{"id":"gomodel:SYNGO_3941","individuals":[{"id":"gomodel:SYNGO_394101210df7-702b-4ca3-b0cd-2cb8fa991eca","type":[{"type":"class","id":"GO:0003674","label":"molecular_function"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-7806-5662"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_39411354704c-a6ac-4d1d-866d-5edab4453877","type":[{"type":"class","id":"ECO:0006003","label":"electron microscopy evidence used in manual 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endocytosis"}],"root-type":[{"type":"class","id":"GO:0008150","label":"biological_process"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-7806-5662"}]},{"id":"gomodel:SYNGO_39417f389760-9ace-42a8-b966-1233f39c05e2","type":[{"type":"class","id":"ECO:0000303","label":"author statement without traceable support used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"source","value":"PMID:11102472"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-7806-5662"}]},{"id":"gomodel:SYNGO_394190cd7ed6-04ab-489b-83aa-d2cdc0d9ca57","type":[{"type":"class","id":"UniProtKB:P53680","label":"AP2S1 Hsap"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"},{"type":"class","id":"CHEBI:36080","label":"protein"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-7806-5662"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_3941bf97b31d-c0a0-47ab-9106-d02c62c766d7","type":[{"type":"class","id":"ECO:0006063","label":"over expression analysis evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"PMID:11102472"},{"key":"contributor","value":"https://orcid.org/0000-0001-7806-5662"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"date","value":"2024-03-06"}]}],"facts":[{"subject":"gomodel:SYNGO_394101210df7-702b-4ca3-b0cd-2cb8fa991eca","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_394190cd7ed6-04ab-489b-83aa-d2cdc0d9ca57","annotations":[{"key":"evidence","value":"gomodel:SYNGO_394132d3b9df-871b-4ada-a976-fe0ee8ef6428","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_39416ff124dc-46f7-47e6-b1ee-5aa5546bd658","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_3941bf97b31d-c0a0-47ab-9106-d02c62c766d7","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-7806-5662"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"subject":"gomodel:SYNGO_394101210df7-702b-4ca3-b0cd-2cb8fa991eca","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:SYNGO_394176c5d954-9cfc-4962-98f9-156ae0598d6b","annotations":[{"key":"evidence","value":"gomodel:SYNGO_39411354704c-a6ac-4d1d-866d-5edab4453877","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_39412707d0c2-5e4b-4ad8-8778-9063689152b8","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_39417f389760-9ace-42a8-b966-1233f39c05e2","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-7806-5662"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0001-7806-5662"},{"key":"date","value":"2018-10-04"},{"key":"title","value":"SYNGO_BP_3941"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: rule: NAS_CPLX_2\nrationale:\nThe AP2 clathrin adapter is generally accepted to be a heterotetramer with subunit composition (AP2A1 OR AP2A2), AP2M1, AP2B1, AP2S1. Note that two gene paralogs are known for the alpha subunit (AP2A). Using an dominant negative peptide of the AP2B1 subunit the AP2 complex is shown to be involved in \u0027synaptic vesicle endocytosis (GO:0048488)\u0027. Transfer of this annotation to the obligatory AP2M1 and AP2S1 subunitsis trivial based on the established protein composition of the AP2 complex.\nP_ref BP:\n[human AP2B1] SynGO ID 2739 (PMID:11102472, EM)\nP_inf CC:\n[AP2S1_MOUSE] SynGO ID 3937 (PMID:25211037, proteomics)\nComplex membership: AP2S1 protein is a fixed member of the AP2 clathrin adapter:\n- Shown in crystal structure (PMID:26960121, see Fig.1+2). Literal excerpt: \"AP2 is a large (300kDa) heterotetrameric complex comprising large α and β2 subunits, a medium μ2 subunit and a small σ2 subunit.\". Experimental description: 04/10/2018 Pim\nSpecies is Aplysia, but the human species assignment is transferred via the NAS mechanism."},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}]}