{"id":"gomodel:SYNGO_287","individuals":[{"id":"gomodel:SYNGO_2872d60c2a8-5a1d-45c1-afe6-1695cce53948","type":[{"type":"class","id":"GO:0099508","label":"voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"}]},{"id":"gomodel:SYNGO_28730814cc4-2578-4cf4-981c-433ce00f53ce","type":[{"type":"class","id":"ECO:0006013","label":"patch-clamp recording evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"PMID:7576657"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_287481a91e6-5e4d-483f-8f36-59668e741744","type":[{"type":"class","id":"RGD:2958","label":"Kcnj3 Rnor"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_2874dcea4f4-c913-4a75-a642-252bf172ad18","type":[{"type":"class","id":"ECO:0000303","label":"author statement without traceable support used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"PMID:7576657"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_287b994a334-dfc7-43e7-8b47-87a7f0e1c038","type":[{"type":"class","id":"ECO:0007695","label":"cell-based assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"source","value":"PMID:7576657"}]},{"id":"gomodel:SYNGO_287f3b88f47-e3d5-4d05-8344-191dbbbfcd1b","type":[{"type":"class","id":"ECO:0006063","label":"over expression analysis evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"source","value":"PMID:7576657"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"}]}],"facts":[{"subject":"gomodel:SYNGO_2872d60c2a8-5a1d-45c1-afe6-1695cce53948","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_287481a91e6-5e4d-483f-8f36-59668e741744","annotations":[{"key":"evidence","value":"gomodel:SYNGO_28730814cc4-2578-4cf4-981c-433ce00f53ce","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_2874dcea4f4-c913-4a75-a642-252bf172ad18","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_287b994a334-dfc7-43e7-8b47-87a7f0e1c038","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_287f3b88f47-e3d5-4d05-8344-191dbbbfcd1b","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2018-06-29"},{"key":"title","value":"SYNGO_MF_287"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: p.1148: (A) Whole-cell currents recorded from oocytes injected with cRNA for m2 muscarinic receptor and GIRK1 with or without CIR ( 8 ng) -- Highlighted 08 Mar 2017.\n\nrule: NAS_MFCC-BP\nrationale:\nProtein has voltage-gated ion channel activity and is localized in teh presynaptic membrane (show with high-resolution technique). The inference to term \u0027voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508)\u0027 is trivial and non-controversial.\nPinf_CC:\n[P63250] SyNGO ID 284 (PMID:19558451, EM). Experimental description: Ref in MM p.1153: Mutant channelswere madeusing standardpolymerasechain reaction(PCR)andmolecularcloningtechniquesandwereverifiedby DNA sequencing. Based on the alignmentof GIRK1 and IRK1 (Kubo et al. 1993: vp.1155: ubo, Y., Baldwin, T.J., Jan, YN., and Jan, L.Y. (1993a). Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature 362, 127-133. -- Highlighted 08 Mar 2017\n\n14/3/2017 Pim\n- Species info traced back to PMID:8022483 that states \"Having cloned the **rat** muscarinic potassium channel, GRIK1, we used ...\""},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_10116"}]}