{"id":"gomodel:SYNGO_171","individuals":[{"id":"gomodel:SYNGO_17116ae3e18-3fce-44ca-a09d-2f7e6b46863a","type":[{"type":"class","id":"ECO:0006063","label":"over expression analysis evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"source","value":"PMID:10482766"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_17154f94340-96ce-40e4-8d67-4ce8d1931521","type":[{"type":"class","id":"ECO:0007695","label":"cell-based assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"date","value":"2024-03-06"},{"key":"source","value":"PMID:10482766"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"}]},{"id":"gomodel:SYNGO_17194a443d9-73b1-44c2-9b47-6911c57d5103","type":[{"type":"class","id":"ECO:0000303","label":"author statement without traceable support used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"source","value":"PMID:10482766"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_171c0fecc4b-1e5a-4f1c-8104-01220de446f7","type":[{"type":"class","id":"RGD:628829","label":"Kcnc2 Rnor"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_171db25e768-9d50-4289-ab0f-7cc656b9779f","type":[{"type":"class","id":"ECO:0006013","label":"patch-clamp recording evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"source","value":"PMID:10482766"}]},{"id":"gomodel:SYNGO_171fd62592a-c114-4259-aa7c-78654da9ca00","type":[{"type":"class","id":"GO:0099508","label":"voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"facts":[{"subject":"gomodel:SYNGO_171fd62592a-c114-4259-aa7c-78654da9ca00","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_171c0fecc4b-1e5a-4f1c-8104-01220de446f7","annotations":[{"key":"evidence","value":"gomodel:SYNGO_17116ae3e18-3fce-44ca-a09d-2f7e6b46863a","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_17154f94340-96ce-40e4-8d67-4ce8d1931521","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_17194a443d9-73b1-44c2-9b47-6911c57d5103","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_171db25e768-9d50-4289-ab0f-7cc656b9779f","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2018-06-29"},{"key":"title","value":"SYNGO_MF_171"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: Ion channel function is shown by expressing channels in CHO cells.\n\nrule: NAS_MFCC-BP\nrationale:\nProtein has voltage-gated ion channel activity and is localized in the presynaptic membrane (show with high-resolution technique). The inference to term \u0027voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508)\u0027 is trivial and non-controversial.\nPinf_CC:\n[P22462] SyNGO ID 170 (PMID:10531438, EM). Experimental description: Study is done with channels expressed in Chinese hamster ovary (CHO) cells. All antibody studies in this paper are on rat. I assume that they use therefore the rat-gene to express in the CHO\u0027s. See MM p.1513: The peptides correspond to a sequence present in the constant region of the rat and mouse Kv3.2 proteins, respectively (residues 171-189 plus an N-terminal cysteine added to facilitate coupling), before the first membrane-spanning domain in an area not conserved among different...\n\n22/2/2017 Pim:\n-Species traced back to **rat** via PMID:7643197 --\u003e PMID:2367536 --\u003e literal excerpt: \"We report the cloning of RKShIIIA, a cDNA encoding a K+ channel sequence expressed in **rat** brain\""},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_10116"}]}