{"id":"gomodel:SYNGO_4578","individuals":[{"id":"gomodel:SYNGO_45782eec2216-9419-4ed2-ac5c-17fbfd2031f3","type":[{"type":"class","id":"ECO:0006003","label":"electron microscopy evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"source","value":"PMID:33913808"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_45784c0131b0-6ced-40ca-b662-2802ad6b0283","type":[{"type":"class","id":"GO:0003674","label":"molecular_function"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular 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assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"PMID:33913808"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_4578d7520880-be2a-4df1-b35b-7dc72f5afc8b","type":[{"type":"class","id":"MGI:MGI:2443804","label":"Kctd8 Mmus"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"}]},{"id":"gomodel:SYNGO_4578e105ce84-5a65-447a-9969-51605424a121","type":[{"type":"class","id":"ECO:0006003","label":"electron microscopy evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"source","value":"PMID:33913808"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"facts":[{"subject":"gomodel:SYNGO_45784c0131b0-6ced-40ca-b662-2802ad6b0283","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_4578d7520880-be2a-4df1-b35b-7dc72f5afc8b","annotations":[{"key":"evidence","value":"gomodel:SYNGO_45782eec2216-9419-4ed2-ac5c-17fbfd2031f3","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_4578a78947ff-56d3-4e7e-aa4f-3c70fefaee40","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"subject":"gomodel:SYNGO_45784c0131b0-6ced-40ca-b662-2802ad6b0283","property":"BFO:0000066","property-label":"BFO:0000066","object":"gomodel:SYNGO_457852ebe5f4-e0ec-421e-b4bb-18979b3f8a96","annotations":[{"key":"evidence","value":"gomodel:SYNGO_45788fd0e46e-35c5-40a1-ab37-de61bf8cccf9","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_4578e105ce84-5a65-447a-9969-51605424a121","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0002-2286-1587"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2023-01-30"},{"key":"title","value":"SYNGO_CC_4578"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: - K+-channel tetramerization domain-containing proteins (KCTDs) are auxiliary GABAB receptor (GBR) subunits.\n- Experiments were performed at the synaptic connection from medial habenula (MHb) to interpeduncular nucleus (IPN).\n-Using pre-embedding immunogold labelling, imaged with TEM, KCTD8 showed some localization at the active zone membrane whereas the majority was localized at the presynaptic plasma membrane at more than 50nm from active zone (Fig. 3c).\n- sparse labeling of postsynapse (Fig. 3c).. Experimental description: Wild-type C57BL/6J mice(Jax, Bar Harbor, ME; #000664) purchased from Jackson Laboratory.\nBTB/POZ domain-containing protein KCTD8.\nAntibody: rabbit anti-KCTD8 (1 ug/ul, Bettler lab, Univ. Basel)"},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_10090"}]}