{"id":"gomodel:SYNGO_5026","individuals":[{"id":"gomodel:SYNGO_5026447966e9-d402-4d06-bbc0-ac26d7dabc9d","type":[{"type":"class","id":"GO:0003674","label":"molecular_function"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0002-4973-5732"}]},{"id":"gomodel:SYNGO_50266d2cead9-b29d-4879-84d8-f99f15dfd94c","type":[{"type":"class","id":"GO:0090128","label":"regulation of synapse maturation"}],"root-type":[{"type":"class","id":"GO:0008150","label":"biological_process"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-4973-5732"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"}]},{"id":"gomodel:SYNGO_5026847e1deb-44de-4bcc-a46c-9b2a791c54a1","type":[{"type":"class","id":"ECO:0006003","label":"electron microscopy evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0002-4973-5732"},{"key":"source","value":"PMID:27624722"}]},{"id":"gomodel:SYNGO_50269400a202-64f7-4242-93c9-562c308f9c5d","type":[{"type":"class","id":"ECO:0006003","label":"electron microscopy evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-4973-5732"},{"key":"source","value":"PMID:27624722"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_5026c7b34f4e-149d-4182-9594-e3f1771da075","type":[{"type":"class","id":"ECO:0001225","label":"knockout evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"source","value":"PMID:27624722"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"contributor","value":"https://orcid.org/0000-0002-4973-5732"}]},{"id":"gomodel:SYNGO_5026ea77882c-2bff-4a20-a719-aa4bf5b6027f","type":[{"type":"class","id":"ECO:0001225","label":"knockout evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-4973-5732"},{"key":"source","value":"PMID:27624722"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"}]},{"id":"gomodel:SYNGO_5026f09153a2-9366-4b97-8d5b-6fba7d28466d","type":[{"type":"class","id":"MGI:MGI:108554","label":"Dab1 Mmus"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-4973-5732"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"}]}],"facts":[{"subject":"gomodel:SYNGO_5026447966e9-d402-4d06-bbc0-ac26d7dabc9d","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:SYNGO_50266d2cead9-b29d-4879-84d8-f99f15dfd94c","annotations":[{"key":"evidence","value":"gomodel:SYNGO_50269400a202-64f7-4242-93c9-562c308f9c5d","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_5026ea77882c-2bff-4a20-a719-aa4bf5b6027f","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0002-4973-5732"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"subject":"gomodel:SYNGO_5026447966e9-d402-4d06-bbc0-ac26d7dabc9d","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_5026f09153a2-9366-4b97-8d5b-6fba7d28466d","annotations":[{"key":"evidence","value":"gomodel:SYNGO_5026847e1deb-44de-4bcc-a46c-9b2a791c54a1","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_5026c7b34f4e-149d-4182-9594-e3f1771da075","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0002-4973-5732"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0002-4973-5732"},{"key":"date","value":"2023-02-18"},{"key":"title","value":"SYNGO_BP_5026"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: Figures 2-4: 3D structures of spines of 8-week-old WT, Reelin-OE (overexpressing) and Dab1-cKO GFP/DAB-labeled granule cells were reconstructed with FIB/SEM microscopy. Reelin and Dab1 both altered newborn granule cells dendritic spine morphology.\n\nAuthors conclude from these analyses that \"This proves that spines are more irregularly shaped in 8-9 weeks Reelin-OE and Dab1-cKO neurons, and suggests that spine structural maturation is affected by the Reelin signaling. Synapse sphericity was smaller in Reelin-OE mice at 8-9 weeks, indicating greater complexity (Fig.4d).\". Experimental description: M\u0026M: \"Conditional knockout Dab1 mice (Dab1-cKO) (Pramatarova et al. 2008) and Reelin-overexpressing (Reelin-OE, gamma strain) (Pujadas et al. 2010) mice were maintained on a C57BL/6 J background. \""},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_10090"}]}