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synthesis"}],"root-type":[{"type":"class","id":"GO:0008150","label":"biological_process"}],"annotations":[{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"R-HSA-110320"},{"key":"rdfs:label","value":"Translesion Synthesis by POLH"},{"key":"contributor","value":"Edited: Orlic-Milacic, Marija, 2014-12-11"},{"key":"skos:note","value":"org.biopax.paxtools.model.level3.Pathway"},{"key":"date","value":"2026-07-02"},{"key":"contributor","value":"Authored: Gopinathrao, G, 2004-02-02 17:30:34"},{"key":"comment","value":"DNA polymerase eta (POLH) consists of 713 amino acids and can bypass thymidine-thymidine dimers, correctly adding two dAMPs opposite to the lesion. Mutations in the POLH gene result in the loss of this bypass activity and account for the XP variant phenotype (XPV) in human xeroderma pigmentosum disorder patients. POLH can carry out TLS past various UV and chemically induced lesions via two steps: (a) preferential incorporation of correct bases opposite to the lesion (b) conditional elongation only at the sites where such correct bases are inserted (Masutani et al. 1999, Masutani et al. 2000)."},{"key":"skos:narrower","value":"gomodel:R-HSA-110313/R-HSA-110313","value-type":"IRI"},{"key":"contributor","value":"Reviewed: Borowiec, James, 2015-01-07"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"providedBy","value":"https://reactome.org"}]},{"id":"gomodel:ev_w_id_R-HSA-110317_BFO_0000050_R-HSA-110320/R-HSA-110320_Reactome_R-HSA-110320","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"date","value":"2026-07-02"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"source","value":"Reactome:R-HSA-110320"}]},{"id":"gomodel:ev_w_id_R-HSA-110319_BFO_0000050_R-HSA-110320/R-HSA-110320_Reactome_R-HSA-110320","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"Reactome:R-HSA-110320"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"providedBy","value":"https://reactome.org"},{"key":"date","value":"2026-07-02"}]},{"id":"gomodel:ev_w_id_R-HSA-5654989_BFO_0000050_R-HSA-110320/R-HSA-110320_Reactome_R-HSA-110320","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2026-07-02"},{"key":"source","value":"Reactome:R-HSA-110320"},{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"}]},{"id":"gomodel:ev_w_id_R-HSA-5655170_BFO_0000050_R-HSA-110320/R-HSA-110320_Reactome_R-HSA-110320","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"providedBy","value":"https://reactome.org"},{"key":"source","value":"Reactome:R-HSA-110320"}]}],"facts":[{"subject":"gomodel:R-HSA-110317","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:R-HSA-110317_UniProt_Q9Y253","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-110317_RO_0002333_R-HSA-110317_UniProt_Q9Y253_Reactome_R-HSA-110317","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-110317_RO_0002333_R-HSA-110317_UniProt_Q9Y253_Reactome_R-HSA-110320","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-110320"}]},{"subject":"gomodel:R-HSA-5654989","property":"RO:0002234","property-label":"RO:0002234","object":"gomodel:R-ALL-113582_nucleoplasm","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-5654989_RO_0002234_R-ALL-113582_nucleoplasm_Reactome_R-HSA-110320","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-5654989_RO_0002234_R-ALL-113582_nucleoplasm_Reactome_R-HSA-5654989","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-110320"}]},{"subject":"gomodel:R-HSA-110317","property":"BFO:0000066","property-label":"BFO:0000066","object":"gomodel:reaction_R-HSA-110317_location_lociGO_0005654","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-110317_BFO_0000066_reaction_R-HSA-110317_location_lociGO_0005654_Reactome_R-HSA-110320","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-110320"},{"key":"comment","value":"Occurs In Rule. This relation was asserted based on the location of the enabling molecule. 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This relation was asserted based on the location of the enabling molecule. "}]},{"subject":"gomodel:R-HSA-5654989","property":"RO:0002233","property-label":"RO:0002233","object":"gomodel:R-ALL-29358_nucleoplasm","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-5654989_RO_0002233_R-ALL-29358_nucleoplasm_Reactome_R-HSA-110320","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-5654989_RO_0002233_R-ALL-29358_nucleoplasm_Reactome_R-HSA-5654989","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-110320"}]},{"subject":"gomodel:R-HSA-5654989","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:R-HSA-110320/R-HSA-110320","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-5654989_BFO_0000050_R-HSA-110320/R-HSA-110320_Reactome_R-HSA-110320","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-110320"}]},{"subject":"gomodel:R-HSA-110317","property":"RO:0002413","property-label":"RO:0002413","object":"gomodel:R-HSA-110319","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-110317_RO_0002413_R-HSA-110319_Reactome_R-HSA-110320","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-110320"},{"key":"comment","value":"Provides Input For Rule. The relation \u0027Insertion of correct bases opposite the lesion by POLH\u0027 \u0027null\u0027 \u0027Elongation by POLH\u0027 was inferred because:\n reaction1 has an output that is an input of reaction 2. "}]},{"subject":"gomodel:R-HSA-5654989","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:R-HSA-5654989_UniProt_P55072","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-5654989_RO_0002333_R-HSA-5654989_UniProt_P55072_Reactome_R-HSA-110320","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-5654989_RO_0002333_R-HSA-5654989_UniProt_P55072_Reactome_R-HSA-5654989","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-110320"}]},{"subject":"gomodel:R-HSA-5655170","property":"RO:0002234","property-label":"RO:0002234","object":"gomodel:R-HSA-5655134_R-HSA-5655170","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-5655170_RO_0002234_R-HSA-5655134_R-HSA-5655170_Reactome_R-HSA-110320","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-5655170_RO_0002234_R-HSA-5655134_R-HSA-5655170_Reactome_R-HSA-5655170","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-110320"}]},{"subject":"gomodel:R-HSA-110319","property":"RO:0002233","property-label":"RO:0002233","object":"gomodel:R-ALL-30555_nucleoplasm","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-110319_RO_0002233_R-ALL-30555_nucleoplasm_Reactome_R-HSA-110319","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-110319_RO_0002233_R-ALL-30555_nucleoplasm_Reactome_R-HSA-110320","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-110320"}]},{"subject":"gomodel:R-HSA-110317","property":"RO:0002234","property-label":"RO:0002234","object":"gomodel:R-ALL-113541_nucleoplasm","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-110317_RO_0002234_R-ALL-113541_nucleoplasm_Reactome_R-HSA-110317","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-110317_RO_0002234_R-ALL-113541_nucleoplasm_Reactome_R-HSA-110320","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-110320"}]},{"subject":"gomodel:R-HSA-5655170","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:R-HSA-5655170_UniProt_Q96PM5","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-5655170_RO_0002333_R-HSA-5655170_UniProt_Q96PM5_Reactome_R-HSA-110320","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-5655170_RO_0002333_R-HSA-5655170_UniProt_Q96PM5_Reactome_R-HSA-5655170","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-110320"}]},{"subject":"gomodel:R-HSA-110319","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:R-HSA-110320/R-HSA-110320","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-110319_BFO_0000050_R-HSA-110320/R-HSA-110320_Reactome_R-HSA-110320","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-110320"}]},{"subject":"gomodel:R-HSA-110317","property":"RO:0002629","property-label":"RO:0002629","object":"gomodel:R-HSA-110319","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-110317_RO_0002629_R-HSA-110319_Reactome_R-HSA-110320","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Entity Regulation Rule 3. The relation \u0027Insertion of correct bases opposite the lesion by POLH\u0027 \u0027null\u0027 \u0027Elongation by POLH\u0027 was inferred because:\n reaction1 has an output that is the enabler of reaction 2."},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-110320"}]}],"annotations":[{"key":"state","value":"development"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2026-07-02"},{"key":"title","value":"Translesion Synthesis by POLH - imported from: Reactome"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"For logical inference, import the integrated tbox ontology http://purl.obolibrary.org/obo/go/extensions/go-lego-reacto.owl"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-110320"},{"key":"comment","value":"http://www.reactome.org"},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"NCBITaxon:9606","value-type":"IRI"}]}