{"id":"gomodel:SYNGO_1324","individuals":[{"id":"gomodel:SYNGO_13241c8206a5-7813-47fb-9064-08a3e63dbe84","type":[{"type":"class","id":"ECO:0007695","label":"cell-based assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"source","value":"PMID:22539847"}]},{"id":"gomodel:SYNGO_1324508723c0-7e6f-42da-80a8-453bc183ba47","type":[{"type":"class","id":"ECO:0000303","label":"author statement without traceable support used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"source","value":"PMID:22539847"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_132465cdd348-245b-4c39-bd1c-baeb23cd8611","type":[{"type":"class","id":"ECO:0006013","label":"patch-clamp recording evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"source","value":"PMID:22539847"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_13249f08d653-3937-422f-8911-6e12c9293323","type":[{"type":"class","id":"RGD:61855","label":"Gabra1 Rnor"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_1324f49cc6ef-673a-4f77-b5e5-ac714ffdd516","type":[{"type":"class","id":"ECO:0006063","label":"over expression analysis evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"PMID:22539847"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_1324f4d1155f-a346-4590-97a7-6a205d0267f2","type":[{"type":"class","id":"GO:0099507","label":"ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]}],"facts":[{"subject":"gomodel:SYNGO_1324f4d1155f-a346-4590-97a7-6a205d0267f2","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_13249f08d653-3937-422f-8911-6e12c9293323","annotations":[{"key":"evidence","value":"gomodel:SYNGO_13241c8206a5-7813-47fb-9064-08a3e63dbe84","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1324508723c0-7e6f-42da-80a8-453bc183ba47","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_132465cdd348-245b-4c39-bd1c-baeb23cd8611","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1324f49cc6ef-673a-4f77-b5e5-ac714ffdd516","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2018-06-29"},{"key":"title","value":"SYNGO_MF_1324"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: Functional characterisation in HEK cells of overexpressed GABAAR alpha 1 and 3 subunints.\n\nrule: NAS_MFCC-BP\nrationale:\nProtein has ligand-gated ion channel receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) is trivial and non-controversial.\nPinf_CC:\n[P62813] SyNGO ID 1301 (PMID:8613776, EM). Experimental description: Heterologous expression of recombinant GABAA receptors. Rat"},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_10116"}]}