{"id":"gomodel:R-HSA-937041","individuals":[{"id":"gomodel:R-HSA-168915","type":[{"type":"class","id":"GO:0004842","label":"ubiquitin-protein transferase activity"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"rdfs:label","value":"K63-linked ubiquitination of RIP1 bound to the activated TLR complex"},{"key":"skos:note","value":"org.biopax.paxtools.model.level3.BiochemicalReaction"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Original Reactome ID: R-HSA-168915"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/97/48887#BiochemicalReaction807","value-type":"IRI"},{"key":"date","value":"2026-07-02"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-HSA-168915"}]},{"id":"gomodel:R-HSA-937041/R-HSA-937041","type":[{"type":"class","id":"GO:0008150","label":"biological_process"}],"root-type":[{"type":"class","id":"GO:0008150","label":"biological_process"}],"annotations":[{"key":"skos:note","value":"org.biopax.paxtools.model.level3.Pathway"},{"key":"comment","value":"Receptor-interacting protein 1 (RIP1) mediates the activation of proinflammatory cytokines via intermediate induction of IKK complex in NFkB pathways [Ea et al. 2006]. Poly(I-C) treatment stimulated the recruitment of RIP1, TRAF6, and TAK1 to the TLR3 receptor complex in human embryonic kidney HEK293 transfected with FLAG-tagged TLR3 [Cusson-Hermance et al. 2005]. RIP1 was shown to be dispensable for TRIF-dependent activation of IRF3, which occurs in a TRIF/TBK1/IKKi-dependent manner [Cusson-Hermance et al. 2005, Sato et al. 2003]"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"R-HSA-937041"},{"key":"contributor","value":"Reviewed: Fitzgerald, Katherine A, 2012-11-13"},{"key":"rdfs:label","value":"IKK complex recruitment mediated by RIP1"},{"key":"contributor","value":"Edited: Shamovsky, V, 2010-11-15"},{"key":"date","value":"2026-07-02"},{"key":"contributor","value":"Reviewed: Gillespie, ME, 2010-11-30"},{"key":"skos:narrower","value":"gomodel:R-HSA-937061/R-HSA-937061","value-type":"IRI"},{"key":"contributor","value":"Authored: Shamovsky, V, 2010-06-01"},{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"}]},{"id":"gomodel:ev_w_id_R-HSA-168915_BFO_0000050_R-HSA-937041/R-HSA-937041_Reactome_R-HSA-937041","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"date","value":"2026-07-02"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"source","value":"Reactome:R-HSA-937041"}]}],"facts":[{"subject":"gomodel:R-HSA-168915","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:R-HSA-937041/R-HSA-937041","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-168915_BFO_0000050_R-HSA-937041/R-HSA-937041_Reactome_R-HSA-937041","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-937041"}]}],"annotations":[{"key":"state","value":"development"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"title","value":"IKK complex recruitment mediated by RIP1 - imported from: Reactome"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"For logical inference, import the integrated tbox ontology http://purl.obolibrary.org/obo/go/extensions/go-lego-reacto.owl"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-937041"},{"key":"comment","value":"http://www.reactome.org"},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"NCBITaxon:9606","value-type":"IRI"}]}