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2022-07-29"},{"key":"date","value":"2026-07-02"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"R-HSA-9768919"},{"key":"comment","value":"NPAS4 is a basic helix loop helix (bHLH) transcription factor that needs to dimerize with another bHLH protein, either ARNT, ARNT2 or ARNTL, in order to be able to bind to target DNA (Ooe et al. 2004; Ooe et al. 2009).\u003cbr\u003e\u003cbr\u003eNPAS4 is implicated as a transcriptional regulator of genes involved in neuronal development such as CDK5 (Yun et al. 2013), CDK5R1 (Yun et al. 2013), RBFOX3 (NeuN) (Yun et al. 2013), BDNF (Pruunsild et al. 2011) and RET (Sribudiani et al. 2011), genes involved in synaptogenesis and synaptic transmission such as NPTX2 (Lin et al. 2008), MDM2 (Yoshihara et al. 2014; Lv et al. 2021), FOS (Ramamoorthi et al. 2011), IQSEC3 (Kim et al. 2021), PLK2 (Weng et al. 2018) and possibly other genes (Lin et al. 2008; Shan et al. 2018), circadian rhythm-related genes such as NAMPT (West et al. 2013), and genes involved in neuroprotection upon injury such as GEM (Takahashi et al. 2021), SYT10 (Woitecki et al. 2016) and possibly other genes (Qiu et al. 2013). In pancreatic beta-cell, NPAS4 is implicated as a regulator of insulin synthesis under stress conditions (Sabatini et al. 2013).\u003cbr\u003e\u003cbr\u003eThe circadian clock regulated gene CRY1 was identified as NPAS4 target gene in sheep brain (West et al. 2013). The DBNL gene, encoding Drebrin, a dendrytic cytoskeleton modulator, was identified as a gene directly upregulated by Npas4 (Ooe et al. 2004)\u003cbr\u003e\u003cbr\u003eNPAS4 is expressed in endothelial cells and may play a role in angiogenesis (Esser et al. 2017).\u003cbr\u003e"}]},{"id":"gomodel:ev_w_id_R-HSA-9769115_BFO_0000050_R-HSA-9768919/R-HSA-9768919_Reactome_R-HSA-9768919_R-HSA-9769115_enabled_by_R-HSA-9769851_R-HSA-9769115_controller","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic 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