{"id":"gomodel:SYNGO_1332","individuals":[{"id":"gomodel:SYNGO_13328b020fec-a01c-4ed5-a1d5-4dd0b1bc0992","type":[{"type":"class","id":"ECO:0006063","label":"over expression analysis evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"source","value":"PMID:22711532"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_1332a32c5be5-cca4-4d26-b86c-165c5c6b2e67","type":[{"type":"class","id":"UniProtKB:P47869","label":"GABRA2 Hsap"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"},{"type":"class","id":"CHEBI:36080","label":"protein"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_1332bface1da-7c64-4672-b8fe-6711455b5eb4","type":[{"type":"class","id":"GO:1904315","label":"transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_1332e4a13732-19eb-41dd-b3ef-866b97d6b7ce","type":[{"type":"class","id":"ECO:0007695","label":"cell-based assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"PMID:22711532"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_1332f953d023-a59e-4242-95f7-8577ab046034","type":[{"type":"class","id":"ECO:0006013","label":"patch-clamp recording evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"PMID:22711532"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"}]}],"facts":[{"subject":"gomodel:SYNGO_1332bface1da-7c64-4672-b8fe-6711455b5eb4","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_1332a32c5be5-cca4-4d26-b86c-165c5c6b2e67","annotations":[{"key":"evidence","value":"gomodel:SYNGO_13328b020fec-a01c-4ed5-a1d5-4dd0b1bc0992","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1332e4a13732-19eb-41dd-b3ef-866b97d6b7ce","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1332f953d023-a59e-4242-95f7-8577ab046034","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2018-06-29"},{"key":"title","value":"SYNGO_MF_1332"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: Electrophysiological characterisation of GABAA alpha 2 subunit overexpressed in HEK cells, with WC patch-clamp.\n\nrule: NAS_MFCC-BP\nrationale:\nProtein has voltage-gated ion channel activity and is localized in teh presynaptic membrane (show with high-resolution technique). The inference to term \u0027ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507)\u0027 is trivial and non-controversial.\nPinf_CC:\n[P23576] SyNGO ID 1267 (PMID:11168550, EM). Experimental description: No information found on species, also not in references to methods in older papers.\n\n29/6/2018 Pim\n- I have selected \u0027human\u0027 as the species of the expressed protein. Since using a weaker NAS mechanism for annotation correct species assignment is not so important."},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}]}