{"id":"gomodel:SYNGO_1132","individuals":[{"id":"gomodel:SYNGO_11322fce5d02-919d-4681-a4a6-6084de32c98e","type":[{"type":"class","id":"ECO:0006063","label":"over expression analysis evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"source","value":"PMID:18562611"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_11323f1e635c-79ee-4b37-b39e-52a4f15ab1e7","type":[{"type":"class","id":"ECO:0000303","label":"author statement without traceable support used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"source","value":"PMID:18562611"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_11324572f9f3-2d26-440e-a26e-181785a7b437","type":[{"type":"class","id":"ECO:0006013","label":"patch-clamp recording evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"source","value":"PMID:18562611"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_1132c0b377bc-bbc5-43d5-9de0-f16a559fea1c","type":[{"type":"class","id":"UniProtKB:Q16478","label":"GRIK5 Hsap"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"},{"type":"class","id":"CHEBI:36080","label":"protein"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"}]},{"id":"gomodel:SYNGO_1132d7c39a84-b89c-49d1-98f0-daec59d647a4","type":[{"type":"class","id":"ECO:0007695","label":"cell-based assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"source","value":"PMID:18562611"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_1132df7d3993-e676-4ba1-848e-468e32f5092f","type":[{"type":"class","id":"GO:0099507","label":"ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]}],"facts":[{"subject":"gomodel:SYNGO_1132df7d3993-e676-4ba1-848e-468e32f5092f","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_1132c0b377bc-bbc5-43d5-9de0-f16a559fea1c","annotations":[{"key":"evidence","value":"gomodel:SYNGO_11322fce5d02-919d-4681-a4a6-6084de32c98e","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_11323f1e635c-79ee-4b37-b39e-52a4f15ab1e7","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_11324572f9f3-2d26-440e-a26e-181785a7b437","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1132d7c39a84-b89c-49d1-98f0-daec59d647a4","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2018-06-29"},{"key":"title","value":"SYNGO_MF_1132"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: GluK5 (GRIK5) receptor.\n\nrule: NAS_MFCC-BP\nrationale:\nProtein has ligand-gated ion channel receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) is trivial and non-controversial.\nPinf_CC:\n[Q61626] SyNGO ID 1116 (PMID:16360275, EM)\n[H9EM65] SyNGO ID 1121 (PMID:12954862, EM). Experimental description: M\u0026M: HEK293 cells were transiently cotrans- fected with GluR6a(Q) and EGFP cDNAs in the ratio 1:1 or GluR6a(Q), KA2, and EGFP cDNAs in the ratio 1:3:1 (unless stated otherwise).\n\n29/6/2018 Pim\n- I have selected \u0027human\u0027 as the species of the expressed protein. Since using a weaker NAS mechanism for annotation correct species assignment is not so important."},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}]}