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These receptors possesses a single extracellular conserved C-type lectin domain (CTLD) with a short cytoplasmic tail that induces intracellular signalling indirectly by binding with the FCERG (High affinity immunoglobulin epsilon receptor subunit gamma) except for DCIR that has a longer cytoplasmic tail with an integral inhibitory signalling motif (Graham \u0026 Brown. 2009, Kerschera et al. 2013). CLEC6A (Dectin-2) binds to high mannose containing pathogen-associated molecular patterns (PAMPs) expressed by fungal hyphae, and CLEC4E (mincle) binds to alpha-mannaosyl PAMPs on fungal, mycobacterial and necrotic cell ligands. Both signaling pathways lead to Toll-like receptor (TLR)-independent production of cytokines such as tumor necrosis factor (TNF) and interleukin 6 (IL6). Similarities with Dectin-1 (CLC7A) signaling pathway suggests that both these CLRs couple SYK activation to NF-kB activation using a complex involving CARD9, BCL10 and MALT1 (Geijtenbeek \u0026 Gringhuis 2009)."},{"key":"contributor","value":"Edited: Garapati, P V, 2014-08-29"},{"key":"rdfs:label","value":"Dectin-2 family"},{"key":"contributor","value":"Reviewed: Geijtenbeek, Teunis B H, 2014-09-02"},{"key":"skos:note","value":"org.biopax.paxtools.model.level3.Pathway"},{"key":"providedBy","value":"https://reactome.org"},{"key":"skos:narrower","value":"gomodel:R-HSA-5621481/R-HSA-5621481","value-type":"IRI"},{"key":"date","value":"2026-07-02"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"R-HSA-5621480"},{"key":"contributor","value":"Authored: Garapati, P V, 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https://reactome.org/content/detail/R-HSA-5621480"}]},{"subject":"gomodel:R-HSA-5621355_enabled_by_UniProt_P06241_R-HSA-5621355_controller","property":"BFO:0000066","property-label":"BFO:0000066","object":"gomodel:reaction_R-HSA-5621355_enabled_by_UniProt_P06241_R-HSA-5621355_controller_location_lociGO_0005829","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-5621355_enabled_by_UniProt_P06241_R-HSA-5621355_controller_BFO_0000066_reaction_R-HSA-5621355_enabled_by_UniProt_P06241_R-HSA-5621355_controller_location_lociGO_0005829_Reactome_R-HSA-5621480","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-5621480"},{"key":"comment","value":"Occurs In Rule. This relation was asserted based on the location of the enabling molecule. "}]},{"subject":"gomodel:R-HSA-5621370","property":"RO:0002629","property-label":"RO:0002629","object":"gomodel:R-HSA-5621363","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-5621370_RO_0002629_R-HSA-5621363_Reactome_R-HSA-5621480","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Entity Regulation Rule 3. The relation \u0027SYK autophosphorylates\u0027 \u0027null\u0027 \u0027SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2\u0027 was inferred because:\n reaction1 has an output that is the enabler of reaction 2."},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-5621480"}]},{"subject":"gomodel:R-HSA-5621363","property":"RO:0002234","property-label":"RO:0002234","object":"gomodel:R-ALL-29370_cytosol","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-5621363_RO_0002234_R-ALL-29370_cytosol_Reactome_R-HSA-5621363","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-5621363_RO_0002234_R-ALL-29370_cytosol_Reactome_R-HSA-5621480","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-5621480"}]}],"annotations":[{"key":"state","value":"development"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"title","value":"Dectin-2 family - imported from: Reactome"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"For logical inference, import the integrated tbox ontology http://purl.obolibrary.org/obo/go/extensions/go-lego-reacto.owl"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-5621480"},{"key":"comment","value":"http://www.reactome.org"},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"NCBITaxon:9606","value-type":"IRI"}]}