{"id":"gomodel:SYNGO_288","individuals":[{"id":"gomodel:SYNGO_2883ab4afa4-97a8-48b2-8f96-2b346020ebb6","type":[{"type":"class","id":"ECO:0006013","label":"patch-clamp recording evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"source","value":"PMID:10956667"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"}]},{"id":"gomodel:SYNGO_288918ea51a-f4d2-4203-bf67-5abccd9ff76c","type":[{"type":"class","id":"MGI:MGI:104781","label":"Kcnj6 Mmus"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_2889384f938-7b33-4c24-b4fd-db9dcf23187b","type":[{"type":"class","id":"GO:0099508","label":"voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"}]},{"id":"gomodel:SYNGO_288c6473493-9701-49d8-9594-4875df1e2397","type":[{"type":"class","id":"ECO:0000303","label":"author statement without traceable support used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"date","value":"2024-03-06"},{"key":"source","value":"PMID:10956667"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_288dd603fc7-2ee4-47d7-8303-e7e6ba05493c","type":[{"type":"class","id":"ECO:0007695","label":"cell-based assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"source","value":"PMID:10956667"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"}]},{"id":"gomodel:SYNGO_288e5d6c8d1-241f-4f7a-9355-22c3871d3ee4","type":[{"type":"class","id":"ECO:0006063","label":"over expression analysis evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"source","value":"PMID:10956667"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"facts":[{"subject":"gomodel:SYNGO_2889384f938-7b33-4c24-b4fd-db9dcf23187b","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_288918ea51a-f4d2-4203-bf67-5abccd9ff76c","annotations":[{"key":"evidence","value":"gomodel:SYNGO_2883ab4afa4-97a8-48b2-8f96-2b346020ebb6","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_288c6473493-9701-49d8-9594-4875df1e2397","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_288dd603fc7-2ee4-47d7-8303-e7e6ba05493c","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_288e5d6c8d1-241f-4f7a-9355-22c3871d3ee4","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2018-06-29"},{"key":"title","value":"SYNGO_MF_288"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: p.36213: FIG. 1. Inwardly rectifying channel currents are seen when GIRK2 and GIRK3 are co-expressed in CHO-K1 cells. CHO-K1 cells expressing GIRK2 and GIRK3 were analyzed by patch clamp in the inside-out configuration in symmetrical 140 mM K\n\nrule: NAS_MFCC-BP\nrationale:\nProtein has voltage-gated ion channel activity and is localized in teh presynaptic membrane (show with high-resolution technique). The inference to term \u0027voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508)\u0027 is trivial and non-controversial.\nPinf_CC:\n[P48542] SyNGO ID 285 (PMID:19558451, EM). Experimental description: Clone species not mentioned in MM: p.36211: CHO-K1 cells were transfected using TransIt.\n\n14/3/2017 Pim\n- Species of KCNJ6 construct traced back to PMID:8658170 where properties of mouse GIRK2 is compared to mutated GIRK2 in \u0027weaver\u0027 mice."},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_10090"}]}