{"id":"gomodel:SYNGO_537","individuals":[{"id":"gomodel:SYNGO_53724785086-b9f4-4df4-a1d8-3d9dede6f0f5","type":[{"type":"class","id":"ECO:0007695","label":"cell-based assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"source","value":"PMID:26187311"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_5374c614843-2106-44d8-85a6-bf00f8400f12","type":[{"type":"class","id":"RGD:3629","label":"Scn10a Rnor"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_5378310fc00-0a06-4297-8066-54117b932d5d","type":[{"type":"class","id":"ECO:0000303","label":"author statement without traceable support used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"PMID:26187311"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_5378f389ac9-04af-4720-8ee3-8428874299b4","type":[{"type":"class","id":"ECO:0006063","label":"over expression analysis evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"source","value":"PMID:26187311"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_537b5dd503a-6d26-47f7-8712-5be44bba070c","type":[{"type":"class","id":"ECO:0006013","label":"patch-clamp recording evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"source","value":"PMID:26187311"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_537e645de47-c3de-47e2-aef0-c26c809ee117","type":[{"type":"class","id":"GO:0099508","label":"voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]}],"facts":[{"subject":"gomodel:SYNGO_537e645de47-c3de-47e2-aef0-c26c809ee117","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_5374c614843-2106-44d8-85a6-bf00f8400f12","annotations":[{"key":"evidence","value":"gomodel:SYNGO_53724785086-b9f4-4df4-a1d8-3d9dede6f0f5","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_5378310fc00-0a06-4297-8066-54117b932d5d","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_5378f389ac9-04af-4720-8ee3-8428874299b4","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_537b5dd503a-6d26-47f7-8712-5be44bba070c","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2018-06-29"},{"key":"title","value":"SYNGO_MF_537"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: This publication shows that Nav1.8 is a sodium (ion) channel.\n\nrule: NAS_MFCC-BP\nrationale:\nProtein has voltage-gated ion channel activity and is localized in teh presynaptic membrane (show with high-resolution technique). The inference to term \u0027voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508)\u0027 is trivial and non-controversial.\nPinf_CC:\n[Q62968] SyNGO ID 535 (PMID:19162133, EM). Experimental description: p.396: We used two cell lines stably expressing Nav1.7 or Nav1.8 (Theriault et al., 2014) to study the effect of fluoxetine, paroxetine, and citalopram on two peripheral Naþ channels. Briefly, the cell lines were generated using the calcium phosphate method. HEK293 cells were transfected with a pIRESneo3/Nav vector. -- Highlighted 10 May 2017\n\n15/5/2017 Pim\n- species of Nav channels is not listed in the Theriault et al., 2014 paper. In this paper the channel properties of Nav channeld in rat DRG neurons are compared to heterologously expressed channels in HEKcells. Logic dictates that these channels are also of rat species to allow for meaningfull comparison of channel properties."},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_10116"}]}