{"id":"gomodel:SYNGO_1347","individuals":[{"id":"gomodel:SYNGO_134721841ba3-3ea9-4b1f-bfaa-4edbc4169648","type":[{"type":"class","id":"ECO:0006013","label":"patch-clamp recording evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"source","value":"PMID:22150645"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_134731297f4b-da6a-4681-95f6-aad4a5008d81","type":[{"type":"class","id":"UniProtKB:P35498","label":"SCN1A Hsap"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"},{"type":"class","id":"CHEBI:36080","label":"protein"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_1347725f8086-21bd-4258-8abc-c28cc152e756","type":[{"type":"class","id":"ECO:0007695","label":"cell-based assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"source","value":"PMID:22150645"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_1347827a9893-8f49-43e7-86d8-ff64b9e96e0e","type":[{"type":"class","id":"ECO:0006063","label":"over expression analysis evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"PMID:22150645"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"}]},{"id":"gomodel:SYNGO_1347cff30fa6-dba5-4e2f-8188-3c435e11ca9c","type":[{"type":"class","id":"ECO:0000303","label":"author statement without traceable support used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"source","value":"PMID:22150645"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"}]},{"id":"gomodel:SYNGO_1347ed906cd4-aa16-4170-9f48-8c6cefe594a4","type":[{"type":"class","id":"GO:0099508","label":"voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]}],"facts":[{"subject":"gomodel:SYNGO_1347ed906cd4-aa16-4170-9f48-8c6cefe594a4","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_134731297f4b-da6a-4681-95f6-aad4a5008d81","annotations":[{"key":"evidence","value":"gomodel:SYNGO_134721841ba3-3ea9-4b1f-bfaa-4edbc4169648","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1347725f8086-21bd-4258-8abc-c28cc152e756","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1347827a9893-8f49-43e7-86d8-ff64b9e96e0e","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1347cff30fa6-dba5-4e2f-8188-3c435e11ca9c","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2018-06-29"},{"key":"title","value":"SYNGO_MF_1347"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: Electrophysiological characterisation of Na(v)1.1 expressed in sA-201 cells using WC patch-clamp.\n\nrule: NAS_MFCC-BP\nrationale:\nProtein has voltage-gated ion channel activity and is localized in the presynaptic membrane (show with high-resolution technique). The inference to term \u0027voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508)\u0027 is trivial and non-controversial.\nPinf_CC:\n[P04774] SyNGO ID 1341 (PMID:18079688, EM). Experimental description: The cDNAs of the human NaV1.1 Na+ channel a subunit (hNaV1.1; GenBank sequence NM_006920.4) and of the human NaV1.2 Na+ channel a subunit (hNaV1.2; NM_021007) were provided by Dr. Jeff Clare (Glaxo- SmithKline, Stevenage, Herts, United Kingdom). The NaV1.1 clone is a shorter splice variant, with a deletion of 11 amino acids in the intracellular loop between DI and DII, which has already been used in several studies (Mantegazza et al., 2005; Rusconi et al., 2007; Cestele et al., 2008; Rusconi et al., 2009) and could be the predominant NaV1.1 variant expressed in brain (Schaller et al., 1992)."},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}]}