{"id":"gomodel:SYNGO_1502","individuals":[{"id":"gomodel:SYNGO_15021a357b4c-8c7d-439a-8f81-30d36a5bf8a6","type":[{"type":"class","id":"UniProtKB:Q15842","label":"KCNJ8 Hsap"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"},{"type":"class","id":"CHEBI:36080","label":"protein"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_150232b93ec8-13c7-4546-9b95-becbfd242f3e","type":[{"type":"class","id":"GO:0099508","label":"voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_15025577894d-19ac-49c0-ae4b-2bc2ce939bf9","type":[{"type":"class","id":"ECO:0007695","label":"cell-based assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"source","value":"PMID:18945825"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_150256cf9a15-2d67-49a7-a1cc-0a2ce52487d9","type":[{"type":"class","id":"ECO:0006013","label":"patch-clamp recording evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"source","value":"PMID:18945825"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_150261ef7a67-3688-4c89-aa3c-782800edfd77","type":[{"type":"class","id":"ECO:0006063","label":"over expression analysis evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"source","value":"PMID:18945825"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"}]},{"id":"gomodel:SYNGO_1502bbd73656-774a-463e-907d-9307b4c3a3cf","type":[{"type":"class","id":"ECO:0000303","label":"author statement without traceable support used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"source","value":"PMID:18945825"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]}],"facts":[{"subject":"gomodel:SYNGO_150232b93ec8-13c7-4546-9b95-becbfd242f3e","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_15021a357b4c-8c7d-439a-8f81-30d36a5bf8a6","annotations":[{"key":"evidence","value":"gomodel:SYNGO_15025577894d-19ac-49c0-ae4b-2bc2ce939bf9","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_150256cf9a15-2d67-49a7-a1cc-0a2ce52487d9","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_150261ef7a67-3688-4c89-aa3c-782800edfd77","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1502bbd73656-774a-463e-907d-9307b4c3a3cf","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2018-06-29"},{"key":"title","value":"SYNGO_MF_1502"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: Patch-clamp measurements of Kir6.1 channels overexpressed in HEK cells.\n\nrule: NAS_MFCC-BP\nrationale:\nProtein has ATP-gated ion channel activity and is localized in the presynaptic membrane (show with high-resolution technique). The inference to term \u0027ATP-gated ion channel activity involved in regulation of presynaptic membrane potential\u0027 is trivial and non-controversial.\nPinf_CC:\n[Q63664] SyNGO ID 1499 (PMID:17883401, EM). Experimental description: Molecular biology. Using oligonucleotide primers and standard PCR methods, we engineered two parental plasmids encoding human Kir6.1 and human Kir6.2 (in pECE)."},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}]}