (biological_process)
671ae02600003666	Tetrahydrofolylpolyglutamate biosynthetic process 1 (Mouse)	2025-12-16	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: folic acid:proton symporter activity [GO:0140211] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: folic acid:proton symporter activity [GO:0140211] (molecular_function) —has target start location→ extracellular region [GO:0005576] (anatomical entity) SKIPPED_FACT: 'folic acid receptor activity [GO:0061714] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'endocytosis [GO:0006897] (biological_process)'
66f5faaa00001204	Retinoid Metabolic Process 1 (Mouse)	2025-12-15	David Hill	success		29 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —provides input for→ all-trans-retinol binding [GO:1904768] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of positive effect→ molecular_function [GO:0003674] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: retinoid binding [GO:0005501] (molecular_function) —causally upstream of positive effect→ molecular_function [GO:0003674] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —part of→ secretion [GO:0046903] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —has output→ all-trans-retinol [CHEBI:17336] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —part of→ chylomicron remodeling [GO:0034371] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: lipid storage [GO:0019915] (biological_process) —has primary input→ all-trans-retinyl ester [CHEBI:63410] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —provides input for→ lipoprotein lipase activity [GO:0004465] (molecular_function) SKIPPED_FACT: Subject 'lipid storage [GO:0019915] (biological_process)' has 'has primary input' relationship to 'all-trans-retinyl ester [CHEBI:63410] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular carrier activity [GO:0140104] (molecular_function) —provides input for→ all-trans-retinol binding [GO:1904768] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl ester [CHEBI:63410] (chemical entity) —part of→ chylomicron [GO:0042627] (cellular_component) SKIPPED_FACT: Subject 'all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function)' has 'has output' relationship to 'all-trans-retinol [CHEBI:17336] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'retinol transport [GO:0034633] (biological_process)' has 'has primary input' relationship to 'all-trans-retinol [CHEBI:17336] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function)' has 'has output' relationship to 'hydron [CHEBI:15378] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —has input→ all-trans-retinyl ester [CHEBI:63410] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —occurs in→ early endosome [GO:0005769] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —has input→ water [CHEBI:15377] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: early endosome [GO:0005769] (anatomical entity) —part of→ hepatocyte [CL:0000182] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —occurs in→ extracellular region [GO:0005576] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —has output→ hydron [CHEBI:15378] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) —part of→ retinoid metabolic process [GO:0001523] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: low-density lipoprotein particle receptor activity [GO:0005041] (molecular_function) —causally upstream of→ all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function) SKIPPED_FACT: Subject 'molecular_function [GO:0003674] (molecular_function)' has 'has input' relationship to 'all-trans-retinyl ester [CHEBI:63410] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular carrier activity [GO:0140104] (molecular_function) —part of→ retinol transport [GO:0034633] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: all-trans-retinol binding [GO:1904768] (molecular_function) —provides input for→ molecular carrier activity [GO:0140104] (molecular_function) SKIPPED_FACT: Subject 'all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376] (molecular_function)' has 'has input' relationship to 'water [CHEBI:15377] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: secretion [GO:0046903] (biological_process) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: lipid storage [GO:0019915] (biological_process) —occurs in→ hepatic stellate cell [CL:0000632] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: retinol transport [GO:0034633] (biological_process) —has primary input→ all-trans-retinol [CHEBI:17336] (chemical entity)
6258b8f300000188	Chondroitin sulfate biosynthetic process 1, chondroitin 6-sulfate proteoglycans (Mouse)	2025-12-08	David Hill	success		4 warnings SKIPPED_FACT: Subject 'secretion [GO:0046903] (biological_process)' has 'has primary input' relationship to 'chondroitin sulfate proteoglycan [CHEBI:26349] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: secretion [GO:0046903] (biological_process) —part of→ chondroitin sulfate proteoglycan biosynthetic process [GO:0050650] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: chondroitin sulfate proteoglycan biosynthetic process [GO:0050650] (biological_process) —occurs in→ Golgi apparatus [GO:0005794] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: secretion [GO:0046903] (biological_process) —has primary input→ chondroitin sulfate proteoglycan [CHEBI:26349] (information biomacromolecule)
622aace900000790	Galactose catabolic process via UDP-galactose (Mouse)	2025-12-08	David Hill	success
62f58d8800001119	Insulin receptor recycling (Mouse)	2025-12-08	David Hill, Li Ni	success		12 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: proton transmembrane transporter activity [GO:0015078] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: endosome to plasma membrane protein transport [GO:0099638] (biological_process) —has target start location→ endosome membrane [GO:0010008] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: endosome to plasma membrane protein transport [GO:0099638] (biological_process) —has target end location→ plasma membrane [GO:0005886] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: endosome to plasma membrane protein transport [GO:0099638] (biological_process) —has primary input→ mINSR Mmus [PR:P15208] (information biomacromolecule) SKIPPED_FACT: 'endopeptidase activity [GO:0004175] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'insulin catabolic process [GO:1901143] (biological_process)' SKIPPED_FACT: Subject 'endosome to plasma membrane protein transport [GO:0099638] (biological_process)' has 'has primary input' relationship to 'mINSR Mmus [PR:P15208] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: proton-transporting V-type ATPase, V0 domain [GO:0033179] (cellular_component) —has part→ Atp6v0a2 Mmus [MGI:MGI:104855] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: proton-transporting V-type ATPase, V0 domain [GO:0033179] (cellular_component) —has part→ Atp6v0c Mmus [MGI:MGI:88116] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: proton-transporting V-type ATPase, V0 domain [GO:0033179] (cellular_component) —has part→ Atp6v0d1 Mmus [MGI:MGI:1201778] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: proton-transporting V-type ATPase, V0 domain [GO:0033179] (cellular_component) —has part→ Atp6v0e Mmus [MGI:MGI:1328318] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: proton-transporting V-type ATPase, V0 domain [GO:0033179] (cellular_component) —has part→ Atp6v0b Mmus [MGI:MGI:1890510] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: proton transmembrane transporter activity [GO:0015078] (molecular_function) —has target end location→ endosome lumen [GO:0031904] (anatomical entity)
62e3212700000746	Insulin-like growth factor receptor signaling pathway 3 (Mouse)	2025-12-08	David Hill	success
62f58d8800006739	Negative regulation of insulin secretion 2 (Mouse)	2025-12-08	David Hill	success		8 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of insulin secretion [GO:0046676] (biological_process) —negatively regulates→ insulin secretion [GO:0030073] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase activity [GO:0004016] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: insulin secretion [GO:0030073] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase activity [GO:0004016] (molecular_function) —part of→ negative regulation of insulin secretion [GO:0046676] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of insulin secretion [GO:0046676] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase inhibitor activity [GO:0010855] (molecular_function) —directly negatively regulates→ adenylate cyclase activity [GO:0004016] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: obsolete vesicle docking involved in exocytosis [GO:0006904] (biological_process) —part of→ insulin secretion [GO:0030073] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of negative effect→ obsolete vesicle docking involved in exocytosis [GO:0006904] (biological_process)
62f58d8800004529	Positive regulation of insulin secretion 6 (Mouse)	2025-12-08	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189] (biological_process) —positively regulates→ insulin secretion [GO:0030073] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: insulin secretion [GO:0030073] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity)
62f58d8800004803	Positive regulation of insulin secretion 7 (Mouse)	2025-12-08	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189] (biological_process) —positively regulates→ insulin secretion [GO:0030073] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: cAMP-dependent protein kinase activity [GO:0004691] (molecular_function) —directly positively regulates→ ryanodine-sensitive calcium-release channel activity [GO:0005219] (molecular_function)
636d9ce800000943	Protein kinase A signaling 1 (Mouse)	2025-12-08	David Hill	filtered	Model has at least one activity with no causal relations	11 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: protein export from nucleus [GO:0006611] (biological_process) —has target start location→ nucleoplasm [GO:0005654] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cAMP/PKA signal transduction [GO:0141156] (biological_process) —occurs in→ hepatocyte [CL:0000182] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cAMP-dependent protein kinase activity [GO:0004691] (molecular_function) —causally upstream of positive effect→ protein export from nucleus [GO:0006611] (biological_process) SKIPPED_FACT: Subject 'protein export from nucleus [GO:0006611] (biological_process)' has 'has primary input' relationship to 'Mlxipl Mmus [MGI:MGI:1927999] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'protein export from nucleus [GO:0006611] (biological_process)' has 'has primary input' relationship to 'Sfn Mmus [MGI:MGI:1891831] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —positively regulates→ transcription by RNA polymerase II [GO:0006366] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: cAMP/PKA signal transduction [GO:0141156] (biological_process) —negatively regulates→ positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein export from nucleus [GO:0006611] (biological_process) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein export from nucleus [GO:0006611] (biological_process) —has primary input→ Mlxipl Mmus [MGI:MGI:1927999] (information biomacromolecule) SKIPPED_FACT: 'protein binding [GO:0005515] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'cAMP/PKA signal transduction [GO:0141156] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: protein export from nucleus [GO:0006611] (biological_process) —has primary input→ Sfn Mmus [MGI:MGI:1891831] (information biomacromolecule)
626b20c100000443	Regulation of gluconeogenesis by TOX4 (Mouse)	2025-12-08	Cristina Casals, David Hill, Suzi Aleksander	success
5f46c3b700002320	Recombinant bridges in male meiosis (Mouse)	2025-12-01	Cristina Casals, David Hill, Patrick Masson	filtered	Model has at least one activity with no causal relations	8 warnings SKIPPED_FACT: 'DNA strand exchange activity [GO:0000150] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'reciprocal meiotic recombination [GO:0007131] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: protein localization to site of double-strand break [GO:1990166] (biological_process) —causally upstream of positive effect→ DNA strand exchange activity [GO:0000150] (molecular_function) SKIPPED_FACT: 'DNA strand exchange activity [GO:0000150] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'double-strand break repair involved in meiotic recombination [GO:1990918] (biological_process)' SKIPPED_FACT: 'DNA strand exchange activity [GO:0000150] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'double-strand break repair via homologous recombination [GO:0000724] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: double-strand break repair involved in meiotic recombination [GO:1990918] (biological_process) —occurs in→ testis [UBERON:0000473] (anatomical entity) SKIPPED_FACT: 'DNA strand exchange activity [GO:0000150] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'double-strand break repair via homologous recombination [GO:0000724] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: reciprocal meiotic recombination [GO:0007131] (biological_process) —occurs in→ testis [UBERON:0000473] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: double-strand break repair via homologous recombination [GO:0000724] (biological_process) —occurs in→ testis [UBERON:0000473] (anatomical entity)
5d29221b00001995	Gm34220 PMID:26658965	2025-11-24	David Hill, Dmitry Sitnikov	filtered	Model has at least one activity with no causal relations	4 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —causally upstream of positive effect→ protein-containing complex binding [GO:0044877] (molecular_function) SKIPPED_FACT: 'DNA-binding transcription factor activity [GO:0003700] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of transcription by RNA polymerase II [GO:0000122] (biological_process) —causally upstream of negative effect→ molecular_function [GO:0003674] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein binding [GO:0005515] (molecular_function) —causally upstream of or within positive effect→ gene expression [GO:0010467] (biological_process)
5df932e000000338	Identification of G Protein-Coupled Receptors (GPCRs) in Primary Cilia and Their Possible Involvement in Body Weight Control - PMID:26053317 - KRC	2025-11-24	David Hill, Karen Christie	success		24 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: Drd1 Mmus [MGI:MGI:99578] (information biomacromolecule) —is active in→ 9+0 non-motile cilium [GO:0097731] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Mchr1 Mmus [MGI:MGI:2180756] (information biomacromolecule) —is active in→ 9+0 non-motile cilium [GO:0097731] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ cilium assembly [GO:0060271] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: ependymal cell [CL:0000065] (anatomical entity) —part of→ 3rd ventricle ependyma [EMAPA:35100] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Npy5r Mmus [MGI:MGI:108082] (information biomacromolecule) —is active in→ 9+0 non-motile cilium [GO:0097731] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Drd5 Mmus [MGI:MGI:94927] (information biomacromolecule) —is active in→ 9+0 non-motile cilium [GO:0097731] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Galr3 Mmus [MGI:MGI:1329003] (information biomacromolecule) —is active in→ 9+0 non-motile cilium [GO:0097731] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Sstr3 Mmus [MGI:MGI:98329] (information biomacromolecule) —is active in→ 9+0 non-motile cilium [GO:0097731] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: mDRD2/iso2 Mmus [PR:P61168-2] (information biomacromolecule) —is active in→ 9+0 non-motile cilium [GO:0097731] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: 9+0 non-motile cilium [GO:0097731] (anatomical entity) —part of→ 3rd ventricle [EMAPA:16900] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: 9+0 non-motile cilium [GO:0097731] (anatomical entity) —part of→ fibroblast [CL:0000057] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Npffr1 Mmus [MGI:MGI:2685082] (information biomacromolecule) —is active in→ 9+0 non-motile cilium [GO:0097731] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cilium assembly [GO:0060271] (biological_process) —causally upstream of positive effect→ adult feeding behavior [GO:0008343] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: mDRD2/iso1 Mmus [PR:P61168-1] (information biomacromolecule) —located in→ Golgi apparatus [GO:0005794] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Golgi apparatus [GO:0005794] (anatomical entity) —part of→ fibroblast [CL:0000057] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Prlhr Mmus [MGI:MGI:2135956] (information biomacromolecule) —is active in→ 9+0 non-motile cilium [GO:0097731] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cilium assembly [GO:0060271] (biological_process) —occurs in→ arcuate nucleus [EMAPA:35142] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: 9+0 non-motile cilium [GO:0097731] (anatomical entity) —part of→ arcuate nucleus [EMAPA:35142] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Galr2 Mmus [MGI:MGI:1337018] (information biomacromolecule) —is active in→ 9+0 non-motile cilium [GO:0097731] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Arl13b Mmus [MGI:MGI:1915396] (information biomacromolecule) —is active in→ 9+0 non-motile cilium [GO:0097731] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Nmur1 Mmus [MGI:MGI:1341898] (information biomacromolecule) —is active in→ 9+0 non-motile cilium [GO:0097731] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: 9+0 non-motile cilium [GO:0097731] (anatomical entity) —part of→ ependymal cell [CL:0000065] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Npy2r Mmus [MGI:MGI:108418] (information biomacromolecule) —is active in→ 9+0 non-motile cilium [GO:0097731] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ adult feeding behavior [GO:0008343] (biological_process)
5df932e000003298	Mouse Trim55 effect on LPS-response	2025-11-24	David Hill	filtered	Model has at least one activity with no causal relations	8 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: Rela Mmus [MGI:MGI:103290] (information biomacromolecule) —located in→ nucleus [GO:0005634] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein localization to nucleus [GO:0034504] (biological_process) —transports or maintains localization of→ Trim55 Mmus [MGI:MGI:3036269] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within negative effect→ macrophage migration [GO:1905517] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: cellular response to lipopolysaccharide [GO:0071222] (biological_process) —occurs in→ macrophage [CL:0000235] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein localization to nucleus [GO:0034504] (biological_process) —part of→ cellular response to lipopolysaccharide [GO:0071222] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within negative effect→ interleukin-6 production [GO:0032635] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: interleukin-6 production [GO:0032635] (biological_process) —part of→ macrophage activation [GO:0042116] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: macrophage migration [GO:1905517] (biological_process) —part of→ macrophage activation [GO:0042116] (biological_process)
5c4605cc00003261	PMID:22431748 mouse LN	2025-11-19	David Hill, Li Ni	filtered	Model has at least one activity with no causal relations	3 warnings SKIPPED_FACT: 'damaged DNA binding [GO:0003684] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'nucleotide-excision repair [GO:0006289] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: Rad23b Mmus [MGI:MGI:105128] (information biomacromolecule) —located in→ nucleus [GO:0005634] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Rad23b Mmus [MGI:MGI:105128] (information biomacromolecule) —located in→ cytoplasm [GO:0005737] (anatomical entity)
580e952200000046	Dio3	2025-11-17	David Hill, Harold Drabkin	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: apoptotic process [GO:0006915] (biological_process) —occurs in→ retinal cone cell [CL:0000573] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: nuclear receptor activity [GO:0004879] (molecular_function) —causally upstream of or within→ apoptotic process [GO:0006915] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: apoptotic process [GO:0006915] (biological_process) —negatively regulates→ retinal cone cell development [GO:0046549] (biological_process)
57c82fad00000695	F13a1 and F13b-mouse-blood clotting	2025-11-17	David Hill	filtered	Model has at least one activity with no causal relations	5 warnings SKIPPED_FACT: Subject 'protein catabolic process [GO:0030163] (biological_process)' has 'has input' relationship to 'F13a1 Mmus [MGI:MGI:1921395] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: biological_process [GO:0008150] (biological_process) —negatively regulates→ protein catabolic process [GO:0030163] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein catabolic process [GO:0030163] (biological_process) —has input→ F13a1 Mmus [MGI:MGI:1921395] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: blood coagulation [GO:0007596] (biological_process) —occurs in→ plasma [EMAPA:35690] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein catabolic process [GO:0030163] (biological_process) —causally upstream of→ protein-glutamine gamma-glutamyltransferase activity [GO:0003810] (molecular_function)
57c82fad00000403	Lhx1-mouse-epiblast	2025-11-17	David Hill	filtered	Model has at least one activity with no causal relations	14 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: protein binding [GO:0005515] (molecular_function) —causally upstream of or within→ cell differentiation [GO:0030154] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-binding transcription factor activity [GO:0003700] (molecular_function) —causally upstream of or within→ cell differentiation [GO:0030154] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: transcription regulator complex [GO:0005667] (cellular_component) —has part→ Otx2 Mmus [MGI:MGI:97451] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell differentiation [GO:0030154] (biological_process) —occurs in→ primitive streak [EMAPA:16072] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transcription regulator complex [GO:0005667] (cellular_component) —has part→ Ldb1 Mmus [MGI:MGI:894762] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: transcription regulator complex [GO:0005667] (cellular_component) —has part→ Foxa2 Mmus [MGI:MGI:1347476] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-binding transcription factor activity [GO:0003700] (molecular_function) —causally upstream of or within→ endoderm development [GO:0007492] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: anatomical structure morphogenesis [GO:0009653] (biological_process) —results in morphogenesis of→ node [EMAPA:16075] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell differentiation [GO:0030154] (biological_process) —causally upstream of→ mesendoderm development [GO:0048382] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-binding transcription factor activity [GO:0003700] (molecular_function) —causally upstream of or within→ anatomical structure morphogenesis [GO:0009653] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: transcription regulator complex [GO:0005667] (cellular_component) —has part→ Lhx1 Mmus [MGI:MGI:99783] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: transcription regulator complex [GO:0005667] (cellular_component) —has part→ Ssbp3 Mmus [MGI:MGI:1919725] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: RNA polymerase II general transcription initiation factor activity [GO:0016251] (molecular_function) —causally upstream of or within→ cell differentiation [GO:0030154] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: endoderm development [GO:0007492] (biological_process) —results in development of→ definitive endoderm [EMAPA:16070] (anatomical entity)
5716c41300000277	Mouse-Cxcl17-macrophage chemotaxis	2025-11-17	David Hill, Kimberly Van Auken	success		9 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: macrophage chemotaxis [GO:0048246] (biological_process) —occurs in→ respiratory system mucosa [UBERON:0004785] (anatomical entity) SKIPPED_FACT: 'chemokine activity [GO:0008009] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'chemokine-mediated signaling pathway [GO:0070098] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: respiratory system mucosa [UBERON:0004785] (anatomical entity) —part of→ lung [UBERON:0002048] (anatomical entity) SKIPPED_FACT: 'G protein-coupled receptor activity [GO:0004930] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'chemokine-mediated signaling pathway [GO:0070098] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: chemokine-mediated signaling pathway [GO:0070098] (biological_process) —occurs in→ macrophage [CL:0000235] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: macrophage chemotaxis [GO:0048246] (biological_process) —results in movement of→ macrophage [CL:0000235] (anatomical entity) SKIPPED_FACT: 'G protein-coupled receptor activity [GO:0004930] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'macrophage chemotaxis [GO:0048246] (biological_process)' SKIPPED_FACT: 'chemokine activity [GO:0008009] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'macrophage chemotaxis [GO:0048246] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of cytosolic calcium ion concentration [GO:0007204] (biological_process) —occurs in→ macrophage [CL:0000235] (anatomical entity)
5835403200000017	mouse-Ncapg2-transcription	2025-11-17	David Hill	filtered	Model has at least one activity with no causal relations	10 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981] (molecular_function) —positively regulates→ RNA polymerase activity [GO:0097747] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-binding transcription factor activity [GO:0003700] (molecular_function) —positively regulates→ RNA polymerase activity [GO:0097747] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: RNA polymerase activity [GO:0097747] (molecular_function) —positively regulates→ stem cell factor receptor activity [GO:0005020] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: RNA polymerase activity [GO:0097747] (molecular_function) —part of→ transcription by RNA polymerase II [GO:0006366] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —directly positively regulates→ histone deacetylase activity [GO:0004407] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: biological regulation [GO:0065007] (biological_process) —positively regulates→ erythrocyte differentiation [GO:0030218] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: histone deacetylase activity [GO:0004407] (molecular_function) —negatively regulates→ RNA polymerase activity [GO:0097747] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: RNA polymerase activity [GO:0097747] (molecular_function) —has input→ Kit Mmus [MGI:MGI:96677] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: Kit signaling pathway [GO:0038109] (biological_process) —negatively regulates→ erythrocyte differentiation [GO:0030218] (biological_process) SKIPPED_FACT: Subject 'RNA polymerase activity [GO:0097747] (molecular_function)' has 'has input' relationship to 'Kit Mmus [MGI:MGI:96677] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
68fac5ed00002148	Lipoxin biosynthetic process 1 (Mouse)	2025-11-13	David Hill	success
68fac5ed00003807	Lipoxin biosynthetic process 2 (Mouse)	2025-11-13	David Hill	success		2 warnings SKIPPED_FACT: Subject 'lipoxin biosynthetic process [GO:2001301] (biological_process)' has 'has primary output' relationship to 'lipoxin B4 [CHEBI:6499] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: lipoxin biosynthetic process [GO:2001301] (biological_process) —has primary output→ lipoxin B4 [CHEBI:6499] (chemical entity)
68d5ebd600003075	Ethanol catabolic process 1 (Mouse)	2025-10-29	David Hill	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: biological regulation [GO:0065007] (biological_process) —positively regulates→ ethanol catabolic process [GO:0006068] (biological_process)
68d5ebd600003142	Ethanol catabolic process 2 (Mouse)	2025-10-29	David Hill	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: biological regulation [GO:0065007] (biological_process) —positively regulates→ ethanol catabolic process [GO:0006068] (biological_process)
68b0f0d000006566	Estrogen biosynthetic process (Mouse)	2025-10-16	David Hill	success
667dfe8d00000886	Androgen biosynthesis 1 (Mouse)	2025-10-15	David Hill	success		7 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: transport [GO:0006810] (biological_process) —has input→ pregnenolone [CHEBI:16581] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transport [GO:0006810] (biological_process) —has target end location→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transport [GO:0006810] (biological_process) —has output→ pregnenolone [CHEBI:16581] (chemical entity) SKIPPED_FACT: Subject 'transport [GO:0006810] (biological_process)' has 'has input' relationship to 'pregnenolone [CHEBI:16581] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transport [GO:0006810] (biological_process) —causally upstream of→ steroid 17-alpha-monooxygenase activity [GO:0004508] (molecular_function) SKIPPED_FACT: Subject 'transport [GO:0006810] (biological_process)' has 'has output' relationship to 'pregnenolone [CHEBI:16581] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transport [GO:0006810] (biological_process) —has target start location→ mitochondrial matrix [GO:0005759] (anatomical entity)
68b0f0d000005924	Cortisol biosynthetic process 1 (Mouse)	2025-10-02	David Hill	filtered	Model has at least one activity with no causal relations	14 warnings SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has output' relationship to 'cortisol [CHEBI:17650] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —part of→ cortisol biosynthetic process [GO:0034651] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: steroid 11-beta-monooxygenase activity [GO:0004507] (molecular_function) —causally upstream of→ transporter activity [GO:0005215] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: 17-hydroxyprogesterone 21-hydroxylase activity [GO:0103069] (molecular_function) —causally upstream of→ transporter activity [GO:0005215] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has primary input→ cortisol [CHEBI:17650] (chemical entity) SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has primary input' relationship to 'cortisol [CHEBI:17650] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has primary input' relationship to '11-deoxycortisol [CHEBI:28324] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has primary input→ 11-deoxycortisol [CHEBI:28324] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —causally upstream of→ steroid 11-beta-monooxygenase activity [GO:0004507] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target start location→ mitochondrial matrix [GO:0005759] (anatomical entity) SKIPPED_FACT: Subject 'cortisol biosynthetic process [GO:0034651] (biological_process)' has 'has primary output' relationship to 'cortisol [CHEBI:17650] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: cortisol biosynthetic process [GO:0034651] (biological_process) —has primary output→ cortisol [CHEBI:17650] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has output→ cortisol [CHEBI:17650] (chemical entity)
68b0f0d000006228	Mineralocorticoid biosynthetic process (Mouse)	2025-09-18	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: mitochondrial matrix [GO:0005759] (anatomical entity) —part of→ mitochondrion [GO:0005739] (anatomical entity) SKIPPED_FACT: Subject 'mineralocorticoid biosynthetic process [GO:0006705] (biological_process)' has 'has primary output' relationship to 'aldosterone [CHEBI:27584] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: mineralocorticoid biosynthetic process [GO:0006705] (biological_process) —has primary output→ aldosterone [CHEBI:27584] (chemical entity)
68b0f0d000004550	C21-steroid hormone biosynthetic process 1 (Mouse)	2025-09-11	David Hill	success		4 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target start location→ mitochondrial matrix [GO:0005759] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: C21-steroid hormone biosynthetic process [GO:0006700] (biological_process) —has primary output→ pregnenolone [CHEBI:16581] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) SKIPPED_FACT: Subject 'C21-steroid hormone biosynthetic process [GO:0006700] (biological_process)' has 'has primary output' relationship to 'pregnenolone [CHEBI:16581] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
689e7a5d00004550	Spermidine biosynthetic process (Mouse)	2025-08-28	David Hill	success
689e7a5d00004513	Spermine biosynthetic process (Mouse)	2025-08-28	David Hill	success
62b4ffe300000240	Perforin maturation leading to granzyme-mediated programmed cell death signaling pathway (Mouse)	2025-08-22	David Hill, Sylvain Poux	success
6882d2b800004038	Positive Regulation of Triglyceride Catabolic Process 2 (Mouse)	2025-08-20	David Hill	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of triglyceride catabolic process [GO:0010898] (biological_process) —positively regulates→ triglyceride catabolic process [GO:0019433] (biological_process)
6882d2b800002308	Triglyceride Catabolic Process 1 (Mouse)	2025-08-20	David Hill	success
6870555700004129	Positive Regulation of Triglyceride Catabolic Process 1 (Mouse)	2025-08-14	David Hill	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of triglyceride catabolic process [GO:0010898] (biological_process) —positively regulates→ triglyceride catabolic process [GO:0019433] (biological_process)
5ce58dde00001215	Mouse-Aatf-antiapoptosis	2025-08-12	David Hill	filtered	Model has at least one activity with no causal relations	15 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of positive effect→ DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228] (molecular_function) —occurs in→ nucleus [GO:0005634] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transcription regulator complex [GO:0005667] (cellular_component) —has part→ Aatf Mmus [MGI:MGI:1929608] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228] (molecular_function) —has part→ RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: endoplasmic reticulum unfolded protein response [GO:0030968] (biological_process) —positively regulates→ protein folding [GO:0006457] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228] (molecular_function) —indirectly negatively regulates→ molecular_function [GO:0003674] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: endoplasmic reticulum unfolded protein response [GO:0030968] (biological_process) —negatively regulates→ translation [GO:0006412] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228] (molecular_function) —part of→ negative regulation of intrinsic apoptotic signaling pathway [GO:2001243] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of intrinsic apoptotic signaling pathway [GO:2001243] (biological_process) —negatively regulates→ intrinsic apoptotic signaling pathway [GO:0097193] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: intrinsic apoptotic signaling pathway [GO:0097193] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: endoplasmic reticulum unfolded protein response [GO:0030968] (biological_process) —positively regulates→ ERAD pathway [GO:0036503] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: transcription regulator complex [GO:0005667] (cellular_component) —has part→ Stat3 Mmus [MGI:MGI:103038] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: endoplasmic reticulum unfolded protein response [GO:0030968] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transcription coactivator activity [GO:0003713] (molecular_function) —directly positively regulates→ DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228] (molecular_function) —part of→ endoplasmic reticulum unfolded protein response [GO:0030968] (biological_process)
63a86a8600001386	Triglyceride biosynthetic process 1 (Mouse)	2025-08-07	David Hill	success		4 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: lipid carrier activity [GO:0005319] (molecular_function) —has target end location→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: lipid carrier activity [GO:0005319] (molecular_function) —provides input for→ 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: lipid carrier activity [GO:0005319] (molecular_function) —has target start location→ mitochondrial outer membrane [GO:0005741] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: glycerol-3-phosphate O-acyltransferase activity [GO:0004366] (molecular_function) —provides input for→ lipid carrier activity [GO:0005319] (molecular_function)
6446bfcb00000174	Triglyceride biosynthetic process 4 (Mouse)	2025-08-07	David Hill	success
5ed1aab700000290	Sodium transport in kidney	2025-07-28	David Hill, Kimberly Van Auken	success		6 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: cortical collecting duct [EMAPA:28130] (anatomical entity) —part of→ metanephros [EMAPA:17373] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: biological_process [GO:0008150] (biological_process) —causally upstream of negative effect→ sodium ion transport [GO:0006814] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: plasma membrane [GO:0005886] (anatomical entity) —part of→ kidney cortex collecting duct epithelial cell [CL:1000549] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: sodium ion transport [GO:0006814] (biological_process) —occurs in→ plasma membrane [GO:0005886] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: kidney cortex collecting duct epithelial cell [CL:1000549] (anatomical entity) —part of→ cortical collecting duct [EMAPA:28130] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: metanephros [EMAPA:17373] (anatomical entity) —part of→ renal system [UBERON:0001008] (anatomical entity)
62e3212700000469	Insulin-like growth factor receptor signaling pathway 2 (Mouse)	2025-07-25	David Hill, Li Ni	success
66c7d41500000544	CAAX-box protein maturation 1 (Mouse)	2025-07-24	David Hill	success
60ad85f700002694	'de novo' AMP biosynthetic process (Mouse)	2025-07-10	David Hill, Li Ni	success
5fce9b7300001742	Strap in alternative splicing-mouse	2025-07-01	David Hill, Li Ni	filtered	Model has at least one activity with no causal relations	16 warnings SKIPPED_FACT: Subject 'alternative mRNA splicing, via spliceosome [GO:0000380] (biological_process)' has 'has input' relationship to 'Nnat Mmus [MGI:MGI:104716] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: anatomical structure development [GO:0048856] (biological_process) —results in development of→ brain [EMAPA:16894] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: U2 snRNP [GO:0005686] (cellular_component) —has part→ Sf3a3 Mmus [MGI:MGI:1922312] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: retinoic acid catabolic process [GO:0034653] (biological_process) —causally upstream of negative effect→ retinoic acid receptor signaling pathway [GO:0048384] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: alternative mRNA splicing, via spliceosome [GO:0000380] (biological_process) —occurs in→ neuron [CL:0000540] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: U2 snRNP [GO:0005686] (cellular_component) —has part→ U2surp Mmus [MGI:MGI:1915208] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: U2 snRNP [GO:0005686] (cellular_component) —has part→ Snrpa1 Mmus [MGI:MGI:1916231] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: alternative mRNA splicing, via spliceosome [GO:0000380] (biological_process) —has input→ Nnat Mmus [MGI:MGI:104716] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein-RNA complex assembly [GO:0022618] (biological_process) —has output→ U2 snRNP [GO:0005686] (cellular_component) UNHANDLED_FACT: Fact not representable in GO-CAM model: alternative mRNA splicing, via spliceosome [GO:0000380] (biological_process) —has input→ Mark3 Mmus [MGI:MGI:1341865] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: retinoic acid receptor signaling pathway [GO:0048384] (biological_process) —part of→ cell differentiation [GO:0030154] (biological_process) SKIPPED_FACT: Subject 'protein-RNA complex assembly [GO:0022618] (biological_process)' has 'has output' relationship to 'U2 snRNP [GO:0005686] (cellular_component)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: U2 snRNP [GO:0005686] (cellular_component) —has part→ Sf3b1 Mmus [MGI:MGI:1932339] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell differentiation [GO:0030154] (biological_process) —results in acquisition of features of→ neuron [CL:0000540] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: U2 snRNP [GO:0005686] (cellular_component) —has part→ Sf3a2 Mmus [MGI:MGI:104912] (information biomacromolecule) SKIPPED_FACT: Subject 'alternative mRNA splicing, via spliceosome [GO:0000380] (biological_process)' has 'has input' relationship to 'Mark3 Mmus [MGI:MGI:1341865] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
667dfe8d00000985	Androgen biosynthetic process 2 (Mouse)	2025-06-06	David Hill	success
6482692800002523	Molybdopterin Cofactor Biosynthetic Process 1 (Mouse)	2025-06-03	David Hill, Li Ni	filtered	Model has at least one activity with no causal relations	4 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane transporter activity [GO:0022857] (molecular_function) —occurs in→ mitochondrial matrix [GO:0005759] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane transporter activity [GO:0022857] (molecular_function) —provides input for→ molybdopterin synthase activity [GO:0030366] (molecular_function) SKIPPED_FACT: Subject 'transmembrane transporter activity [GO:0022857] (molecular_function)' has 'has input' relationship to 'precursor Z(1-) [CHEBI:59648] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane transporter activity [GO:0022857] (molecular_function) —has input→ precursor Z(1-) [CHEBI:59648] (chemical entity)
633b013300000306	Tricarboxylic acid cycle 1 (Mouse)	2025-04-24	David Hill	success		6 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: oxoglutarate dehydrogenase complex [GO:0045252] (cellular_component) —has part→ Ogdh Mmus [MGI:MGI:1098267] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: isocitrate dehydrogenase complex (NAD+) [GO:0045242] (cellular_component) —has part→ Idh3g Mmus [MGI:MGI:1099463] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: isocitrate dehydrogenase complex (NAD+) [GO:0045242] (cellular_component) —has part→ Idh3b Mmus [MGI:MGI:2158650] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: isocitrate dehydrogenase complex (NAD+) [GO:0045242] (cellular_component) —has part→ Idh3a Mmus [MGI:MGI:1915084] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: oxoglutarate dehydrogenase complex [GO:0045252] (cellular_component) —has part→ Dlst Mmus [MGI:MGI:1926170] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: oxoglutarate dehydrogenase complex [GO:0045252] (cellular_component) —has part→ Dld Mmus [MGI:MGI:107450] (information biomacromolecule)
66a3e0bb00001992	'De novo' GDP-fucose biosynthetic process 1 (Mouse)	2025-04-17	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: GDP-fucose transmembrane transporter activity [GO:0005457] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: GDP-fucose transmembrane transporter activity [GO:0005457] (molecular_function) —has target end location→ Golgi lumen [GO:0005796] (anatomical entity)
66c7d41500000616	CAAX-box protein maturation 2 (Mouse)	2025-04-17	David Hill	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: S-[(2E,6E)-farnesyl]-L-cysteine residue [CHEBI:86019] (chemical entity) —part of→ protein [CHEBI:36080] (information biomacromolecule)
675b862c00000923	Carnitine shuttle 1 (Mouse)	2025-04-17	David Hill	filtered	Model has at least one activity with no causal relations	12 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: porin activity [GO:0015288] (molecular_function) —part of→ carnitine transport [GO:0015879] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: porin activity [GO:0015288] (molecular_function) —has primary input→ carnitine [CHEBI:17126] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: porin activity [GO:0015288] (molecular_function) —provides input for→ carnitine O-palmitoyltransferase activity [GO:0004095] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: O-acyl-L-carnitine transmembrane transporter activity [GO:0015227] (molecular_function) —has target start location→ mitochondrial intermembrane space [GO:0005758] (anatomical entity) SKIPPED_FACT: Subject 'porin activity [GO:0015288] (molecular_function)' has 'has primary input' relationship to 'carnitine [CHEBI:17126] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: carnitine transmembrane transporter activity [GO:0015226] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: carnitine transmembrane transporter activity [GO:0015226] (molecular_function) —provides input for→ porin activity [GO:0015288] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: carnitine transmembrane transporter activity [GO:0015226] (molecular_function) —has target start location→ extracellular region [GO:0005576] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: porin activity [GO:0015288] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: biological regulation [GO:0065007] (biological_process) —negatively regulates→ carnitine shuttle [GO:0006853] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: O-acyl-L-carnitine transmembrane transporter activity [GO:0015227] (molecular_function) —has target end location→ mitochondrial matrix [GO:0005759] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: porin activity [GO:0015288] (molecular_function) —has target end location→ mitochondrial intermembrane space [GO:0005758] (anatomical entity)
66b5638000000056	GDP-L-fucose salvage (Mouse)	2025-04-17	David Hill	success		4 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: GDP-fucose transmembrane transporter activity [GO:0005457] (molecular_function) —has target end location→ Golgi lumen [GO:0005796] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: fucose transmembrane transporter activity [GO:0015150] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: fucose transmembrane transporter activity [GO:0015150] (molecular_function) —has target start location→ extracellular region [GO:0005576] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: GDP-fucose transmembrane transporter activity [GO:0005457] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity)
67369e7600004836	Tetrahydrobiopterin biosynthetic process 1 (Mouse)	2025-04-16	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: biological regulation [GO:0065007] (biological_process) —positively regulates→ tetrahydrobiopterin metabolic process [GO:0046146] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: biological regulation [GO:0065007] (biological_process) —negatively regulates→ tetrahydrobiopterin metabolic process [GO:0046146] (biological_process)
633b013300001469	Pyruvate catabolic process 2 (Mouse)	2025-04-15	David Hill	filtered	Model has at least one activity with no causal relations	8 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: voltage-gated monoatomic anion channel activity [GO:0008308] (molecular_function) —has target end location→ mitochondrial intermembrane space [GO:0005758] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: pyruvate dehydrogenase complex [GO:0045254] (cellular_component) —has part→ Dld Mmus [MGI:MGI:107450] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: voltage-gated monoatomic anion channel activity [GO:0008308] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: pyruvate transmembrane transporter activity [GO:0050833] (molecular_function) —has target end location→ mitochondrial matrix [GO:0005759] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: pyruvate dehydrogenase complex [GO:0045254] (cellular_component) —has part→ Dlat Mmus [MGI:MGI:2385311] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: pyruvate dehydrogenase complex [GO:0045254] (cellular_component) —has part→ protein-containing complex [GO:0032991] (cellular_component) UNHANDLED_FACT: Fact not representable in GO-CAM model: pyruvate dehydrogenase complex [GO:0045254] (cellular_component) —has part→ Pdhx Mmus [MGI:MGI:1351627] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: pyruvate transmembrane transporter activity [GO:0050833] (molecular_function) —has target start location→ mitochondrial intermembrane space [GO:0005758] (anatomical entity)
67369e7600001890	Tetrahydrofolate Interconversion 2 (Mouse)	2025-04-03	David Hill	success		1 warning SKIPPED_FACT: 'tetrahydrofolylpolyglutamate synthase activity [GO:0004326] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'folate cycle [GO:0035999] (biological_process)'
66187e4700003043	GDP-mannose biosynthetic process from glucose (Mouse)	2025-04-02	David Hill	success		2 warnings SKIPPED_FACT: Subject 'GDP-mannose biosynthetic process [GO:0009298] (biological_process)' has 'has primary output' relationship to 'GDP-alpha-D-mannose(2-) [CHEBI:57527] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: GDP-mannose biosynthetic process [GO:0009298] (biological_process) —has primary output→ GDP-alpha-D-mannose(2-) [CHEBI:57527] (chemical entity)
6516135700001077	Heme B biosynthetic process (Mouse)	2025-04-01	David Hill	filtered	Model has at least one activity with no causal relations	22 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has output→ 5-ammoniolevulinate [CHEBI:356416] (chemical entity) SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has output' relationship to 'coproporphyrinogen III(4-) [CHEBI:57309] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target start location→ mitochondrial matrix [GO:0005759] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has primary input→ coproporphyrinogen III(4-) [CHEBI:57309] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target end location→ mitochondrial matrix [GO:0005759] (anatomical entity) SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has primary input' relationship to 'protoporphyrin(2-) [CHEBI:57306] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has output' relationship to '5-ammoniolevulinate [CHEBI:356416] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has primary input' relationship to 'coproporphyrinogen III(4-) [CHEBI:57309] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has output' relationship to 'protoporphyrin(2-) [CHEBI:57306] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has primary input→ 5-ammoniolevulinate [CHEBI:356416] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: heme B transmembrane transporter activity [GO:0170003] (molecular_function) —has target start location→ mitochondrial matrix [GO:0005759] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has primary input→ protoporphyrin(2-) [CHEBI:57306] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: heme B transmembrane transporter activity [GO:0170003] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target start location→ mitochondrial intermembrane space [GO:0005758] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has output→ coproporphyrinogen III(4-) [CHEBI:57309] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target end location→ mitochondrial intermembrane space [GO:0005758] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —part of→ heme B biosynthetic process [GO:0006785] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has output→ protoporphyrin(2-) [CHEBI:57306] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: 5-aminolevulinate synthase activity [GO:0003870] (molecular_function) —provides input for→ transporter activity [GO:0005215] (molecular_function) SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has primary input' relationship to '5-ammoniolevulinate [CHEBI:356416] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
6516135700000961	Heme O biosynthetic process (Mouse)	2025-04-01	David Hill, Li Ni	filtered	Model has at least one activity with no causal relations	20 warnings SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has primary input' relationship to 'protoporphyrin(2-) [CHEBI:57306] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —part of→ heme O biosynthetic process [GO:0048034] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target start location→ mitochondrial matrix [GO:0005759] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has primary input→ coproporphyrinogen III(4-) [CHEBI:57309] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target end location→ mitochondrial matrix [GO:0005759] (anatomical entity) SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has primary input' relationship to '5-ammoniolevulinate [CHEBI:356416] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has primary input→ 5-ammoniolevulinate [CHEBI:356416] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has primary input→ protoporphyrin(2-) [CHEBI:57306] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target start location→ mitochondrial intermembrane space [GO:0005758] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has output→ coproporphyrinogen III(4-) [CHEBI:57309] (chemical entity) SKIPPED_FACT: Subject 'protoporphyrin(2-) [CHEBI:57306] (chemical entity)' has 'has output' relationship to 'transporter activity [GO:0005215] (molecular_function)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has output' relationship to '5-ammoniolevulinate [CHEBI:356416] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target end location→ mitochondrial intermembrane space [GO:0005758] (anatomical entity) SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has output' relationship to 'coproporphyrinogen III(4-) [CHEBI:57309] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: protoporphyrin(2-) [CHEBI:57306] (chemical entity) —has output→ transporter activity [GO:0005215] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: 5-aminolevulinate synthase activity [GO:0003870] (molecular_function) —provides input for→ transporter activity [GO:0005215] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has primary input' relationship to 'coproporphyrinogen III(4-) [CHEBI:57309] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has output→ 5-ammoniolevulinate [CHEBI:356416] (chemical entity)
627d95ee00001794	Oligosaccharide catabolic process (Mouse)	2025-04-01	David Hill	filtered	Model has at least one activity with no causal relations	6 warnings SKIPPED_FACT: Subject 'glucosamine oligosaccharide [CHEBI:22485] (chemical entity)' has 'has output' relationship to 'transporter activity [GO:0005215] (molecular_function)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: glucosamine oligosaccharide [CHEBI:22485] (chemical entity) —has output→ transporter activity [GO:0005215] (molecular_function) SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has input' relationship to 'glucosamine oligosaccharide [CHEBI:22485] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —occurs in→ lysosomal membrane [GO:0005765] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has input→ glucosamine oligosaccharide [CHEBI:22485] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: lysosomal membrane [GO:0005765] (anatomical entity) —part of→ lysosome [GO:0005764] (anatomical entity)
635b1e3e00000433	Xylulose-5-Phosphate biosynthetic process 2 (Mouse)	2025-04-01	David Hill	success
6796b94c00001607	'de novo' NAD biosynthetic process (Mouse)	2025-03-31	David Hill	success		4 warnings SKIPPED_FACT: Subject ''de novo' NAD+ biosynthetic process from L-tryptophan [GO:0034354] (biological_process)' has 'has primary output' relationship to 'NAD(1-) [CHEBI:57540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: L-tryptophan catabolic process [GO:0006569] (biological_process) —has primary output→ 2-ammonio-3-(3-oxoprop-1-enyl)but-2-enedioate(1-) [CHEBI:77803] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: 'de novo' NAD+ biosynthetic process from L-tryptophan [GO:0034354] (biological_process) —has primary output→ NAD(1-) [CHEBI:57540] (chemical entity) SKIPPED_FACT: Subject 'L-tryptophan catabolic process [GO:0006569] (biological_process)' has 'has primary output' relationship to '2-ammonio-3-(3-oxoprop-1-enyl)but-2-enedioate(1-) [CHEBI:77803] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
678073a900002053	NAD salvage 1 (Mouse)	2025-03-31	David Hill	success		8 warnings SKIPPED_FACT: Subject 'NAD+ biosynthetic process via the salvage pathway [GO:0034355] (biological_process)' has 'has primary input' relationship to 'nicotinamide [CHEBI:17154] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: NAD+ biosynthetic process via the salvage pathway [GO:0034355] (biological_process) —has primary output→ NAD(1-) [CHEBI:57540] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: NAD+ biosynthetic process via the salvage pathway [GO:0034355] (biological_process) —has primary input→ nicotinamide [CHEBI:17154] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: extrinsic component of membrane [GO:0019898] (anatomical entity) —part of→ transport vesicle [GO:0030133] (anatomical entity) SKIPPED_FACT: Subject 'NADP+ biosynthetic process [GO:0006741] (biological_process)' has 'has primary output' relationship to 'NADP(3-) [CHEBI:58349] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: NADP+ biosynthetic process [GO:0006741] (biological_process) —has primary output→ NADP(3-) [CHEBI:58349] (chemical entity) SKIPPED_FACT: Subject 'NAD+ biosynthetic process via the salvage pathway [GO:0034355] (biological_process)' has 'has primary output' relationship to 'NAD(1-) [CHEBI:57540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: Nmnat2 Mmus [MGI:MGI:2444155] (information biomacromolecule) —located in→ extrinsic component of membrane [GO:0019898] (anatomical entity)
6796b94c00003358	NAD salvage 4 (Mouse)	2025-03-31	David Hill	success		6 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: biosynthetic process [GO:0009058] (biological_process) —has primary output→ NADP(3-) [CHEBI:58349] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: NAD+ biosynthetic process via the salvage pathway [GO:0034355] (biological_process) —has primary input→ N-ribosylnicotinamide [CHEBI:15927] (chemical entity) SKIPPED_FACT: Subject 'biosynthetic process [GO:0009058] (biological_process)' has 'has primary output' relationship to 'NADP(3-) [CHEBI:58349] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'NAD+ biosynthetic process via the salvage pathway [GO:0034355] (biological_process)' has 'has primary output' relationship to 'NAD(1-) [CHEBI:57540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: NAD+ biosynthetic process via the salvage pathway [GO:0034355] (biological_process) —has primary output→ NAD(1-) [CHEBI:57540] (chemical entity) SKIPPED_FACT: Subject 'NAD+ biosynthetic process via the salvage pathway [GO:0034355] (biological_process)' has 'has primary input' relationship to 'N-ribosylnicotinamide [CHEBI:15927] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
6796b94c00004222	NAD salvage 5 (Mouse)	2025-03-31	David Hill	success		4 warnings SKIPPED_FACT: Subject 'biosynthetic process [GO:0009058] (biological_process)' has 'has primary output' relationship to 'NADP(3-) [CHEBI:58349] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: NAD+ biosynthetic process via the salvage pathway [GO:0034355] (biological_process) —has primary output→ NAD(1-) [CHEBI:57540] (chemical entity) SKIPPED_FACT: Subject 'NAD+ biosynthetic process via the salvage pathway [GO:0034355] (biological_process)' has 'has primary output' relationship to 'NAD(1-) [CHEBI:57540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: biosynthetic process [GO:0009058] (biological_process) —has primary output→ NADP(3-) [CHEBI:58349] (chemical entity)
622aace900000696	Fructose biosynthetic process (Mouse)	2025-03-17	David Hill	success
62f58d8800007392	Negative regulation of insulin secretion 3 (Mouse)	2025-03-10	David Hill	filtered	Model has at least one activity with no causal relations	13 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: potassium channel activator activity [GO:0099104] (molecular_function) —part of→ G protein-coupled receptor signaling pathway [GO:0007186] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: potassium channel activator activity [GO:0099104] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase activity [GO:0004016] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: insulin secretion [GO:0030073] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase activity [GO:0004016] (molecular_function) —part of→ G protein-coupled receptor signaling pathway [GO:0007186] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase inhibitor activity [GO:0010855] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: proteinase-activated receptor activity [GO:0001648] (molecular_function) —directly positively regulates→ potassium channel activator activity [GO:0099104] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase inhibitor activity [GO:0010855] (molecular_function) —directly negatively regulates→ adenylate cyclase activity [GO:0004016] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: potassium channel activator activity [GO:0099104] (molecular_function) —directly positively regulates→ potassium channel activity [GO:0005267] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: biological regulation [GO:0065007] (biological_process) —negatively regulates→ insulin secretion [GO:0030073] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase inhibitor activity [GO:0010855] (molecular_function) —part of→ G protein-coupled receptor signaling pathway [GO:0007186] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: G protein-coupled receptor signaling pathway [GO:0007186] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: proteinase-activated receptor activity [GO:0001648] (molecular_function) —directly positively regulates→ adenylate cyclase inhibitor activity [GO:0010855] (molecular_function)
67c10cc400000664	NAD catabolic process (Mouse)	2025-03-05	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: NAD+ catabolic process [GO:0019677] (biological_process) —has primary input→ NAD(+) [CHEBI:15846] (chemical entity) SKIPPED_FACT: Subject 'NAD+ catabolic process [GO:0019677] (biological_process)' has 'has primary input' relationship to 'NAD(+) [CHEBI:15846] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
6348a65d00001281	pyruvate metabolic process 1 (Mouse)	2025-02-27	David Hill	filtered	Model has at least one activity with no causal relations
6796b94c00001431	NAD salvage 3 (Mouse)	2025-02-26	David Hill	success		6 warnings SKIPPED_FACT: Subject 'NAD+ biosynthetic process via the salvage pathway [GO:0034355] (biological_process)' has 'has primary output' relationship to 'NAD(1-) [CHEBI:57540] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'NAD+ biosynthetic process via the salvage pathway [GO:0034355] (biological_process)' has 'has primary input' relationship to 'nicotinamide [CHEBI:17154] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: biosynthetic process [GO:0009058] (biological_process) —has primary output→ NADP(3-) [CHEBI:58349] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: NAD+ biosynthetic process via the salvage pathway [GO:0034355] (biological_process) —has primary input→ nicotinamide [CHEBI:17154] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: NAD+ biosynthetic process via the salvage pathway [GO:0034355] (biological_process) —has primary output→ NAD(1-) [CHEBI:57540] (chemical entity) SKIPPED_FACT: Subject 'biosynthetic process [GO:0009058] (biological_process)' has 'has primary output' relationship to 'NADP(3-) [CHEBI:58349] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
6690711d00001584	Protein O-linked fucosylation 1 (Mouse)	2025-02-20	David Hill	filtered	Model has at least one activity with no causal relations
675b862c00001162	Alpha-linolenic acid metabolic process (Mouse)	2025-01-21	David Hill	success		19 warnings SKIPPED_FACT: 'transporter activity [GO:0005215] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid biosynthetic process [GO:0006633] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: fatty acid biosynthetic process [GO:0006633] (biological_process) —has primary output→ (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate [CHEBI:77016] (chemical entity) SKIPPED_FACT: Subject 'transport [GO:0006810] (biological_process)' has 'has primary input' relationship to '(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate [CHEBI:77016] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transport [GO:0006810] (biological_process) —has primary input→ (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate [CHEBI:77016] (chemical entity) SKIPPED_FACT: Subject 'fatty acid biosynthetic process [GO:0006633] (biological_process)' has 'has primary output' relationship to '(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate [CHEBI:77016] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: fatty acid biosynthetic process [GO:0006633] (biological_process) —has primary input→ alpha-linolenate [CHEBI:32387] (chemical entity) SKIPPED_FACT: 'acetyl-CoA C-acyltransferase activity [GO:0003988] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid biosynthetic process [GO:0006633] (biological_process)' SKIPPED_FACT: Subject 'fatty acid biosynthetic process [GO:0006633] (biological_process)' has 'has primary input' relationship to 'alpha-linolenate [CHEBI:32387] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: '3-hydroxyacyl-CoA dehydratase activity [GO:0018812] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid biosynthetic process [GO:0006633] (biological_process)' SKIPPED_FACT: 'acetyl-CoA C-acyltransferase activity [GO:0003988] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target start location→ peroxisomal matrix [GO:0005782] (anatomical entity) SKIPPED_FACT: 'acyl-CoA oxidase activity [GO:0003997] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid biosynthetic process [GO:0006633] (biological_process)' SKIPPED_FACT: '(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity [GO:0003857] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: long-chain fatty acid transmembrane transporter activity [GO:0005324] (molecular_function) —has target end location→ peroxisomal matrix [GO:0005782] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transport [GO:0006810] (biological_process) —has target end location→ endoplasmic reticulum lumen [GO:0005788] (anatomical entity) SKIPPED_FACT: '(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity [GO:0003857] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid biosynthetic process [GO:0006633] (biological_process)' SKIPPED_FACT: 'acetyl-CoA C-acyltransferase activity [GO:0003988] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid biosynthetic process [GO:0006633] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: long-chain fatty acid transmembrane transporter activity [GO:0005324] (molecular_function) —has target end location→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity) SKIPPED_FACT: '3-hydroxyacyl-CoA dehydratase activity [GO:0018812] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'fatty acid biosynthetic process [GO:0006633] (biological_process)'
675b862c00001348	Linoleic acid metabolic process (Mouse)	2025-01-21	David Hill	success		18 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: fatty acid beta-oxidation [GO:0006635] (biological_process) —part of→ fatty acid biosynthetic process [GO:0006633] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: long-chain fatty acid transmembrane transporter activity [GO:0005324] (molecular_function) —has target start location→ endoplasmic reticulum lumen [GO:0005788] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: fatty acid beta-oxidation [GO:0006635] (biological_process) —has output→ (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid [CHEBI:65136] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: long-chain fatty acid transmembrane transporter activity [GO:0005324] (molecular_function) —has target end location→ peroxisomal matrix [GO:0005782] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —part of→ fatty acid biosynthetic process [GO:0006633] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: fatty acid beta-oxidation [GO:0006635] (biological_process) —causally upstream of→ transporter activity [GO:0005215] (molecular_function) SKIPPED_FACT: Subject 'fatty acid beta-oxidation [GO:0006635] (biological_process)' has 'has output' relationship to '(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid [CHEBI:65136] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: fatty acid beta-oxidation [GO:0006635] (biological_process) —has input→ (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA [CHEBI:63546] (chemical entity) SKIPPED_FACT: Subject 'fatty acid biosynthetic process [GO:0006633] (biological_process)' has 'has primary input' relationship to 'linoleate [CHEBI:30245] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'fatty acid biosynthetic process [GO:0006633] (biological_process)' has 'has primary output' relationship to '(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid [CHEBI:65136] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has primary input→ (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid [CHEBI:65136] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: long-chain fatty acid transmembrane transporter activity [GO:0005324] (molecular_function) —causally upstream of→ fatty acid beta-oxidation [GO:0006635] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: fatty acid biosynthetic process [GO:0006633] (biological_process) —has primary output→ (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid [CHEBI:65136] (chemical entity) SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has primary input' relationship to '(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid [CHEBI:65136] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: fatty acid biosynthetic process [GO:0006633] (biological_process) —has primary input→ linoleate [CHEBI:30245] (chemical entity) SKIPPED_FACT: Subject 'fatty acid beta-oxidation [GO:0006635] (biological_process)' has 'has input' relationship to '(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA [CHEBI:63546] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target start location→ peroxisomal matrix [GO:0005782] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target end location→ endoplasmic reticulum lumen [GO:0005788] (anatomical entity)
67369e7600005945	Tetrahydrobiopterin biosynthetic process 2 (Mouse)	2024-12-17	David Hill	success		8 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —provides input for→ sepiapterin reductase (NADP+) activity [GO:0004757] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —has input→ dyspropterin [CHEBI:17804] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —has output→ sepiapterin [CHEBI:16095] (chemical entity) SKIPPED_FACT: Subject 'oxidoreductase activity [GO:0016491] (molecular_function)' has 'has output' relationship to 'sepiapterin [CHEBI:16095] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: biological regulation [GO:0065007] (biological_process) —positively regulates→ tetrahydrobiopterin biosynthetic process [GO:0006729] (biological_process) SKIPPED_FACT: Subject 'oxidoreductase activity [GO:0016491] (molecular_function)' has 'has input' relationship to 'dyspropterin [CHEBI:17804] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —part of→ tetrahydrobiopterin biosynthetic process [GO:0006729] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: oxidoreductase activity [GO:0016491] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity)
67369e7600004463	NADPH regeneration 1 (Mouse)	2024-12-09	David Hill	success
67369e7600003532	Tetrahydrofolate Interconversion 3 (Mouse)	2024-12-05	David Hill	success		6 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —part of→ formate biosynthetic process [GO:0015943] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target start location→ mitochondrial matrix [GO:0005759] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: formate-tetrahydrofolate ligase activity [GO:0004329] (molecular_function) —provides input for→ transporter activity [GO:0005215] (molecular_function) SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has primary input' relationship to 'formate [CHEBI:15740] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has primary input→ formate [CHEBI:15740] (chemical entity)
67369e7600003835	Tetrahydrofolate Interconversion 4 (Mouse)	2024-12-05	David Hill	success		8 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: formate biosynthetic process [GO:0015943] (biological_process) —has primary output→ formate [CHEBI:15740] (chemical entity) SKIPPED_FACT: Subject 'formate biosynthetic process [GO:0015943] (biological_process)' has 'has primary output' relationship to 'formate [CHEBI:15740] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has primary input' relationship to 'formate [CHEBI:15740] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —part of→ formate biosynthetic process [GO:0015943] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target start location→ mitochondrial matrix [GO:0005759] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: formate-tetrahydrofolate ligase activity [GO:0004329] (molecular_function) —provides input for→ transporter activity [GO:0005215] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has primary input→ formate [CHEBI:15740] (chemical entity)
67369e7600001117	Tetrahydrofolylpolyglutamate biosynthetic process 2 (Mouse)	2024-11-27	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: folic acid transmembrane transporter activity [GO:0008517] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: folic acid transmembrane transporter activity [GO:0008517] (molecular_function) —has target end location→ extracellular region [GO:0005576] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: folic acid transmembrane transporter activity [GO:0008517] (molecular_function) —has target end location→ mitochondrial matrix [GO:0005759] (anatomical entity)
62f58d8800000378	Insulin-like growth factor receptor signaling pathway 4 (Mouse)	2024-11-13	David Hill	success
62f58d8800007837	Negative regulation of insulin secretion 4 (Mouse)	2024-11-13	David Hill	success		6 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: G protein-coupled receptor signaling pathway [GO:0007186] (biological_process) —negatively regulates→ insulin secretion [GO:0030073] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase inhibitor activity [GO:0010855] (molecular_function) —directly negatively regulates→ adenylate cyclase activity [GO:0004016] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: G protein-coupled receptor signaling pathway [GO:0007186] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase activity [GO:0004016] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: insulin secretion [GO:0030073] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase activity [GO:0004016] (molecular_function) —part of→ G protein-coupled receptor signaling pathway [GO:0007186] (biological_process)
632cf60a00000887	Negative regulation of insulin secretion 5 (Mouse)	2024-11-13	David Hill	success		6 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase inhibitor activity [GO:0010855] (molecular_function) —directly negatively regulates→ adenylate cyclase activity [GO:0004016] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: G protein-coupled receptor signaling pathway [GO:0007186] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase activity [GO:0004016] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: G protein-coupled receptor signaling pathway [GO:0007186] (biological_process) —negatively regulates→ insulin secretion [GO:0030073] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: insulin secretion [GO:0030073] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase activity [GO:0004016] (molecular_function) —part of→ G protein-coupled receptor signaling pathway [GO:0007186] (biological_process)
62f58d8800007784	Positive regulation of insulin secretion 10 (Mouse)	2024-11-13	David Hill	success		14 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: G protein activity [GO:0003925] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function) —part of→ G protein-coupled receptor signaling pathway [GO:0007186] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function) —directly positively regulates→ inositol 1,4,5-trisphosphate-gated calcium channel activity [GO:0005220] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: G protein activity [GO:0003925] (molecular_function) —directly positively regulates→ phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: insulin secretion [GO:0030073] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: G protein-coupled receptor signaling pathway [GO:0007186] (biological_process) —positively regulates→ insulin secretion [GO:0030073] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: G protein activity [GO:0003925] (molecular_function) —part of→ G protein-coupled receptor signaling pathway [GO:0007186] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: proteinase-activated receptor activity [GO:0001648] (molecular_function) —directly positively regulates→ G protein activity [GO:0003925] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: diacylglycerol-dependent serine/threonine kinase activity [GO:0004697] (molecular_function) —part of→ G protein-coupled receptor signaling pathway [GO:0007186] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435] (molecular_function) —directly positively regulates→ diacylglycerol-dependent serine/threonine kinase activity [GO:0004697] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: diacylglycerol-dependent serine/threonine kinase activity [GO:0004697] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: inositol 1,4,5-trisphosphate-gated calcium channel activity [GO:0005220] (molecular_function) —part of→ G protein-coupled receptor signaling pathway [GO:0007186] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: G protein-coupled receptor signaling pathway [GO:0007186] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity)
633b013300000089	Positive regulation of insulin secretion 11 (Mouse)	2024-11-13	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: insulin secretion [GO:0030073] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200] (biological_process) —positively regulates→ insulin secretion [GO:0030073] (biological_process)
62f58d8800004064	Positive regulation of insulin secretion 4 (Mouse)	2024-11-13	David Hill, Li Ni	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207] (biological_process) —positively regulates→ insulin secretion [GO:0030073] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: insulin secretion [GO:0030073] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity)
62f58d8800005633	Positive regulation of insulin secretion 8 (Mouse)	2024-11-13	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189] (biological_process) —positively regulates→ insulin secretion [GO:0030073] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: insulin secretion [GO:0030073] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity)
62f58d8800006039	Positive regulation of insulin secretion 9 (Mouse)	2024-11-13	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: insulin secretion [GO:0030073] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189] (biological_process) —positively regulates→ insulin secretion [GO:0030073] (biological_process)
67086be200001721	Retinoid Metabolic Process 2 (Mouse)	2024-10-22	David Hill	filtered	Model has at least one activity with no causal relations	9 warnings SKIPPED_FACT: 'molecular sequestering activity [GO:0140313] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'biological regulation [GO:0065007] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of→ molecular carrier activity [GO:0140104] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —has primary input→ all-trans-retinol [CHEBI:17336] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: retinoid metabolic process [GO:0001523] (biological_process) —constitutively upstream of→ phototransduction, visible light [GO:0007603] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: transport [GO:0006810] (biological_process) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transport [GO:0006810] (biological_process) —has target end location→ extracellular region [GO:0005576] (anatomical entity) SKIPPED_FACT: Subject 'molecular_function [GO:0003674] (molecular_function)' has 'has primary input' relationship to 'all-trans-retinol [CHEBI:17336] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: biological regulation [GO:0065007] (biological_process) —negatively regulates→ glomerular filtration [GO:0003094] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —part of→ transport [GO:0006810] (biological_process)
66f5faaa00001017	Angiotensin Maturation 7 (Mouse)	2024-10-08	David Hill	success
66f5faaa00001076	Angiotensin Maturation 8 (Mouse)	2024-10-08	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has output→ Agt Mmus [MGI:MGI:87963] (information biomacromolecule) SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has output' relationship to 'Agt Mmus [MGI:MGI:87963] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association
66f5faaa00001130	Angiotensin Maturation 9 (Mouse)	2024-10-08	David Hill	success		2 warnings SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has output' relationship to 'Agt Mmus [MGI:MGI:87963] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has output→ Agt Mmus [MGI:MGI:87963] (information biomacromolecule)
66e382fb00003093	Angiotensin Maturation 1 (Mouse)	2024-10-07	David Hill	success		2 warnings SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has output' relationship to 'Agt Mmus [MGI:MGI:87963] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has output→ Agt Mmus [MGI:MGI:87963] (information biomacromolecule)
66f5faaa00000347	Angiotensin Maturation 2 (Mouse)	2024-10-07	David Hill	success		7 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: aspartate 4-decarboxylase activity [GO:0047688] (molecular_function) —has input→ Agt Mmus [MGI:MGI:87963] (information biomacromolecule) SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has output' relationship to 'Agt Mmus [MGI:MGI:87963] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'aspartate 4-decarboxylase activity [GO:0047688] (molecular_function)' has 'has input' relationship to 'Agt Mmus [MGI:MGI:87963] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: aspartate 4-decarboxylase activity [GO:0047688] (molecular_function) —has output→ Agt Mmus [MGI:MGI:87963] (information biomacromolecule) SKIPPED_FACT: Subject 'aspartate 4-decarboxylase activity [GO:0047688] (molecular_function)' has 'has output' relationship to 'Agt Mmus [MGI:MGI:87963] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association MULTIPLE_ACTIVITIES: Multiple activities for subject receptor ligand activity [GO:0048018] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has output→ Agt Mmus [MGI:MGI:87963] (information biomacromolecule)
66f5faaa00000441	Angiotensin Maturation 3 (Mouse)	2024-10-07	David Hill	success		2 warnings SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has output' relationship to 'Agt Mmus [MGI:MGI:87963] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has output→ Agt Mmus [MGI:MGI:87963] (information biomacromolecule)
66f5faaa00000519	Angiotensin Maturation 4 (Mouse)	2024-10-07	David Hill	success		2 warnings SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has output' relationship to 'Agt Mmus [MGI:MGI:87963] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has output→ Agt Mmus [MGI:MGI:87963] (information biomacromolecule)
66f5faaa00000806	Angiotensin Maturation 5 (Mouse)	2024-10-07	David Hill	success		2 warnings SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has output' relationship to 'Agt Mmus [MGI:MGI:87963] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has output→ Agt Mmus [MGI:MGI:87963] (information biomacromolecule)
66f5faaa00000924	Angiotensin Maturation 6 (Mouse)	2024-10-07	David Hill	success		2 warnings SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has output' relationship to 'Agt Mmus [MGI:MGI:87963] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has output→ Agt Mmus [MGI:MGI:87963] (information biomacromolecule)
66c7d41500001389	Protein geranylgeranylation 1 (Mouse)	2024-10-03	David Hill	success
66e382fb00001225	Protein sumoylation (Mouse)	2024-09-25	David Hill	success
66c7d41500003582	Protein Modification 2 (Mouse)	2024-09-19	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: formylglycine-generating oxidase activity [GO:0120147] (molecular_function) —directly positively regulates→ sulfuric ester hydrolase activity [GO:0008484] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of biological process [GO:0050789] (biological_process) —negatively regulates→ post-translational protein modification [GO:0043687] (biological_process)
622aace900000734	lactose biosynthetic process (Mouse)	2024-09-12	David Hill	success		4 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: D-glucose transmembrane transporter activity [GO:0055056] (molecular_function) —has target end location→ Golgi lumen [GO:0005796] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: UDP-galactose transmembrane transporter activity [GO:0005459] (molecular_function) —has target end location→ Golgi lumen [GO:0005796] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: UDP-galactose transmembrane transporter activity [GO:0005459] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: D-glucose transmembrane transporter activity [GO:0055056] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity)
66c7d41500002843	Protein histidyl modification to diphthamide (Mouse)	2024-09-12	David Hill	success		7 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: diphthamide residue [CHEBI:16692] (chemical entity) —part of→ mEEF2 Mmus [PR:P58252] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: diphthine methyl ester residue [CHEBI:79005] (chemical entity) —part of→ mEEF2 Mmus [PR:P58252] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: 2-(3-amino-3-carboxypropyl)-L-histidine zwitterion residue [CHEBI:73743] (chemical entity) —part of→ mEEF2 Mmus [PR:P58252] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein-containing complex [GO:0032991] (cellular_component) —has part→ Dph3 Mmus [MGI:MGI:1922658] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: diphthine residue [CHEBI:48230] (chemical entity) —part of→ mEEF2 Mmus [PR:P58252] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: histidine residue [CHEBI:32535] (chemical entity) —part of→ mEEF2 Mmus [PR:P58252] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein-containing complex [GO:0032991] (cellular_component) —has part→ 2-(3-amino-3-carboxypropyl)histidine synthase complex [GO:0120513] (cellular_component)
66c7d41500000350	Peptidyl-lysine modification to peptidyl-hypusine (Mouse)	2024-08-29	David Hill	success		5 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: Eif5a Mmus [MGI:MGI:106248] (information biomacromolecule) —has part→ deoxyhypusine(2+) residue [CHEBI:82657] (chemical entity) SKIPPED_FACT: Subject 'protein maturation [GO:0051604] (biological_process)' has 'has output' relationship to 'Dohh Mmus [MGI:MGI:1915964] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: Eif5a Mmus [MGI:MGI:106248] (information biomacromolecule) —has part→ hypusine(2+) residue [CHEBI:91175] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Eif5a Mmus [MGI:MGI:106248] (information biomacromolecule) —has part→ gomodel:66c7d41500000350/66c7d41500000386 UNHANDLED_FACT: Fact not representable in GO-CAM model: protein maturation [GO:0051604] (biological_process) —has output→ Dohh Mmus [MGI:MGI:1915964] (information biomacromolecule)
66c7d41500000243	Peptidyl-tyrosine sulfation 1 (Mouse)	2024-08-28	David Hill	success		4 warnings SKIPPED_FACT: '3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'peptidyl-tyrosine sulfation [GO:0006478] (biological_process)' SKIPPED_FACT: '3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to '5'-adenylyl sulfate transmembrane transport [GO:1902558] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964] (molecular_function) —has target end location→ Golgi lumen [GO:0005796] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity)
66c7d41500000309	Peptidyl-tyrosine sulfation 2 (Mouse)	2024-08-28	David Hill	success		4 warnings SKIPPED_FACT: '3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to '5'-adenylyl sulfate transmembrane transport [GO:1902558] (biological_process)' SKIPPED_FACT: '3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to '5'-adenylyl sulfate transmembrane transport [GO:1902558] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964] (molecular_function) —has target end location→ Golgi lumen [GO:0005796] (anatomical entity)
66b5638000002250	Malate-aspartate shuttle 1 (Mouse)	2024-08-22	David Hill	success
6690711d00001433	Protein O-linked glycosylation 1 (Mouse)	2024-07-18	David Hill	success
66187e4700003220	Negative regulation of GDP-mannose biosynthetic process (Mouse)	2024-07-11	David Hill	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: biological regulation [GO:0065007] (biological_process) —negatively regulates→ GDP-mannose biosynthetic process [GO:0009298] (biological_process)
668d5f2700000078	UDP-D-xylose biosynthetic process (Mouse)	2024-07-11	David Hill	filtered	Model has at least one activity with no causal relations	12 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: UDP-glucuronate transmembrane transporter activity [GO:0005461] (molecular_function) —has output→ UDP-alpha-D-glucuronate(3-) [CHEBI:58052] (chemical entity) SKIPPED_FACT: Subject 'biosynthetic process [GO:0009058] (biological_process)' has 'has primary output' relationship to 'UDP-alpha-D-xylose(2-) [CHEBI:57632] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: biosynthetic process [GO:0009058] (biological_process) —has primary output→ UDP-alpha-D-xylose(2-) [CHEBI:57632] (chemical entity) SKIPPED_FACT: Subject 'UDP-glucuronate transmembrane transporter activity [GO:0005461] (molecular_function)' has 'has input' relationship to 'UDP-alpha-D-glucuronate(3-) [CHEBI:58052] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: UDP-glucuronate transmembrane transporter activity [GO:0005461] (molecular_function) —part of→ biosynthetic process [GO:0009058] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: UDP-glucuronate transmembrane transporter activity [GO:0005461] (molecular_function) —has target end location→ Golgi lumen [GO:0005796] (anatomical entity) SKIPPED_FACT: Subject 'UDP-glucuronate transmembrane transporter activity [GO:0005461] (molecular_function)' has 'has output' relationship to 'UDP-alpha-D-glucuronate(3-) [CHEBI:58052] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'UDP-glucose 6-dehydrogenase activity [GO:0003979] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'biosynthetic process [GO:0009058] (biological_process)' SKIPPED_FACT: Subject 'biosynthetic process [GO:0009058] (biological_process)' has 'has primary output' relationship to 'UDP-alpha-D-glucuronate(3-) [CHEBI:58052] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: biosynthetic process [GO:0009058] (biological_process) —has primary output→ UDP-alpha-D-glucuronate(3-) [CHEBI:58052] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: UDP-glucuronate transmembrane transporter activity [GO:0005461] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: UDP-glucuronate transmembrane transporter activity [GO:0005461] (molecular_function) —has input→ UDP-alpha-D-glucuronate(3-) [CHEBI:58052] (chemical entity)
668d5f2700000154	UDP-glucuronate biosynthetic process (Mouse)	2024-07-11	David Hill	success		4 warnings SKIPPED_FACT: Subject 'biosynthetic process [GO:0009058] (biological_process)' has 'has primary output' relationship to 'UDP-alpha-D-glucuronate(3-) [CHEBI:58052] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: UDP-glucuronate transmembrane transporter activity [GO:0005461] (molecular_function) —has target end location→ endoplasmic reticulum lumen [GO:0005788] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: UDP-glucuronate transmembrane transporter activity [GO:0005461] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: biosynthetic process [GO:0009058] (biological_process) —has primary output→ UDP-alpha-D-glucuronate(3-) [CHEBI:58052] (chemical entity)
6482692800001393	Biotin Metabolic Process 1 (Mouse)	2024-06-27	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: sodium-dependent multivitamin transmembrane transporter activity [GO:0008523] (molecular_function) —has target start location→ extracellular region [GO:0005576] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: sodium-dependent multivitamin transmembrane transporter activity [GO:0008523] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity)
623d156d00000029	Glycogen biosynthetic process (Mouse)	2024-06-27	David Hill	success		1 warning SKIPPED_FACT: 'ubiquitin-protein transferase activity [GO:0004842] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'glycogen biosynthetic process [GO:0005978] (biological_process)'
65f3ae5c00002270	Positive regulation of glycogen catabolic process 2 (Mouse)	2024-05-02	David Hill	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: biological regulation [GO:0065007] (biological_process) —positively regulates→ glycogen catabolic process [GO:0005980] (biological_process)
63894f2500001789	Fmr1 binds N6-methyladenosine (m6A)-containing mRNAs and promotes their nuclear export (Mouse)	2024-03-28	David Hill, Sylvain Poux	success
65f3ae5c00002208	Positive regulation of glycogen catabolic process 1 (Mouse)	2024-03-28	David Hill	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: biological regulation [GO:0065007] (biological_process) —positively regulates→ glycogen catabolic process [GO:0005980] (biological_process)
61283a3000000217	cobalamin metabolic process 1, adenosylation of cobalamin (Mouse)	2024-02-20	David Hill, Li Ni	success
60d5209a00001406	'de novo' XMP biosynthetic process (Mouse)	2024-01-18	David Hill	success
57ea2dae00000004	Enho-mouse-energy	2024-01-11	David Hill	filtered	Model has at least one activity with no causal relations	18 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: peptidyl-threonine phosphorylation [GO:0018107] (biological_process) —part of→ protein phosphorylation [GO:0006468] (biological_process) SKIPPED_FACT: Subject 'protein serine/threonine kinase activity [GO:0004674] (molecular_function)' has 'has input' relationship to 'AKT kinase [PR:000029189] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'protein serine/threonine kinase activity [GO:0004674] (molecular_function)' has 'has input' relationship to 'AKT kinase [PR:000029189] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: insulin secretion [GO:0030073] (biological_process) —causally upstream of→ insulin receptor signaling pathway [GO:0008286] (biological_process) SKIPPED_FACT: 'hormone activity [GO:0005179] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'biological_process [GO:0008150] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: protein phosphorylation [GO:0006468] (biological_process) —part of→ insulin receptor signaling pathway [GO:0008286] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: peptidyl-serine phosphorylation [GO:0018105] (biological_process) —part of→ protein phosphorylation [GO:0006468] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein serine/threonine kinase activity [GO:0004674] (molecular_function) —part of→ peptidyl-serine phosphorylation [GO:0018105] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: peptidyl-threonine phosphorylation [GO:0018107] (biological_process) —part of→ protein serine/threonine kinase activity [GO:0004674] (molecular_function) SKIPPED_FACT: Subject 'protein phosphorylation [GO:0006468] (biological_process)' has 'has input' relationship to 'AKT kinase [PR:000029189] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: insulin receptor signaling pathway [GO:0008286] (biological_process) —part of→ glucose homeostasis [GO:0042593] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: biological_process [GO:0008150] (biological_process) —negatively regulates→ insulin secretion [GO:0030073] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: biological_process [GO:0008150] (biological_process) —negatively regulates→ lipid biosynthetic process [GO:0008610] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein serine/threonine kinase activity [GO:0004674] (molecular_function) —has input→ AKT kinase [PR:000029189] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: AKT kinase [PR:000029189] (information biomacromolecule) —RO:0002162→ Mus musculus [NCBITaxon:10090] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: biological_process [GO:0008150] (biological_process) —negatively regulates→ insulin receptor signaling pathway [GO:0008286] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein phosphorylation [GO:0006468] (biological_process) —has input→ AKT kinase [PR:000029189] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: insulin receptor signaling pathway [GO:0008286] (biological_process) —positively regulates→ RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] (molecular_function)
64e7eefa00000854	Tumor necrosis factor-mediated signaling pathway 1 (Mouse)	2023-11-03	David Hill	success		3 warnings SKIPPED_FACT: 'ubiquitin protein ligase activity [GO:0061630] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'positive regulation of canonical NF-kappaB signal transduction [GO:0043123] (biological_process)' SKIPPED_FACT: 'ubiquitin ligase activator activity [GO:1990757] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'protein polyubiquitination [GO:0000209] (biological_process)' SKIPPED_FACT: 'protein-macromolecule adaptor activity [GO:0030674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'protein polyubiquitination [GO:0000209] (biological_process)'
6258b8f300000398	Heparan sulfate proteoglycan biosynthetic process (Mouse)	2023-10-24	David Hill, Li Ni	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleotide-sugar transmembrane transporter activity [GO:0005338] (molecular_function) —has target end location→ Golgi apparatus [GO:0005794] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleotide-sugar transmembrane transporter activity [GO:0005338] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity)
6516135700000632	Carnitine biosynthetic process (Mouse)	2023-10-23	David Hill	filtered	Model has at least one activity with no causal relations	14 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: carnitine transmembrane transporter activity [GO:0015226] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has primary input→ (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine(1+) [CHEBI:141499] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target start location→ mitochondrial matrix [GO:0005759] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: gamma-butyrobetaine dioxygenase activity [GO:0008336] (molecular_function) —causally upstream of→ carnitine transmembrane transporter activity [GO:0015226] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: trimethyllysine dioxygenase activity [GO:0050353] (molecular_function) —provides input for→ transporter activity [GO:0005215] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —provides input for→ aldehyde-lyase activity [GO:0016832] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: carnitine transmembrane transporter activity [GO:0015226] (molecular_function) —has primary input→ carnitine [CHEBI:17126] (chemical entity) SKIPPED_FACT: Subject 'carnitine transmembrane transporter activity [GO:0015226] (molecular_function)' has 'has primary input' relationship to 'carnitine [CHEBI:17126] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —part of→ carnitine biosynthetic process [GO:0045329] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: carnitine transmembrane transporter activity [GO:0015226] (molecular_function) —has target end location→ extracellular region [GO:0005576] (anatomical entity) SKIPPED_FACT: Subject 'transporter activity [GO:0005215] (molecular_function)' has 'has primary input' relationship to '(3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine(1+) [CHEBI:141499] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: carnitine transmembrane transporter activity [GO:0015226] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: carnitine transmembrane transporter activity [GO:0015226] (molecular_function) —part of→ carnitine transmembrane transport [GO:1902603] (biological_process)
MGI_MGI_107676	Tank (MGI:MGI:107676)	2023-10-02	David Hill, Harold Drabkin	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical NF-kappaB signal transduction [GO:0007249] (biological_process) —part of→ tumor necrosis factor-mediated signaling pathway [GO:0033209] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804] (biological_process) —negatively regulates→ tumor necrosis factor-mediated signaling pathway [GO:0033209] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of canonical NF-kappaB signal transduction [GO:0043123] (biological_process) —positively regulates→ canonical NF-kappaB signal transduction [GO:0007249] (biological_process)
MGI_MGI_2183158	Ash1l (MGI:MGI:2183158)	2023-09-29	David Hill, Dmitry Sitnikov, Harold Drabkin, Karen Christie	filtered	Model has at least one activity with no causal relations	25 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ single fertilization [GO:0007338] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ post-embryonic development [GO:0009791] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: transcription by RNA polymerase II [GO:0006366] (biological_process) —occurs in→ macrophage [CL:0000235] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ skeletal system development [GO:0001501] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: MAPK cascade [GO:0000165] (biological_process) —occurs in→ macrophage [CL:0000235] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of MAPK cascade [GO:0043409] (biological_process) —negatively regulates→ MAPK cascade [GO:0000165] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ negative regulation of MAPK cascade [GO:0043409] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ decidualization [GO:0046697] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ tarsal gland development [GO:1903699] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: transcription by RNA polymerase II [GO:0006366] (biological_process) —has output→ Tnfaip3 Mmus [MGI:MGI:1196377] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ uterine gland development [GO:1903709] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ uterus morphogenesis [GO:0061038] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ regulation of gene expression [GO:0010468] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ negative regulation of inflammatory response [GO:0050728] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ negative regulation of acute inflammatory response [GO:0002674] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —positively regulates→ transcription by RNA polymerase II [GO:0006366] (biological_process) SKIPPED_FACT: Subject 'transcription by RNA polymerase II [GO:0006366] (biological_process)' has 'has output' relationship to 'Tnfaip3 Mmus [MGI:MGI:1196377] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: inflammatory response [GO:0006954] (biological_process) —occurs in→ macrophage [CL:0000235] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ flagellated sperm motility [GO:0030317] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: interleukin-6 production [GO:0032635] (biological_process) —occurs in→ macrophage [CL:0000235] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —occurs in→ macrophage [CL:0000235] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of inflammatory response [GO:0050728] (biological_process) —negatively regulates→ inflammatory response [GO:0006954] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ interleukin-6 production [GO:0032635] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ sebaceous gland development [GO:0048733] (biological_process)
MGI_MGI_2444070	Nlrc3 (MGI:MGI:2444070)	2023-09-29	David Hill	filtered	Model has at least one activity with no causal relations	6 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ response to lipopolysaccharide [GO:0032496] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ regulation of protein ubiquitination [GO:0031396] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical NF-kappaB signal transduction [GO:0007249] (biological_process) —occurs in→ macrophage [CL:0000235] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of canonical NF-kappaB signal transduction [GO:0043124] (biological_process) —negatively regulates→ canonical NF-kappaB signal transduction [GO:0007249] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical NF-kappaB signal transduction [GO:0007249] (biological_process) —occurs in→ monocyte [CL:0000576] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ negative regulation of canonical NF-kappaB signal transduction [GO:0043124] (biological_process)
MGI_MGI_88276	Ctnnb1 (MGI:MGI:88276)	2023-09-28	Alexander Diehl, David Hill, Dmitry Sitnikov, Harold Drabkin, Karen Christie, Li Ni	filtered	Model has at least one activity with no causal relations	431 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ kidney development [GO:0001822] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: Z disc [GO:0030018] (anatomical entity) —part of→ cardiac muscle cell [CL:0000746] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ renal outer medulla development [GO:0072054] (biological_process) SKIPPED_FACT: Subject 'positive regulation of DNA-templated transcription [GO:0045893] (biological_process)' has 'has input' relationship to 'Hnf1a Mmus [MGI:MGI:98504] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of epithelial cell proliferation involved in prostate gland development [GO:0060769] (biological_process) —positively regulates→ epithelial cell proliferation involved in prostate gland development [GO:0060767] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ lung-associated mesenchyme development [GO:0060484] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ elbow mesenchyme [EMAPA:17416] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: renal outer medulla development [GO:0072054] (biological_process) —results in development of→ renal medullary interstitium [EMAPA:18326] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ positive regulation of epithelial cell proliferation involved in prostate gland development [GO:0060769] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: osteoclast differentiation [GO:0030316] (biological_process) —occurs in→ lower jaw incisor [EMAPA:17918] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell-cell junction [GO:0005911] (anatomical entity) —part of→ epithelial cell of lung [CL:0000082] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: membrane [GO:0016020] (anatomical entity) —part of→ basal cell [CL:0000646] (anatomical entity) SKIPPED_FACT: Subject 'negative regulation of DNA-templated transcription [GO:0045892] (biological_process)' has 'has input' relationship to 'Sox9 Mmus [MGI:MGI:98371] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: plasma membrane [GO:0005886] (anatomical entity) —part of→ cerebral cortex ventricular layer [EMAPA:17547] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ epithelial cell [CL:0000066] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ hindlimb bud [EMAPA:16779] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ cell fate determination [GO:0001709] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —located in→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: basolateral plasma membrane [GO:0016323] (anatomical entity) —part of→ epithelial cell [CL:0000066] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: adherens junction [GO:0005912] (anatomical entity) —part of→ gut endothelial cell [CL:0000131] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: plasma membrane [GO:0005886] (anatomical entity) —part of→ acinar cell [CL:0000622] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —located in→ cell projection membrane [GO:0031253] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ negative regulation of transcription by RNA polymerase II [GO:0000122] (biological_process) SKIPPED_FACT: Subject 'negative regulation of DNA-templated transcription [GO:0045892] (biological_process)' has 'has input' relationship to 'Runx2 Mmus [MGI:MGI:99829] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: renal inner medulla development [GO:0072053] (biological_process) —results in development of→ medullary renal tubule [EMAPA:31414] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of cell differentiation [GO:0045596] (biological_process) —occurs in→ latero-nasal process [EMAPA:16805] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: apical part of cell [GO:0045177] (anatomical entity) —part of→ CNS neuron (sensu Vertebrata) [CL:0000117] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: fibroblast growth factor receptor signaling pathway [GO:0008543] (biological_process) —occurs in→ lung [EMAPA:16728] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: epithelial cell differentiation [GO:0030855] (biological_process) —results in acquisition of features of→ epithelial cell [CL:0000066] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: skin development [GO:0043588] (biological_process) —results in development of→ skin [EMAPA:17525] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of osteoblast differentiation [GO:0045667] (biological_process) —occurs in→ femur [EMAPA:19143] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: adherens junction [GO:0005912] (anatomical entity) —part of→ brain ventricle [EMAPA:32674] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: fascia adherens [GO:0005916] (anatomical entity) —part of→ cardiac muscle cell [CL:0000746] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical Wnt signaling pathway [GO:0060070] (biological_process) —occurs in→ foregut [EMAPA:16548] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ bone resorption [GO:0045453] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: lung cell differentiation [GO:0060479] (biological_process) —occurs in→ lung [EMAPA:16728] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ synapse organization [GO:0050808] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ epithelial tube branching involved in lung morphogenesis [GO:0060441] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ neural plate development [GO:0001840] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ regulation of transcription by RNA polymerase II [GO:0006357] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: cytosol [GO:0005829] (anatomical entity) —part of→ myoblast [CL:0000056] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell-cell junction [GO:0005911] (anatomical entity) —overlaps→ epithelial cell [CL:0000066] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of MAPK cascade [GO:0043410] (biological_process) —positively regulates→ MAPK cascade [GO:0000165] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ trachea morphogenesis [GO:0060439] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ anterior/posterior axis specification [GO:0009948] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: mesenchymal cell proliferation involved in lung development [GO:0060916] (biological_process) —acts on population of→ smooth muscle myoblast [CL:0000514] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Z disc [GO:0030018] (anatomical entity) —part of→ heart [EMAPA:16105] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —located in→ microvillus membrane [GO:0031528] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ skeletal system development [GO:0001501] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of osteoclast differentiation [GO:0045670] (biological_process) —regulates→ osteoclast differentiation [GO:0030316] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ embryonic digit morphogenesis [GO:0042733] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of cell population proliferation [GO:0042127] (biological_process) —regulates→ cell population proliferation [GO:0008283] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —part of→ transcription regulator complex [GO:0005667] (cellular_component) UNHANDLED_FACT: Fact not representable in GO-CAM model: basolateral plasma membrane [GO:0016323] (anatomical entity) —part of→ cochlear inner hair cell [CL:0000589] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ mammary gland epithelium [EMAPA:17760] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ cell population proliferation [GO:0008283] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical Wnt signaling pathway [GO:0060070] (biological_process) —occurs in→ ovary [EMAPA:17962] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ regulation of epithelial cell differentiation [GO:0030856] (biological_process) SKIPPED_FACT: Subject 'negative regulation of DNA-templated transcription [GO:0045892] (biological_process)' has 'has input' relationship to 'Runx2 Mmus [MGI:MGI:99829] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ epidermis [EMAPA:17528] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ intracellular protein localization [GO:0008104] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ hemopoiesis [GO:0030097] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: plasma membrane [GO:0005886] (anatomical entity) —part of→ trophectoderm [EMAPA:16046] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ positive regulation of epithelial to mesenchymal transition [GO:0010718] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ lung cell differentiation [GO:0060479] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ cell fate specification [GO:0001708] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of DNA-templated transcription [GO:0045893] (biological_process) —has input→ Lef1 Mmus [MGI:MGI:96770] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ in utero embryonic development [GO:0001701] (biological_process) SKIPPED_FACT: Subject 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' has 'has input' relationship to 'Defa1 Mmus [MGI:MGI:94880] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: anterior/posterior axis specification [GO:0009948] (biological_process) —occurs in→ embryo [EMAPA:16039] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: chondrocyte differentiation [GO:0002062] (biological_process) —results in acquisition of features of→ chondrocyte [CL:0000138] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ cell differentiation [GO:0030154] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical Wnt signaling pathway [GO:0060070] (biological_process) —occurs in→ renal medullary interstitium [EMAPA:18326] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ embryonic forelimb morphogenesis [GO:0035115] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ fungiform papilla formation [GO:0061198] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of transcription by RNA polymerase II [GO:0006357] (biological_process) —has input→ Fgf8 Mmus [MGI:MGI:99604] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: cytoplasm [GO:0005737] (anatomical entity) —part of→ epidermis [EMAPA:17528] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: smooth muscle cell differentiation [GO:0051145] (biological_process) —occurs in→ lung [EMAPA:16728] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of DNA-templated transcription [GO:0045893] (biological_process) —has input→ Cul4a Mmus [MGI:MGI:1914487] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: T cell proliferation [GO:0042098] (biological_process) —acts on population of→ T cell [CL:0000084] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: plasma membrane [GO:0005886] (anatomical entity) —part of→ neurecto-epithelial cell [CL:0000710] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: plasma membrane [GO:0005886] (anatomical entity) —part of→ trophectodermal cell [CL:1000274] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ renal inner medulla development [GO:0072053] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ positive regulation of DNA-templated transcription [GO:0045893] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ neural stem cell [CL:0000047] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell differentiation [GO:0030154] (biological_process) —results in acquisition of features of→ crystallin accumulating cell [CL:0000306] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cytokine-mediated signaling pathway [GO:0019221] (biological_process) —positively regulates→ canonical NF-kappaB signal transduction [GO:0007249] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ cerebral cortex ventricular layer [EMAPA:17547] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —has input→ Pou3f2 Mmus [MGI:MGI:101895] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: basolateral plasma membrane [GO:0016323] (anatomical entity) —part of→ small intestine crypt of lieberkuhn [EMAPA:35777] (anatomical entity) SKIPPED_FACT: 'chromatin binding [GO:0003682] (molecular_function)' already has 'occurs in' relationship; ignoring 'occurs in' relationship to 'small intestine crypt of lieberkuhn [EMAPA:35777] (anatomical entity)' UNHANDLED_FACT: Fact not representable in GO-CAM model: cytoplasm [GO:0005737] (anatomical entity) —part of→ osteoblast [CL:0000062] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: basolateral plasma membrane [GO:0016323] (anatomical entity) —part of→ luminal epithelial cell of mammary gland [CL:0002326] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —has input→ Gata6 Mmus [MGI:MGI:107516] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: neuroblast proliferation [GO:0007405] (biological_process) —occurs in→ cerebral cortex [EMAPA:17544] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ negative regulation of osteoclast differentiation [GO:0045671] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: animal organ development [GO:0048513] (biological_process) —results in development of→ urethra of male [EMAPA:18692] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: endodermal cell fate commitment [GO:0001711] (biological_process) —results in commitment to→ endodermal cell [CL:0000223] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ cell morphogenesis [GO:0000902] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ cell-cell adhesion [GO:0098609] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ positive regulation of mesenchymal cell proliferation [GO:0002053] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: adherens junction organization [GO:0034332] (biological_process) —occurs in→ tail future spinal cord [EMAPA:16755] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ proximal/distal pattern formation [GO:0009954] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ canonical Wnt signaling pathway [GO:0060070] (biological_process) SKIPPED_FACT: Subject 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' has 'has input' relationship to 'Dct Mmus [MGI:MGI:102563] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'chromatin binding [GO:0003682] (molecular_function)' already has 'occurs in' relationship; ignoring 'occurs in' relationship to 'lung [EMAPA:16728] (anatomical entity)' UNHANDLED_FACT: Fact not representable in GO-CAM model: membrane [GO:0016020] (anatomical entity) —part of→ prostate epithelium [EMAPA:35711] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell differentiation [GO:0030154] (biological_process) —results in acquisition of features of→ acinar cell [CL:0000622] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: thymus development [GO:0048538] (biological_process) —results in development of→ thymus [EMAPA:18768] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ lung development [GO:0030324] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of cell differentiation [GO:0045596] (biological_process) —negatively regulates→ cell differentiation [GO:0030154] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: plasma membrane [GO:0005886] (anatomical entity) —part of→ pancreas [EMAPA:17503] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell fate determination [GO:0001709] (biological_process) —results in determination of→ CNS neuron (sensu Vertebrata) [CL:0000117] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —located in→ bicellular tight junction [GO:0005923] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: lung-associated mesenchyme development [GO:0060484] (biological_process) —results in development of→ lung [EMAPA:16728] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ embryonic foregut morphogenesis [GO:0048617] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: basolateral plasma membrane [GO:0016323] (anatomical entity) —part of→ tracheal epithelial cell [CL:0000307] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ heart development [GO:0007507] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: fungiform papilla formation [GO:0061198] (biological_process) —results in formation of anatomical entity→ taste bud [EMAPA:35850] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell-cell junction [GO:0005911] (anatomical entity) —part of→ epithelial cell [CL:0000066] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ positive regulation of osteoblast differentiation [GO:0045669] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ ectoderm development [GO:0007398] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ nephron tubule formation [GO:0072079] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical NF-kappaB signal transduction [GO:0007249] (biological_process) —occurs in→ integumental system [EMAPA:17524] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ skin development [GO:0043588] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ morphogenesis of embryonic epithelium [GO:0016331] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: apoptotic signaling pathway [GO:0097190] (biological_process) —occurs in→ primary oocyte [CL:0000654] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: osteoblast differentiation [GO:0001649] (biological_process) —results in acquisition of features of→ osteoblast [CL:0000062] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: dorsal/ventral pattern formation [GO:0009953] (biological_process) —occurs in→ telencephalon [EMAPA:16910] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ positive regulation of cell population proliferation [GO:0008284] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ epithelial cell differentiation involved in prostate gland development [GO:0060742] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell differentiation [GO:0030154] (biological_process) —occurs in→ pancreas [EMAPA:17503] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ embryonic hindlimb morphogenesis [GO:0035116] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003340] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ negative regulation of apoptotic signaling pathway [GO:2001234] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell differentiation [GO:0030154] (biological_process) —results in acquisition of features of→ chondrocyte [CL:0000138] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ positive regulation of endothelial cell differentiation [GO:0045603] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ animal organ development [GO:0048513] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ neural tube [EMAPA:16164] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ vasculogenesis [GO:0001570] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: plasma membrane [GO:0005886] (anatomical entity) —part of→ liver [EMAPA:16846] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ ectodermal cell [CL:0000221] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: membrane [GO:0016020] (anatomical entity) —part of→ cardiac muscle cell [CL:0000746] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —has input→ Dct Mmus [MGI:MGI:102563] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of epithelial cell differentiation [GO:0030856] (biological_process) —occurs in→ prostate epithelium [EMAPA:35711] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ male genitalia development [GO:0030539] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: apicolateral plasma membrane [GO:0016327] (anatomical entity) —part of→ ependymal cell [CL:0000065] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: bicellular tight junction [GO:0005923] (anatomical entity) —part of→ reticular membrane [EMAPA:35735] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: apical part of cell [GO:0045177] (anatomical entity) —part of→ corpus striatum [EMAPA:17549] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ synaptic vesicle transport [GO:0048489] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —located in→ nucleus [GO:0005634] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ trophoblast cell [CL:0000351] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —located in→ adherens junction [GO:0005912] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-templated transcription [GO:0006351] (biological_process) —occurs in→ upper arm mesenchyme [EMAPA:17426] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ positive regulation of branching involved in lung morphogenesis [GO:0061047] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of mesenchymal cell proliferation [GO:0002053] (biological_process) —occurs in→ lung [EMAPA:16728] (anatomical entity) SKIPPED_FACT: Subject 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' has 'has input' relationship to 'Dct Mmus [MGI:MGI:102563] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of neuroblast proliferation [GO:0002052] (biological_process) —positively regulates→ neuroblast proliferation [GO:0007405] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of transcription by RNA polymerase II [GO:0000122] (biological_process) —has input→ Foxa2 Mmus [MGI:MGI:1347476] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —has input→ Mycn Mmus [MGI:MGI:97357] (information biomacromolecule) SKIPPED_FACT: Subject 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' has 'has input' relationship to 'Pou3f2 Mmus [MGI:MGI:101895] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of DNA-templated transcription [GO:0045892] (biological_process) —has input→ Sox9 Mmus [MGI:MGI:98371] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ neuron migration [GO:0001764] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: endoderm formation [GO:0001706] (biological_process) —results in formation of anatomical entity→ definitive endoderm [EMAPA:16070] (anatomical entity) SKIPPED_FACT: Subject 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' has 'has input' relationship to 'Msgn1 Mmus [MGI:MGI:1860483] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of T cell proliferation [GO:0042129] (biological_process) —regulates→ T cell proliferation [GO:0042098] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: embryonic hindlimb morphogenesis [GO:0035116] (biological_process) —results in morphogenesis of→ hindlimb [EMAPA:17458] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —located in→ lateral plasma membrane [GO:0016328] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: T cell differentiation in thymus [GO:0033077] (biological_process) —occurs in→ thymus [EMAPA:18768] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical Wnt signaling pathway [GO:0060070] (biological_process) —occurs in→ integumental system [EMAPA:17524] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: osteoclast differentiation [GO:0030316] (biological_process) —results in acquisition of features of→ osteoclast [CL:0000092] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: epithelial cell differentiation involved in prostate gland development [GO:0060742] (biological_process) —results in acquisition of features of→ epithelial cell [CL:0000066] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of epithelial cell differentiation [GO:0030856] (biological_process) —regulates→ epithelial cell differentiation [GO:0030855] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: transcription by RNA polymerase II [GO:0006366] (biological_process) —occurs in→ epithelial cell of lung [CL:0000082] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transcription regulator complex [GO:0005667] (cellular_component) —part of→ pituitary gland [EMAPA:35998] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ regulation of cell differentiation [GO:0045595] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical Wnt signaling pathway [GO:0060070] (biological_process) —occurs in→ primary oocyte [CL:0000654] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell fate specification [GO:0001708] (biological_process) —results in specification of→ chondrocyte [CL:0000138] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ tongue [EMAPA:17185] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743] (biological_process) —positively regulates→ fibroblast growth factor receptor signaling pathway [GO:0008543] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of DNA-templated transcription [GO:0045893] (biological_process) —positively regulates→ DNA-templated transcription [GO:0006351] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: ectoderm development [GO:0007398] (biological_process) —results in development of→ embryo ectoderm [EMAPA:16069] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —located in→ Z disc [GO:0030018] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: fungiform papilla formation [GO:0061198] (biological_process) —results in formation of anatomical entity→ fungiform papillae [EMAPA:18272] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of osteoclast differentiation [GO:0045670] (biological_process) —occurs in→ femur [EMAPA:19143] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —positively regulates→ transcription by RNA polymerase II [GO:0006366] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: adherens junction [GO:0005912] (anatomical entity) —part of→ hindgut epithelium [EMAPA:16717] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: basolateral plasma membrane [GO:0016323] (anatomical entity) —part of→ metanephros [EMAPA:17373] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ positive regulation of MAPK cascade [GO:0043410] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ left lung epithelium [EMAPA:17655] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ pancreas [EMAPA:17503] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ dorsal/ventral pattern formation [GO:0009953] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: forebrain development [GO:0030900] (biological_process) —results in development of→ telencephalon [EMAPA:16910] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ dorsal/ventral axis specification [GO:0009950] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: transcription by RNA polymerase II [GO:0006366] (biological_process) —occurs in→ lung [EMAPA:16728] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —part of→ catenin complex [GO:0016342] (cellular_component) UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical Wnt signaling pathway [GO:0060070] (biological_process) —occurs in→ humerus [EMAPA:19106] (anatomical entity) SKIPPED_FACT: Subject 'positive regulation of DNA-templated transcription [GO:0045893] (biological_process)' has 'has input' relationship to 'Cul4a Mmus [MGI:MGI:1914487] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: cell-cell junction [GO:0005911] (anatomical entity) —part of→ submandibular gland primordium epithelium [EMAPA:17756] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cytoplasm [GO:0005737] (anatomical entity) —part of→ oocyte [CL:0000023] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of DNA-templated transcription [GO:0045893] (biological_process) —has input→ Hnf1a Mmus [MGI:MGI:98504] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: cytoplasm [GO:0005737] (anatomical entity) —part of→ hindlimb bud [EMAPA:16779] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ adherens junction organization [GO:0034332] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ negative regulation of oligodendrocyte differentiation [GO:0048715] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-templated transcription [GO:0006351] (biological_process) —occurs in→ upper leg mesenchyme [EMAPA:17501] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ gastrulation with mouth forming second [GO:0001702] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ regulation of cell population proliferation [GO:0042127] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical Wnt signaling pathway [GO:0060070] (biological_process) —occurs in→ osteoblast [CL:0000062] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ small intestine crypt of lieberkuhn [EMAPA:35777] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: renal inner medulla development [GO:0072053] (biological_process) —results in development of→ renal medullary interstitium [EMAPA:18326] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ embryonic heart tube development [GO:0035050] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ negative regulation of DNA-templated transcription [GO:0045892] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: mesenchymal cell proliferation [GO:0010463] (biological_process) —acts on population of→ mesenchymal stem cell [CL:0000134] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ osteoblast [CL:0000062] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: oocyte development [GO:0048599] (biological_process) —occurs in→ ovary [EMAPA:17962] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —located in→ apical part of cell [GO:0045177] (anatomical entity) SKIPPED_FACT: Subject 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' has 'has input' relationship to 'Dct Mmus [MGI:MGI:102563] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: cytoplasm [GO:0005737] (anatomical entity) —part of→ tongue [EMAPA:17185] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —located in→ intercalated disc [GO:0014704] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell population proliferation [GO:0008283] (biological_process) —acts on population of→ ectodermal cell [CL:0000221] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ regulation of apoptotic process [GO:0042981] (biological_process) SKIPPED_FACT: Subject 'regulation of transcription by RNA polymerase II [GO:0006357] (biological_process)' has 'has input' relationship to 'Fgf8 Mmus [MGI:MGI:99604] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: hair follicle morphogenesis [GO:0031069] (biological_process) —results in morphogenesis of→ vibrissa follicle [EMAPA:26720] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of chondrocyte differentiation [GO:0032331] (biological_process) —negatively regulates→ chondrocyte differentiation [GO:0002062] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ positive regulation of determination of dorsal identity [GO:2000017] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell differentiation [GO:0030154] (biological_process) —results in acquisition of features of→ goblet cell [CL:0000160] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: adherens junction [GO:0005912] (anatomical entity) —part of→ skin [EMAPA:17525] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ regulation of gene expression [GO:0010468] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: Z disc [GO:0030018] (anatomical entity) —part of→ cell of skeletal muscle [CL:0000188] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: epithelial cell proliferation involved in prostate gland development [GO:0060767] (biological_process) —occurs in→ prostate epithelium [EMAPA:35711] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: osteoclast differentiation [GO:0030316] (biological_process) —occurs in→ forelimb long bone [EMAPA:35350] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of cell population proliferation [GO:0008284] (biological_process) —positively regulates→ cell population proliferation [GO:0008283] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ positive regulation of gene expression [GO:0010628] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell-cell junction [GO:0005911] (anatomical entity) —part of→ morula cell [CL:0000360] (anatomical entity) SKIPPED_FACT: Subject 'positive regulation of DNA-templated transcription [GO:0045893] (biological_process)' has 'has input' relationship to 'Lef1 Mmus [MGI:MGI:96770] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ glandular secretory epithelial cell [CL:0000150] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: plasma membrane [GO:0005886] (anatomical entity) —part of→ neural stem cell [CL:0000047] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of mesenchymal cell proliferation [GO:0002053] (biological_process) —occurs in→ bronchus smooth muscle [EMAPA:35195] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —located in→ basolateral plasma membrane [GO:0016323] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: mesenchymal cell proliferation [GO:0010463] (biological_process) —acts on population of→ smooth muscle myoblast [CL:0000514] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: basolateral plasma membrane [GO:0016323] (anatomical entity) —part of→ intestinal villus [EMAPA:35784] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: fascia adherens [GO:0005916] (anatomical entity) —part of→ left ventricle cardiac muscle [EMAPA:17339] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ smooth muscle cell differentiation [GO:0051145] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —has input→ Defa1 Mmus [MGI:MGI:94880] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ regulation of myelination [GO:0031641] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: membrane [GO:0016020] (anatomical entity) —part of→ heart [EMAPA:16105] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell population proliferation [GO:0008283] (biological_process) —occurs in→ lung [EMAPA:16728] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ T cell differentiation in thymus [GO:0033077] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: epithelial tube branching involved in lung morphogenesis [GO:0060441] (biological_process) —occurs in→ lung [EMAPA:16728] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: plasma membrane [GO:0005886] (anatomical entity) —part of→ hepatocyte [CL:0000182] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical Wnt signaling pathway [GO:0060070] (biological_process) —occurs in→ lung [EMAPA:16728] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ regulation of secondary heart field cardioblast proliferation [GO:0003266] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: hair follicle placode formation [GO:0060789] (biological_process) —results in formation of anatomical entity→ skin [EMAPA:17525] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical Wnt signaling pathway [GO:0060070] (biological_process) —occurs in→ epidermal cell [CL:0000362] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of DNA-templated transcription [GO:0045892] (biological_process) —negatively regulates→ DNA-templated transcription [GO:0006351] (biological_process) SKIPPED_FACT: Subject 'positive regulation of DNA-templated transcription [GO:0045893] (biological_process)' has 'has input' relationship to 'Hnf1a Mmus [MGI:MGI:98504] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: neuroblast proliferation [GO:0007405] (biological_process) —acts on population of→ neuroblast (sensu Vertebrata) [CL:0000031] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ gut endothelial cell [CL:0000131] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ osteoclast differentiation [GO:0030316] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ hepatocyte [CL:0000182] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of apoptotic process [GO:0042981] (biological_process) —regulates→ apoptotic process [GO:0006915] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ central nervous system vasculogenesis [GO:0022009] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: mesenchymal cell proliferation involved in lung development [GO:0060916] (biological_process) —occurs in→ lung [EMAPA:16728] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ layer formation in cerebral cortex [GO:0021819] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: adherens junction [GO:0005912] (anatomical entity) —part of→ neurecto-epithelial cell [CL:0000710] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: embryonic foregut morphogenesis [GO:0048617] (biological_process) —results in morphogenesis of→ foregut [EMAPA:16548] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: male genitalia development [GO:0030539] (biological_process) —results in development of→ genital tubercle of male [EMAPA:17969] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ glial cell fate determination [GO:0007403] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —has input→ Msgn1 Mmus [MGI:MGI:1860483] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ mammary mesenchyme [EMAPA:17761] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: adherens junction [GO:0005912] (anatomical entity) —part of→ ependymal cell [CL:0000065] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ branching involved in blood vessel morphogenesis [GO:0001569] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ regulation of osteoblast differentiation [GO:0045667] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —has input→ Dll4 Mmus [MGI:MGI:1859388] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: epithelial cell differentiation [GO:0030855] (biological_process) —results in acquisition of features of→ epithelial cell of lung [CL:0000082] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell morphogenesis [GO:0000902] (biological_process) —part of→ epithelial cell development [GO:0002064] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: fibroblast growth factor receptor signaling pathway [GO:0008543] (biological_process) —occurs in→ mesenchymal stem cell [CL:0000134] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ embryonic axis specification [GO:0000578] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of DNA-templated transcription [GO:0045892] (biological_process) —has input→ Runx2 Mmus [MGI:MGI:99829] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell-matrix adhesion [GO:0007160] (biological_process) —occurs in→ alimentary system epithelium [EMAPA:32683] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell fate specification [GO:0001708] (biological_process) —results in specification of→ osteoblast [CL:0000062] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ chorioallantoic placenta [EMAPA:31873] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: intercalated disc [GO:0014704] (anatomical entity) —part of→ heart [EMAPA:16105] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ metanephros morphogenesis [GO:0003338] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: Z disc [GO:0030018] (anatomical entity) —part of→ diaphragm [EMAPA:17701] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —located in→ cytoplasm [GO:0005737] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ negative regulation of chondrocyte differentiation [GO:0032331] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: osteoclast differentiation [GO:0030316] (biological_process) —occurs in→ vertebra [EMAPA:32740] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: adherens junction [GO:0005912] (anatomical entity) —part of→ blastoderm cell [CL:0000353] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: apical part of cell [GO:0045177] (anatomical entity) —part of→ epithelial cell [CL:0000066] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cytoplasm [GO:0005737] (anatomical entity) —part of→ ectodermal cell [CL:0000221] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —located in→ cell-cell junction [GO:0005911] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ acinar cell [CL:0000622] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of chondrocyte differentiation [GO:0032331] (biological_process) —occurs in→ humerus [EMAPA:19106] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ vasculature development [GO:0001944] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: adherens junction [GO:0005912] (anatomical entity) —part of→ extraembryonic visceral endoderm [EMAPA:16058] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: MAPK cascade [GO:0000165] (biological_process) —occurs in→ fibroblast [CL:0000057] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: intercalated disc [GO:0014704] (anatomical entity) —part of→ cardiac muscle cell [CL:0000746] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of branching involved in lung morphogenesis [GO:0061047] (biological_process) —positively regulates→ epithelial tube branching involved in lung morphogenesis [GO:0060441] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical Wnt signaling pathway [GO:0060070] (biological_process) —occurs in→ chondrocyte [CL:0000138] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cytoplasm [GO:0005737] (anatomical entity) —part of→ ovary [EMAPA:17962] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell maturation [GO:0048469] (biological_process) —results in maturation of→ chondrocyte [CL:0000138] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ odontogenesis of dentin-containing tooth [GO:0042475] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ forebrain development [GO:0030900] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —located in→ apical junction complex [GO:0043296] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ lower leg muscle [EMAPA:19318] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: bicellular tight junction [GO:0005923] (anatomical entity) —overlaps→ Deiter's cell [CL:0000635] (anatomical entity) SKIPPED_FACT: Subject 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' has 'has input' relationship to 'Mycn Mmus [MGI:MGI:97357] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: embryonic forelimb morphogenesis [GO:0035115] (biological_process) —results in morphogenesis of→ elbow joint primordium [EMAPA:17710] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: oligodendrocyte differentiation [GO:0048709] (biological_process) —occurs in→ forebrain [EMAPA:16895] (anatomical entity) SKIPPED_FACT: Subject 'positive regulation of DNA-templated transcription [GO:0045893] (biological_process)' has 'has input' relationship to 'Lef1 Mmus [MGI:MGI:96770] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ chondrocyte [CL:0000138] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: apoptotic signaling pathway [GO:0097190] (biological_process) —occurs in→ intestinal villus [EMAPA:35784] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: renal outer medulla development [GO:0072054] (biological_process) —results in development of→ medullary renal tubule [EMAPA:31414] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —located in→ membrane [GO:0016020] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: neuron migration [GO:0001764] (biological_process) —results in movement of→ CNS neuron (sensu Vertebrata) [CL:0000117] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: apical part of cell [GO:0045177] (anatomical entity) —part of→ neural tube [EMAPA:16164] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of osteoblast differentiation [GO:0045667] (biological_process) —regulates→ osteoblast differentiation [GO:0001649] (biological_process) SKIPPED_FACT: Subject 'negative regulation of transcription by RNA polymerase II [GO:0000122] (biological_process)' has 'has input' relationship to 'Foxa2 Mmus [MGI:MGI:1347476] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'chromatin binding [GO:0003682] (molecular_function)' already has 'occurs in' relationship; ignoring 'occurs in' relationship to 'paneth cell [CL:0000510] (anatomical entity)' SKIPPED_FACT: Subject 'intracellular protein localization [GO:0008104] (biological_process)' has 'has primary input' relationship to 'Apc Mmus [MGI:MGI:88039] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: epithelial cell differentiation involved in prostate gland development [GO:0060742] (biological_process) —occurs in→ prostate epithelium [EMAPA:35711] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ chemical synaptic transmission [GO:0007268] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of osteoclast differentiation [GO:0045671] (biological_process) —negatively regulates→ osteoclast differentiation [GO:0030316] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: apical junction complex [GO:0043296] (anatomical entity) —part of→ neural tube [EMAPA:16164] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell differentiation [GO:0030154] (biological_process) —occurs in→ intestinal villus [EMAPA:35784] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: oligodendrocyte differentiation [GO:0048709] (biological_process) —results in acquisition of features of→ oligodendrocyte [CL:0000128] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: oligodendrocyte differentiation [GO:0048709] (biological_process) —occurs in→ spinal cord [EMAPA:17577] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ oocyte development [GO:0048599] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: apoptotic process [GO:0006915] (biological_process) —occurs in→ limb interdigital region [EMAPA:32618] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ pancreas development [GO:0031016] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ limb development [GO:0060173] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ endoderm formation [GO:0001706] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell-cell junction [GO:0005911] (anatomical entity) —part of→ metanephros [EMAPA:17373] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: microvillus membrane [GO:0031528] (anatomical entity) —part of→ gut endothelial cell [CL:0000131] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: apical part of cell [GO:0045177] (anatomical entity) —part of→ cerebral cortex [EMAPA:17544] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell morphogenesis [GO:0000902] (biological_process) —results in morphogenesis of→ epithelial cell [CL:0000066] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ trachea formation [GO:0060440] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: adherens junction [GO:0005912] (anatomical entity) —part of→ apicolateral plasma membrane [GO:0016327] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: apical part of cell [GO:0045177] (anatomical entity) —part of→ neurecto-epithelial cell [CL:0000710] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of osteoblast differentiation [GO:0045669] (biological_process) —positively regulates→ osteoblast differentiation [GO:0001649] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: limb development [GO:0060173] (biological_process) —results in development of→ hindlimb [EMAPA:17458] (anatomical entity) SKIPPED_FACT: Subject 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' has 'has input' relationship to 'Dll4 Mmus [MGI:MGI:1859388] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ regulation of osteoclast differentiation [GO:0045670] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: DNA-templated transcription [GO:0006351] (biological_process) —occurs in→ mesenchymal stem cell [CL:0000134] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: adherens junction [GO:0005912] (anatomical entity) —part of→ compacted morula [EMAPA:16040] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: intracellular protein localization [GO:0008104] (biological_process) —has primary input→ Apc Mmus [MGI:MGI:88039] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: skeletal system development [GO:0001501] (biological_process) —results in development of→ limb long bone [EMAPA:35495] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of epithelial cell differentiation [GO:0030858] (biological_process) —occurs in→ lung alveolus [EMAPA:32682] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —part of→ beta-catenin destruction complex [GO:0030877] (cellular_component) UNHANDLED_FACT: Fact not representable in GO-CAM model: pancreas development [GO:0031016] (biological_process) —results in development of→ pancreas [EMAPA:17503] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ tissue homeostasis [GO:0001894] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ branching involved in ureteric bud morphogenesis [GO:0001658] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: apical junction complex [GO:0043296] (anatomical entity) —part of→ reticular membrane [EMAPA:35735] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ thymus development [GO:0048538] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ negative regulation of neuron apoptotic process [GO:0043524] (biological_process) SKIPPED_FACT: Subject 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' has 'has input' relationship to 'Bmp4 Mmus [MGI:MGI:88180] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —located in→ apicolateral plasma membrane [GO:0016327] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: adherens junction [GO:0005912] (anatomical entity) —part of→ primitive endoderm [EMAPA:16051] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: microvillus membrane [GO:0031528] (anatomical entity) —part of→ gut [EMAPA:16247] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ regulation of T cell proliferation [GO:0042129] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ hair cycle process [GO:0022405] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ cell-matrix adhesion [GO:0007160] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: canonical Wnt signaling pathway [GO:0060070] (biological_process) —occurs in→ mesenchymal stem cell [CL:0000134] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —part of→ protein-containing complex [GO:0032991] (cellular_component) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ mesenchymal cell proliferation involved in lung development [GO:0060916] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: bicellular tight junction [GO:0005923] (anatomical entity) —overlaps→ cochlear outer hair cell [CL:0000601] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell fate determination [GO:0001709] (biological_process) —occurs in→ telencephalon [EMAPA:16910] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —has input→ Defa5 Mmus [MGI:MGI:99583] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: plasma membrane [GO:0005886] (anatomical entity) —part of→ intestinal epithelial cell [CL:0002563] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell morphogenesis [GO:0000902] (biological_process) —occurs in→ lens pit [EMAPA:16799] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: lateral plasma membrane [GO:0016328] (anatomical entity) —part of→ colon epithelium [EMAPA:18941] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ renal vesicle formation [GO:0072033] (biological_process) SKIPPED_FACT: Subject 'negative regulation of DNA-templated transcription [GO:0045892] (biological_process)' has 'has input' relationship to 'Sox9 Mmus [MGI:MGI:98371] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: osteoclast differentiation [GO:0030316] (biological_process) —results in acquisition of features of→ osteoblast [CL:0000062] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ endodermal cell fate commitment [GO:0001711] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell population proliferation [GO:0008283] (biological_process) —acts on population of→ primordial germ cell [CL:0000670] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ lens morphogenesis in camera-type eye [GO:0002089] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ negative regulation of cell differentiation [GO:0045596] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: apoptotic signaling pathway [GO:0097190] (biological_process) —occurs in→ ovary [EMAPA:17962] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: apical junction complex [GO:0043296] (anatomical entity) —part of→ Deiter's cell [CL:0000635] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: transcription regulator complex [GO:0005667] (cellular_component) —part of→ future pituitary [EMAPA:32796] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ paneth cell [CL:0000510] (anatomical entity) SKIPPED_FACT: 'chromatin binding [GO:0003682] (molecular_function)' already has 'occurs in' relationship; ignoring 'occurs in' relationship to 'epithelial cell of lung [CL:0000082] (anatomical entity)' UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ genitalia morphogenesis [GO:0035112] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ intestinal epithelial cell [CL:0002563] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ positive regulation of epithelial cell differentiation [GO:0030858] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ right lung epithelium [EMAPA:17663] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —located in→ lamellipodium [GO:0030027] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: oocyte development [GO:0048599] (biological_process) —results in development of→ primary oocyte [CL:0000654] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: membrane [GO:0016020] (anatomical entity) —part of→ testis [EMAPA:17972] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of osteoblast differentiation [GO:0045667] (biological_process) —occurs in→ skeleton [EMAPA:17213] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: basolateral plasma membrane [GO:0016323] (anatomical entity) —part of→ pancreas [EMAPA:17503] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: dorsal/ventral axis specification [GO:0009950] (biological_process) —occurs in→ hindlimb bud ectoderm [EMAPA:16780] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process) —has input→ Bmp4 Mmus [MGI:MGI:88180] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: endodermal cell fate commitment [GO:0001711] (biological_process) —occurs in→ foregut diverticulum endoderm [EMAPA:16250] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ T cell differentiation [GO:0030217] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ gut [EMAPA:16247] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ oviduct development [GO:0060066] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ positive regulation of neuroblast proliferation [GO:0002052] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: nucleus [GO:0005634] (anatomical entity) —part of→ mesenchymal stem cell [CL:0000134] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of mesenchymal cell proliferation [GO:0002053] (biological_process) —positively regulates→ mesenchymal cell proliferation [GO:0010463] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of cell population proliferation [GO:0042127] (biological_process) —occurs in→ primordial germ cell of gonad [EMAPA:16578] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —located in→ plasma membrane [GO:0005886] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: apical junction complex [GO:0043296] (anatomical entity) —part of→ neurecto-epithelial cell [CL:0000710] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: limb development [GO:0060173] (biological_process) —results in development of→ forelimb [EMAPA:17412] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of apoptotic signaling pathway [GO:2001234] (biological_process) —negatively regulates→ apoptotic signaling pathway [GO:0097190] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ lung induction [GO:0060492] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: trachea formation [GO:0060440] (biological_process) —results in formation of anatomical entity→ respiratory tract [EMAPA:16737] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Ctnnb1 Mmus [MGI:MGI:88276] (information biomacromolecule) —located in→ fascia adherens [GO:0005916] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ hair follicle placode formation [GO:0060789] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of oligodendrocyte differentiation [GO:0048715] (biological_process) —negatively regulates→ oligodendrocyte differentiation [GO:0048709] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: osteoclast differentiation [GO:0030316] (biological_process) —occurs in→ hindlimb long bone [EMAPA:35403] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: vasculature development [GO:0001944] (biological_process) —occurs in→ central nervous system [EMAPA:16470] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: adherens junction [GO:0005912] (anatomical entity) —part of→ embryo [EMAPA:16039] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: plasma membrane [GO:0005886] (anatomical entity) —part of→ lactocyte [CL:0002325] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ hair follicle morphogenesis [GO:0031069] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: hair follicle morphogenesis [GO:0031069] (biological_process) —results in morphogenesis of→ hair follicle [EMAPA:18771] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of cell population proliferation [GO:0042127] (biological_process) —occurs in→ genital tubercle [EMAPA:17382] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cell population proliferation [GO:0008283] (biological_process) —occurs in→ alimentary system epithelium [EMAPA:32683] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: neuron migration [GO:0001764] (biological_process) —occurs in→ cerebral cortex [EMAPA:17544] (anatomical entity) SKIPPED_FACT: Subject 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' has 'has input' relationship to 'Defa5 Mmus [MGI:MGI:99583] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of epithelial cell differentiation [GO:0030858] (biological_process) —positively regulates→ epithelial cell differentiation [GO:0030855] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: branching involved in blood vessel morphogenesis [GO:0001569] (biological_process) —occurs in→ retina blood vessel [EMAPA:36520] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: molecular_function [GO:0003674] (molecular_function) —causally upstream of or within→ cell maturation [GO:0048469] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: apicolateral plasma membrane [GO:0016327] (anatomical entity) —part of→ brain ventricle [EMAPA:32674] (anatomical entity) SKIPPED_FACT: Subject 'positive regulation of transcription by RNA polymerase II [GO:0045944] (biological_process)' has 'has input' relationship to 'Gata6 Mmus [MGI:MGI:107516] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: plasma membrane [GO:0005886] (anatomical entity) —part of→ spinal cord [EMAPA:17577] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: T cell differentiation [GO:0030217] (biological_process) —occurs in→ spleen [EMAPA:18767] (anatomical entity)
MGI_MGI_1340031	Nfkbil1 (MGI:MGI:1340031)	2023-09-28	David Hill	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of canonical NF-kappaB signal transduction [GO:0043124] (biological_process) —negatively regulates→ canonical NF-kappaB signal transduction [GO:0007249] (biological_process)
64e7eefa00001233	Extrinsic apoptotic signaling pathway via death domain receptors 1(Mouse)	2023-09-20	David Hill	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: execution phase of apoptosis [GO:0097194] (biological_process) —part of→ extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (biological_process)
60897d8500000785	Chrd mouse	2023-09-15	Dmitry Sitnikov, Li Ni	filtered	Model has at least one activity with no causal relations	50 warnings SKIPPED_FACT: 'BMP signaling pathway [GO:0030509] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'cranial skeletal system development [GO:1904888] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: SMAD protein signal transduction [GO:0060395] (biological_process) —has input→ Smad9 Mmus [MGI:MGI:1859993] (information biomacromolecule) SKIPPED_FACT: 'BMP signaling pathway [GO:0030509] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'embryonic heart tube development [GO:0035050] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'artery morphogenesis [GO:0048844] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Fgf8 Mmus [MGI:MGI:99604] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'venous blood vessel morphogenesis [GO:0048845] (biological_process)' SKIPPED_FACT: Subject 'SMAD protein signal transduction [GO:0060395] (biological_process)' has 'has input' relationship to 'Smad1 Mmus [MGI:MGI:109452] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'SMAD protein signal transduction [GO:0060395] (biological_process)' SKIPPED_FACT: 'presynaptic modulation of chemical synaptic transmission [GO:0099171] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'exploration behavior [GO:0035640] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'neural crest formation [GO:0014029] (biological_process)' SKIPPED_FACT: Subject 'regulation of protein localization [GO:0032880] (biological_process)' has 'has input' relationship to 'Chrd Mmus [MGI:MGI:1313268] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Fgf8 Mmus [MGI:MGI:99604] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'regulation of synaptic plasticity [GO:0048167] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Shh Mmus [MGI:MGI:98297] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'epithelial cell fate commitment [GO:0072148] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: SMAD protein signal transduction [GO:0060395] (biological_process) —has input→ Smad1 Mmus [MGI:MGI:109452] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'descending aorta development [GO:0035906] (biological_process)' SKIPPED_FACT: Subject 'maintenance of protein location [GO:0045185] (biological_process)' has 'has input' relationship to 'Chrd Mmus [MGI:MGI:1313268] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'excitatory chemical synaptic transmission [GO:0098976] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'exploration behavior [GO:0035640] (biological_process)' SKIPPED_FACT: 'presynaptic modulation of chemical synaptic transmission [GO:0099171] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'long-term synaptic potentiation [GO:0060291] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: SMAD protein signal transduction [GO:0060395] (biological_process) —has input→ Smad5 Mmus [MGI:MGI:1328787] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'presynaptic modulation of chemical synaptic transmission [GO:0099171] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Tbx1 Mmus [MGI:MGI:98493] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'protein import [GO:0017038] (biological_process)' has 'has input' relationship to 'Chrd Mmus [MGI:MGI:1313268] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'BMP signaling pathway [GO:0030509] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'smoothened signaling pathway [GO:0007224] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Tbx1 Mmus [MGI:MGI:98493] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: maintenance of protein location [GO:0045185] (biological_process) —has input→ Chrd Mmus [MGI:MGI:1313268] (information biomacromolecule) SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Chrd Mmus [MGI:MGI:1313268] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'BMP signaling pathway [GO:0030509] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'fibroblast growth factor receptor signaling pathway [GO:0008543] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Chrd Mmus [MGI:MGI:1313268] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'synapse maturation [GO:0060074] (biological_process)' SKIPPED_FACT: 'heparan sulfate proteoglycan binding [GO:0043395] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'maintenance of protein location [GO:0045185] (biological_process)' SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'visual learning [GO:0008542] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: regulation of protein localization [GO:0032880] (biological_process) —has input→ Chrd Mmus [MGI:MGI:1313268] (information biomacromolecule) SKIPPED_FACT: 'BMP signaling pathway [GO:0030509] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'artery morphogenesis [GO:0048844] (biological_process)' SKIPPED_FACT: 'heparan sulfate proteoglycan binding [GO:0043395] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'protein import [GO:0017038] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: synapse maturation [GO:0060074] (biological_process) —occurs in→ neuron [CL:0000540] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Shh Mmus [MGI:MGI:98297] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'BMP signaling pathway [GO:0030509] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: protein import [GO:0017038] (biological_process) —has input→ Chrd Mmus [MGI:MGI:1313268] (information biomacromolecule) SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Nog Mmus [MGI:MGI:104327] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'presynaptic modulation of chemical synaptic transmission [GO:0099171] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'short-term synaptic potentiation [GO:1990926] (biological_process)' SKIPPED_FACT: Subject 'SMAD protein signal transduction [GO:0060395] (biological_process)' has 'has input' relationship to 'Smad5 Mmus [MGI:MGI:1328787] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'BMP signaling pathway [GO:0030509] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'venous blood vessel morphogenesis [GO:0048845] (biological_process)' SKIPPED_FACT: Subject 'gene expression [GO:0010467] (biological_process)' has 'has input' relationship to 'Fgf8 Mmus [MGI:MGI:99604] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'AMPA glutamate receptor clustering [GO:0097113] (biological_process)' SKIPPED_FACT: Subject 'SMAD protein signal transduction [GO:0060395] (biological_process)' has 'has input' relationship to 'Smad9 Mmus [MGI:MGI:1859993] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: gene expression [GO:0010467] (biological_process) —has input→ Nog Mmus [MGI:MGI:104327] (information biomacromolecule) SKIPPED_FACT: 'molecular_function [GO:0003674] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'neuron fate commitment [GO:0048663] (biological_process)'
6494e2e900002018	Glyceraldehyde-3-phosphate biosynthetic process 1 (Mouse)	2023-07-24	David Hill	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: glyceraldehyde-3-phosphate biosynthetic process [GO:0046166] (biological_process) —occurs in→ white fat [EMAPA:35926] (anatomical entity)
62b4ffe300006559	Insulin receptor signaling pathway 2 (Mouse)	2023-07-07	David Hill	success
62d0afa500001077	Insulin-like growth factor receptor signaling pathway 1 (Mouse)	2023-07-07	David Hill, Suzi Aleksander	success
646ff70100005161	Vitamin B6 Metabolic Process 1 (Mouse)	2023-06-09	David Hill	success		4 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: vitamin B6 metabolic process [GO:0042816] (biological_process) —has primary input→ pyridoxaminium(1+) [CHEBI:57761] (chemical entity) SKIPPED_FACT: Subject 'vitamin B6 metabolic process [GO:0042816] (biological_process)' has 'has primary output' relationship to 'pyridoxal 5'-phosphate(2-) [CHEBI:597326] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: vitamin B6 metabolic process [GO:0042816] (biological_process) —has primary output→ pyridoxal 5'-phosphate(2-) [CHEBI:597326] (chemical entity) SKIPPED_FACT: Subject 'vitamin B6 metabolic process [GO:0042816] (biological_process)' has 'has primary input' relationship to 'pyridoxaminium(1+) [CHEBI:57761] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
646ff70100005246	Vitamin B6 Metabolic Process 2 (Mouse)	2023-06-09	David Hill	success		4 warnings SKIPPED_FACT: Subject 'vitamin B6 metabolic process [GO:0042816] (biological_process)' has 'has primary output' relationship to 'pyridoxal 5'-phosphate(2-) [CHEBI:597326] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: vitamin B6 metabolic process [GO:0042816] (biological_process) —has primary input→ pyridoxine [CHEBI:16709] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: vitamin B6 metabolic process [GO:0042816] (biological_process) —has primary output→ pyridoxal 5'-phosphate(2-) [CHEBI:597326] (chemical entity) SKIPPED_FACT: Subject 'vitamin B6 metabolic process [GO:0042816] (biological_process)' has 'has primary input' relationship to 'pyridoxine [CHEBI:16709] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
646ff70100001061	Coenzyme A catabolic process 3 (Mouse)	2023-06-02	David Hill	success
645d887900000340	Coenzyme A biosynthetic process 1 (Mouse)	2023-05-19	David Hill	success
6446bfcb00001336	Vitamin B2 (riboflavin) metabolic process to FAD (Mouse)	2023-05-16	David Hill	success		6 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: riboflavin transmembrane transporter activity [GO:0032217] (molecular_function) —has target start location→ extracellular region [GO:0005576] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: biosynthetic process [GO:0009058] (biological_process) —has primary output→ FAD [CHEBI:16238] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: riboflavin transmembrane transporter activity [GO:0032217] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: biosynthetic process [GO:0009058] (biological_process) —has primary input→ riboflavin(1-) [CHEBI:57986] (chemical entity) SKIPPED_FACT: Subject 'biosynthetic process [GO:0009058] (biological_process)' has 'has primary input' relationship to 'riboflavin(1-) [CHEBI:57986] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association SKIPPED_FACT: Subject 'biosynthetic process [GO:0009058] (biological_process)' has 'has primary output' relationship to 'FAD [CHEBI:16238] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
6446bfcb00001243	Thiamine diphosphate biosynthetic process 2 (Mouse)	2023-05-09	David Hill	success		6 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: thiamine-diphosphate kinase activity [GO:0050331] (molecular_function) —occurs in→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: thiamine-diphosphate kinase activity [GO:0050331] (molecular_function) —provides input for→ thiamine triphosphate phosphatase activity [GO:0050333] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: thiamine diphosphokinase activity [GO:0004788] (molecular_function) —provides input for→ thiamine-diphosphate kinase activity [GO:0050331] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: thiamine transmembrane transporter activity [GO:0015234] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: thiamine pyrophosphate transmembrane transporter activity [GO:0090422] (molecular_function) —has target end location→ mitochondrial matrix [GO:0005759] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: thiamine-diphosphate kinase activity [GO:0050331] (molecular_function) —part of→ thiamine diphosphate biosynthetic process [GO:0009229] (biological_process)
6446bfcb00001208	Thiamine diphosphate biosynthetic process 1 (Mouse)	2023-05-08	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: thiamine transmembrane transporter activity [GO:0015234] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: thiamine pyrophosphate transmembrane transporter activity [GO:0090422] (molecular_function) —has target end location→ mitochondrial matrix [GO:0005759] (anatomical entity)
6446bfcb00001000	Positive regulation of epidermal growth factor receptor signaling pathway 1 (Mouse)	2023-05-05	David Hill	success		3 warnings SKIPPED_FACT: 'ubiquitin protein ligase activity [GO:0061630] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742] (biological_process) —positively regulates→ epidermal growth factor receptor signaling pathway [GO:0007173] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059] (biological_process) —negatively regulates→ epidermal growth factor receptor signaling pathway [GO:0007173] (biological_process)
6446bfcb00000544	Negative regulation of epidermal growth factor receptor signaling pathway 2 (Mouse)	2023-05-03	David Hill	success		9 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: ubiquitin-dependent protein catabolic process [GO:0006511] (biological_process) —occurs in→ lysosome [GO:0005764] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: ubiquitin conjugating enzyme activity [GO:0061631] (molecular_function) —part of→ protein ubiquitination [GO:0016567] (biological_process) SKIPPED_FACT: Subject 'ubiquitin-dependent protein catabolic process [GO:0006511] (biological_process)' has 'has input' relationship to 'Egfr Mmus [MGI:MGI:95294] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: ubiquitin-dependent protein catabolic process [GO:0006511] (biological_process) —has input→ Egfr Mmus [MGI:MGI:95294] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: ubiquitin activating enzyme activity [GO:0004839] (molecular_function) —directly positively regulates→ ubiquitin conjugating enzyme activity [GO:0061631] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: ubiquitin activating enzyme activity [GO:0004839] (molecular_function) —part of→ protein ubiquitination [GO:0016567] (biological_process) SKIPPED_FACT: 'protein ubiquitination [GO:0016567] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'ubiquitin-dependent protein catabolic process [GO:0006511] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: ubiquitin conjugating enzyme activity [GO:0061631] (molecular_function) —directly positively regulates→ ubiquitin protein ligase activity [GO:0061630] (molecular_function) SKIPPED_FACT: 'ubiquitin protein ligase activity [GO:0061630] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059] (biological_process)'
6446bfcb00000319	Negative regulation of epidermal growth factor receptor signaling pathway 1 (Mouse)	2023-05-02	David Hill	success		9 warnings SKIPPED_FACT: 'ubiquitin protein ligase activity [GO:0061630] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: ubiquitin conjugating enzyme activity [GO:0061631] (molecular_function) —directly positively regulates→ ubiquitin protein ligase activity [GO:0061630] (molecular_function) SKIPPED_FACT: Subject 'ubiquitin-dependent protein catabolic process [GO:0006511] (biological_process)' has 'has input' relationship to 'Egfr Mmus [MGI:MGI:95294] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: ubiquitin-dependent protein catabolic process [GO:0006511] (biological_process) —occurs in→ lysosome [GO:0005764] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: ubiquitin-dependent protein catabolic process [GO:0006511] (biological_process) —has input→ Egfr Mmus [MGI:MGI:95294] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: ubiquitin activating enzyme activity [GO:0004839] (molecular_function) —directly positively regulates→ ubiquitin conjugating enzyme activity [GO:0061631] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: ubiquitin conjugating enzyme activity [GO:0061631] (molecular_function) —part of→ protein ubiquitination [GO:0016567] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: ubiquitin activating enzyme activity [GO:0004839] (molecular_function) —part of→ protein ubiquitination [GO:0016567] (biological_process) SKIPPED_FACT: 'protein ubiquitination [GO:0016567] (biological_process)' already has 'part of' relationship; ignoring 'part of' relationship to 'ubiquitin-dependent protein catabolic process [GO:0006511] (biological_process)'
6446bfcb00000006	Triglyceride biosynthetic process 2 (Mouse)	2023-04-26	David Hill	success		4 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: lipid carrier activity [GO:0005319] (molecular_function) —provides input for→ 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: lipid carrier activity [GO:0005319] (molecular_function) —has target start location→ mitochondrial outer membrane [GO:0005741] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: glycerol-3-phosphate O-acyltransferase activity [GO:0004366] (molecular_function) —provides input for→ lipid carrier activity [GO:0005319] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: lipid carrier activity [GO:0005319] (molecular_function) —has target end location→ endoplasmic reticulum membrane [GO:0005789] (anatomical entity)
6446bfcb00000031	Triglyceride biosynthetic process 3 (Mouse)	2023-04-26	David Hill	success
5fce9b7300000434	BMP2-MAPK signaling mouse	2023-03-16	David Hill	success		6 warnings SKIPPED_FACT: 'MAP kinase kinase activity [GO:0004708] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'osteoblast differentiation [GO:0001649] (biological_process)' SKIPPED_FACT: 'MAP kinase kinase kinase kinase activity [GO:0008349] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'osteoblast differentiation [GO:0001649] (biological_process)' SKIPPED_FACT: 'MAP kinase activity [GO:0004707] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'MAPK cascade [GO:0000165] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: MAP kinase kinase kinase kinase activity [GO:0008349] (molecular_function) —directly positively regulates→ MAP kinase kinase activity [GO:0004708] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: MAP kinase kinase activity [GO:0004708] (molecular_function) —directly positively regulates→ MAP kinase activity [GO:0004707] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: MAP kinase kinase activity [GO:0004708] (molecular_function) —part of→ MAPK cascade [GO:0000165] (biological_process)
5fce9b7300000367	BMP2-SMAD signaling mouse	2023-03-16	David Hill	filtered	Model has at least one activity with no causal relations	8 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target end location→ nucleus [GO:0005634] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: cytosol [GO:0005829] (anatomical entity) —part of→ mesenchymal cell [CL:0008019] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein binding [GO:0005515] (molecular_function) —directly positively regulates→ transporter activity [GO:0005215] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —directly positively regulates→ DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —part of→ protein import into nucleus [GO:0006606] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: BMP signaling pathway [GO:0030509] (biological_process) —negatively regulates→ muscle cell differentiation [GO:0042692] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —transports or maintains localization of→ Smad1 Mmus [MGI:MGI:109452] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: transporter activity [GO:0005215] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity)
623d156d00000699	Glycogen catabolic process 1 (Mouse)	2023-03-16	David Hill	success
623d156d00000752	Glycogen catabolic process 2 (Mouse)	2023-03-16	David Hill	success
623d156d00000939	Glycogen catabolic process 3 (Mouse)	2023-03-16	David Hill	success
627d95ee00000275	Heparan sulfate proteoglycan catabolic process (Mouse)	2023-03-16	David Hill	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: protein localization to lysosome [GO:0061462] (biological_process) —causally upstream of positive effect→ heparan sulfate proteoglycan catabolic process [GO:0030200] (biological_process)
6246724f00001700	Hyaluronan catabolic process (Mouse)	2023-03-16	David Hill	success		6 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: endosome to lysosome transport [GO:0008333] (biological_process) —causally upstream of positive effect→ hyalurononglucosaminidase activity [GO:0004415] (molecular_function) SKIPPED_FACT: 'cargo receptor activity [GO:0038024] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'receptor-mediated endocytosis [GO:0006898] (biological_process)' SKIPPED_FACT: 'cargo receptor activity [GO:0038024] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'hyaluronan catabolic process [GO:0030214] (biological_process)' SKIPPED_FACT: 'cargo receptor activity [GO:0038024] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'receptor-mediated endocytosis [GO:0006898] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: hyalurononglucosaminidase activity [GO:0004415] (molecular_function) —causally upstream of positive effect→ endosome to lysosome transport [GO:0008333] (biological_process) SKIPPED_FACT: 'cargo receptor activity [GO:0038024] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'hyaluronan catabolic process [GO:0030214] (biological_process)'
5ce58dde00001327	mouse Dixdc1-Wnt signaling	2023-03-16	David Hill	success
5745387b00001516	Canonical glycolysis 1 (Mouse)	2023-03-15	David Hill, Sharan Prakash	success
633b013300001238	Pyruvate catabolic process 1 (Mouse)	2023-02-21	David Hill	success		2 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: lactate transmembrane transporter activity [GO:0015129] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: lactate transmembrane transporter activity [GO:0015129] (molecular_function) —has target end location→ extracellular region [GO:0005576] (anatomical entity)
636d9ce800001945	Negative regulation of glycolytic process through fructose-6-phosphate 1 (Mouse)	2022-12-21	David Hill	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of glycolytic process through fructose-6-phosphate [GO:1904539] (biological_process) —negatively regulates→ glycolytic process through fructose-6-phosphate [GO:0061615] (biological_process)
639bc18f00000430	Negative regulation of glycolytic process through fructose-6-phosphate 2 (Mouse)	2022-12-21	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of glycolytic process [GO:0045820] (biological_process) —negatively regulates→ glycolytic process through fructose-6-phosphate [GO:0061615] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of glycolytic process [GO:0045820] (biological_process) —occurs in→ liver [EMAPA:16846] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: glycolytic process through fructose-6-phosphate [GO:0061615] (biological_process) —occurs in→ liver [EMAPA:16846] (anatomical entity)
63894f2500002043	Positive regulation of glycolytic process 1 (Mouse)	2022-12-21	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of glycolytic process [GO:0045821] (biological_process) —positively regulates→ glycolytic process through fructose-6-phosphate [GO:0061615] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of glycolytic process [GO:0045821] (biological_process) —occurs in→ liver [EMAPA:16846] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: glycolytic process through fructose-6-phosphate [GO:0061615] (biological_process) —occurs in→ liver [EMAPA:16846] (anatomical entity)
63894f2500000385	Negative regulation of glycolysis 1 (Mouse)	2022-12-12	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: glycolytic process through fructose-6-phosphate [GO:0061615] (biological_process) —occurs in→ liver [EMAPA:16846] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of glycolytic process through fructose-6-phosphate [GO:1904539] (biological_process) —negatively regulates→ glycolytic process through fructose-6-phosphate [GO:0061615] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: negative regulation of glycolytic process through fructose-6-phosphate [GO:1904539] (biological_process) —occurs in→ liver [EMAPA:16846] (anatomical entity)
636d9ce800002041	Positive regulation of gluconeogenesis 1 (Mouse)	2022-12-07	David Hill	success		1 warning UNHANDLED_FACT: Fact not representable in GO-CAM model: positive regulation of gluconeogenesis [GO:0045722] (biological_process) —positively regulates→ gluconeogenesis [GO:0006094] (biological_process)
635b1e3e00000382	Xylulose-5-Phosphate biosynthetic process 1 (Mouse)	2022-11-30	David Hill	success
636d9ce800000147	Cellular response to glucagon stimulus (Mouse)	2022-11-21	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: cellular response to glucagon stimulus [GO:0071377] (biological_process) —positively regulates→ gluconeogenesis [GO:0006094] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: cellular response to glucagon stimulus [GO:0071377] (biological_process) —positively regulates→ glycogen catabolic process [GO:0005980] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: cellular response to glucagon stimulus [GO:0071377] (biological_process) —occurs in→ hepatocyte [CL:0000182] (anatomical entity)
62d0afa500000298	Gluconeogenesis 3 (Mouse)	2022-11-11	David Hill	success
635b1e3e00000228	Autoactivation of Mouse Trypsinogens	2022-10-31	Karen Christie	filtered	Model has at least one activity with no causal relations
635b1e3e00000304	trypsinogen T7 activation	2022-10-31	Karen Christie	success
6348a65d00002622	Ascorbic acid biosynthetic process 1 (Mouse)	2022-10-28	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: biosynthetic process [GO:0009058] (biological_process) —occurs in→ liver [EMAPA:16846] (anatomical entity) SKIPPED_FACT: Subject 'biosynthetic process [GO:0009058] (biological_process)' has 'has primary output' relationship to 'L-ascorbate [CHEBI:38290] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: biosynthetic process [GO:0009058] (biological_process) —has primary output→ L-ascorbate [CHEBI:38290] (chemical entity)
6348a65d00002993	Ascorbic acid biosynthetic process 2 (Mouse)	2022-10-28	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: biosynthetic process [GO:0009058] (biological_process) —occurs in→ liver [EMAPA:16846] (anatomical entity) SKIPPED_FACT: Subject 'biosynthetic process [GO:0009058] (biological_process)' has 'has primary output' relationship to 'L-ascorbate [CHEBI:38290] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: biosynthetic process [GO:0009058] (biological_process) —has primary output→ L-ascorbate [CHEBI:38290] (chemical entity)
61e0e55600001225	Gluconeogenesis 1 (Mouse)	2022-10-25	David Hill	success
62f58d8800001500	Insulin processing 1 (Mouse)	2022-09-27	David Hill	filtered	Model has at least one activity with no causal relations	7 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: zinc ion transmembrane transporter activity [GO:0005385] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Golgi to secretory granule transport [GO:0055107] (biological_process) —causally upstream of positive effect→ serine-type endopeptidase activity [GO:0004252] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: zinc ion binding [GO:0008270] (molecular_function) —causally upstream of positive effect→ Golgi to secretory granule transport [GO:0055107] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888] (biological_process) —causally upstream of positive effect→ zinc ion binding [GO:0008270] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: insulin processing [GO:0030070] (biological_process) —occurs in→ type B pancreatic cell [CL:0000169] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein-disulfide reductase activity [GO:0015035] (molecular_function) —causally upstream of positive effect→ endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: zinc ion transmembrane transporter activity [GO:0005385] (molecular_function) —has target end location→ secretory granule [GO:0030141] (anatomical entity)
60ad85f700003015	'de novo' GMP biosynthetic process (Mouse)	2022-09-19	David Hill	success
60ad85f700002947	'de novo' IMP biosynthetic process (Mouse)	2022-09-19	David Hill	success
60897d8500000531	AMP salvage (Mouse)	2022-09-19	David Hill	filtered	Model has at least one activity with no causal relations	2 warnings SKIPPED_FACT: Subject 'AMP salvage [GO:0044209] (biological_process)' has 'has primary output' relationship to 'adenosine 5'-monophosphate [CHEBI:16027] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: AMP salvage [GO:0044209] (biological_process) —has primary output→ adenosine 5'-monophosphate [CHEBI:16027] (chemical entity)
622aace900000443	Fructose catabolic process (Mouse)	2022-09-12	David Hill, Harold Drabkin	success
62f58d8800002020	Negative regulation of insulin secretion 1 (Mouse)	2022-09-07	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: inward rectifier potassium channel activity [GO:0005242] (molecular_function) —directly negatively regulates→ voltage-gated calcium channel activity [GO:0005245] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: voltage-gated calcium channel activity [GO:0005245] (molecular_function) —occurs in→ plasma membrane [GO:0005886] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: voltage-gated calcium channel activity [GO:0005245] (molecular_function) —part of→ negative regulation of insulin secretion [GO:0046676] (biological_process)
62d0afa500000132	Gluconeogenesis 2 (Mouse)	2022-08-29	David Hill	success		4 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: tricarboxylic acid transmembrane transporter activity [GO:0015142] (molecular_function) —provides input for→ phosphopyruvate hydratase activity [GO:0004634] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: tricarboxylic acid transmembrane transporter activity [GO:0015142] (molecular_function) —part of→ gluconeogenesis [GO:0006094] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: phosphoenolpyruvate carboxykinase (GTP) activity [GO:0004613] (molecular_function) —provides input for→ tricarboxylic acid transmembrane transporter activity [GO:0015142] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: tricarboxylic acid transmembrane transporter activity [GO:0015142] (molecular_function) —occurs in→ mitochondrial membrane [GO:0031966] (anatomical entity)
62d0afa500000472	Insulin receptor signalling pathway 3 (Mouse)	2022-07-20	David Hill	success
62b4ffe300006474	B cell receptor signaling pathway 1 (Mouse)	2022-07-14	David Hill	filtered	Model has at least one activity with no causal relations	7 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: protein tyrosine kinase activity [GO:0004713] (molecular_function) —directly positively regulates→ protein tyrosine kinase activity [GO:0004713] (molecular_function) SKIPPED_FACT: Subject 'protein tyrosine kinase activity [GO:0004713] (molecular_function)' has 'has input' relationship to 'Cd79a Mmus [MGI:MGI:101774] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: protein tyrosine kinase activity [GO:0004713] (molecular_function) —has input→ Cd79b Mmus [MGI:MGI:96431] (information biomacromolecule) UNHANDLED_FACT: Fact not representable in GO-CAM model: protein tyrosine kinase activity [GO:0004713] (molecular_function) —part of→ B cell receptor signaling pathway [GO:0050853] (biological_process) UNHANDLED_FACT: Fact not representable in GO-CAM model: transmembrane signaling receptor activity [GO:0004888] (molecular_function) —directly positively regulates→ protein tyrosine kinase activity [GO:0004713] (molecular_function) SKIPPED_FACT: Subject 'protein tyrosine kinase activity [GO:0004713] (molecular_function)' has 'has input' relationship to 'Cd79b Mmus [MGI:MGI:96431] (information biomacromolecule)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: protein tyrosine kinase activity [GO:0004713] (molecular_function) —has input→ Cd79a Mmus [MGI:MGI:101774] (information biomacromolecule)
62b4ffe300003222	Oligosaccharide biosynthetic process, ABO blood group B-like antigen 2 (Mouse)	2022-07-05	David Hill	success
62b4ffe300003210	Oligosaccharide biosynthetic process, ABO blood group A-like antigen 2 (Mouse)	2022-07-05	David Hill	success
6246724f00001645	hyaluronan biosynthetic process (Mouse)	2022-05-16	David Hill	success
627d95ee00000044	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process (Mouse)	2022-05-13	David Hill	success		5 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964] (molecular_function) —has target end location→ Golgi lumen [GO:0005796] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: sulfate transmembrane transporter activity [GO:0015116] (molecular_function) —has target end location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964] (molecular_function) —has target start location→ cytosol [GO:0005829] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: sulfate transmembrane transporter activity [GO:0015116] (molecular_function) —has target start location→ extracellular region [GO:0005576] (anatomical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: Golgi lumen [GO:0005796] (anatomical entity) —part of→ Golgi apparatus [GO:0005794] (anatomical entity)
626b20c100000185	Glycosaminoglycan biosynthetic process, linker formation (Mouse)	2022-05-11	David Hill	success
5b318d0900000302	IRE1-mediated unfolded protein response (Mouse)	2022-04-19	David Hill, Kimberly Van Auken, Marie-Claire Harrison	filtered	Model has at least one activity with no causal relations
622aace900001389	Pentose-phosphate shunt 2 (Mouse)	2022-03-30	David Hill	success
622aace900001416	5-phosphoribose 1-diphosphate biosynthetic process (Mouse)	2022-03-25	David Hill	success
61b2b68300000156	signaling receptor ligand precursor processing 1 (Mouse)	2021-12-10	David Hill	success
60897d8500000524	GMP salvage 1 (Mouse)	2021-08-06	David Hill	success
5fa76ad400000265	dAMP catabolic process to allantoin (Mouse)	2021-07-28	David Hill	success		3 warnings UNHANDLED_FACT: Fact not representable in GO-CAM model: dAMP catabolic process [GO:0046059] (biological_process) —has primary output→ allantoin [CHEBI:15676] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: dAMP catabolic process [GO:0046059] (biological_process) —ends with→ 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity [GO:0051997] (molecular_function) SKIPPED_FACT: Subject 'dAMP catabolic process [GO:0046059] (biological_process)' has 'has primary output' relationship to 'allantoin [CHEBI:15676] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association
5fa76ad400000018	AMP catabolic process 2 (Mouse)	2021-07-27	David Hill	success		6 warnings SKIPPED_FACT: '5'-nucleotidase activity [GO:0008253] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'AMP catabolic process [GO:0006196] (biological_process)' SKIPPED_FACT: 'AMP deaminase activity [GO:0003876] (molecular_function)' already has 'part of' relationship; ignoring 'part of' relationship to 'ADP catabolic process [GO:0046032] (biological_process)' UNHANDLED_FACT: Fact not representable in GO-CAM model: 5'-nucleotidase activity [GO:0008253] (molecular_function) —provides input for→ G protein-coupled adenosine receptor activity [GO:0001609] (molecular_function) UNHANDLED_FACT: Fact not representable in GO-CAM model: purine nucleoside transmembrane transporter activity [GO:0015211] (molecular_function) —transports or maintains localization of→ adenosine 5'-monophosphate(2-) [CHEBI:456215] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: purine nucleoside transmembrane transporter activity [GO:0015211] (molecular_function) —transports or maintains localization of→ adenosine [CHEBI:16335] (chemical entity) UNHANDLED_FACT: Fact not representable in GO-CAM model: G protein-coupled adenosine receptor activity [GO:0001609] (molecular_function) —part of→ G protein-coupled adenosine receptor signaling pathway [GO:0001973] (biological_process)
60897d8500000494	IMP salvage (Mouse)	2021-07-27	David Hill	filtered	Model has at least one activity with no causal relations	2 warnings SKIPPED_FACT: Subject 'IMP salvage [GO:0032264] (biological_process)' has 'has primary output' relationship to 'IMP [CHEBI:17202] (chemical entity)', but that subject is not the molecular function of an activity unit; skipping molecular association UNHANDLED_FACT: Fact not representable in GO-CAM model: IMP salvage [GO:0032264] (biological_process) —has primary output→ IMP [CHEBI:17202] (chemical entity)
60e7989d00001485	Tetrahydrofolate interconversion 1a (Mouse)	2021-07-27	David Hill	success
60e7989d00000281	UDP biosynthetic process (Mouse)	2021-07-27	David Hill	success
60d5209a00000883	UMP salvage (Mouse)	2021-07-27	David Hill	success
5fadbcf000002164	NT5C3A substrates, human	2020-11-20	David Hill	filtered	Model has at least one activity with no causal relations

Release date: 2026-08-28
Pipeline name: pipeline-from-goa
Pipeline branch: main
Generated on: 2026-08-29T14:10:14+00:00
gocam-py version: 0.12.0.post65.dev0+8382d25a