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Fig. 2; LRRTM2 has a pre-synaptogenic activity when transfected in COS cells cocultured with hippocampal neurons\nLiteral:\n\"we measured the amount of synapsin clustering associated with transfected COS cells and not associated with MAP2-positive dendrites to exclude interneuronal synapses. Robust synaptogenic activity was observed for LRRTM2-CFP\"\n\n24/5/2017 Pim\n- Fig.3: non-neuronal cells transfected with LRRTM2-CFP (rat protein) and NMDAR (simulating a postsynaptic neuron) are able to induce presynaptic differentiation of a neuron (detectable glutamate release from SV\u0027s)\n\nFig. 4; clustering of synapsin was induced by beads coated with LRRTM2 LRR-AP\nLiteral:\n\"LRRTM2 LRR-AP, was linked via biotinylated anti-myc antibody onto neutravidin beads. Contact of these LRR-APcoated beads with isolated axons of hippocampal neurons induced clustering of synapsin or VGLUT1 at contact sites (Figures 4A and 4B, right panels). Beads coated with the control AP protein did not display synaptogenic activity (Figures 4A and 4B, left panels). Random counts revealed synapsin clustering at\n34.1% of LRR-AP bead contacts and only 2.1% of control AP bead contacts (n \u003d 50 fields). The mean synapsin intensity under all LRR-AP beads was 6.3-fold higher than that under control AP beads (p \u003c 0.0001). Clustering of the active zone marker bassoon could also be detected at LRR-AP bead-axon contact sites. In fact, there appeared to be separation between the bassoon-labeled active zone and the VGLUT1-positive vesicle pool, with the active zone most closely apposed to the bead surface (Figure 4B, right panel, inset...\". Experimental description: Rat LRRTM2 for overexpression experiments was used\n\nLitaral form Supplemental Experimental Procedures\n\"Cloning full-length LRRTMs\nFull length cDNAs for LRRTMs were made using RT-PCR from p11 rat brain total RNA.\""},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_10116"}]}