{"id":"gomodel:684b6c8100002679","individuals":[{"id":"gomodel:684b6c8100002679/684b6c8100002680","type":[{"type":"class","id":"CHEBI:58432","label":"histaminium"}],"root-type":[{"type":"class","id":"CHEBI:24431","label":"chemical entity"}],"annotations":[{"key":"providedBy","value":"https://www.uniprot.org"},{"key":"date","value":"2025-06-24"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"}]},{"id":"gomodel:684b6c8100002679/684b6c8100002681","type":[{"type":"class","id":"GO:0005576","label":"extracellular region"}],"root-type":[{"type":"class","id":"UBERON:0001062","label":"anatomical entity"},{"type":"class","id":"GO:0110165","label":"cellular anatomical structure"},{"type":"class","id":"GO:0005575","label":"cellular_component"}],"annotations":[{"key":"providedBy","value":"https://www.uniprot.org"},{"key":"date","value":"2026-03-12"},{"key":"comment","value":"Automated change 2026-03-12: GO:0005615 replaced by GO:0005576"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"}]},{"id":"gomodel:684b6c8100002679/684b6c8100002682","type":[{"type":"class","id":"ECO:0000314","label":"direct assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://www.uniprot.org"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"source","value":"PMID:8280179"},{"key":"date","value":"2025-06-24"}]},{"id":"gomodel:684b6c8100002679/684b6c8100003060","type":[{"type":"class","id":"GO:0004969","label":"histamine receptor activity"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"date","value":"2025-06-24"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"providedBy","value":"https://www.uniprot.org"}]},{"id":"gomodel:684b6c8100002679/684b6c8100003061","type":[{"type":"class","id":"UniProtKB:P25021","label":"HRH2 Hsap"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"},{"type":"class","id":"CHEBI:36080","label":"protein"}],"annotations":[{"key":"date","value":"2025-06-24"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"providedBy","value":"https://www.uniprot.org"}]},{"id":"gomodel:684b6c8100002679/684b6c8100003062","type":[{"type":"class","id":"GO:0007189","label":"adenylate cyclase-activating G protein-coupled receptor signaling pathway"}],"root-type":[{"type":"class","id":"GO:0008150","label":"biological_process"}],"annotations":[{"key":"date","value":"2025-06-25"},{"key":"providedBy","value":"https://www.uniprot.org"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"}]},{"id":"gomodel:684b6c8100002679/684b6c8100003063","type":[{"type":"class","id":"GO:0005886","label":"plasma membrane"}],"root-type":[{"type":"class","id":"UBERON:0001062","label":"anatomical entity"},{"type":"class","id":"GO:0110165","label":"cellular anatomical structure"},{"type":"class","id":"GO:0005575","label":"cellular_component"}],"annotations":[{"key":"providedBy","value":"https://www.uniprot.org"},{"key":"date","value":"2025-06-24"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"}]},{"id":"gomodel:684b6c8100002679/684b6c8100003064","type":[{"type":"class","id":"ECO:0000314","label":"direct assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"PMID:39462031"},{"key":"date","value":"2025-06-24"},{"key":"providedBy","value":"https://www.uniprot.org"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"}]},{"id":"gomodel:684b6c8100002679/684b6c8100003065","type":[{"type":"class","id":"ECO:0000304","label":"author statement supported by traceable reference used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"PMID:9725260"},{"key":"providedBy","value":"https://www.uniprot.org"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"date","value":"2025-06-24"}]},{"id":"gomodel:684b6c8100002679/684b6c8100003066","type":[{"type":"class","id":"ECO:0000304","label":"author statement supported by traceable reference used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://www.uniprot.org"},{"key":"source","value":"PMID:1714721"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"date","value":"2025-06-24"}]},{"id":"gomodel:684b6c8100002679/684b6c8100003067","type":[{"type":"class","id":"ECO:0000314","label":"direct assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://www.uniprot.org"},{"key":"source","value":"PMID:39462031"},{"key":"date","value":"2025-06-24"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"}]},{"id":"gomodel:684b6c8100002679/684b6c8100003241","type":[{"type":"class","id":"GO:0003925","label":"G protein activity"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"date","value":"2025-06-24"},{"key":"providedBy","value":"https://www.uniprot.org"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"}]},{"id":"gomodel:684b6c8100002679/684b6c8100003242","type":[{"type":"class","id":"UniProtKB:P63092","label":"GNAS Hsap"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"},{"type":"class","id":"CHEBI:36080","label":"protein"}],"annotations":[{"key":"date","value":"2025-06-24"},{"key":"providedBy","value":"https://www.uniprot.org"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"}]},{"id":"gomodel:684b6c8100002679/684b6c8100003243","type":[{"type":"class","id":"GO:0007189","label":"adenylate cyclase-activating G protein-coupled receptor signaling pathway"}],"root-type":[{"type":"class","id":"GO:0008150","label":"biological_process"}],"annotations":[{"key":"date","value":"2025-06-24"},{"key":"providedBy","value":"https://www.uniprot.org"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"}]},{"id":"gomodel:684b6c8100002679/684b6c8100003244","type":[{"type":"class","id":"GO:0009898","label":"cytoplasmic side of plasma membrane"}],"root-type":[{"type":"class","id":"UBERON:0001062","label":"anatomical entity"},{"type":"class","id":"GO:0110165","label":"cellular anatomical structure"},{"type":"class","id":"GO:0005575","label":"cellular_component"}],"annotations":[{"key":"providedBy","value":"https://www.uniprot.org"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"date","value":"2025-06-24"}]},{"id":"gomodel:684b6c8100002679/684b6c8100003245","type":[{"type":"class","id":"ECO:0000314","label":"direct assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"PMID:10200251"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"providedBy","value":"https://www.uniprot.org"},{"key":"date","value":"2025-06-24"}]},{"id":"gomodel:684b6c8100002679/684b6c8100003246","type":[{"type":"class","id":"ECO:0000314","label":"direct assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://www.uniprot.org"},{"key":"source","value":"PMID:10200251"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"date","value":"2025-06-24"}]},{"id":"gomodel:684b6c8100002679/684b6c8100003247","type":[{"type":"class","id":"ECO:0000314","label":"direct assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://www.uniprot.org"},{"key":"source","value":"PMID:12135370"},{"key":"date","value":"2025-06-24"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"}]},{"id":"gomodel:684b6c8100002679/684b6c8100003248","type":[{"type":"class","id":"ECO:0000314","label":"direct assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"providedBy","value":"https://www.uniprot.org"},{"key":"date","value":"2025-06-24"},{"key":"source","value":"PMID:39462031"}]},{"id":"gomodel:684b6c8100002679/684b6c8100003311","type":[{"type":"class","id":"UniProtKB:P63092","label":"GNAS Hsap"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"},{"type":"class","id":"CHEBI:36080","label":"protein"}],"annotations":[{"key":"date","value":"2025-06-25"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"providedBy","value":"https://www.uniprot.org"}]},{"id":"gomodel:684b6c8100002679/684b6c8100003312","type":[{"type":"class","id":"ECO:0000314","label":"direct assay evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2025-06-24"},{"key":"providedBy","value":"https://www.uniprot.org"},{"key":"source","value":"PMID:38418462"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"}]}],"facts":[{"subject":"gomodel:684b6c8100002679/684b6c8100003060","property":"BFO:0000066","property-label":"BFO:0000066","object":"gomodel:684b6c8100002679/684b6c8100003063","annotations":[{"key":"evidence","value":"gomodel:684b6c8100002679/684b6c8100003066","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"date","value":"2025-06-24"},{"key":"providedBy","value":"https://www.uniprot.org"}]},{"subject":"gomodel:684b6c8100002679/684b6c8100003060","property":"RO:0002233","property-label":"RO:0002233","object":"gomodel:684b6c8100002679/684b6c8100003311","annotations":[{"key":"evidence","value":"gomodel:684b6c8100002679/684b6c8100003312","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"date","value":"2025-06-24"},{"key":"providedBy","value":"https://www.uniprot.org"}]},{"subject":"gomodel:684b6c8100002679/684b6c8100002680","property":"RO:0001025","property-label":"RO:0001025","object":"gomodel:684b6c8100002679/684b6c8100002681","annotations":[{"key":"evidence","value":"gomodel:684b6c8100002679/684b6c8100002682","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"date","value":"2025-06-24"},{"key":"providedBy","value":"https://www.uniprot.org"}]},{"subject":"gomodel:684b6c8100002679/684b6c8100003241","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:684b6c8100002679/684b6c8100003243","annotations":[{"key":"evidence","value":"gomodel:684b6c8100002679/684b6c8100003246","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"date","value":"2025-06-24"},{"key":"providedBy","value":"https://www.uniprot.org"}]},{"subject":"gomodel:684b6c8100002679/684b6c8100003060","property":"RO:0002629","property-label":"RO:0002629","object":"gomodel:684b6c8100002679/684b6c8100003241","annotations":[{"key":"evidence","value":"gomodel:684b6c8100002679/684b6c8100003248","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"date","value":"2025-06-24"},{"key":"providedBy","value":"https://www.uniprot.org"}]},{"subject":"gomodel:684b6c8100002679/684b6c8100002680","property":"RO:0012005","property-label":"RO:0012005","object":"gomodel:684b6c8100002679/684b6c8100003060","annotations":[{"key":"evidence","value":"gomodel:684b6c8100002679/684b6c8100003067","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"date","value":"2025-06-24"},{"key":"providedBy","value":"https://www.uniprot.org"}]},{"subject":"gomodel:684b6c8100002679/684b6c8100003060","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:684b6c8100002679/684b6c8100003062","annotations":[{"key":"evidence","value":"gomodel:684b6c8100002679/684b6c8100003065","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"date","value":"2025-06-24"},{"key":"providedBy","value":"https://www.uniprot.org"}]},{"subject":"gomodel:684b6c8100002679/684b6c8100003241","property":"BFO:0000066","property-label":"BFO:0000066","object":"gomodel:684b6c8100002679/684b6c8100003244","annotations":[{"key":"evidence","value":"gomodel:684b6c8100002679/684b6c8100003247","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"date","value":"2025-06-24"},{"key":"providedBy","value":"https://www.uniprot.org"}]},{"subject":"gomodel:684b6c8100002679/684b6c8100003060","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:684b6c8100002679/684b6c8100003061","annotations":[{"key":"evidence","value":"gomodel:684b6c8100002679/684b6c8100003064","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"date","value":"2025-06-24"},{"key":"providedBy","value":"https://www.uniprot.org"}]},{"subject":"gomodel:684b6c8100002679/684b6c8100003241","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:684b6c8100002679/684b6c8100003242","annotations":[{"key":"evidence","value":"gomodel:684b6c8100002679/684b6c8100003245","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"date","value":"2025-06-24"},{"key":"providedBy","value":"https://www.uniprot.org"}]}],"annotations":[{"key":"state","value":"production"},{"key":"contributor","value":"https://orcid.org/0000-0001-7646-0052"},{"key":"date","value":"2026-03-12"},{"key":"title","value":"Histamine/HRH2 ligand/receptor (Human)"},{"key":"providedBy","value":"https://www.uniprot.org"},{"key":"comment","value":"Automated change 2026-03-12: GO:0005615 replaced by GO:0005576"},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"NCBITaxon:9606","value-type":"IRI"}]}