{"id":"gomodel:SYNGO_172","individuals":[{"id":"gomodel:SYNGO_1721b87ffde-d41e-402c-b6aa-04ee7b7b7214","type":[{"type":"class","id":"ECO:0000303","label":"author statement without traceable support used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"source","value":"PMID:10482766"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_1722dcf0179-f6b4-48fd-9590-3e65672cd03a","type":[{"type":"class","id":"GO:0099508","label":"voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_1727266a164-9e38-4f99-add6-113a9ac0329d","type":[{"type":"class","id":"ECO:0007695","label":"cell-based assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"source","value":"PMID:10482766"}]},{"id":"gomodel:SYNGO_172a035e297-8e7e-41dc-b06d-87e464e4358b","type":[{"type":"class","id":"ECO:0006063","label":"over expression analysis evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"date","value":"2024-03-06"},{"key":"source","value":"PMID:10482766"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_172cb47ece3-1999-4c45-8f93-1b1c2063a61f","type":[{"type":"class","id":"ECO:0006013","label":"patch-clamp recording evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"source","value":"PMID:10482766"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_172eddd8839-ed1f-4e0c-af01-c10908307a05","type":[{"type":"class","id":"RGD:2955","label":"Kcnc1 Rnor"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"facts":[{"subject":"gomodel:SYNGO_1722dcf0179-f6b4-48fd-9590-3e65672cd03a","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_172eddd8839-ed1f-4e0c-af01-c10908307a05","annotations":[{"key":"evidence","value":"gomodel:SYNGO_1721b87ffde-d41e-402c-b6aa-04ee7b7b7214","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1727266a164-9e38-4f99-add6-113a9ac0329d","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_172a035e297-8e7e-41dc-b06d-87e464e4358b","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_172cb47ece3-1999-4c45-8f93-1b1c2063a61f","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2018-06-29"},{"key":"title","value":"SYNGO_MF_172"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: Ion channel function is shown by expressing channels in CHO cells.\n\nrule: NAS_MFCC-BP\nrationale:\nProtein has voltage-gated ion channel activity and is localized in teh presynaptic membrane (show with high-resolution technique). The inference to term \u0027voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508)\u0027 is trivial and non-controversial.\nPinf_CC:\n[P25122] SyNGO ID 15 (PMID:20857303, EM). Experimental description: Study is done with channels expressed in Chinese hamster ovary (CHO) cells. All antibody studies in this paper are on rat. I assume that they use therefore the rat-gene to express in the CHO\u0027s. See MM p.1513: The peptides correspond to a sequence present in the constant region of the rat and mouse Kv3.2 proteins, respectively (residues 171-189 plus an N-terminal cysteine added to facilitate coupling), before the first membrane-spanning domain in an area not conserved among different K\n\n22/2/2017 Pim:\n-The species of the Kcnc1 construct is not stated in the article. I agree with the expert that a **rat** species is assumed safely (other constructs and tissues are rat). This paper is used to annotate rat Kcnc1 by SWIS and RGD GO contricutors. We settle for *rat* species too."},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_10116"}]}