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Deletion of HPT1 in \u003ci\u003eS. cerevisiae\u003c/i\u003e leads to de-repression of enzymes involved in the de novo pathway, resulting in constitutively active purine nucleotide biosynthesis. On the other hand, overexpression of feedback-insensitive mutant hpt1 in the presence of guanine leads to guanylic nucleotide overaccumulation and massive cell death. Notably, deficiency of HPRT activity in humans results in increased production of purine nucleotides and is also regarded as the cause of Lesch-Nyhan syndrome. References: |CITS:[17052198]||CITS: [15565584]||CITS: [10217799]||CITS: [12746440]||CITS: [9335580]||CITS: [18245832]||CITS: [18067674]|"}]},{"id":"gomodel:YeastPathways_PWY3O-743/6a7e360900001571","type":[{"type":"class","id":"ECO:0000245","label":"automatically integrated combinatorial evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2026-08-25"},{"key":"with","value":"SGD_PWY:PWY3O-743"},{"key":"source","value":"GO_REF:0000123"},{"key":"contributor","value":"https://orcid.org/0000-0001-5472-917X"},{"key":"providedBy","value":"http://www.yeastgenome.org"}]},{"id":"gomodel:ev_w_id_GUANINE-DEAMINASE-RXN_BFO_0000050_YeastPathways_PWY3O-743/YeastPathways_PWY3O-743_SGD_PWY_YeastPathways_PWY3O-743","type":[{"type":"class","id":"ECO:0000245","label":"automatically integrated combinatorial evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"with","value":"SGD_PWY:PWY3O-743"},{"key":"source","value":"GO_REF:0000123"},{"key":"date","value":"2023-09-14"},{"key":"providedBy","value":"http://www.yeastgenome.org"},{"key":"contributor","value":"GOC:sgd_curators"}]},{"id":"gomodel:ev_w_id_GUANPRIBOSYLTRAN-RXN_BFO_0000050_YeastPathways_PWY3O-743/YeastPathways_PWY3O-743_SGD_PWY_YeastPathways_PWY3O-743","type":[{"type":"class","id":"ECO:0000245","label":"automatically integrated combinatorial evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"http://www.yeastgenome.org"},{"key":"contributor","value":"GOC:sgd_curators"},{"key":"date","value":"2023-09-14"},{"key":"with","value":"SGD_PWY:PWY3O-743"},{"key":"source","value":"GO_REF:0000123"}]},{"id":"gomodel:ev_w_id_XANPRIBOSYLTRAN-RXN_BFO_0000050_YeastPathways_PWY3O-743/YeastPathways_PWY3O-743_SGD_PWY_YeastPathways_PWY3O-743","type":[{"type":"class","id":"ECO:0000245","label":"automatically integrated combinatorial evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"http://www.yeastgenome.org"},{"key":"source","value":"GO_REF:0000123"},{"key":"contributor","value":"GOC:sgd_curators"},{"key":"with","value":"SGD_PWY:PWY3O-743"},{"key":"date","value":"2023-09-14"}]}],"facts":[{"subject":"gomodel:GUANINE-DEAMINASE-RXN","property":"RO:0002233","property-label":"RO:0002233","object":"gomodel:CHEBI_16235_GUANINE-DEAMINASE-RXN","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_GUANINE-DEAMINASE-RXN_RO_0002233_CHEBI_16235_GUANINE-DEAMINASE-RXN_SGD_PWY_YeastPathways_PWY3O-743","value-type":"IRI"},{"key":"contributor","value":"GOC:sgd_curators"},{"key":"date","value":"2023-09-14"},{"key":"providedBy","value":"http://www.yeastgenome.org"},{"key":"comment","value":"Imported from Saccharomyces Genome Database: https://pathway.yeastgenome.org/YEAST/NEW-IMAGE?object\u003dPWY3O-743"}]},{"subject":"gomodel:GUANINE-DEAMINASE-RXN","property":"BFO:0000066","property-label":"BFO:0000066","object":"gomodel:reaction_GUANINE-DEAMINASE-RXN_location_lociGO_0005829","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_GUANINE-DEAMINASE-RXN_BFO_0000066_reaction_GUANINE-DEAMINASE-RXN_location_lociGO_0005829_SGD_PWY_YeastPathways_PWY3O-743","value-type":"IRI"},{"key":"contributor","value":"GOC:sgd_curators"},{"key":"date","value":"2023-09-14"},{"key":"providedBy","value":"http://www.yeastgenome.org"},{"key":"comment","value":"Imported from Saccharomyces Genome Database: https://pathway.yeastgenome.org/YEAST/NEW-IMAGE?object\u003dPWY3O-743"},{"key":"comment","value":"Occurs In Rule. 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