{"id":"gomodel:SYNGO_1130","individuals":[{"id":"gomodel:SYNGO_113002f2d0cf-d34e-4caa-a928-da0e916de7ba","type":[{"type":"class","id":"ECO:0007695","label":"cell-based assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"source","value":"PMID:20026616"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_11305cc16be6-250f-4191-8436-2beb31a2b64a","type":[{"type":"class","id":"UniProtKB:Q16478","label":"GRIK5 Hsap"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"},{"type":"class","id":"CHEBI:36080","label":"protein"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_11307e4e846a-06a2-40c9-97ce-8b1f36a3bf93","type":[{"type":"class","id":"ECO:0006063","label":"over expression analysis evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"source","value":"PMID:20026616"}]},{"id":"gomodel:SYNGO_1130899d23b4-cdf9-4e94-89df-f436b069a714","type":[{"type":"class","id":"ECO:0000303","label":"author statement without traceable support used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"source","value":"PMID:20026616"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_1130b3522afd-793b-4d54-9204-e75719a0bd28","type":[{"type":"class","id":"GO:0099507","label":"ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_1130da43713a-cee2-4593-905a-d483ed6fe3ae","type":[{"type":"class","id":"ECO:0006013","label":"patch-clamp recording evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"source","value":"PMID:20026616"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"facts":[{"subject":"gomodel:SYNGO_1130b3522afd-793b-4d54-9204-e75719a0bd28","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_11305cc16be6-250f-4191-8436-2beb31a2b64a","annotations":[{"key":"evidence","value":"gomodel:SYNGO_113002f2d0cf-d34e-4caa-a928-da0e916de7ba","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_11307e4e846a-06a2-40c9-97ce-8b1f36a3bf93","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1130899d23b4-cdf9-4e94-89df-f436b069a714","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1130da43713a-cee2-4593-905a-d483ed6fe3ae","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2018-06-29"},{"key":"title","value":"SYNGO_MF_1130"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: KA2 (kainate) receptor.\n\nrule: NAS_MFCC-BP\nrationale:\nProtein has ligand-gated ion channel receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) is trivial and non-controversial.\nPinf_CC:\n[Q61626] SyNGO ID 1121 (PMID:12954862, EM). Experimental description: For these experiments, the GluK4 plasmid from the Heinemann laboratory was subcloned into the pCIneo vector (Promega Corporation, Madison, WI, USA) for use in mammalian cells.\n\n29/6/2018 Pim\n- I have selected \u0027human\u0027 as the species of the expressed protein. The leader of the lab that contributed the cDNA (Heinemann SF) passed away several years ago."},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}]}