{"id":"gomodel:SYNGO_1503","individuals":[{"id":"gomodel:SYNGO_15031b14dac3-dba1-40c4-9fc4-c40ed3535927","type":[{"type":"class","id":"ECO:0006063","label":"over expression analysis evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"source","value":"PMID:18945825"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_15032e5715cb-8d22-4c31-a8dd-6f8ca43640b2","type":[{"type":"class","id":"GO:0099508","label":"voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"}]},{"id":"gomodel:SYNGO_150354a1e032-069f-429f-988d-82fee3e1c4d4","type":[{"type":"class","id":"ECO:0007695","label":"cell-based assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"source","value":"PMID:18945825"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_15035bd8a037-493e-41ae-9f5b-7b6d144ff643","type":[{"type":"class","id":"ECO:0006013","label":"patch-clamp recording evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"source","value":"PMID:18945825"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_1503d1d9102b-a260-403a-a485-816adbc4a6ae","type":[{"type":"class","id":"UniProtKB:Q14654","label":"KCNJ11 Hsap"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"},{"type":"class","id":"CHEBI:36080","label":"protein"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_1503d2645061-de3e-4717-9068-2efa211867a9","type":[{"type":"class","id":"ECO:0000303","label":"author statement without traceable support used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"PMID:18945825"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]}],"facts":[{"subject":"gomodel:SYNGO_15032e5715cb-8d22-4c31-a8dd-6f8ca43640b2","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_1503d1d9102b-a260-403a-a485-816adbc4a6ae","annotations":[{"key":"evidence","value":"gomodel:SYNGO_15031b14dac3-dba1-40c4-9fc4-c40ed3535927","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_150354a1e032-069f-429f-988d-82fee3e1c4d4","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_15035bd8a037-493e-41ae-9f5b-7b6d144ff643","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1503d2645061-de3e-4717-9068-2efa211867a9","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2018-06-29"},{"key":"title","value":"SYNGO_MF_1503"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: Patch-clamp measurements of Kir6.2 channels overexpressed in HEK cells.\n\nrule: NAS_MFCC-BP\nrationale:\nProtein has ATP-gated ion channel activity and is localized in the presynaptic membrane (show with high-resolution technique). The inference to term \u0027ATP-gated ion channel activity involved in regulation of presynaptic membrane potential\u0027 is trivial and non-controversial.\nPinf_CC:\n[P70673] SyNGO ID 1500 (PMID:17883401, EM). Experimental description: Molecular biology. Using oligonucleotide primers and standard PCR methods, we engineered two parental plasmids encoding human Kir6.1 and human Kir6.2 (in pECE)."},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}]}