{"id":"gomodel:SYNGO_1337","individuals":[{"id":"gomodel:SYNGO_133749faa9e6-91b0-409b-bab8-a9d728c4b083","type":[{"type":"class","id":"ECO:0006013","label":"patch-clamp recording evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"PMID:26950270"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"}]},{"id":"gomodel:SYNGO_133777a5844a-c7f1-44a5-a5f1-c70ccfeb0289","type":[{"type":"class","id":"GO:0099507","label":"ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_1337877ae68d-1b56-46b5-a4b6-b15aee6f1c73","type":[{"type":"class","id":"ECO:0007695","label":"cell-based assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"date","value":"2024-03-06"},{"key":"source","value":"PMID:26950270"}]},{"id":"gomodel:SYNGO_133793844243-d666-492c-8d50-8818233eb9cc","type":[{"type":"class","id":"UniProtKB:P18505","label":"GABRB1 Hsap"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"},{"type":"class","id":"CHEBI:36080","label":"protein"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_1337e09c1ef5-cd03-42d4-89ac-1714da9bb209","type":[{"type":"class","id":"ECO:0006063","label":"over expression analysis evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"source","value":"PMID:26950270"}]},{"id":"gomodel:SYNGO_1337e6b9619d-bbc5-48d6-881e-54ab1dab8a7e","type":[{"type":"class","id":"ECO:0000303","label":"author statement without traceable support used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"source","value":"PMID:26950270"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"date","value":"2024-03-06"}]}],"facts":[{"subject":"gomodel:SYNGO_133777a5844a-c7f1-44a5-a5f1-c70ccfeb0289","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_133793844243-d666-492c-8d50-8818233eb9cc","annotations":[{"key":"evidence","value":"gomodel:SYNGO_133749faa9e6-91b0-409b-bab8-a9d728c4b083","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1337877ae68d-1b56-46b5-a4b6-b15aee6f1c73","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1337e09c1ef5-cd03-42d4-89ac-1714da9bb209","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1337e6b9619d-bbc5-48d6-881e-54ab1dab8a7e","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2018-06-29"},{"key":"title","value":"SYNGO_MF_1337"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: WC patch-clamp current measurements of beta1 containing GABAR\u0027s expressed in HEK cells.\n\nrule: NAS_MFCC-BP\nrationale:\nProtein has ligand-gated ion channel receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) is trivial and non-controversial.\nPinf_CC:\n[P15431] SyNGO ID 1269 (PMID:14686901, EM)\n[P15431] SyNGO ID 1274 (PMID:15174078, EM). Experimental description: Complementary DNA Constructs\nThe complementary DNAs (cDNAs) encoding human GABAA receptor subunits a1 (NM_000806.5), b1 (NM_000812.3), b3 (NM_021912.4 variant 2), c2L (NM_198904.2), and EGFP (LC008490.1) were cloned into the pcDNA3.1(1) vector."},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}]}