{"id":"gomodel:SYNGO_1351","individuals":[{"id":"gomodel:SYNGO_13510c733a6c-4f9f-4a6f-b2cc-d15a631b6bbc","type":[{"type":"class","id":"GO:0099507","label":"ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_1351403eb935-8054-4cc2-a92c-7608b5a26c90","type":[{"type":"class","id":"ECO:0000303","label":"author statement without traceable support used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"source","value":"PMID:19666514"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_1351c53ee590-14ec-4bd8-9f9c-d898ee6b2d93","type":[{"type":"class","id":"UniProtKB:Q13224","label":"GRIN2B Hsap"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"},{"type":"class","id":"CHEBI:36080","label":"protein"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_1351de56cf8e-f62f-4de9-b047-eddbb81fd65e","type":[{"type":"class","id":"ECO:0007695","label":"cell-based assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"source","value":"PMID:19666514"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_1351e3e39328-c548-4860-abfb-4e63957fb7de","type":[{"type":"class","id":"ECO:0006013","label":"patch-clamp recording evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"source","value":"PMID:19666514"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_1351e6dbcfb5-5334-4868-aeb5-ffb64aec5f61","type":[{"type":"class","id":"ECO:0006063","label":"over expression analysis evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"PMID:19666514"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]}],"facts":[{"subject":"gomodel:SYNGO_13510c733a6c-4f9f-4a6f-b2cc-d15a631b6bbc","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_1351c53ee590-14ec-4bd8-9f9c-d898ee6b2d93","annotations":[{"key":"evidence","value":"gomodel:SYNGO_1351403eb935-8054-4cc2-a92c-7608b5a26c90","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1351de56cf8e-f62f-4de9-b047-eddbb81fd65e","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1351e3e39328-c548-4860-abfb-4e63957fb7de","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1351e6dbcfb5-5334-4868-aeb5-ffb64aec5f61","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2018-06-29"},{"key":"title","value":"SYNGO_MF_1351"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: Electrophysiological characterisation of NR2B overexposed in HEK cells using WC patch-clamp.\n\nrule: NAS_MFCC-BP\nrationale:\nProtein has ligand-gated ion channel receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term \u0027ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507)\u0027 is trivial and non-controversial.\nPinf_CC:\n[Q00960] SyNGO ID 1350 (PMID:19666514, EM)\n[Q00960] SyNGO ID 1386 (PMID:23159309, EM). Experimental description: No information on species of cloned receptors: HEK293 cells plated on glass coverslips in 35-mm Petri dishes were transfected with 2.\n\n29/6/2018 Pim\n- I have selected \u0027human\u0027 as the species of the expressed protein. Since using a weaker NAS mechanism for annotation correct species assignment is not so important."},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}]}