{"id":"gomodel:SYNGO_1129","individuals":[{"id":"gomodel:SYNGO_11295adda167-1030-48ea-bf43-5b6594bf2ad1","type":[{"type":"class","id":"ECO:0000303","label":"author statement without traceable support used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"source","value":"PMID:20026616"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_11296c271eee-67b3-4394-b010-3ee84e4c44cd","type":[{"type":"class","id":"GO:0099507","label":"ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_112995569eec-5145-401c-859b-98be3d394cf7","type":[{"type":"class","id":"UniProtKB:Q16099","label":"GRIK4 Hsap"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"},{"type":"class","id":"CHEBI:36080","label":"protein"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"}]},{"id":"gomodel:SYNGO_11299e0561a0-f530-4445-b838-efe09309a3a8","type":[{"type":"class","id":"ECO:0006013","label":"patch-clamp recording evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"PMID:20026616"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"}]},{"id":"gomodel:SYNGO_1129a09fa8bc-4e6f-4359-a9ad-2dd4f9b5b33e","type":[{"type":"class","id":"ECO:0007695","label":"cell-based assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"PMID:20026616"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"}]},{"id":"gomodel:SYNGO_1129d368b4e8-2a08-4ba6-9f1f-bef2753144dd","type":[{"type":"class","id":"ECO:0006063","label":"over expression analysis evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"source","value":"PMID:20026616"},{"key":"date","value":"2024-03-06"}]}],"facts":[{"subject":"gomodel:SYNGO_11296c271eee-67b3-4394-b010-3ee84e4c44cd","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:SYNGO_112995569eec-5145-401c-859b-98be3d394cf7","annotations":[{"key":"evidence","value":"gomodel:SYNGO_11295adda167-1030-48ea-bf43-5b6594bf2ad1","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_11299e0561a0-f530-4445-b838-efe09309a3a8","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1129a09fa8bc-4e6f-4359-a9ad-2dd4f9b5b33e","value-type":"IRI"},{"key":"evidence","value":"gomodel:SYNGO_1129d368b4e8-2a08-4ba6-9f1f-bef2753144dd","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2024-03-06"},{"key":"providedBy","value":"https://syngo.vu.nl"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0001-9425-2935"},{"key":"contributor","value":"https://orcid.org/0000-0002-2514-0216"},{"key":"date","value":"2018-06-29"},{"key":"title","value":"SYNGO_MF_1129"},{"key":"providedBy","value":"https://syngo.vu.nl"},{"key":"comment","value":"Rationale: KA1 (kainate) receptor.\n\nrule: NAS_MFCC-BP\nrationale:\nProtein has ligand-gated ion channel receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) is trivial and non-controversial.\nPinf_CC:\n[Q8BMF5] SyNGO ID 1120 (PMID:12954862, EM). Experimental description: For these experiments, the GluK4 plasmid from the Heinemann laboratory was subcloned into the pCIneo vector (Promega Corporation, Madison, WI, USA) for use in mammalian cells.\n\n29/6/2018 Pim\n- I have selected \u0027human\u0027 as the species of the expressed protein. The leader of the lab that contributed the cDNA (Heinemann SF) passed away several years ago."},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}]}