{"id":"gomodel:SYNGO_18","individuals":[{"id":"gomodel:SYNGO_1862b07c81-33e0-4818-9adc-493f697a26c9","type":[{"type":"class","id":"GO:0099508","label":"voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_18709a4d88-77a5-411f-88eb-947a2f26487d","type":[{"type":"class","id":"MGI:MGI:96661","label":"Kcna4 Mmus"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_18b1f92fde-409a-419a-a599-367853726e5a","type":[{"type":"class","id":"ECO:0001225","label":"knockout evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"source","value":"PMID:22615428"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_18befaa163-28ac-4151-a07a-c529bf427fc3","type":[{"type":"class","id":"ECO:0000303","label":"author statement without traceable support used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"source","value":"PMID:22615428"}]},{"id":"gomodel:SYNGO_18dd08b419-d082-48a5-ba9b-127107248baf","type":[{"type":"class","id":"ECO:0006013","label":"patch-clamp recording evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"source","value":"PMID:22615428"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"facts":[{"subject":"gomodel:SYNGO_1862b07c81-33e0-4818-9adc-493f697a26c9","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_18709a4d88-77a5-411f-88eb-947a2f26487d","annotations":[{"key":"evidence","value":"gomodel:SYNGO_18b1f92fde-409a-419a-a599-367853726e5a","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_18befaa163-28ac-4151-a07a-c529bf427fc3","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_18dd08b419-d082-48a5-ba9b-127107248baf","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2018-06-29"},{"key":"title","value":"SYNGO_MF_18"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: 14615029 (SynGO ID #13) fig 8G-J: Localisation in presynaptic terminal\n22615428 fig 6: in the presence of Ba2+, mean ± SEM firing rates were significantly (P \u003c 0.001) higher in Kv1.4-/- than in WT CP neurons\n\nBiochemical process is inferred from: localisation of the channel and its general function and effect on excitability. Evidence on excitability not from single synapses but from the whole neuron\n\nSpecs 22615428:\nSpecies: Adult (4- to 8-week-old) wild-type (WT) mice and mice harbouring targeted genetic disruption of the Kcna4 (Kv1.4-/- ) (London et al. 1998), Kcnd2 (Kv4.2-/- ) (Guo et al. 2005) or Kcnd3 (Kv4.3-/-) (Niwa et al. 2008) locus were used in the experiments here.\nProcess: in the presence of Ba2+, mean ± SEM firing rates were significantly (P \u003c 0.001) higher in Kv1.4-/- than in WT CP neurons.\n\nrule: NAS_MFCC-BP\nrationale:\nProtein has voltage-gated ion channel activity and is localized in teh presynaptic membrane (show with high-resulution technique). The inference to term \u0027voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508)\u0027 is trivial and non-controversial.\nPinf_CC:\n[Q61423] SyNGO ID 13 (PMID:22615428, EM). Experimental description: M\u0026M: \"Adult (4- to 8-week-old) wild-type (WT) mice and mice harbouring targeted genetic disruption of the **Kcna4 (Kv1.4-/- )** (London et al. 1998), Kcnd2 (Kv4.2-/- ) (Guo et al. 2005) or Kcnd3 (Kv4.3-/-) (Niwa et al. 2008) locus were used in the experiments here.\""},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_10090"}]}