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They investigate the role of neurofilaments by creating a triple knockout mouse by knocking out alpha-internexin, NFH and NFL and address the role of these proteins in synaptic transmission. Tetanic stimulation of Schaffer-collateral pathway in slices induced LTP of fEPSPs in control but not knockout conditions, which suggest a role of these protein in synaptic transmission. Although this is not a direct confirmation of the function of alpha-internexin, the function of this protein is redundant with the function of neurofilaments.. Experimental description: From supplementary information:\n\"Adult male or female mice of the C57BL/6J-rich strain, aged 3 - 12 months were used in all experiments\""},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_10090"}]}