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As a key enzymatic component in the signaling pathway, ABL supports repellent signaling (by recruiting the necessary actin binding proteins) and also feeds back on the receptor (by down regulating through phosphorylation) to adjust the sensitivity of the pathway.\u003cbr\u003eABL cooperates with multiple effectors, including the actin binding protein Capulet (Capt) and Orbit/MAST/CLASP, suggesting that ABL simultaneously coordinates the dynamics of two major cytoskeletal systems to achieve growth cone repellent guidance."}]},{"id":"gomodel:ev_w_id_R-HSA-376141_BFO_0000050_R-HSA-428890/R-HSA-428890_Reactome_R-HSA-428890","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2023-06-21"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"providedBy","value":"https://reactome.org"},{"key":"source","value":"Reactome:R-HSA-428890"}]},{"id":"gomodel:ev_w_id_R-HSA-428883_BFO_0000050_R-HSA-428890/R-HSA-428890_Reactome_R-HSA-428890","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"date","value":"2023-06-21"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"source","value":"Reactome:R-HSA-428890"}]},{"id":"gomodel:ev_w_id_R-HSA-428885_BFO_0000050_R-HSA-428890/R-HSA-428890_Reactome_R-HSA-428890","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2023-06-21"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"source","value":"Reactome:R-HSA-428890"},{"key":"providedBy","value":"https://reactome.org"}]},{"id":"gomodel:ev_w_id_R-HSA-428888_BFO_0000050_R-HSA-428890/R-HSA-428890_Reactome_R-HSA-428890","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"Reactome:R-HSA-428890"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"providedBy","value":"https://reactome.org"},{"key":"date","value":"2023-06-21"}]}],"facts":[{"subject":"gomodel:R-HSA-428883","property":"RO:0002234","property-label":"RO:0002234","object":"gomodel:R-HSA-428875_R-HSA-428883","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428883_RO_0002234_R-HSA-428875_R-HSA-428883_Reactome_R-HSA-428883","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428883_RO_0002234_R-HSA-428875_R-HSA-428883_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-428888","property":"RO:0002234","property-label":"RO:0002234","object":"gomodel:CHEBI_456216_R-HSA-428888","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428888_RO_0002234_CHEBI_456216_R-HSA-428888_Reactome_R-HSA-428888","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428888_RO_0002234_CHEBI_456216_R-HSA-428888_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-376141","property":"RO:0002413","property-label":"RO:0002413","object":"gomodel:R-HSA-428885","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-376141_RO_0002413_R-HSA-428885_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"},{"key":"comment","value":"Provides Input For Rule. The relation \u0027Interaction of ABL with ROBO1:SLIT2\u0027 \u0027null\u0027 \u0027Activation of CLASP\u0027 was inferred because:\n reaction1 has an output that is an input of reaction 2. "}]},{"subject":"gomodel:R-HSA-428883","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:R-HSA-428890/R-HSA-428890","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428883_BFO_0000050_R-HSA-428890/R-HSA-428890_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-204364","property":"RO:0002233","property-label":"RO:0002233","object":"gomodel:R-HSA-375997_R-HSA-204364","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-204364_RO_0002233_R-HSA-375997_R-HSA-204364_Reactome_R-HSA-204364","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-204364_RO_0002233_R-HSA-375997_R-HSA-204364_Reactome_R-HSA-376176","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-204364","property":"RO:0002234","property-label":"RO:0002234","object":"gomodel:R-HSA-390371_R-HSA-204364","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-204364_RO_0002234_R-HSA-390371_R-HSA-204364_Reactome_R-HSA-204364","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-204364_RO_0002234_R-HSA-390371_R-HSA-204364_Reactome_R-HSA-376176","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-428888","property":"RO:0002233","property-label":"RO:0002233","object":"gomodel:CHEBI_30616_R-HSA-428888","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428888_RO_0002233_CHEBI_30616_R-HSA-428888_Reactome_R-HSA-428888","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428888_RO_0002233_CHEBI_30616_R-HSA-428888_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-376141","property":"RO:0002413","property-label":"RO:0002413","object":"gomodel:R-HSA-428883","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-376141_RO_0002413_R-HSA-428883_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"},{"key":"comment","value":"Provides Input For Rule. The relation \u0027Interaction of ABL with ROBO1:SLIT2\u0027 \u0027null\u0027 \u0027Recruitment of CAP to ABL\u0027 was inferred because:\n reaction1 has an output that is an input of reaction 2. "}]},{"subject":"gomodel:R-HSA-376141","property":"RO:0002233","property-label":"RO:0002233","object":"gomodel:R-HSA-376002_R-HSA-376141","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-376141_RO_0002233_R-HSA-376002_R-HSA-376141_Reactome_R-HSA-376141","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-376141_RO_0002233_R-HSA-376002_R-HSA-376141_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-428885","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:R-HSA-428890/R-HSA-428890","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428885_BFO_0000050_R-HSA-428890/R-HSA-428890_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-376141","property":"RO:0002233","property-label":"RO:0002233","object":"gomodel:R-HSA-390371_R-HSA-376141","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-376141_RO_0002233_R-HSA-390371_R-HSA-376141_Reactome_R-HSA-376141","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-376141_RO_0002233_R-HSA-390371_R-HSA-376141_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-428888","property":"RO:0002234","property-label":"RO:0002234","object":"gomodel:R-HSA-376027_R-HSA-428888","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428888_RO_0002234_R-HSA-376027_R-HSA-428888_Reactome_R-HSA-428888","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428888_RO_0002234_R-HSA-376027_R-HSA-428888_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-428883","property":"RO:0002233","property-label":"RO:0002233","object":"gomodel:R-HSA-428873_R-HSA-428883","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428883_RO_0002233_R-HSA-428873_R-HSA-428883_Reactome_R-HSA-428883","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428883_RO_0002233_R-HSA-428873_R-HSA-428883_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-204364","property":"RO:0002411","property-label":"RO:0002411","object":"gomodel:R-HSA-376141","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-204364_RO_0002411_R-HSA-376141_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-428885","property":"RO:0002234","property-label":"RO:0002234","object":"gomodel:R-HSA-428876_R-HSA-428885","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428885_RO_0002234_R-HSA-428876_R-HSA-428885_Reactome_R-HSA-428885","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428885_RO_0002234_R-HSA-428876_R-HSA-428885_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-376141","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:R-HSA-428890/R-HSA-428890","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-376141_BFO_0000050_R-HSA-428890/R-HSA-428890_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-376141","property":"RO:0002629","property-label":"RO:0002629","object":"gomodel:R-HSA-428888","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-376141_RO_0002629_R-HSA-428888_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Entity Regulation Rule 3. The relation \u0027Interaction of ABL with ROBO1:SLIT2\u0027 \u0027null\u0027 \u0027Phosphorylation of ROBO1 by ABL kinase\u0027 was inferred because:\n reaction1 has an output that is the enabler of reaction 2."},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-428883","property":"RO:0002233","property-label":"RO:0002233","object":"gomodel:R-HSA-428868_R-HSA-428883","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428883_RO_0002233_R-HSA-428868_R-HSA-428883_Reactome_R-HSA-428883","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428883_RO_0002233_R-HSA-428868_R-HSA-428883_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-204364","property":"RO:0002233","property-label":"RO:0002233","object":"gomodel:R-HSA-204361_R-HSA-204364","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-204364_RO_0002233_R-HSA-204361_R-HSA-204364_Reactome_R-HSA-204364","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-204364_RO_0002233_R-HSA-204361_R-HSA-204364_Reactome_R-HSA-376176","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-428885","property":"RO:0002233","property-label":"RO:0002233","object":"gomodel:R-HSA-428867_R-HSA-428885","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428885_RO_0002233_R-HSA-428867_R-HSA-428885_Reactome_R-HSA-428885","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428885_RO_0002233_R-HSA-428867_R-HSA-428885_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-428888","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:376138_R-HSA-376002","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428888_RO_0002333_376138_R-HSA-376002_Reactome_R-HSA-428888","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428888_RO_0002333_376138_R-HSA-376002_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-428888","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:R-HSA-428890/R-HSA-428890","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428888_BFO_0000050_R-HSA-428890/R-HSA-428890_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-376141","property":"RO:0002234","property-label":"RO:0002234","object":"gomodel:R-HSA-428873_R-HSA-376141","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-376141_RO_0002234_R-HSA-428873_R-HSA-376141_Reactome_R-HSA-376141","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-376141_RO_0002234_R-HSA-428873_R-HSA-376141_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-376141","property":"RO:0002413","property-label":"RO:0002413","object":"gomodel:R-HSA-428888","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-376141_RO_0002413_R-HSA-428888_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"},{"key":"comment","value":"Provides Input For Rule. The relation \u0027Interaction of ABL with ROBO1:SLIT2\u0027 \u0027null\u0027 \u0027Phosphorylation of ROBO1 by ABL kinase\u0027 was inferred because:\n reaction1 has an output that is an input of reaction 2. "}]},{"subject":"gomodel:R-HSA-428885","property":"RO:0002233","property-label":"RO:0002233","object":"gomodel:R-HSA-428873_R-HSA-428885","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428885_RO_0002233_R-HSA-428873_R-HSA-428885_Reactome_R-HSA-428885","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428885_RO_0002233_R-HSA-428873_R-HSA-428885_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]},{"subject":"gomodel:R-HSA-428888","property":"RO:0002233","property-label":"RO:0002233","object":"gomodel:R-HSA-428873_R-HSA-428888","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428888_RO_0002233_R-HSA-428873_R-HSA-428888_Reactome_R-HSA-428888","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-428888_RO_0002233_R-HSA-428873_R-HSA-428888_Reactome_R-HSA-428890","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"}]}],"annotations":[{"key":"state","value":"development"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"title","value":"Role of ABL in ROBO-SLIT signaling - imported from: Reactome"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"For logical inference, import the integrated tbox ontology http://purl.obolibrary.org/obo/go/extensions/go-lego-reacto.owl"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-428890"},{"key":"comment","value":"http://www.reactome.org"},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"NCBITaxon:9606","value-type":"IRI"}]}