{"id":"gomodel:R-HSA-425986","individuals":[{"id":"gomodel:R-HSA-4084678_R-HSA-425983_controller","type":[{"type":"class","id":"obo:go/extensions/reacto.owl#REACTO_R-HSA-4084678","label":"SLC9A6,7"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"},{"type":"class","id":"CHEBI:36080","label":"protein"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"rdfs:label","value":"SLC9A6,7"},{"key":"comment","value":"located_in early endosome membrane"},{"key":"skos:note","value":"org.biopax.paxtools.model.level3.Protein"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#Protein20804","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-HSA-4084678"}]},{"id":"gomodel:R-HSA-425963_R-HSA-425994_controller","type":[{"type":"class","id":"obo:go/extensions/reacto.owl#REACTO_R-HSA-425963","label":"SLC9A1-5"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"},{"type":"class","id":"CHEBI:36080","label":"protein"}],"annotations":[{"key":"skos:note","value":"org.biopax.paxtools.model.level3.Protein"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#Protein20798","value-type":"IRI"},{"key":"date","value":"2023-06-21"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-HSA-425963"},{"key":"comment","value":"located_in plasma membrane"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"providedBy","value":"https://reactome.org"},{"key":"rdfs:label","value":"SLC9A1-5"}]},{"id":"gomodel:R-HSA-425965","type":[{"type":"class","id":"GO:0015385","label":"sodium:proton antiporter activity"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-HSA-425965"},{"key":"comment","value":"Transporter Rule.  This reaction represents the activity of transporting "},{"key":"skos:note","value":"org.biopax.paxtools.model.level3.BiochemicalReaction"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#BiochemicalReaction6706","value-type":"IRI"},{"key":"rdfs:label","value":"Na+/H+ exchanger transport (at late endosome membrane)"},{"key":"date","value":"2023-06-21"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"providedBy","value":"https://reactome.org"}]},{"id":"gomodel:R-HSA-425972_R-HSA-425965_controller","type":[{"type":"class","id":"obo:go/extensions/reacto.owl#REACTO_R-HSA-425972","label":"SLC9A9"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"},{"type":"class","id":"CHEBI:36080","label":"protein"}],"annotations":[{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-HSA-425972"},{"key":"skos:note","value":"org.biopax.paxtools.model.level3.Protein"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#Protein20810","value-type":"IRI"},{"key":"comment","value":"located_in late endosome membrane"},{"key":"rdfs:label","value":"SLC9A9"},{"key":"date","value":"2023-06-21"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"providedBy","value":"https://reactome.org"}]},{"id":"gomodel:R-HSA-425983","type":[{"type":"class","id":"GO:0015385","label":"sodium:proton antiporter activity"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"comment","value":"Transporter Rule.  This reaction represents the activity of transporting "},{"key":"skos:note","value":"org.biopax.paxtools.model.level3.BiochemicalReaction"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-HSA-425983"},{"key":"rdfs:label","value":"Na+/H+ exchanger transport (at early endosome membrane)"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#BiochemicalReaction6704","value-type":"IRI"}]},{"id":"gomodel:R-HSA-425994","type":[{"type":"class","id":"GO:0015385","label":"sodium:proton antiporter activity"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"contributor","value":"GOC:reactome_curators"},{"key":"skos:note","value":"org.biopax.paxtools.model.level3.BiochemicalReaction"},{"key":"comment","value":"Transporter Rule.  This reaction represents the activity of transporting "},{"key":"rdfs:label","value":"Na+/H+ exchanger transport (at cell membrane)"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-HSA-425994"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#BiochemicalReaction6703","value-type":"IRI"}]},{"id":"gomodel:R-HSA-426005_R-HSA-426015_controller","type":[{"type":"class","id":"obo:go/extensions/reacto.owl#REACTO_R-HSA-426005","label":"SLC9A7/8"}],"root-type":[{"type":"class","id":"CHEBI:33695","label":"information biomacromolecule"},{"type":"class","id":"CHEBI:24431","label":"chemical entity"},{"type":"class","id":"CHEBI:36080","label":"protein"}],"annotations":[{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-HSA-426005"},{"key":"date","value":"2023-06-21"},{"key":"skos:note","value":"org.biopax.paxtools.model.level3.Protein"},{"key":"rdfs:label","value":"SLC9A7/8"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"providedBy","value":"https://reactome.org"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#Protein20807","value-type":"IRI"},{"key":"comment","value":"located_in Golgi membrane"}]},{"id":"gomodel:R-HSA-426015","type":[{"type":"class","id":"GO:0015385","label":"sodium:proton antiporter activity"}],"root-type":[{"type":"class","id":"GO:0003674","label":"molecular_function"},{"type":"class","id":"obo:go/extensions/reacto.owl#molecular_event","label":"Molecular Event"}],"annotations":[{"key":"rdfs:label","value":"Na+/H+ exchanger transport (at trans-golgi membrane)"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#BiochemicalReaction6705","value-type":"IRI"},{"key":"date","value":"2023-06-21"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"comment","value":"Transporter Rule.  This reaction represents the activity of transporting "},{"key":"skos:note","value":"org.biopax.paxtools.model.level3.BiochemicalReaction"},{"key":"providedBy","value":"https://reactome.org"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-HSA-426015"}]},{"id":"gomodel:ev_w_id_R-HSA-425965_BFO_0000066_reaction_R-HSA-425965_location_lociGO_0031902_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"date","value":"2023-06-21"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"source","value":"Reactome:R-HSA-425986"}]},{"id":"gomodel:ev_w_id_R-HSA-425965_RO_0002333_R-HSA-425972_R-HSA-425965_controller_Reactome_R-HSA-425965","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"date","value":"2023-06-21"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"source","value":"Reactome:R-HSA-425965"}]},{"id":"gomodel:ev_w_id_R-HSA-425965_RO_0002333_R-HSA-425972_R-HSA-425965_controller_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"source","value":"Reactome:R-HSA-425986"}]},{"id":"gomodel:ev_w_id_R-HSA-425965_RO_0004009_transported_CHEBI_15378_R-HSA-425965_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000363","label":"computational inference used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2023-06-21"},{"key":"source","value":"Reactome:R-HSA-425986"},{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"}]},{"id":"gomodel:ev_w_id_R-HSA-425965_RO_0004009_transported_CHEBI_29101_R-HSA-425965_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000363","label":"computational inference used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2023-06-21"},{"key":"source","value":"Reactome:R-HSA-425986"},{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"}]},{"id":"gomodel:ev_w_id_R-HSA-425983_BFO_0000066_reaction_R-HSA-425983_location_lociGO_0031901_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"GOC:reactome_curators"},{"key":"providedBy","value":"https://reactome.org"},{"key":"date","value":"2023-06-21"},{"key":"source","value":"Reactome:R-HSA-425986"}]},{"id":"gomodel:ev_w_id_R-HSA-425983_RO_0002333_R-HSA-4084678_R-HSA-425983_controller_Reactome_R-HSA-425983","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"source","value":"Reactome:R-HSA-425983"},{"key":"date","value":"2023-06-21"}]},{"id":"gomodel:ev_w_id_R-HSA-425983_RO_0002333_R-HSA-4084678_R-HSA-425983_controller_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"Reactome:R-HSA-425986"},{"key":"date","value":"2023-06-21"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"providedBy","value":"https://reactome.org"}]},{"id":"gomodel:ev_w_id_R-HSA-425983_RO_0004009_transported_CHEBI_15378_R-HSA-425983_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000363","label":"computational inference used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2023-06-21"},{"key":"source","value":"Reactome:R-HSA-425986"},{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"}]},{"id":"gomodel:ev_w_id_R-HSA-425983_RO_0004009_transported_CHEBI_29101_R-HSA-425983_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000363","label":"computational inference used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"Reactome:R-HSA-425986"},{"key":"date","value":"2023-06-21"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"providedBy","value":"https://reactome.org"}]},{"id":"gomodel:ev_w_id_R-HSA-425994_BFO_0000066_reaction_R-HSA-425994_location_lociGO_0005886_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"Reactome:R-HSA-425986"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"providedBy","value":"https://reactome.org"},{"key":"date","value":"2023-06-21"}]},{"id":"gomodel:ev_w_id_R-HSA-425994_RO_0002333_R-HSA-425963_R-HSA-425994_controller_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"source","value":"Reactome:R-HSA-425986"},{"key":"providedBy","value":"https://reactome.org"}]},{"id":"gomodel:ev_w_id_R-HSA-425994_RO_0002333_R-HSA-425963_R-HSA-425994_controller_Reactome_R-HSA-425994","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"Reactome:R-HSA-425994"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"}]},{"id":"gomodel:ev_w_id_R-HSA-425994_RO_0004009_transported_CHEBI_15378_R-HSA-425994_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000363","label":"computational inference used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"GOC:reactome_curators"},{"key":"providedBy","value":"https://reactome.org"},{"key":"date","value":"2023-06-21"},{"key":"source","value":"Reactome:R-HSA-425986"}]},{"id":"gomodel:ev_w_id_R-HSA-425994_RO_0004009_transported_CHEBI_29101_R-HSA-425994_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000363","label":"computational inference used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"source","value":"Reactome:R-HSA-425986"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"}]},{"id":"gomodel:ev_w_id_R-HSA-426015_BFO_0000066_reaction_R-HSA-426015_location_lociGO_0000139_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"GOC:reactome_curators"},{"key":"source","value":"Reactome:R-HSA-425986"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"}]},{"id":"gomodel:ev_w_id_R-HSA-426015_RO_0002333_R-HSA-426005_R-HSA-426015_controller_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"GOC:reactome_curators"},{"key":"source","value":"Reactome:R-HSA-425986"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"}]},{"id":"gomodel:ev_w_id_R-HSA-426015_RO_0002333_R-HSA-426005_R-HSA-426015_controller_Reactome_R-HSA-426015","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"Reactome:R-HSA-426015"},{"key":"providedBy","value":"https://reactome.org"},{"key":"date","value":"2023-06-21"},{"key":"contributor","value":"GOC:reactome_curators"}]},{"id":"gomodel:ev_w_id_R-HSA-426015_RO_0004009_transported_CHEBI_15378_R-HSA-426015_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000363","label":"computational inference used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"Reactome:R-HSA-425986"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"}]},{"id":"gomodel:ev_w_id_R-HSA-426015_RO_0004009_transported_CHEBI_29101_R-HSA-426015_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000363","label":"computational inference used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"source","value":"Reactome:R-HSA-425986"}]},{"id":"gomodel:reaction_R-HSA-425965_location_lociGO_0031902","type":[{"type":"class","id":"GO:0031902","label":"late endosome membrane"}],"root-type":[{"type":"class","id":"UBERON:0001062","label":"anatomical entity"},{"type":"class","id":"GO:0110165","label":"cellular anatomical structure"},{"type":"class","id":"GO:0005575","label":"cellular_component"}],"annotations":[{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"}]},{"id":"gomodel:reaction_R-HSA-425983_location_lociGO_0031901","type":[{"type":"class","id":"GO:0031901","label":"early endosome membrane"}],"root-type":[{"type":"class","id":"UBERON:0001062","label":"anatomical entity"},{"type":"class","id":"GO:0110165","label":"cellular anatomical structure"},{"type":"class","id":"GO:0005575","label":"cellular_component"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"date","value":"2023-06-21"},{"key":"contributor","value":"GOC:reactome_curators"}]},{"id":"gomodel:reaction_R-HSA-425994_location_lociGO_0005886","type":[{"type":"class","id":"GO:0005886","label":"plasma membrane"}],"root-type":[{"type":"class","id":"UBERON:0001062","label":"anatomical entity"},{"type":"class","id":"GO:0110165","label":"cellular anatomical structure"},{"type":"class","id":"GO:0005575","label":"cellular_component"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"}]},{"id":"gomodel:reaction_R-HSA-426015_location_lociGO_0000139","type":[{"type":"class","id":"GO:0000139","label":"Golgi membrane"}],"root-type":[{"type":"class","id":"UBERON:0001062","label":"anatomical entity"},{"type":"class","id":"GO:0110165","label":"cellular anatomical structure"},{"type":"class","id":"GO:0005575","label":"cellular_component"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"date","value":"2023-06-21"},{"key":"contributor","value":"GOC:reactome_curators"}]},{"id":"gomodel:transported_CHEBI_15378_R-HSA-425965","type":[{"type":"class","id":"CHEBI:15378","label":"hydron"}],"root-type":[{"type":"class","id":"CHEBI:24431","label":"chemical entity"}],"annotations":[{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#SmallMolecule253","value-type":"IRI"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-ALL-425999"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-ALL-70106"},{"key":"rdfs:label","value":"H+"},{"key":"providedBy","value":"https://reactome.org"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#SmallMolecule88","value-type":"IRI"},{"key":"comment","value":"located_in late endosome lumen"},{"key":"comment","value":"located_in cytosol"},{"key":"skos:note","value":"org.biopax.paxtools.model.level3.SmallMolecule"}]},{"id":"gomodel:transported_CHEBI_15378_R-HSA-425983","type":[{"type":"class","id":"CHEBI:15378","label":"hydron"}],"root-type":[{"type":"class","id":"CHEBI:24431","label":"chemical entity"}],"annotations":[{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-ALL-70106"},{"key":"rdfs:label","value":"H+"},{"key":"providedBy","value":"https://reactome.org"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#SmallMolecule88","value-type":"IRI"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#SmallMolecule252","value-type":"IRI"},{"key":"date","value":"2023-06-21"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-ALL-425978"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"skos:note","value":"org.biopax.paxtools.model.level3.SmallMolecule"},{"key":"comment","value":"located_in early endosome lumen"},{"key":"comment","value":"located_in cytosol"}]},{"id":"gomodel:transported_CHEBI_15378_R-HSA-425994","type":[{"type":"class","id":"CHEBI:15378","label":"hydron"}],"root-type":[{"type":"class","id":"CHEBI:24431","label":"chemical entity"}],"annotations":[{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#SmallMolecule88","value-type":"IRI"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-ALL-70106"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-ALL-351626"},{"key":"rdfs:label","value":"H+"},{"key":"providedBy","value":"https://reactome.org"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#SmallMolecule154","value-type":"IRI"},{"key":"comment","value":"located_in extracellular region"},{"key":"date","value":"2023-06-21"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"comment","value":"located_in cytosol"},{"key":"skos:note","value":"org.biopax.paxtools.model.level3.SmallMolecule"}]},{"id":"gomodel:transported_CHEBI_15378_R-HSA-426015","type":[{"type":"class","id":"CHEBI:15378","label":"hydron"}],"root-type":[{"type":"class","id":"CHEBI:24431","label":"chemical entity"}],"annotations":[{"key":"comment","value":"located_in Golgi lumen"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-ALL-425969"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"skos:note","value":"org.biopax.paxtools.model.level3.SmallMolecule"},{"key":"comment","value":"located_in cytosol"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#SmallMolecule2049","value-type":"IRI"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-ALL-70106"},{"key":"rdfs:label","value":"H+"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#SmallMolecule88","value-type":"IRI"},{"key":"providedBy","value":"https://reactome.org"},{"key":"date","value":"2023-06-21"}]},{"id":"gomodel:transported_CHEBI_29101_R-HSA-425965","type":[{"type":"class","id":"CHEBI:29101","label":"sodium(1+)"}],"root-type":[{"type":"class","id":"CHEBI:24431","label":"chemical entity"}],"annotations":[{"key":"rdfs:label","value":"Na+"},{"key":"skos:note","value":"org.biopax.paxtools.model.level3.SmallMolecule"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-ALL-425977"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#SmallMolecule2050","value-type":"IRI"},{"key":"comment","value":"located_in late endosome lumen"},{"key":"comment","value":"located_in cytosol"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-ALL-83910"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#SmallMolecule181","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"}]},{"id":"gomodel:transported_CHEBI_29101_R-HSA-425983","type":[{"type":"class","id":"CHEBI:29101","label":"sodium(1+)"}],"root-type":[{"type":"class","id":"CHEBI:24431","label":"chemical entity"}],"annotations":[{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-ALL-83910"},{"key":"date","value":"2023-06-21"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#SmallMolecule2048","value-type":"IRI"},{"key":"comment","value":"located_in early endosome lumen"},{"key":"rdfs:label","value":"Na+"},{"key":"skos:note","value":"org.biopax.paxtools.model.level3.SmallMolecule"},{"key":"comment","value":"located_in cytosol"},{"key":"providedBy","value":"https://reactome.org"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#SmallMolecule181","value-type":"IRI"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-ALL-425971"},{"key":"contributor","value":"GOC:reactome_curators"}]},{"id":"gomodel:transported_CHEBI_29101_R-HSA-425994","type":[{"type":"class","id":"CHEBI:29101","label":"sodium(1+)"}],"root-type":[{"type":"class","id":"CHEBI:24431","label":"chemical entity"}],"annotations":[{"key":"date","value":"2023-06-21"},{"key":"comment","value":"located_in extracellular region"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#SmallMolecule159","value-type":"IRI"},{"key":"rdfs:label","value":"Na+"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-ALL-74113"},{"key":"skos:note","value":"org.biopax.paxtools.model.level3.SmallMolecule"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"comment","value":"located_in cytosol"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#SmallMolecule181","value-type":"IRI"},{"key":"providedBy","value":"https://reactome.org"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-ALL-83910"}]},{"id":"gomodel:transported_CHEBI_29101_R-HSA-426015","type":[{"type":"class","id":"CHEBI:29101","label":"sodium(1+)"}],"root-type":[{"type":"class","id":"CHEBI:24431","label":"chemical entity"}],"annotations":[{"key":"comment","value":"located_in Golgi lumen"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"skos:note","value":"org.biopax.paxtools.model.level3.SmallMolecule"},{"key":"rdfs:label","value":"Na+"},{"key":"providedBy","value":"https://reactome.org"},{"key":"date","value":"2023-06-21"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-ALL-83910"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#SmallMolecule181","value-type":"IRI"},{"key":"skos:exactMatch","value":"http://www.reactome.org/biopax/84/48887#SmallMolecule2045","value-type":"IRI"},{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"Reactome:R-ALL-425958"},{"key":"comment","value":"located_in cytosol"}]},{"id":"gomodel:R-HSA-425986/R-HSA-425986","type":[{"type":"class","id":"GO:0008150","label":"biological_process"}],"root-type":[{"type":"class","id":"GO:0008150","label":"biological_process"}],"annotations":[{"key":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","value":"R-HSA-425986"},{"key":"skos:note","value":"org.biopax.paxtools.model.level3.Pathway"},{"key":"comment","value":"The SLC9 gene family encode proteins (sodium/proton exchangers, NHE or NHX) which exchange sodium (influx) for protons (efflux) electroneutrally. This mechanism is important because many metabolic processes generate acids which need to be removed to maintain pH. This is the major proton extruding system in cells, driven by the inward sodium ion chemical gradient. To date, there are eleven NHE genes, NHE1-11. NHE1-5 exchange cations at the cell membrane. NHE6-9 exchange cations at endosomal membranes or the trans-golgi network membranes."},{"key":"date","value":"2023-06-21"},{"key":"contributor","value":"Authored: Jassal, Bijay, 2009-06-11"},{"key":"contributor","value":"Edited: Jassal, Bijay, 2009-06-11"},{"key":"rdfs:label","value":"Sodium/Proton exchangers"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"providedBy","value":"https://reactome.org"},{"key":"skos:narrower","value":"gomodel:R-HSA-425393/R-HSA-425393","value-type":"IRI"},{"key":"contributor","value":"Reviewed: He, L, 2009-08-24"}]},{"id":"gomodel:end_loc_http://purl.obolibrary.org/obo/GO_0005576_R-HSA-425994","type":[{"type":"class","id":"GO:0005576","label":"extracellular region"}],"root-type":[{"type":"class","id":"UBERON:0001062","label":"anatomical entity"},{"type":"class","id":"GO:0110165","label":"cellular anatomical structure"},{"type":"class","id":"GO:0005575","label":"cellular_component"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"}]},{"id":"gomodel:end_loc_http://purl.obolibrary.org/obo/GO_0005829_R-HSA-426015","type":[{"type":"class","id":"GO:0005829","label":"cytosol"}],"root-type":[{"type":"class","id":"UBERON:0001062","label":"anatomical entity"},{"type":"class","id":"GO:0110165","label":"cellular anatomical structure"},{"type":"class","id":"GO:0005575","label":"cellular_component"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"}]},{"id":"gomodel:end_loc_http://purl.obolibrary.org/obo/GO_0031905_R-HSA-425983","type":[{"type":"class","id":"GO:0031905","label":"early endosome lumen"}],"root-type":[{"type":"class","id":"UBERON:0001062","label":"anatomical entity"},{"type":"class","id":"GO:0110165","label":"cellular anatomical structure"},{"type":"class","id":"GO:0005575","label":"cellular_component"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"}]},{"id":"gomodel:end_loc_http://purl.obolibrary.org/obo/GO_0031906_R-HSA-425965","type":[{"type":"class","id":"GO:0031906","label":"late endosome lumen"}],"root-type":[{"type":"class","id":"UBERON:0001062","label":"anatomical entity"},{"type":"class","id":"GO:0110165","label":"cellular anatomical structure"},{"type":"class","id":"GO:0005575","label":"cellular_component"}],"annotations":[{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"}]},{"id":"gomodel:ev_w_id_R-HSA-425965_BFO_0000050_R-HSA-425986/R-HSA-425986_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"source","value":"Reactome:R-HSA-425986"}]},{"id":"gomodel:ev_w_id_R-HSA-425965_RO_0002338_start_loc_http://purl.obolibrary.org/obo/GO_0005829_R-HSA-425965_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000363","label":"computational inference used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"source","value":"Reactome:R-HSA-425986"}]},{"id":"gomodel:ev_w_id_R-HSA-425965_RO_0002339_end_loc_http://purl.obolibrary.org/obo/GO_0031906_R-HSA-425965_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000363","label":"computational inference used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"source","value":"Reactome:R-HSA-425986"}]},{"id":"gomodel:ev_w_id_R-HSA-425983_BFO_0000050_R-HSA-425986/R-HSA-425986_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"Reactome:R-HSA-425986"},{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"}]},{"id":"gomodel:ev_w_id_R-HSA-425983_RO_0002338_start_loc_http://purl.obolibrary.org/obo/GO_0005829_R-HSA-425983_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000363","label":"computational inference used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"Reactome:R-HSA-425986"},{"key":"providedBy","value":"https://reactome.org"},{"key":"date","value":"2023-06-21"},{"key":"contributor","value":"GOC:reactome_curators"}]},{"id":"gomodel:ev_w_id_R-HSA-425983_RO_0002339_end_loc_http://purl.obolibrary.org/obo/GO_0031905_R-HSA-425983_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000363","label":"computational inference used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"source","value":"Reactome:R-HSA-425986"}]},{"id":"gomodel:ev_w_id_R-HSA-425994_BFO_0000050_R-HSA-425986/R-HSA-425986_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"Reactome:R-HSA-425986"},{"key":"date","value":"2023-06-21"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"providedBy","value":"https://reactome.org"}]},{"id":"gomodel:ev_w_id_R-HSA-425994_RO_0002338_start_loc_http://purl.obolibrary.org/obo/GO_0005829_R-HSA-425994_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000363","label":"computational inference used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2023-06-21"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"providedBy","value":"https://reactome.org"},{"key":"source","value":"Reactome:R-HSA-425986"}]},{"id":"gomodel:ev_w_id_R-HSA-425994_RO_0002339_end_loc_http://purl.obolibrary.org/obo/GO_0005576_R-HSA-425994_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000363","label":"computational inference used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"source","value":"Reactome:R-HSA-425986"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"}]},{"id":"gomodel:ev_w_id_R-HSA-426015_BFO_0000050_R-HSA-425986/R-HSA-425986_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000313","label":"imported information used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"date","value":"2023-06-21"},{"key":"source","value":"Reactome:R-HSA-425986"},{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"}]},{"id":"gomodel:ev_w_id_R-HSA-426015_RO_0002338_start_loc_http://purl.obolibrary.org/obo/GO_0005796_R-HSA-426015_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000363","label":"computational inference used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"source","value":"Reactome:R-HSA-425986"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"}]},{"id":"gomodel:ev_w_id_R-HSA-426015_RO_0002339_end_loc_http://purl.obolibrary.org/obo/GO_0005829_R-HSA-426015_Reactome_R-HSA-425986","type":[{"type":"class","id":"ECO:0000363","label":"computational inference used in automatic assertion"}],"root-type":[{"type":"class","id":"ECO:0000000","label":"evidence"}],"annotations":[{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"source","value":"Reactome:R-HSA-425986"}]},{"id":"gomodel:start_loc_http://purl.obolibrary.org/obo/GO_0005796_R-HSA-426015","type":[{"type":"class","id":"GO:0005796","label":"Golgi lumen"}],"root-type":[{"type":"class","id":"UBERON:0001062","label":"anatomical entity"},{"type":"class","id":"GO:0110165","label":"cellular anatomical structure"},{"type":"class","id":"GO:0005575","label":"cellular_component"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"date","value":"2023-06-21"},{"key":"contributor","value":"GOC:reactome_curators"}]},{"id":"gomodel:start_loc_http://purl.obolibrary.org/obo/GO_0005829_R-HSA-425965","type":[{"type":"class","id":"GO:0005829","label":"cytosol"}],"root-type":[{"type":"class","id":"UBERON:0001062","label":"anatomical entity"},{"type":"class","id":"GO:0110165","label":"cellular anatomical structure"},{"type":"class","id":"GO:0005575","label":"cellular_component"}],"annotations":[{"key":"providedBy","value":"https://reactome.org"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"}]},{"id":"gomodel:start_loc_http://purl.obolibrary.org/obo/GO_0005829_R-HSA-425983","type":[{"type":"class","id":"GO:0005829","label":"cytosol"}],"root-type":[{"type":"class","id":"UBERON:0001062","label":"anatomical entity"},{"type":"class","id":"GO:0110165","label":"cellular anatomical structure"},{"type":"class","id":"GO:0005575","label":"cellular_component"}],"annotations":[{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"}]},{"id":"gomodel:start_loc_http://purl.obolibrary.org/obo/GO_0005829_R-HSA-425994","type":[{"type":"class","id":"GO:0005829","label":"cytosol"}],"root-type":[{"type":"class","id":"UBERON:0001062","label":"anatomical entity"},{"type":"class","id":"GO:0110165","label":"cellular anatomical structure"},{"type":"class","id":"GO:0005575","label":"cellular_component"}],"annotations":[{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"}]}],"facts":[{"subject":"gomodel:R-HSA-425965","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:R-HSA-425986/R-HSA-425986","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425965_BFO_0000050_R-HSA-425986/R-HSA-425986_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"}]},{"subject":"gomodel:R-HSA-425994","property":"RO:0004009","property-label":"RO:0004009","object":"gomodel:transported_CHEBI_29101_R-HSA-425994","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425994_RO_0004009_transported_CHEBI_29101_R-HSA-425994_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"}]},{"subject":"gomodel:R-HSA-426015","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:R-HSA-425986/R-HSA-425986","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-426015_BFO_0000050_R-HSA-425986/R-HSA-425986_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"}]},{"subject":"gomodel:R-HSA-425983","property":"RO:0002338","property-label":"RO:0002338","object":"gomodel:start_loc_http://purl.obolibrary.org/obo/GO_0005829_R-HSA-425983","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425983_RO_0002338_start_loc_http://purl.obolibrary.org/obo/GO_0005829_R-HSA-425983_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"},{"key":"comment","value":"This relation was inferred because something that was an input to the reaction started out in the target location null and then, as a consequence of the reaction/process was transported to null"}]},{"subject":"gomodel:R-HSA-425965","property":"RO:0002338","property-label":"RO:0002338","object":"gomodel:start_loc_http://purl.obolibrary.org/obo/GO_0005829_R-HSA-425965","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425965_RO_0002338_start_loc_http://purl.obolibrary.org/obo/GO_0005829_R-HSA-425965_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"},{"key":"comment","value":"This relation was inferred because something that was an input to the reaction started out in the target location null and then, as a consequence of the reaction/process was transported to null"}]},{"subject":"gomodel:R-HSA-426015","property":"RO:0004009","property-label":"RO:0004009","object":"gomodel:transported_CHEBI_29101_R-HSA-426015","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-426015_RO_0004009_transported_CHEBI_29101_R-HSA-426015_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"}]},{"subject":"gomodel:R-HSA-425983","property":"RO:0004009","property-label":"RO:0004009","object":"gomodel:transported_CHEBI_15378_R-HSA-425983","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425983_RO_0004009_transported_CHEBI_15378_R-HSA-425983_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"}]},{"subject":"gomodel:R-HSA-426015","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:R-HSA-426005_R-HSA-426015_controller","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-426015_RO_0002333_R-HSA-426005_R-HSA-426015_controller_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-426015_RO_0002333_R-HSA-426005_R-HSA-426015_controller_Reactome_R-HSA-426015","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"}]},{"subject":"gomodel:R-HSA-425983","property":"RO:0004009","property-label":"RO:0004009","object":"gomodel:transported_CHEBI_29101_R-HSA-425983","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425983_RO_0004009_transported_CHEBI_29101_R-HSA-425983_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"}]},{"subject":"gomodel:R-HSA-425994","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:R-HSA-425963_R-HSA-425994_controller","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425994_RO_0002333_R-HSA-425963_R-HSA-425994_controller_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425994_RO_0002333_R-HSA-425963_R-HSA-425994_controller_Reactome_R-HSA-425994","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"}]},{"subject":"gomodel:R-HSA-425994","property":"RO:0004009","property-label":"RO:0004009","object":"gomodel:transported_CHEBI_15378_R-HSA-425994","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425994_RO_0004009_transported_CHEBI_15378_R-HSA-425994_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"}]},{"subject":"gomodel:R-HSA-425965","property":"BFO:0000066","property-label":"BFO:0000066","object":"gomodel:reaction_R-HSA-425965_location_lociGO_0031902","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425965_BFO_0000066_reaction_R-HSA-425965_location_lociGO_0031902_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"},{"key":"comment","value":"Occurs In Rule. This relation was asserted based on the location of the enabling molecule. "}]},{"subject":"gomodel:R-HSA-426015","property":"RO:0004009","property-label":"RO:0004009","object":"gomodel:transported_CHEBI_15378_R-HSA-426015","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-426015_RO_0004009_transported_CHEBI_15378_R-HSA-426015_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"}]},{"subject":"gomodel:R-HSA-426015","property":"RO:0002338","property-label":"RO:0002338","object":"gomodel:start_loc_http://purl.obolibrary.org/obo/GO_0005796_R-HSA-426015","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-426015_RO_0002338_start_loc_http://purl.obolibrary.org/obo/GO_0005796_R-HSA-426015_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"},{"key":"comment","value":"This relation was inferred because something that was an input to the reaction started out in the target location null and then, as a consequence of the reaction/process was transported to null"}]},{"subject":"gomodel:R-HSA-425994","property":"BFO:0000066","property-label":"BFO:0000066","object":"gomodel:reaction_R-HSA-425994_location_lociGO_0005886","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425994_BFO_0000066_reaction_R-HSA-425994_location_lociGO_0005886_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"},{"key":"comment","value":"Occurs In Rule. This relation was asserted based on the location of the enabling molecule. "}]},{"subject":"gomodel:R-HSA-425965","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:R-HSA-425972_R-HSA-425965_controller","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425965_RO_0002333_R-HSA-425972_R-HSA-425965_controller_Reactome_R-HSA-425965","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425965_RO_0002333_R-HSA-425972_R-HSA-425965_controller_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"}]},{"subject":"gomodel:R-HSA-426015","property":"BFO:0000066","property-label":"BFO:0000066","object":"gomodel:reaction_R-HSA-426015_location_lociGO_0000139","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-426015_BFO_0000066_reaction_R-HSA-426015_location_lociGO_0000139_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"},{"key":"comment","value":"Occurs In Rule. This relation was asserted based on the location of the enabling molecule. "}]},{"subject":"gomodel:R-HSA-426015","property":"RO:0002339","property-label":"RO:0002339","object":"gomodel:end_loc_http://purl.obolibrary.org/obo/GO_0005829_R-HSA-426015","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-426015_RO_0002339_end_loc_http://purl.obolibrary.org/obo/GO_0005829_R-HSA-426015_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"},{"key":"comment","value":"This relation was inferred because something that was an input to the reaction started in null and then, as a consequence of the reaction/process was transported to the target end location null"}]},{"subject":"gomodel:R-HSA-425994","property":"RO:0002339","property-label":"RO:0002339","object":"gomodel:end_loc_http://purl.obolibrary.org/obo/GO_0005576_R-HSA-425994","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425994_RO_0002339_end_loc_http://purl.obolibrary.org/obo/GO_0005576_R-HSA-425994_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"},{"key":"comment","value":"This relation was inferred because something that was an input to the reaction started in null and then, as a consequence of the reaction/process was transported to the target end location null"}]},{"subject":"gomodel:R-HSA-425994","property":"RO:0002338","property-label":"RO:0002338","object":"gomodel:start_loc_http://purl.obolibrary.org/obo/GO_0005829_R-HSA-425994","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425994_RO_0002338_start_loc_http://purl.obolibrary.org/obo/GO_0005829_R-HSA-425994_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"},{"key":"comment","value":"This relation was inferred because something that was an input to the reaction started out in the target location null and then, as a consequence of the reaction/process was transported to null"}]},{"subject":"gomodel:R-HSA-425965","property":"RO:0004009","property-label":"RO:0004009","object":"gomodel:transported_CHEBI_15378_R-HSA-425965","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425965_RO_0004009_transported_CHEBI_15378_R-HSA-425965_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"}]},{"subject":"gomodel:R-HSA-425965","property":"RO:0002339","property-label":"RO:0002339","object":"gomodel:end_loc_http://purl.obolibrary.org/obo/GO_0031906_R-HSA-425965","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425965_RO_0002339_end_loc_http://purl.obolibrary.org/obo/GO_0031906_R-HSA-425965_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"},{"key":"comment","value":"This relation was inferred because something that was an input to the reaction started in null and then, as a consequence of the reaction/process was transported to the target end location null"}]},{"subject":"gomodel:R-HSA-425983","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:R-HSA-425986/R-HSA-425986","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425983_BFO_0000050_R-HSA-425986/R-HSA-425986_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"}]},{"subject":"gomodel:R-HSA-425983","property":"RO:0002339","property-label":"RO:0002339","object":"gomodel:end_loc_http://purl.obolibrary.org/obo/GO_0031905_R-HSA-425983","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425983_RO_0002339_end_loc_http://purl.obolibrary.org/obo/GO_0031905_R-HSA-425983_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"},{"key":"comment","value":"This relation was inferred because something that was an input to the reaction started in null and then, as a consequence of the reaction/process was transported to the target end location null"}]},{"subject":"gomodel:R-HSA-425965","property":"RO:0004009","property-label":"RO:0004009","object":"gomodel:transported_CHEBI_29101_R-HSA-425965","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425965_RO_0004009_transported_CHEBI_29101_R-HSA-425965_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"}]},{"subject":"gomodel:R-HSA-425983","property":"RO:0002333","property-label":"RO:0002333","object":"gomodel:R-HSA-4084678_R-HSA-425983_controller","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425983_RO_0002333_R-HSA-4084678_R-HSA-425983_controller_Reactome_R-HSA-425983","value-type":"IRI"},{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425983_RO_0002333_R-HSA-4084678_R-HSA-425983_controller_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"}]},{"subject":"gomodel:R-HSA-425994","property":"BFO:0000050","property-label":"BFO:0000050","object":"gomodel:R-HSA-425986/R-HSA-425986","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425994_BFO_0000050_R-HSA-425986/R-HSA-425986_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"}]},{"subject":"gomodel:R-HSA-425983","property":"BFO:0000066","property-label":"BFO:0000066","object":"gomodel:reaction_R-HSA-425983_location_lociGO_0031901","annotations":[{"key":"evidence","value":"gomodel:ev_w_id_R-HSA-425983_BFO_0000066_reaction_R-HSA-425983_location_lociGO_0031901_Reactome_R-HSA-425986","value-type":"IRI"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"},{"key":"comment","value":"Occurs In Rule. This relation was asserted based on the location of the enabling molecule. "}]}],"annotations":[{"key":"state","value":"development"},{"key":"contributor","value":"GOC:reactome_curators"},{"key":"date","value":"2023-06-21"},{"key":"title","value":"Sodium/Proton exchangers - imported from: Reactome"},{"key":"providedBy","value":"https://reactome.org"},{"key":"comment","value":"For logical inference, import the integrated tbox ontology http://purl.obolibrary.org/obo/go/extensions/go-lego-reacto.owl"},{"key":"comment","value":"Imported from Reactome: https://reactome.org/content/detail/R-HSA-425986"},{"key":"comment","value":"http://www.reactome.org"},{"key":"https://w3id.org/biolink/vocab/in_taxon","value":"NCBITaxon:9606","value-type":"IRI"}]}