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stress"}],"root-type":[{"type":"class","id":"GO:0008150","label":"biological_process"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"hint-layout-x","value":"1256.25"},{"key":"hint-layout-y","value":"75"},{"key":"date","value":"2025-08-26"},{"key":"providedBy","value":"http://www.wormbase.org"}]},{"id":"gomodel:5667fdd400000696/689e7a5d00002002","type":[{"type":"class","id":"ECO:0000315","label":"mutant phenotype evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2025-08-19"},{"key":"source","value":"PMID:9353332"},{"key":"providedBy","value":"http://www.wormbase.org"}]},{"id":"gomodel:5667fdd400000696/69a0c46f00004726","type":[{"type":"class","id":"GO:0005576","label":"extracellular region"}],"root-type":[{"type":"class","id":"UBERON:0001062","label":"anatomical entity"},{"type":"class","id":"GO:0110165","label":"cellular anatomical structure"},{"type":"class","id":"GO:0005575","label":"cellular_component"}],"annotations":[{"key":"date","value":"2026-03-12"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"providedBy","value":"http://www.wormbase.org"}]},{"id":"gomodel:5667fdd400000696/69a0c46f00004727","type":[{"type":"class","id":"ECO:0000250","label":"sequence similarity evidence used in manual assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2026-03-12"},{"key":"source","value":"PMID:12654724"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"with","value":"UniProtKB:P01308"},{"key":"providedBy","value":"http://www.wormbase.org"}]}],"facts":[{"subject":"gomodel:5667fdd400000696/5667fdd400000701","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:5667fdd400000696/56cbaef000000094","annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2016-05-04"}]},{"subject":"gomodel:5667fdd400000696/568b0f9600000505","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:5667fdd400000696/56cbaef000000094","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/689e7a5d00001993","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2025-08-19"},{"key":"providedBy","value":"http://www.wormbase.org"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000708","property":"RO:0002212","property-label":"RO:0002212","object":"gomodel:5667fdd400000696/56cbaef000000094","annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2016-05-04"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000711","property":"BFO:0000066","property-label":"BFO:0000066","object":"gomodel:5667fdd400000696/568b0f9600000503","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/568b0f9600000504","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2016-01-28"},{"key":"comment","value":"Thus, the expression pattern and localization of SGK-1 closely resembles that of PDK-1 (Paradis et al., 1999), but  is  distinct  from  the  cellular  localization  of  AKT-1::GFP and AKT-2::GFP, which preferentially stain the cytoplasmic membrane (Paradis and Ruvkun, 1998; our unpublished data)."}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000708","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:5667fdd400000696/5716c41300000184","annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2016-05-04"}]},{"subject":"gomodel:5667fdd400000696/568b0f9600000488","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:5667fdd400000696/56cbaef000000094","annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2016-05-04"}]},{"subject":"gomodel:5667fdd400000696/56aac7ad00000000","property":"BFO:0000066","property-label":"BFO:0000066","object":"gomodel:5667fdd400000696/56aac7ad00000002","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/689e7a5d00001996","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2025-08-19"},{"key":"providedBy","value":"http://www.wormbase.org"}]},{"subject":"gomodel:5667fdd400000696/56aac7ad00000000","property":"RO:0002630","property-label":"RO:0002630","object":"gomodel:5667fdd400000696/5667fdd400000715","annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2023-03-16"},{"key":"comment","value":"Automated change 2023-03-16: RO:0002408 replaced by RO:0002630"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000697","property":"BFO:0000066","property-label":"BFO:0000066","object":"gomodel:5667fdd400000696/69a0c46f00004726","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/69a0c46f00004727","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2026-03-12"},{"key":"providedBy","value":"http://www.wormbase.org"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000699","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:5667fdd400000696/56cbaef000000094","annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2016-02-25"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000701","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:5667fdd400000696/568b0f9600000492","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/568b0f9600000493","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2016-01-27"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000697","property":"RO:0002233","property-label":"RO:0002233","object":"gomodel:5667fdd400000696/568b0f9600000465","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/568b0f9600000477","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2016-05-12"},{"key":"comment","value":"ES: Binding of INS-6 to the hIR was evaluated by competitive displacement of 125I-labeled human insulin (Fig.5A). Its relative affinity is 0.6% (Fig. 5A, open circles). Although low relative to insulin (Fig. 5A, closed circles), such binding is at least 10-fold tighter than that of mini-proinsulin (Fig. 5A, triangles). Competition between insulin and INS-6 suggests that the two ligands bind to overlapping or structurally linked sites. In independent assays of transmembrane signaling, INS-6 stimulates autophosphorylation of the cytoplasmic domain of the hIR to the same extent as insulin at corresponding levels of ectodomain occupancy (i.e., INS-6 functions as an agonist). Radioimmunoassays demonstrated that such activity is not the result of contamination by insulin. "}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000697","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:5667fdd400000696/56cbaef000000094","annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2016-03-16"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000711","property":"RO:0002630","property-label":"RO:0002630","object":"gomodel:5667fdd400000696/5667fdd400000715","annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2023-03-16"},{"key":"comment","value":"Automated change 2023-03-16: RO:0002408 replaced by RO:0002630"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000706","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:5667fdd400000696/56cbaef000000094","annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2016-05-04"}]},{"subject":"gomodel:5667fdd400000696/689e7a5d00001974","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:5667fdd400000696/689e7a5d00002001","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/689e7a5d00002002","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2025-08-19"},{"key":"providedBy","value":"http://www.wormbase.org"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000708","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:5667fdd400000696/568b0f9600000497","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/568b0f9600000500","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2016-01-28"},{"key":"comment","value":"The amino-terminal region of CePTEN contains the phosphatase catalytic\ndomain, and this region shares 38% sequence identity with the\ncorresponding domain of human PTEN (Fig. 1B)."}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000715","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:5667fdd400000696/689e7a5d00001997","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/689e7a5d00001998","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2025-08-19"},{"key":"providedBy","value":"http://www.wormbase.org"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000697","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:5667fdd400000696/568b0f9600000463","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/568b0f9600000464","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2016-05-12"}]},{"subject":"gomodel:5667fdd400000696/568b0f9600000505","property":"BFO:0000066","property-label":"BFO:0000066","object":"gomodel:5667fdd400000696/568b0f9600000507","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/568b0f9600000508","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2016-01-28"},{"key":"comment","value":"Thus, the expression pattern and localization of SGK-1 closely resembles that of PDK-1 (Paradis et al., 1999), but is distinct from the cellular localization of AKT-1::GFP and AKT-2::GFP, which preferentially stain the cytoplasmic membrane (Paradis and Ruvkun, 1998; our unpublished data)."}]},{"subject":"gomodel:5667fdd400000696/56aac7ad00000000","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:5667fdd400000696/56cbaef000000094","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/689e7a5d00001995","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2025-08-19"},{"key":"providedBy","value":"http://www.wormbase.org"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000715","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:5667fdd400000696/568b0f9600000275","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/689e7a5d00001978","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2025-08-19"},{"key":"providedBy","value":"http://www.wormbase.org"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000711","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:5667fdd400000696/568b0f9600000501","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/568b0f9600000502","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2016-01-28"},{"key":"comment","value":"Both AKT-1, AKT-2,  and SGK-1 purified  from  a  wild-type  background  phosphorylated DAF-16 (Figure 4A)."}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000708","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:5667fdd400000696/5716c41300000183","annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2016-05-04"}]},{"subject":"gomodel:5667fdd400000696/689e7a5d00001974","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:5667fdd400000696/689e7a5d00001975","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/689e7a5d00001977","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2025-08-19"},{"key":"providedBy","value":"http://www.wormbase.org"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000711","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:5667fdd400000696/56cbaef000000094","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/689e7a5d00001992","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2025-08-19"},{"key":"providedBy","value":"http://www.wormbase.org"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000706","property":"RO:0002629","property-label":"RO:0002629","object":"gomodel:5667fdd400000696/56aac7ad00000000","annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2023-03-16"},{"key":"comment","value":"Automated change 2023-03-16: RO:0002406 replaced by RO:0002629"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000699","property":"BFO:0000066","property-label":"BFO:0000066","object":"gomodel:5667fdd400000696/5667fdd400000700","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/568b0f9600000486","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2016-01-27"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000699","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:5667fdd400000696/568b0f9600000461","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/568b0f9600000485","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2016-01-27"}]},{"subject":"gomodel:5667fdd400000696/568b0f9600000505","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:5667fdd400000696/568b0f9600000506","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/56aac7ad00000004","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2016-02-01"},{"key":"comment","value":"Both AKT-1, AKT-2, and SGK-1 purified from a wild-type background phosphorylated DAF-16 (Figure 4A)."}]},{"subject":"gomodel:5667fdd400000696/689e7a5d00001974","property":"BFO:0000066","property-label":"BFO:0000066","object":"gomodel:5667fdd400000696/689e7a5d00001999","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/689e7a5d00002000","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2025-08-19"},{"key":"providedBy","value":"http://www.wormbase.org"}]},{"subject":"gomodel:5667fdd400000696/56aac7ad00000000","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:5667fdd400000696/56aac7ad00000001","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/689e7a5d00001994","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2025-08-19"},{"key":"providedBy","value":"http://www.wormbase.org"}]},{"subject":"gomodel:5667fdd400000696/568b0f9600000488","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:5667fdd400000696/568b0f9600000489","annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2016-01-27"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000699","property":"RO:0002629","property-label":"RO:0002629","object":"gomodel:5667fdd400000696/568b0f9600000488","annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2023-03-16"},{"key":"comment","value":"Automated change 2023-03-16: RO:0002213 replaced by RO:0002629"}]},{"subject":"gomodel:5667fdd400000696/568b0f9600000505","property":"RO:0002630","property-label":"RO:0002630","object":"gomodel:5667fdd400000696/5667fdd400000715","annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2023-03-16"},{"key":"comment","value":"Automated change 2023-03-16: RO:0002408 replaced by RO:0002630"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000697","property":"RO:0002629","property-label":"RO:0002629","object":"gomodel:5667fdd400000696/5667fdd400000699","annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2023-03-16"},{"key":"comment","value":"Automated change 2023-03-16: RO:0002406 replaced by RO:0002629"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000706","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:5667fdd400000696/568b0f9600000498","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/568b0f9600000499","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2016-01-28"},{"key":"comment","value":"Both AKT-1, AKT-2, and SGK-1 purified from a wild-type background phosphorylated DAF-16 (Figure 4A). In contrast, all three kinases purified\nfrom a pdk-1 mutant background were not able to phosphorylate DAF-16 (Figure 4A). This demonstrates that functional PDK-1 is required to activate AKT-1, AKT-2, and SGK-1 in vivo."}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000706","property":"RO:0002629","property-label":"RO:0002629","object":"gomodel:5667fdd400000696/568b0f9600000505","annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2023-03-16"},{"key":"comment","value":"Automated change 2023-03-16: RO:0002406 replaced by RO:0002629"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000715","property":"BFO:0000066","property-label":"BFO:0000066","object":"gomodel:5667fdd400000696/5667fdd400000716","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/689e7a5d00001991","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2025-08-19"},{"key":"providedBy","value":"http://www.wormbase.org"}]},{"subject":"gomodel:5667fdd400000696/568b0f9600000488","property":"RO:0002629","property-label":"RO:0002629","object":"gomodel:5667fdd400000696/5667fdd400000701","annotations":[{"key":"evidence","value":"gomodel:5667fdd400000696/568b0f9600000491","value-type":"IRI"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2023-03-16"},{"key":"comment","value":"Automated change 2023-03-16: RO:0002406 replaced by RO:0002629"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000701","property":"RO:0002629","property-label":"RO:0002629","object":"gomodel:5667fdd400000696/5667fdd400000706","annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2023-03-16"},{"key":"comment","value":"Automated change 2023-03-16: RO:0002406 replaced by RO:0002629"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000708","property":"RO:0002630","property-label":"RO:0002630","object":"gomodel:5667fdd400000696/5667fdd400000706","annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2023-03-16"},{"key":"comment","value":"Automated change 2023-03-16: RO:0002408 replaced by RO:0002630"}]},{"subject":"gomodel:5667fdd400000696/5667fdd400000706","property":"RO:0002629","property-label":"RO:0002629","object":"gomodel:5667fdd400000696/5667fdd400000711","annotations":[{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2023-03-16"},{"key":"comment","value":"Automated change 2023-03-16: RO:0002406 replaced by RO:0002629"}]}],"annotations":[{"key":"state","value":"development"},{"key":"contributor","value":"https://orcid.org/0000-0002-1706-4196"},{"key":"date","value":"2026-03-12"},{"key":"title","value":"Signaling - C. elegans insulin receptor signaling"},{"key":"providedBy","value":"http://www.wormbase.org"},{"key":"http://www.geneontology.org/formats/oboInOwl#id","value":"gomodel:5667fdd400000696"},{"key":"comment","value":"Automated change 2022-09-22: GO:0044214 replaced by GO:0005886"},{"key":"comment","value":"Automated change 2023-03-16: RO:0002213 replaced by RO:0002629"},{"key":"comment","value":"Automated change 2023-03-16: RO:0002406 replaced by RO:0002629"},{"key":"comment","value":"Automated change 2023-03-16: RO:0002408 replaced by RO:0002630"},{"key":"comment","value":"Automated change 2023-07-20: GO:0038028 replaced by GO:0008286"},{"key":"comment","value":"Based on Figure 1 from PMID:24395814"},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"NCBITaxon:6239","value-type":"IRI"}]}