{"id":"gomodel:SYNGO_1380","individuals":[{"id":"gomodel:SYNGO_1380016c28f2-717e-4e3b-b5d4-34d656a6a323","type":[{"type":"class","id":"GO:0099507","label":"ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_138009ea8f53-eabd-45a2-88b9-550a2510cf8d","type":[{"type":"class","id":"ECO:0007695","label":"cell-based assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"source","value":"PMID:8886398"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_13802dc2c48f-cd96-41fe-9579-9392e5518cec","type":[{"type":"class","id":"ECO:0006063","label":"over expression analysis evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"source","value":"PMID:8886398"}]},{"id":"gomodel:SYNGO_138064edb968-a8e6-4801-beb4-ae414d617bfa","type":[{"type":"class","id":"ECO:0000303","label":"author statement without traceable support used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"source","value":"PMID:8886398"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_1380c54ff030-11b0-4198-be94-9e069b6b4999","type":[{"type":"class","id":"ECO:0006013","label":"patch-clamp recording evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"PMID:8886398"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_1380c8aedd1b-3276-4941-895c-df7bebed48ab","type":[{"type":"class","id":"RGD:2740","label":"Grin2d Rnor"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"facts":[{"subject":"gomodel:SYNGO_1380016c28f2-717e-4e3b-b5d4-34d656a6a323","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_1380c8aedd1b-3276-4941-895c-df7bebed48ab","annotations":[{"key":"evidence","value":"gomodel:SYNGO_138009ea8f53-eabd-45a2-88b9-550a2510cf8d","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_13802dc2c48f-cd96-41fe-9579-9392e5518cec","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_138064edb968-a8e6-4801-beb4-ae414d617bfa","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1380c54ff030-11b0-4198-be94-9e069b6b4999","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2018-06-29"},{"key":"title","value":"SYNGO_MF_1380"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: Electrophysiological characterisation of NR2D subunit overexposed in HEK cells.\n\nrule: NAS_MFCC-BP\nrationale:\nProtein has ligand-gated ion channel receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term \u0027ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507)\u0027 is trivial and non-controversial.\nPinf_CC:\n[G1TPJ8] SyNGO ID 1379 (PMID:9174077, confocal)\n[Q62645] SyNGO ID 1387 (PMID:23159309, EM). Experimental description: Thefull-length cDNAs encoding the rat NR1 (splicevariant\nla, fromS.Nakanishi,InstituteforImmunology,Kyoto\nUniversity, Japan), NR2B, NR2C and NR2D (from J. Boul-\nter, The SalkInstitute, MolecularNeurobiologyLaboratory,\nSanDiego,U.S.A.) were sub cloned from there combinant displayed on an IBM compatible PC runningp Clamp(Axon,\nphagemid pBluescript SK(-) into the polylinker site of a\nmammalianexpressionvectorcontaininga cytomegalovirus\n(CMV)promoter(pcDNA1/Amp;Invitrogen)."},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_10116"}]}