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entity"},{"type":"class","id":"GO:0110165","label":"cellular anatomical structure"},{"type":"class","id":"GO:0005575","label":"cellular_component"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"}]},{"id":"gomodel:reaction_R-HSA-174427_location_lociGO_0005654","type":[{"type":"class","id":"GO:0005654","label":"nucleoplasm"}],"root-type":[{"type":"class","id":"UBERON:0001062","label":"anatomical entity"},{"type":"class","id":"GO:0110165","label":"cellular anatomical structure"},{"type":"class","id":"GO:0005575","label":"cellular_component"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"}]},{"id":"gomodel:R-HSA-174430/R-HSA-174425_GO_0032201_individual","type":[{"type":"class","id":"GO:0032201","label":"telomere maintenance via semi-conservative replication"}],"root-type":[{"type":"class","id":"GO:0008150","label":"biological_process"}],"annotations":[{"key":"rdfs:label","value":"reaction:The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere: is xrefed to this process"},{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"comment","value":"Asserted direct link between reaction and biological process, independent of current pathway"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"R-HSA-174425"},{"key":"date","value":"2026-07-02"}]},{"id":"gomodel:R-HSA-174430/R-HSA-174427_GO_0032201_individual","type":[{"type":"class","id":"GO:0032201","label":"telomere maintenance via semi-conservative replication"}],"root-type":[{"type":"class","id":"GO:0008150","label":"biological_process"}],"annotations":[{"key":"date","value":"2026-07-02"},{"key":"comment","value":"Asserted direct link between reaction and biological process, independent of current pathway"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"rdfs:label","value":"reaction:The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere: is xrefed to this process"},{"key":"providedBy","value":"https://reactome.org"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"R-HSA-174427"}]},{"id":"gomodel:R-HSA-174430/R-HSA-174430","type":[{"type":"class","id":"GO:0032201","label":"telomere maintenance via semi-conservative replication"}],"root-type":[{"type":"class","id":"GO:0008150","label":"biological_process"}],"annotations":[{"key":"comment","value":"DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis. In eukaryotic cells, the primer is synthesized by DNA polymerase alpha:primase. First, the DNA primase portion of this complex synthesizes approximately 6-10 nucleotides of RNA primer and then the DNA polymerase portion synthesizes an additional 20 nucleotides of DNA. There have been reports that TRF1 inhibits this activity at telomeres, though the mechanism and physiological relevance of this inhibition remain to be elucidated."},{"key":"contributor","value":"Authored: Blackburn, EH, Seidel, J, 2006-03-09 19:41:08"},{"key":"contributor","value":"Reviewed: Price, C, 2006-07-13 18:33:38"},{"key":"skos:narrower","value":"gomodel:R-HSA-174417/R-HSA-174417","value-type":"IRI"},{"key":"rdfs:label","value":"Telomere C-strand synthesis initiation"},{"key":"contributor","value":"Edited: Orlic-Milacic, Marija, 2020-05-04"},{"key":"providedBy","value":"https://reactome.org"},{"key":"date","value":"2026-07-02"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"contributor","value":"Reviewed: Hayashi, Makoto T, 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The relation \u0027The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere\u0027 \u0027null\u0027 \u0027The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere\u0027 was inferred because:\n reaction1 has an output that is an input of reaction 2. 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This relation was asserted based on the location of the enabling molecule. 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imported from: Reactome"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"For logical inference, import the integrated tbox ontology http://purl.obolibrary.org/obo/go/extensions/go-lego-reacto.owl"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-174430"},{"key":"comment","value":"http://www.reactome.org"},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"NCBITaxon:9606","value-type":"IRI"}]}