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change 2024-03-14: GO:0099056 replaced by GO:0042734"},{"key":"comment","value":"Rationale: Areas of interest: latero-ventral hippocampus (CA1 radiatum and CA3 lucidum-radiatum), the deep layers (V-VI) of the primary motor cortex\n\nUsing electron micrographs, EphA4 was detected with anti-EphA4 immunoperoxidase labeling in the adult mouse hippocampus within axon terminals and dendritic spines. Some dendritic shafts were occasionally labeled in the mouse hippocampus. No immunoperoxidase staining was found in EphA4 KO mice.\n\nUsing pre-embedding immunogold labeling in electron micrographs of CA1, anti-EphA4 silver-intensified immunogold particles (SIGPs) were significantly concentrated in axon terminals (plasma membrane and vesicles).\n\nFig 3. On Western Blots, EphA4 is detected in presynaptic active zone fractions from purified synaptosomes that are positive for SNAP25 and synaptophysin (and negative for PSD95 and GluR2/3)\nFig 4. EphA4 is preferentially detected in axon terminals and dendritic spines in area CA3 of hippocampus, using immunoperoxidase staining in EM.\nFig 5 and quantification in Fig 6. EphA4 is preferentially detected in axon terminals in area CA1 of hippocampus, using pre-embedding immunogold labeling in EM.\nFig 7 and quantification in Fig 8. At the organelle level using pre-embedding immunogold labeling in EM, EphA4 is detected: at vesicles, plasma membrane, and other (core of the profiles but not clearly attributable to specific organelles) of axon terminals in area CA1 of hippocampus; majority at vesicles, but also at plasma membrane and other in CA3 and motor cortex.\n\n2017/6/2017 Pim\n- \"integral component ..\" inferred from transmembrane topology of EphB2.. Experimental description: The electron microscopic analysis was carried out on brain tissue from one EphA4 KO (EphA4-/-), one wild-type littermate (EphA4+/+) (Dottori et al. 1998) and 4 C57BL/6 adult male mice."},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"http://purl.obolibrary.org/obo/NCBITaxon_10090"}]}