{"id":"gomodel:SYNGO_5582","individuals":[{"id":"gomodel:SYNGO_558218b8bae1-53d0-4f71-992d-465708cc494b","type":[{"type":"class","id":"UniProtKB:Q9Y4G6","label":"TLN2 Hsap"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-4973-5732"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_55824f986f7e-196d-4128-b5c4-42e77836a460","type":[{"type":"class","id":"ECO:0000314","label":"direct assay evidence used in manual 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assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-4973-5732"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"source","value":"PMID:15479735"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_558270999778-ca0e-49b7-a6b7-ba334e0df4e8","type":[{"type":"class","id":"ECO:0000314","label":"direct assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-4973-5732"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"source","value":"PMID:15479735"}]},{"id":"gomodel:SYNGO_5582c1334e54-d5f9-4b86-991e-2c94d5744fdf","type":[{"type":"class","id":"ECO:0006063","label":"over expression analysis evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-4973-5732"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"source","value":"PMID:15479735"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"}]},{"id":"gomodel:SYNGO_5582c4512829-27bb-4f1b-af73-f54af17ca81d","type":[{"type":"class","id":"GO:0099140","label":"presynaptic actin cytoskeleton organization"}],"root-type":[{"type":"class","id":"GO:0008150","label":"biological_process"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-4973-5732"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_5582f5756048-491d-4cf6-8afa-1be9161b8c24","type":[{"type":"class","id":"GO:0003674","label":"molecular_function"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0002-4973-5732"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"date","value":"2024-03-06"}]}],"facts":[{"subject":"gomodel:SYNGO_5582f5756048-491d-4cf6-8afa-1be9161b8c24","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:SYNGO_5582c4512829-27bb-4f1b-af73-f54af17ca81d","annotations":[{"key":"evidence","value":"gomodel:SYNGO_55824f986f7e-196d-4128-b5c4-42e77836a460","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_5582c1334e54-d5f9-4b86-991e-2c94d5744fdf","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0002-4973-5732"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"subject":"gomodel:SYNGO_5582f5756048-491d-4cf6-8afa-1be9161b8c24","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_558218b8bae1-53d0-4f71-992d-465708cc494b","annotations":[{"key":"evidence","value":"gomodel:SYNGO_558255cafeac-8a76-469f-80f7-90a05ca2adf8","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_558270999778-ca0e-49b7-a6b7-ba334e0df4e8","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0002-4973-5732"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0002-4973-5732"},{"key":"date","value":"2023-11-28"},{"key":"title","value":"SYNGO_BP_5582"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: Figure 2: Talin-2 interacts with PIPK (phosphatidylinositol-(4)-phosphate 5-kinase type Iγ).\n\nFigure 3: Microinjection of PIPK pep disrupts the actin cytoskeleton at synapses.\n\nFigure 5: over-expression of human talin 2 head (aa 1-438, GST fusion protein) at lamprey synapses causes ultrastructural changes. (analogous data in Figure 4 for PIPK)\n\nAuthors conclude:\n\"the interaction of PIP kinase with talin in presynaptic compartments provides a mechanism to coordinate PI(4,5)P2 synthesis, actin dynamics, and endocytosis, and further supports a functional link between actin and clathrin-mediated endocytosis.\". Experimental description: evidence is shown for both Human and Lamprey Talin-2, we annotated the former;\n\"Human PIPKIγ tail (aa 635-662) and human talin 2 head (aa 1-438) were expressed as GST fusion proteins and purified using a standard protocol\""},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}]}