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ced5 mutants exhibit synaptic vesicle clustering defects in AIY interneurons (assessed using confocal microscopy imaging of wild type and mutant worms expressing RAB3-GFP). CED5 effect on SV clustering depends on UNC-40 localisation. CED5 acts through the GTPase CED10 and, in turn, through MIG10. Like ced5 mutants, both ced10 (Figs 3H, I and N) and mig10 mutants (Figs 4C, E and F) also display SV clustering defects that may occur via organisation of presynaptic actin. Neither ced5 nor mig10 mutants affect localisation of active zone proteins SYD1 and SYD2.. Experimental description: Materials and Methods \"Worms were raised on NGM plates at 20°C using OP50 Escherichia coli as a food source.\""},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_6239"}]}